메뉴 건너뛰기




Volumn 31, Issue , 2017, Pages 339-356

Role of neuro-immunological factors in the pathophysiology of mood disorders: Implications for novel therapeutics for treatment resistant depression

Author keywords

Depression; IL 1 ; IL 6; Microglia; Mood disorders; Neuroimmunology; Neuroinflammation; P2X7; TNF

Indexed keywords

GLUCOCORTICOID RECEPTOR ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PROSTAGLANDIN E2; QUINOLINIC ACID; TUMOR NECROSIS FACTOR; CYTOKINE;

EID: 85007518913     PISSN: 18663370     EISSN: 18663389     Source Type: Book Series    
DOI: 10.1007/7854_2016_43     Document Type: Chapter
Times cited : (43)

References (113)
  • 1
    • 0037831023 scopus 로고    scopus 로고
    • The epidemiology of major depressive disorder: Results from the National Comorbidity Survey Replication (NCS-R)
    • National Comorbidity Survey Replication
    • Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, Rush AJ, Walters EE, Wang PS, National Comorbidity Survey Replication (2003) The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 289:3095–3105
    • (2003) JAMA , vol.289 , pp. 3095-3105
    • Kessler, R.C.1    Berglund, P.2    Demler, O.3    Jin, R.4    Koretz, D.5    Merikangas, K.R.6    Rush, A.J.7    Walters, E.E.8    Wang, P.S.9
  • 2
    • 84922075404 scopus 로고    scopus 로고
    • Faster, better, stronger: Towards new antidepressant therapeutic strategies
    • O’Leary OF, Dinan TG, Cryan JF (2015) Faster, better, stronger: towards new antidepressant therapeutic strategies. Eur J Pharmacol 753:32–50
    • (2015) Eur J Pharmacol , vol.753 , pp. 32-50
    • O’Leary, O.F.1    Dinan, T.G.2    Cryan, J.F.3
  • 3
    • 84942552433 scopus 로고    scopus 로고
    • Towards new mechanisms: An update on therapeutics for treatment-resistant major depressive disorder
    • Papakostas GI, Ionescu DF (2015) Towards new mechanisms: an update on therapeutics for treatment-resistant major depressive disorder. Mol Psychiatry 20:1142–1150
    • (2015) Mol Psychiatry , vol.20 , pp. 1142-1150
    • Papakostas, G.I.1    Ionescu, D.F.2
  • 7
    • 33845213789 scopus 로고    scopus 로고
    • Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy
    • O’Brien SM, Scully P, Fitzgerald P, Scott LV, Dinan TG (2007) Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy. J Psychiatric Res 41:326–331
    • (2007) J Psychiatric Res , vol.41 , pp. 326-331
    • O’Brien, S.M.1    Scully, P.2    Fitzgerald, P.3    Scott, L.V.4    Dinan, T.G.5
  • 10
    • 84945254083 scopus 로고    scopus 로고
    • Neuroscience, mental health and the immune system: Overcoming the brain-mind-body trichotomy
    • Pariante CM (2016) Neuroscience, mental health and the immune system: overcoming the brain-mind-body trichotomy. Epidemiol Psychiatr Sci 25(2):101–105
    • (2016) Epidemiol Psychiatr Sci , vol.25 , Issue.2 , pp. 101-105
    • Pariante, C.M.1
  • 11
    • 84973595854 scopus 로고    scopus 로고
    • Integrating neuroimmune systems in the neurobiology of depression
    • Wohleb ES, Franklin T, Iwata M, Duman RS (2016) Integrating neuroimmune systems in the neurobiology of depression. Nat Rev Neurosci 17:497–511
    • (2016) Nat Rev Neurosci , vol.17 , pp. 497-511
    • Wohleb, E.S.1    Franklin, T.2    Iwata, M.3    Duman, R.S.4
  • 13
    • 84949292691 scopus 로고    scopus 로고
    • Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances
    • Haapakoski R, Ebmeier KP, Alenius H, Kivimaki M (2016) Innate and adaptive immunity in the development of depression: an update on current knowledge and technological advances. Prog Neuropsychopharmacol Biol Psychiatry 66:63–72
    • (2016) Prog Neuropsychopharmacol Biol Psychiatry , vol.66 , pp. 63-72
    • Haapakoski, R.1    Ebmeier, K.P.2    Alenius, H.3    Kivimaki, M.4
  • 14
    • 84925945862 scopus 로고    scopus 로고
    • The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders
    • Morris G, Berk M (2015) The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders. BMC Med 13:68
    • (2015) BMC Med , vol.13 , pp. 68
    • Morris, G.1    Berk, M.2
  • 16
    • 84929379817 scopus 로고    scopus 로고
