Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system

Journal of Affective Disorders

Volumn 148, Issue 1, 2013, Pages 136-140

  Carvalho, L A ^a,b   Torre, J P ^b   Papadopoulos, A S ^c   Poon, L ^c   Juruena, M F ^c   Markopoulou, K ^c   Cleare, A J ^c   Pariante, C M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c BETHLEM ROYAL HOSPITAL   (United Kingdom)

Author keywords

Antidepressant agents; Biological markers; Cytokines; Endophenotype; Neuroinflammation; Psychoneuroimmunology

Indexed keywords

ANTIDEPRESSANT AGENT; HYDROCORTISONE; INTERLEUKIN 10; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; VASCULOTROPIN;

ADULT; ARTICLE; BECK ANXIETY INVENTORY; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEPRESSION; DRUG EFFICACY; DSM-IV; FEMALE; HOSPITAL PATIENT; HUMAN; HYDROCORTISONE BLOOD LEVEL; INFLAMMATION; INTERNATIONAL CLASSIFICATION OF DISEASES; MALE; MOOD DISORDER; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADULT; ANTIDEPRESSIVE AGENTS; CASE-CONTROL STUDIES; CYTOKINES; DEPRESSION; FEMALE; HUMANS; HYDROCORTISONE; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-4; INTERLEUKIN-6; MALE; MIDDLE AGED; TREATMENT OUTCOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84876988698     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2012.10.036     Document Type: Article

References (36)

