Salvianolic acid A inhibits calpain activation and eNOS uncoupling during focal cerebral ischemia in mice

Phytomedicine

Volumn 25, Issue , 2017, Pages 8-14

  Mahmood, Qaisar ^a   Wang, Guang Fa ^b   Wu, Gang ^a   Wang, Huan ^a   Zhou, Chang Xin ^a   Yang, Hong Yu ^b   Liu, Zhi Rong ^c   Han, Feng ^a   Zhao, Kui ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

eNOS uncoupling; Neurovascular protection; Oxidative stress; Salvianolic acid A; Stroke

Indexed keywords

CALCINEURIN; CALPAIN; CYSTEINE PROTEINASE INHIBITOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; PLANT EXTRACT; PROTEIN KINASE B; SALVIANOLIC ACID A; SPECTRIN; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; CAFFEIC ACID DERIVATIVE; HERBACEOUS AGENT; LACTIC ACID DERIVATIVE; NEUROPROTECTIVE AGENT;

ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; CHINESE HERB; CONTROLLED STUDY; GLUCOSE METABOLISM; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NITROSATIVE STRESS; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; SALVIAE MILTIORRHIZAE BUNGE; SIGNAL TRANSDUCTION; ANIMAL; BRAIN; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYTOTHERAPY; REPERFUSION INJURY; SALVIA MILTIORRHIZA; UPREGULATION;

ANIMALS; BRAIN; BRAIN ISCHEMIA; CAFFEIC ACIDS; CALPAIN; DRUGS, CHINESE HERBAL; INFARCTION, MIDDLE CEREBRAL ARTERY; LACTATES; MALE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PHYTOTHERAPY; REPERFUSION INJURY; SALVIA MILTIORRHIZA; UP-REGULATION;

EID: 85007048799     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2016.12.004     Document Type: Article

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