    • Anti-inflammatory intervention in depression--reply
    • Kohler O, Benros ME, Krogh J (2015) Anti-inflammatory intervention in depression--reply. JAMA Psychiatry 72:512–513
    • (2015) JAMA Psychiatry , vol.72 , pp. 512-513
    • Kohler, O.1    Benros, M.E.2    Krogh, J.3
  • 19
    • 84942518278 scopus 로고    scopus 로고
    • Revisiting the mechanisms of CNS immune privilege
    • Louveau A, Harris TH, Kipnis J (2015) Revisiting the mechanisms of CNS immune privilege. Trends Immunol 36:569–577
    • (2015) Trends Immunol , vol.36 , pp. 569-577
    • Louveau, A.1    Harris, T.H.2    Kipnis, J.3
  • 20
    • 78651412528 scopus 로고    scopus 로고
    • Immune modulation of learning, memory, neural plasticity and neurogenesis
    • Yirmiya R, Goshen I (2011) Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav Immun 25:181–213
    • (2011) Brain Behav Immun , vol.25 , pp. 181-213
    • Yirmiya, R.1    Goshen, I.2
  • 22
    • 84878138965 scopus 로고    scopus 로고
    • Inflammation and neurological diseaserelated genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities
    • Savitz J, Frank MB, Victor T, Bebak M, Marino JH, Bellgowan PS, McKinney BA, Bodurka J, Kent Teague T, Drevets WC (2013) Inflammation and neurological diseaserelated genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities. Brain Behav Immun 31:161–171
    • (2013) Brain Behav Immun , vol.31 , pp. 161-171
    • Savitz, J.1    Frank, M.B.2    Victor, T.3    Bebak, M.4    Marino, J.H.5    Bellgowan, P.S.6    McKinney, B.A.7    Bodurka, J.8    Kent Teague, T.9    Drevets, W.C.10
  • 23
    • 64549126898 scopus 로고    scopus 로고
    • Bipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide
    • Savitz J, Drevets WC (2009) Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide. Neurosci Biobehav Rev 33:699–771
    • (2009) Neurosci Biobehav Rev , vol.33 , pp. 699-771
    • Savitz, J.1    Drevets, W.C.2
  • 24
    • 84877704720 scopus 로고    scopus 로고
    • Genetics of bipolar disorder
    • Craddock N, Sklar P (2013) Genetics of bipolar disorder. Lancet 381:1654–1662
    • (2013) Lancet , vol.381 , pp. 1654-1662
    • Craddock, N.1    Sklar, P.2
  • 27
    • 79953662385 scopus 로고    scopus 로고
    • Immune system to brain signaling: Neuropsychopharmacological implications
    • Capuron L, Miller AH (2011) Immune system to brain signaling: neuropsychopharmacological implications. Pharmacol Ther 130:226–238
    • (2011) Pharmacol Ther , vol.130 , pp. 226-238
    • Capuron, L.1    Miller, A.H.2
  • 28
    • 85014119974 scopus 로고    scopus 로고
    • Monocyte trafficking to the brain with stress and inflammation: A novel axis of immune-to-brain communication that influences mood and behavior
    • Wohleb ES, McKim DB, Sheridan JF, Godbout JP (2014) Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior. Front Neurosci 8:447
    • (2014) Front Neurosci , vol.8 , pp. 447
    • Wohleb, E.S.1    McKim, D.B.2    Sheridan, J.F.3    Godbout, J.P.4
  • 31
    • 84942524460 scopus 로고    scopus 로고
    • Microglia: Dynamic mediators of synapse development and plasticity
    • Wu Y, Dissing-Olesen L, MacVicar BA, Stevens B (2015) Microglia: dynamic mediators of synapse development and plasticity. Trends Immunol 36:605–613
    • (2015) Trends Immunol , vol.36 , pp. 605-613
    • Wu, Y.1    Dissing-Olesen, L.2    Macvicar, B.A.3    Stevens, B.4
  • 32
    • 77956231165 scopus 로고    scopus 로고
    • Glia: The many ways to modulate synaptic plasticity
    • Ben Achour S, Pascual O (2010) Glia: the many ways to modulate synaptic plasticity. Neurochem Int 57:440–445
    • (2010) Neurochem Int , vol.57 , pp. 440-445
    • Ben Achour, S.1    Pascual, O.2
  • 33
    • 84957436714 scopus 로고    scopus 로고
    • Microglial M1/M2 polarization and metabolic states
    • Orihuela R, McPherson CA, Harry GJ (2016) Microglial M1/M2 polarization and metabolic states. Br J Pharmacol 173(4):649–665
    • (2016) Br J Pharmacol , vol.173 , Issue.4 , pp. 649-665
    • Orihuela, R.1    McPherson, C.A.2    Harry, G.J.3
  • 34
    • 84979730436 scopus 로고    scopus 로고
    • A polarizing question: Do M1 and M2 microglia exist?