1. C. Anacker, P.A. Zunszain, A. Cattaneo, L.A. Carvalho, M.J. Garabedian, S. Thuret, J. Price, and C.M. Pariante Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor Molecular Psychiatry 16 2011 738 750
2. I.G. Barbosa, R.B. Huguet, L.P. Sousa, M.N. Abreu, N.P. Rocha, M.E. Bauer, L.A. Carvalho, and A.L. Teixeira Circulating levels of GDNF in bipolar disorder Neuroscience Letters 502 2011 103 106
3. I.G. Barbosa, N.P. Rocha, R.B. Huguet, R.A. Ferreira, J.V. Salgado, L.A. Carvalho, C.M. Pariante, and A.L. Teixeira Executive dysfunction in euthymic bipolar disorder patients and its association with plasma biomarkers Journal of Affective Disorders 137 2012 151 155
4. A.T. Beck, N. Epstein, G. Brown, and R.A. Steer An inventory for measuring clinical anxiety: psychometric properties Journal of Consulting and Clinical Psychology 56 1988 893 897
5. A.T. Beck, M. Kovacs, and A. Weissman Assessment of suicidal intention: the scale for suicide ideation Journal of Consulting and Clinical Psychology 47 1979 343 352
6. A.T. Beck, A. Weissman, D. Lester, and L. Trexler The measurement of pessimism: the hopelessness scale Journal of Consulting and Clinical Psychology 42 1974 861 865
7. L.A. Carvalho, and C.M. Pariante In vitro modulation of the glucocorticoid receptor by antidepressants Stress 11 2008 411 424
8. L.A. Carvalho, M.F. Juruena, A.S. Papadopoulos, L. Poon, R. Kerwin, A.J. Cleare, and C.M. Pariante Clomipramine in vitro reduces glucocorticoid receptor function in healthy subjects but not in patients with major depression Neuropsychopharmacology 33 13 2008 3182 3189
9. R.L. Casey, M. Masuda, and T.H. Holmes Quantitative study of recall of life events Journal of Psychosomatic Research 11 1967 239 247
10. David Taylor, Carol Paton, Robert Kerwin, 2007. The Maudsley Prescribing Guidelines. Informa Healthcare.
11. Y. Dowlati, N. Herrmann, W. Swardfager, H. Liu, L. Sham, E.K. Reim, and K.L. Lanctot A meta-analysis of cytokines in major depression Biological Psychiatry 67 2010 446 457
12. N.M. Fournier, and R.S. Duman Role of vascular endothelial growth factor in adult hippocampal neurogenesis: implications for the pathophysiology and treatment of depression Behavioural Brain Research 227 2012 440 449
13. M. Hamilton A rating scale for depression Journal of Neurology, Neurosurgery, Psychiatry 23 1960 56 62
14. J. Hannestad, N. DellaGioia, and M. Bloch The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis Neuropsychopharmacology 36 2011 2452 2459
15. M.E. Hernandez, D. Mendieta, D. Martinez-Fong, F. Loria, J. Moreno, I. Estrada, R. Bojalil, and L. Pavon Variations in circulating cytokine levels during 52 week course of treatment with SSRI for major depressive disorder European Neuropsychopharmacology 18 2008 917 924
16. S.A. Hiles, A.L. Baker, M.T. de, and J. Attia A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: exploring the causes of heterogeneity Brain, Behavior, and Immunity 26 2012 1180 1188
17. A.E. Hinojosa, B. Garcia-Bueno, J.C. Leza, and J.L. Madrigal CCL2/MCP-1 modulation of microglial activation and proliferation Journal of Neuroinflammation 8 2011 77
18. M.B. Howren, D.M. Lamkin, and J. Suls Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis Psychosomatic Medicine 71 2009 171 186
19. J. Isung, F. Mobarrez, P. Nordstrom, M. Asberg, and J. Jokinen Low plasma vascular endothelial growth factor (VEGF) associated with completed suicide World Journal of Biological Psychiatry 2011
20. S.M. Lehto, L. Niskanen, J. Miettola, T. Tolmunen, H. Viinamaki, and P. Mantyselka Serum anti-inflammatory markers in general population subjects with elevated depressive symptoms Neuroscience Letters 484 2010 201 205
21. J.L. Madrigal, B. Garcia-Bueno, A.E. Hinojosa, P. Polak, D.L. Feinstein, and J.C. Leza Regulation of MCP-1 production in brain by stress and noradrenaline-modulating drugs Journal of Neurochemistry 113 2010 543 551
22. H. Morimoto, M. Hirose, M. Takahashi, M. Kawaguchi, H. Ise, P.E. Kolattukudy, M. Yamada, and U. Ikeda MCP-1 induces cardioprotection against ischaemia/reperfusion injury: role of reactive oxygen species Cardiovascular Research 78 2008 554 562
23. A.M. Myint, B.E. Leonard, H.W. Steinbusch, and Y.K. Kim Th1, Th2, and Th3 cytokine alterations in major depression Journal of Affective Disorder 88 2005 167 173
24. S.M. O'Brien, P. Scully, P. Fitzgerald, L.V. Scott, and T.G. Dinan Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy Journal of Psychiatric Research 41 2007 326 331
25. J.E. Piletz, A. Halaris, O. Iqbal, D. Hoppensteadt, J. Fareed, H. Zhu, J. Sinacore, and D.C. Lindsay Pro-inflammatory biomakers in depression: treatment with venlafaxine World Journal of Biological Psychiatry 2009 1 11
26. Einar Andreas Rødland Simes procedure is 'valid on average' Biometrika 93 2006 742 746
27. S. Rajagopalan, R. Brook, M. Rubenfire, E. Pitt, E. Young, and B. Pitt Abnormal brachial artery flow-mediated vasodilation in young adults with major depression American Journal of Cardiology 88 196-8 2001 A7
28. H.A. Sackeim The definition and meaning of treatment-resistant depression Journal of Clinical Psychiatry 62 16 2001 10 17
29. J. Schlatter, F. Ortuno, and S. Cervera-Enguix Lymphocyte subsets and lymphokine production in patients with melancholic versus nonmelancholic depression Psychiatry Research 128 2004 259 265
30. Segi-Nishida, E.; Warner-Schmidt, J.L.; Duman, R.S.; 2008. Electroconvulsive seizure and VEGF increase the proliferation of neural stem-like cells in rat hippocampus. Proceedings of the National academy of Sciences of the United States of America 105, 11352-11357.
31. M.E. Thase, and A.J. Rush When at first you don't succeed: sequential strategies for antidepressant nonresponders Journal of Clinical Psychiatry 58 13 1997 23 29
32. M. Viikki, S. Anttila, O. Kampman, A. Illi, M. Huuhka, E. Setala-Soikkeli, N. Mononen, T. Lehtimaki, and E. Leinonen Vascular endothelial growth factor (VEGF) polymorphism is associated with treatment-resistant depression Neuroscience Letters 477 2010 105 108
33. World Health Organisation, 1992. The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. Geneva.
34. S.C. Wooderson, M.F. Juruena, A. Fekadu, C. Commane, C. Donaldson, M. Cowan, M. Tomlinson, L. Poon, K. Markopoulou, L. Rane, J. Donocik, C. Tunnard, B. Masterson, and A.J. Cleare Prospective evaluation of specialist inpatient treatment for refractory affective disorders Journal of Affective Disorders 131 1-3 2011 92 103
35. R. Yoshimura, H. Hori, A. Ikenouchi-Sugita, W. Umene-Nakano, N. Ueda, and J. Nakamura Higher plasma interleukin-6 (IL-6) level is associated with SSRI- and SNRI-refractory depression Progress in Neuropsychopharmacological and Biological Psychiatry 33 2009 722 726
36. Zunszain, P.A.; Anacker, C.; Cattaneo, A.; Carvalho, L.A.; Pariante, C.M.; 2010. Glucocorticoids, cytokines and brain abnormalities in depression. Progress in Neuropsychopharmacological and Biological Psychiatry