Myelin specific Th1 cells are necessary for post-traumatic protective autoimmunity

Journal of Neuroimmunology

Volumn 130, Issue 1-2, 2002, Pages 78-85

  Kipnis, Jonathan ^a   Yoles, Eti ^a   Mizrahi, Tal ^a   Ben Nur, Auraham ^a   Schwartz, Michal ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Myelin specific Th1 cell; Neuroprotection; Post traumatic protective autoimmunity

Indexed keywords

FREUND ADJUVANT; MYELIN BASIC PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL SURVIVAL; CONTROLLED STUDY; CRUSH TRAUMA; DISEASE PREDISPOSITION; DISEASE RESISTANCE; EMULSION; FEMALE; MOUSE; NERVE DEGENERATION; NERVE INJURY; NEUROPROTECTION; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; RAT; T LYMPHOCYTE SUBPOPULATION; TH1 CELL;

ANIMALS; AUTOIMMUNITY; BRAIN INJURIES; CD4-POSITIVE T-LYMPHOCYTES; CELL SURVIVAL; FEMALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; MYELIN BASIC PROTEINS; MYELIN PROTEINS; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY; TH1 CELLS; VACCINATION; X-RAYS;

EID: 0036708987     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(02)00219-9     Document Type: Article

References (24)

1. Borghans J.A., De Boer R.J., Sercarz E., Kumar V. T cell vaccination in experimental autoimmune encephalomyelitis: a mathematical model. J. Immunol. 161:1998;1087-1093.
2. Butovsky O., Hauben E., Schwartz M. Morphological aspects of spinal cord autoimmune neuroprotection: colocalization of T cells with B7-2 (CD86) and prevention of cyst formation. Faseb J. 15:2001;1065-1067.
3. Cohen I.R., Schwartz M. Autoimmune maintenance and neuroprotection of the central nervous system. J. Neuroimmunol. 100:1999;111-114.
4. Hafler D.A., Weiner H.L. T cells in multiple sclerosis and inflammatory central nervous system diseases. Immunol. Rev. 100:1987;307-332.
5. Hammarberg H., Lidman O., Lundberg C., Eltayeb S.Y., Gielen A.W., Muhallab S., Svenningsson A., Linda H., van Der Meide P.H., Cullheim S., Olsson T., Piehl F. Neuroprotection by encephalomyelitis: rescue of mechanically injured neurons and neurotrophin production by CNS-infiltrating T and natural killer cells. J. Neurosci. 20:2000;5283-5291.
6. Hammarberg H., Piehl F., Risling M., Cullheim S. Differential regulation of trophic factor receptor mRNAs in spinal motoneurons after sciatic nerve transection and ventral root avulsion in the rat. J. Comp. Neurol. 426:2000;587-601.
7. Hauben E., Butovsky O., Nevo U., Yoles E., Moalem G., Agranov G., Mor F., Leibowitz-Amit R., Pevsner E., Akselrod S., Neeman M., Cohen I.R., Schwartz M. Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion. J. Neurosci. 20:2000;6421-6430.
8. Hauben E., Nevo U., Yoles E., Moalem G., Agranov E., Mor F., Akselrod S., Neeman M., Cohen I.R., Schwartz M. Autoimmune T cells as potential neuroprotective therapy for spinal cord injury. Lancet. 355:2000;286-287.
9. Hohlfeld R., Kerschensteiner M., Stadelmann C., Lassmann H., Wekerle H. The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis. J. Neuroimmunol. 107:2000;161-166.
10. Kipnis J., Yoles E., Porat Z., Cohen A., Mor F., Sela M., Cohen I.R., Schwartz M. T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies. Proc. Natl. Acad. Sci. U. S. A. 97:2000;7446-7451.
11. Kipnis J., Yoles E., Schori H., Hauben E., Shaked I., Schwartz M. Neuronal survival after CNS insult is determined by a genetically encoded autoimmune response. J. Neurosci. 21:2001;4564-4571.
12. Lenz D.C., Wolf N.A., Swanborg R.H. Strain variation in autoimmunity: attempted tolerization of DA rats results in the induction of experimental autoimmune encephalomyelitis. J. Immunol. 163:1999;1763-1768.
13. Lundberg C., Lidman O., Holmdahl R., Olsson T., Piehl F. Neurodegeneration and glial activation patterns after mechanical nerve injury are differentially regulated by non-MHC genes in congenic inbred rat strains. J. Comp. Neurol. 431:2001;75-87.
14. Moalem G., Leibowitz-Amit R., Yoles E., Mor F., Cohen I.R., Schwartz M. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat. Med. 5:1999;49-55.
15. Moalem G., Gdalyahu A., Shani Y., Otten U., Lazarovici P., Cohen I.R., Schwartz M. Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity. J. Autoimmun. 20:2000;6421-6430.
16. Moalem G., Yoles E., Leibowitz-Amit R., Muller-Gilor S., Mor F., Cohen I.R., Schwartz M. Autoimmune T cells retard the loss of function in injured rat optic nerves. [In Process Citation] J. Neuroimmunol. 106:2000;189-197.
17. Schori H., Yoles E., Schwartz M. T-cell-based immunity counteracts the potential toxicity of glutamate in the central nervous system. J. Neuroimmunol. 119:2001;199-204.
18. Schwartz M., Kipnis J. Protective autoimmunity: regulation and prospects for vaccination after brain and spinal cord injuries. Trends Mol. Med. 7:2001;252-258.
19. Shibaki A., Katz S.I. Induction of skewed Th1/Th2 T-cell differentiation via subcutaneous immunization with Freund's adjuvant. Exp. Dermatol. 11:2002;126-134.
20. Steinman L. Multiple sclerosis: a two-stage disease. Nat. Immunol. 2:2001;762-764.
21. Wekerle H. Immune pathogenesis of multiple sclerosis. Brain autoimmune reactivity and its control by neuronal function. Mult. Scler. 4:1998;136-137.
22. Yoles E., Schwartz M. Degeneration of spared axons following partial white matter lesion: implications for optic nerve neuropathies. Exp. Neurol. 153:1998;1-7.
23. Yoles E., Hauben E., Palgi O., Agranov E., Gothilf A., Cohen A., Kuchroo V., Cohen I.R., Weiner H., Schwartz M. Protective autoimmunity is a physiological response to CNS trauma. J. Neurosci. 21:2001;3740-3748.
24. Zhang L., Mia M.Y., Zheng C.L., Hossain M.A., Yamasaki F., Tokunaga O., Kohashi O. The preventive effects of incomplete Freund's adjuvant and other vehicles on the development of adjuvant-induced arthritis in Lewis rats. Immunology. 98:1999;267-272.