    • Ransohoff RM (2016) A polarizing question: do M1 and M2 microglia exist? Nat Neurosci 19:987–991
    • (2016) Nat Neurosci , vol.19 , pp. 987-991
    • Ransohoff, R.M.1
  • 35
    • 84958106930 scopus 로고    scopus 로고
    • Differential roles of M1 and M2 microglia in neurodegenerative diseases
    • Tang Y, Le W (2015) Differential roles of M1 and M2 microglia in neurodegenerative diseases. Mol Neurobiol 53(2):1181–1194
    • (2015) Mol Neurobiol , vol.53 , Issue.2 , pp. 1181-1194
    • Tang, Y.1    Le, W.2
  • 36
    • 84902549638 scopus 로고    scopus 로고
    • Neuroinflammation and M2 microglia: The good, the bad, and the inflamed
    • Cherry JD, Olschowka JA, O’Banion MK (2014) Neuroinflammation and M2 microglia: the good, the bad, and the inflamed. J Neuroinflammation 11:98
    • (2014) J Neuroinflammation , vol.11 , pp. 98
    • Cherry, J.D.1    Olschowka, J.A.2    O’Banion, M.K.3
  • 37
    • 84899418705 scopus 로고    scopus 로고
    • Microglia and brain macrophages in the molecular age: From origin to neuropsychiatric disease
    • Prinz M, Priller J (2014) Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. Nat Rev Neurosci 15:300–312
    • (2014) Nat Rev Neurosci , vol.15 , pp. 300-312
    • Prinz, M.1    Priller, J.2
  • 39
    • 84872168596 scopus 로고    scopus 로고
    • Microglia: Scapegoat, saboteur, or something else?
    • Aguzzi A, Barres BA, Bennett ML (2013) Microglia: scapegoat, saboteur, or something else? Science 339:156–161
    • (2013) Science , vol.339 , pp. 156-161
    • Aguzzi, A.1    Barres, B.A.2    Bennett, M.L.3
  • 40
    • 84858025498 scopus 로고    scopus 로고
    • The role of glial cells in synapse elimination
    • Chung WS, Barres BA (2012) The role of glial cells in synapse elimination. Curr Opin Neurobiol 22:438–445
    • (2012) Curr Opin Neurobiol , vol.22 , pp. 438-445
    • Chung, W.S.1    Barres, B.A.2
  • 43
  • 46
    • 2542596271 scopus 로고    scopus 로고
    • T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions
    • Kipnis J, Cohen H, Cardon M, Ziv Y, Schwartz M (2004) T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions. Proc Natl Acad Sci U S A 101:8180–8185
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8180-8185
    • Kipnis, J.1    Cohen, H.2    Cardon, M.3    Ziv, Y.4    Schwartz, M.5
  • 49
    • 84893115383 scopus 로고    scopus 로고
    • Innate immunity to Toxoplasma gondii infection
    • Yarovinsky F (2014) Innate immunity to Toxoplasma gondii infection. Nat Rev Immunol 14:109–121
    • (2014) Nat Rev Immunol , vol.14 , pp. 109-121
    • Yarovinsky, F.1
  • 50
    • 0033049143 scopus 로고    scopus 로고
    • Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
    • Moalem G, Leibowitz-Amit R, Yoles E, Mor F, Cohen IR, Schwartz M (1999) Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med 5:49–55
    • (1999) Nat Med , vol.5 , pp. 49-55
    • Moalem, G.1    Leibowitz-Amit, R.2    Yoles, E.3    Mor, F.4    Cohen, I.R.5    Schwartz, M.6
  • 52
    • 0036708987 scopus 로고    scopus 로고
    • Myelin specific Th1 cells are necessary for post-traumatic protective autoimmunity
    • Kipnis J, Mizrahi T, Yoles E, Ben-Nun A, Schwartz M (2002) Myelin specific Th1 cells are necessary for post-traumatic protective autoimmunity. J Neuroimmunol 130:78–85
    • (2002) J Neuroimmunol , vol.130 , pp. 78-85
    • Kipnis, J.1    Mizrahi, T.2    Yoles, E.3    Ben-Nun, A.4    Schwartz, M.5
  • 54
    • 85007557181 scopus 로고    scopus 로고
    • Role of the Kynurenine metabolism pathway in inflammation-induced depression: Preclinical approaches
