An intrinsically disordered APLF links Ku, DNA-PKcs, and XRCC4-DNA ligase IV in an extended flexible non-homologous end joining complex

Journal of Biological Chemistry

Volumn 291, Issue 53, 2016, Pages 26987-27006

  Hammel, Michal ^a   Yu, Yaping ^b   Radhakrishnan, Sarvan K ^b   Chokshi, Chirayu ^a   Tsai, Miaw Sheue ^a   Matsumoto, Yoshihiro ^c   Kuzdovich, Monica ^a   Remesh, Soumya G ^a   Fang, Shujuan ^b   Tomkinson, Alan E ^c   Lees Miller, Susan P ^b   Tainer, John A ^a,d  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; CHROMOSOMES; ENZYMES; JOINING; NUCLEIC ACIDS; PHOSPHORYLATION; PROTEINS; X RAY SCATTERING;

CO-OPERATIVE ASSEMBLY; DNA DOUBLE STRAND BREAKS; DNA-DEPENDENT PROTEIN KINASE; EVOLUTIONARY CONSERVATIONS; INTRINSICALLY DISORDERED PROTEINS; MUTATIONAL ANALYSIS; NONHOMOLOGOUS END JOINING; SOLUTION ARCHITECTURES;

DNA;

DNA LIGASE; DOUBLE STRANDED RNA; KU ANTIGEN; UNCLASSIFIED DRUG; XRCC4 PROTEIN; XRCCA4 DNA LIGASE IV; APLF PROTEIN, HUMAN; ATP DEPENDENT DNA LIGASE; CROSS LINKING REAGENT; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA BINDING PROTEIN; DNA DEPENDENT PROTEIN KINASE; LIG4 PROTEIN, HUMAN; NUCLEAR PROTEIN; PRKDC PROTEIN, HUMAN; PROTEIN BINDING; XRCC4 PROTEIN, HUMAN; XRCC5 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; CHROMATIN; CONTROLLED STUDY; EUKARYOTE; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RADIATION SCATTERING; CHEMISTRY; DNA END JOINING REPAIR; DOUBLE STRANDED DNA BREAK; GENETICS; HELA CELL LINE; IMMUNOPRECIPITATION; METABOLISM; MOLECULAR MODEL; PHOSPHORYLATION; PROTEIN CONFORMATION; SMALL ANGLE SCATTERING; WESTERN BLOTTING; X RAY DIFFRACTION;

BLOTTING, WESTERN; CROSS-LINKING REAGENTS; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; DNA LIGASE ATP; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; IMMUNOPRECIPITATION; KU AUTOANTIGEN; MODELS, MOLECULAR; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; SCATTERING, SMALL ANGLE; X-RAY DIFFRACTION;

EID: 85007590861     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.751867     Document Type: Article

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