    • Dantzer R (2016) Role of the Kynurenine metabolism pathway in inflammation-induced depression: preclinical approaches. Curr Top Behav Neurosci. doi:10.1007/7854_2016_6
    • (2016) Curr Top Behav Neurosci
    • Dantzer, R.1
  • 56
  • 57
    • 0033794577 scopus 로고    scopus 로고
    • Characterization of binding sites for chemokines MCP-1 and MIP-1alpha on human brain microvessels
    • Andjelkovic AV, Pachter JS (2000) Characterization of binding sites for chemokines MCP-1 and MIP-1alpha on human brain microvessels. J Neurochem 75:1898–1906
    • (2000) J Neurochem , vol.75 , pp. 1898-1906
    • Andjelkovic, A.V.1    Pachter, J.S.2
  • 63
    • 84873279865 scopus 로고    scopus 로고
    • The role of the innate immune system in psychiatric disorders
    • Jones KA, Thomsen C (2013) The role of the innate immune system in psychiatric disorders. Mol Cell Neurosci 53:52–62
    • (2013) Mol Cell Neurosci , vol.53 , pp. 52-62
    • Jones, K.A.1    Thomsen, C.2
  • 64
    • 70449376943 scopus 로고    scopus 로고
    • Cytokines and glucocorticoid receptor signaling. Relevance to major depression
    • Pace TW, Miller AH (2009) Cytokines and glucocorticoid receptor signaling. Relevance to major depression. Ann N Y Acad Sci 1179:86–105
    • (2009) Ann N Y Acad Sci , vol.1179 , pp. 86-105
    • Pace, T.W.1    Miller, A.H.2
  • 66
    • 84906331370 scopus 로고    scopus 로고
    • A review of the relationship between proinflammatory cytokines and major depressive disorder
    • Young JJ, Bruno D, Pomara N (2014) A review of the relationship between proinflammatory cytokines and major depressive disorder. J Affect Disord 169:15–20
    • (2014) J Affect Disord , vol.169 , pp. 15-20
    • Young, J.J.1    Bruno, D.2    Pomara, N.3
  • 67
    • 84893345725 scopus 로고    scopus 로고
    • Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder
    • Carvalho LA, Bergink V, Sumaski L, Wijkhuijs J, Hoogendijk WJ, Birkenhager TK, Drexhage HA (2014) Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder. Transl Psychiatry 4:e344
    • (2014) Transl Psychiatry , vol.4
    • Carvalho, L.A.1    Bergink, V.2    Sumaski, L.3    Wijkhuijs, J.4    Hoogendijk, W.J.5    Birkenhager, T.K.6    Drexhage, H.A.7
  • 71
    • 80054745701 scopus 로고    scopus 로고
    • The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: A meta-analysis
    • Hannestad J, DellaGioia N, Bloch M (2011) The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis. Neuropsychopharmacology 36:2452–2459
    • (2011) Neuropsychopharmacology , vol.36 , pp. 2452-2459
    • Hannestad, J.1    Dellagioia, N.2    Bloch, M.3
  • 72
    • 84863718439 scopus 로고    scopus 로고
    • Symptomatic treatment of interferonalpha-induced depression in hepatitis C: A systematic review
    • Baraldi S, Hepgul N, Mondelli V, Pariante CM (2012) Symptomatic treatment of interferonalpha-induced depression in hepatitis C: a systematic review. J Clin Psychopharmacol 32:531–543
    • (2012) J Clin Psychopharmacol , vol.32 , pp. 531-543
    • Baraldi, S.1    Hepgul, N.2    Mondelli, V.3    Pariante, C.M.4
  • 74
    • 63449122724 scopus 로고    scopus 로고
    • Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression
    • Miller AH, Maletic V, Raison CL (2009) Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 65:732–741
    • (2009) Biol Psychiatry , vol.65 , pp. 732-741
    • Miller, A.H.1    Maletic, V.2    Raison, C.L.3
  • 75
    • 70349734652 scopus 로고    scopus 로고
    • Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals?
    • Capuron L, Fornwalt FB, Knight BT, Harvey PD, Ninan PT, Miller AH (2009) Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals? J Affect Disord 119:181–185
    • (2009) J Affect Disord , vol.119 , pp. 181-185
    • Capuron, L.1    Fornwalt, F.B.2    Knight, B.T.3    Harvey, P.D.4    Ninan, P.T.5    Miller, A.H.6
  • 76
    • 48949116081 scopus 로고    scopus 로고
    • Differences in depressive thoughts between major depressive disorder, IFN-alpha-induced depression, and depressive disorders among cancer patients
    • Pasquini M, Speca A, Mastroeni S, Delle Chiaie R, Sternberg CN, Biondi M (2008) Differences in depressive thoughts between major depressive disorder, IFN-alpha-induced depression, and depressive disorders among cancer patients. J Psychosom Res 65:153–156
    • (2008) J Psychosom Res , vol.65 , pp. 153-156
    • Pasquini, M.1    Speca, A.2    Mastroeni, S.3    Delle Chiaie, R.4    Sternberg, C.N.5    Biondi, M.6
  • 78
    • 84920365937 scopus 로고    scopus 로고
    • Prophylactic antidepressant treatment of interferon-induced depression in chronic hepatitis C: A systematic review and meta-analysis
    • Udina M, Hidalgo D, Navines R, Forns X, Sola R, Farre M, Capuron L, Vieta E, Martin-Santos R (2014) Prophylactic antidepressant treatment of interferon-induced depression in chronic hepatitis C: a systematic review and meta-analysis. J Clin Psychiatry 75:e1113–e1121
    • (2014) J Clin Psychiatry , vol.75 , pp. e1113-e1121
    • Udina, M.1    Hidalgo, D.2    Navines, R.3    Forns, X.4    Sola, R.5    Farre, M.6    Capuron, L.7    Vieta, E.8    Martin-Santos, R.9
  • 86
    • 36148988466 scopus 로고    scopus 로고
    • Effects of etanercept therapy on fatigue and symptoms of depression in subjects treated for moderate to severe plaque psoriasis for up to 96 weeks
    • Krishnan R, Cella D, Leonardi C, Papp K, Gottlieb AB, Dunn M, Chiou CF, Patel V, Jahreis A (2007) Effects of etanercept therapy on fatigue and symptoms of depression in subjects treated for moderate to severe plaque psoriasis for up to 96 weeks. Br J Dermatol 157:1275–1277
    • (2007) Br J Dermatol , vol.157 , pp. 1275-1277
    • Krishnan, R.1    Cella, D.2    Leonardi, C.3    Papp, K.4    Gottlieb, A.B.5    Dunn, M.6    Chiou, C.F.7    Patel, V.8    Jahreis, A.9
  • 87
    • 33646101010 scopus 로고    scopus 로고
    • TNFalpha signaling in depression and anxiety: Behavioral consequences of individual receptor targeting
    • Simen BB, Duman CH, Simen AA, Duman RS (2006) TNFalpha signaling in depression and anxiety: behavioral consequences of individual receptor targeting. Biol Psychiatry 59:775–785
    • (2006) Biol Psychiatry , vol.59 , pp. 775-785
    • Simen, B.B.1    Duman, C.H.2    Simen, A.A.3    Duman, R.S.4
  • 88
    • 0034333060 scopus 로고    scopus 로고
    • Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factoralpha gene: Implications for emotional behavior
    • Yamada K, Iida R, Miyamoto Y, Saito K, Sekikawa K, Seishima M, Nabeshima T (2000) Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factoralpha gene: implications for emotional behavior. J Neuroimmunol 111:131–138
    • (2000) J Neuroimmunol , vol.111 , pp. 131-138
    • Yamada, K.1    Iida, R.2    Miyamoto, Y.3    Saito, K.4    Sekikawa, K.5    Seishima, M.6    Nabeshima, T.7
  • 89
    • 84876443867 scopus 로고    scopus 로고
    • Chronic administration of infliximab (TNF-alpha inhibitor) decreases depression and anxiety-like behaviour in rat model of chronic mild stress
    • Karson A, Demirtas T, Bayramgurler D, Balci F, Utkan T (2013) Chronic administration of infliximab (TNF-alpha inhibitor) decreases depression and anxiety-like behaviour in rat model of chronic mild stress. Basic Clin Pharmacol Toxicol 112:335–340
    • (2013) Basic Clin Pharmacol Toxicol , vol.112 , pp. 335-340
    • Karson, A.1    Demirtas, T.2    Bayramgurler, D.3    Balci, F.4    Utkan, T.5
  • 90
    • 84875277496 scopus 로고    scopus 로고
    • Antidepressant effects of TNF-alpha blockade in an animal model of depression
    • Krugel U, Fischer J, Radicke S, Sack U, Himmerich H (2013) Antidepressant effects of TNF-alpha blockade in an animal model of depression. J Psychiatric Res 47:611–616
    • (2013) J Psychiatric Res , vol.47 , pp. 611-616
    • Krugel, U.1    Fischer, J.2    Radicke, S.3    Sack, U.4    Himmerich, H.5
  • 91
    • 84871986003 scopus 로고    scopus 로고
    • A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: The role of baseline inflammatory biomarkers
    • Raison CL, Rutherford RE, Woolwine BJ, Shuo C, Schettler P, Drake DF, Haroon E, Miller AH (2013) A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry 70:31–41
    • (2013) JAMA Psychiatry , vol.70 , pp. 31-41
    • Raison, C.L.1    Rutherford, R.E.2    Woolwine, B.J.3    Shuo, C.4    Schettler, P.5    Drake, D.F.6    Haroon, E.7    Miller, A.H.8
  • 92
    • 84906329529 scopus 로고    scopus 로고
    • Targeting classical IL-6 signalling or IL-6 trans-signalling in depression?
    • Maes M, Anderson G, Kubera M, Berk M (2014) Targeting classical IL-6 signalling or IL-6 trans-signalling in depression? Expert Opin Ther Targets 18:495–512
    • (2014) Expert Opin Ther Targets , vol.18 , pp. 495-512
    • Maes, M.1    Erson, G.2    Kubera, M.3    Berk, M.4
  • 94
    • 0033453996 scopus 로고    scopus 로고
    • Interleukin-1 beta production in dysthymia before and after pharmacotherapy
    • Anisman H, Ravindran AV, Griffiths J, Merali Z (1999) Interleukin-1 beta production in dysthymia before and after pharmacotherapy. Biol Psychiatry 46:1649–1655
    • (1999) Biol Psychiatry , vol.46 , pp. 1649-1655
    • Anisman, H.1    Ravindran, A.V.2    Griffiths, J.3    Merali, Z.4
  • 95
    • 52649171401 scopus 로고    scopus 로고
    • Symptoms of postpartum depression associated with elevated levels of interleukin-1 beta during the first month postpartum
    • Corwin EJ, Johnston N, Pugh L (2008) Symptoms of postpartum depression associated with elevated levels of interleukin-1 beta during the first month postpartum. Biol Res Nurs 10:128–133
    • (2008) Biol Res Nurs , vol.10 , pp. 128-133
    • Corwin, E.J.1    Johnston, N.2    Pugh, L.3
  • 96
    • 75149139478 scopus 로고    scopus 로고
    • Interleukin-1beta serum levels is increased in antidepressant-free elderly depressed patients
    • Diniz BS, Teixeira AL, Talib L, Gattaz WF, Forlenza OV (2010) Interleukin-1beta serum levels is increased in antidepressant-free elderly depressed patients. Am J Geriatr Psychiatry 18:172–176
    • (2010) Am J Geriatr Psychiatry , vol.18 , pp. 172-176
    • Diniz, B.S.1    Teixeira, A.L.2    Talib, L.3    Gattaz, W.F.4    Forlenza, O.V.5
  • 97
    • 68149110223 scopus 로고    scopus 로고
    • Evidence for IL-1 receptor blockade as a therapeutic strategy for the treatment of depression
    • Koo JW, Duman RS (2009) Evidence for IL-1 receptor blockade as a therapeutic strategy for the treatment of depression. Curr Opin Investig Drugs 10:664–671
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 664-671
    • Koo, J.W.1    Duman, R.S.2
  • 99
    • 38649092266 scopus 로고    scopus 로고
    • IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress
    • Koo JW, Duman RS (2008) IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci U S A 105:751–756
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 751-756
    • Koo, J.W.1    Duman, R.S.2
  • 101
    • 0242456112 scopus 로고    scopus 로고
    • Interleukin 1 beta enhances conditioned fear memory in rats: Possible involvement of glucocorticoids
    • Song C, Phillips AG, Leonard B (2003) Interleukin 1 beta enhances conditioned fear memory in rats: possible involvement of glucocorticoids. Eur J Neurosci 18:1739–1743
    • (2003) Eur J Neurosci , vol.18 , pp. 1739-1743
    • Song, C.1    Phillips, A.G.2    Leonard, B.3
  • 105
    • 84905216515 scopus 로고    scopus 로고
    • Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: Association with diseases, impact on receptor functions and potential use as diagnosis biomarkers
    • Caseley EA, Muench SP, Roger S, Mao HJ, Baldwin SA, Jiang LH (2014) Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkers. Int J Mol Sci 15:13344–13371
    • (2014) Int J Mol Sci , vol.15 , pp. 13344-13371
    • Caseley, E.A.1    Muench, S.P.2    Roger, S.3    Mao, H.J.4    Baldwin, S.A.5    Jiang, L.H.6
  • 106
    • 84881489108 scopus 로고    scopus 로고
    • Insights into the molecular mechanisms underlying mammalian P2X7 receptor functions and contributions in diseases, revealed by structural modeling and single nucleotide polymorphisms
    • Jiang LH, Baldwin JM, Roger S, Baldwin SA (2013) Insights into the molecular mechanisms underlying mammalian P2X7 receptor functions and contributions in diseases, revealed by structural modeling and single nucleotide polymorphisms. Front Pharmacol 4:55
    • (2013) Front Pharmacol , vol.4 , pp. 55
    • Jiang, L.H.1    Baldwin, J.M.2    Roger, S.3    Baldwin, S.A.4
  • 107
    • 77955776526 scopus 로고    scopus 로고
    • Two haplotypes of the P2X(7) receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1beta secretion
    • Stokes L, Fuller SJ, Sluyter R, Skarratt KK, Gu BJ, Wiley JS (2010) Two haplotypes of the P2X(7) receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1beta secretion. FASEB J 24:2916–2927
    • (2010) FASEB J , vol.24 , pp. 2916-2927
    • Stokes, L.1    Fuller, S.J.2    Sluyter, R.3    Skarratt, K.K.4    Gu, B.J.5    Wiley, J.S.6
  • 108
    • 84895769853 scopus 로고    scopus 로고
    • Lack of association of P2RX7 gene rs2230912 polymorphism with mood disorders: A meta-analysis
    • Feng WP, Zhang B, Li W, Liu J (2014) Lack of association of P2RX7 gene rs2230912 polymorphism with mood disorders: a meta-analysis. PLoS One 9:e88575
    • (2014) Plos One , vol.9
    • Feng, W.P.1    Zhang, B.2    Li, W.3    Liu, J.4
  • 109
    • 45549084470 scopus 로고    scopus 로고
    • Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression
    • Goshen I, Kreisel T, Ben-Menachem-Zidon O, Licht T, Weidenfeld J, Ben-Hur T, Yirmiya R (2008) Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol Psychiatry 13:717–728
    • (2008) Mol Psychiatry , vol.13 , pp. 717-728
    • Goshen, I.1    Kreisel, T.2    Ben-Menachem-Zidon, O.3    Licht, T.4    Weidenfeld, J.5    Ben-Hur, T.6    Yirmiya, R.7
  • 110
    • 77950022786 scopus 로고    scopus 로고
    • Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients
    • Rao JS, Harry GJ, Rapoport SI, Kim HW (2010) Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Mol Psychiatry 15:384–392
    • (2010) Mol Psychiatry , vol.15 , pp. 384-392
    • Rao, J.S.1    Harry, G.J.2    Rapoport, S.I.3    Kim, H.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.