-
1
-
-
1542344000
-
Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice
-
Alp NJ, McAteer MA, Khoo J, Choudhury RP, Channon KM. Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice. Arterioscler Thromb Vasc Biol 24: 445-450, 2004.
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 445-450
-
-
Alp, N.J.1
McAteer, M.A.2
Khoo, J.3
Choudhury, R.P.4
Channon, K.M.5
-
2
-
-
85047690420
-
Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression
-
Alp NJ, Mussa S, Khoo J, Cai S, Guzik T, Jefferson A, Goh N, Rockett KA, Channon KM. Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression. J Clin Invest 112: 725-735, 2003.
-
(2003)
J Clin Invest
, vol.112
, pp. 725-735
-
-
Alp, N.J.1
Mussa, S.2
Khoo, J.3
Cai, S.4
Guzik, T.5
Jefferson, A.6
Goh, N.7
Rockett, K.A.8
Channon, K.M.9
-
3
-
-
0037022206
-
Insulin causes endothelial dysfunction in humans: Sites and mechanisms
-
Arcaro G, Cretti A, Balzano S, Lechi A, Muggeo M, Bonora E, Bonadonna RC. Insulin causes endothelial dysfunction in humans: sites and mechanisms. Circulation 105: 576-582, 2002.
-
(2002)
Circulation
, vol.105
, pp. 576-582
-
-
Arcaro, G.1
Cretti, A.2
Balzano, S.3
Lechi, A.4
Muggeo, M.5
Bonora, E.6
Bonadonna, R.C.7
-
4
-
-
33745168947
-
Endothelial microparticles and platelet and leukocyte activation in patients with the metabolic syndrome
-
Arteaga RB, Chirinos JA, Soriano AO, Jy W, Horstman L, Jimenez JJ, Mendez A, Ferreira A, de Marchena E, Ahn YS. Endothelial microparticles and platelet and leukocyte activation in patients with the metabolic syndrome. Am J Cardiol 98: 70-74, 2006.
-
(2006)
Am J Cardiol
, vol.98
, pp. 70-74
-
-
Arteaga, R.B.1
Chirinos, J.A.2
Soriano, A.O.3
Jy, W.4
Horstman, L.5
Jimenez, J.J.6
Mendez, A.7
Ferreira, A.8
de Marchena, E.9
Ahn, Y.S.10
-
5
-
-
19944428563
-
Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis
-
Bauer PM, Yu J, Chen Y, Hickey R, Bernatchez PN, Looft-Wilson R, Huang Y, Giordano F, Stan RV, Sessa WC. Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis. Proc Natl Acad Sci USA 102: 204-209, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 204-209
-
-
Bauer, P.M.1
Yu, J.2
Chen, Y.3
Hickey, R.4
Bernatchez, P.N.5
Looft-Wilson, R.6
Huang, Y.7
Giordano, F.8
Stan, R.V.9
Sessa, W.C.10
-
6
-
-
27644537902
-
Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: Insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression
-
Bendall JK, Alp NJ, Warrick N, Cai S, Adlam D, Rockett K, Yokoyama M, Kawashima S, Channon KM. Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression. Circ Res 97: 864-871, 2005.
-
(2005)
Circ Res
, vol.97
, pp. 864-871
-
-
Bendall, J.K.1
Alp, N.J.2
Warrick, N.3
Cai, S.4
Adlam, D.5
Rockett, K.6
Yokoyama, M.7
Kawashima, S.8
Channon, K.M.9
-
7
-
-
14844327786
-
Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitricoxide synthase: Differences in the effects of monomethyl-and dimethylarginines in the presence and absence of tetrahydrobiopterin
-
Cardounel AJ, Xia Y, Zweier JL. Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitricoxide synthase: differences in the effects of monomethyl-and dimethylarginines in the presence and absence of tetrahydrobiopterin. J Biol Chem 280: 7540-7549, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 7540-7549
-
-
Cardounel, A.J.1
Xia, Y.2
Zweier, J.L.3
-
8
-
-
55249112287
-
Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme
-
Chen CA, Druhan LJ, Varadharaj S, Chen YR, Zweier JL. Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme. J Biol Chem 283: 27038-27047, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 27038-27047
-
-
Chen, C.A.1
Druhan, L.J.2
Varadharaj, S.3
Chen, Y.R.4
Zweier, J.L.5
-
9
-
-
41149105370
-
Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia
-
Cosentino F, Hurlimann D, Delli Gatti C, Chenevard R, Blau N, Alp NJ, Channon KM, Eto M, Lerch P, Enseleit F, Ruschitzka F, Volpe M, Luscher TF, Noll G. Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia. Heart 94: 487-492, 2008.
-
(2008)
Heart
, vol.94
, pp. 487-492
-
-
Cosentino, F.1
Hurlimann, D.2
Delli Gatti, C.3
Chenevard, R.4
Blau, N.5
Alp, N.J.6
Channon, K.M.7
Eto, M.8
Lerch, P.9
Enseleit, F.10
Ruschitzka, F.11
Volpe, M.12
Luscher, T.F.13
Noll, G.14
-
10
-
-
41849144894
-
Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO versus superoxide production by eNOS
-
Crabtree MJ, Smith CL, Lam G, Goligorsky MS, Gross SS. Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO versus superoxide production by eNOS. Am J Physiol Heart Circ Physiol 294: H1530-H1540, 2008.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.294
-
-
Crabtree, M.J.1
Smith, C.L.2
Lam, G.3
Goligorsky, M.S.4
Gross, S.S.5
-
11
-
-
46849095596
-
Regulation of eNOS-derived superoxide by endogenous methylarginines
-
Druhan LJ, Forbes SP, Pope AJ, Chen CA, Zweier JL, Cardounel AJ. Regulation of eNOS-derived superoxide by endogenous methylarginines. Biochemistry 47: 7256-7263, 2008.
-
(2008)
Biochemistry
, vol.47
, pp. 7256-7263
-
-
Druhan, L.J.1
Forbes, S.P.2
Pope, A.J.3
Chen, C.A.4
Zweier, J.L.5
Cardounel, A.J.6
-
12
-
-
35448929005
-
4
-
4. Proc Natl Acad Sci USA 104: 15081-15086, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 15081-15086
-
-
Dumitrescu, C.1
Biondi, R.2
Xia, Y.3
Cardounel, A.J.4
Druhan, L.J.5
Ambrosio, G.6
Zweier, J.L.7
-
13
-
-
33746234766
-
eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: A role for eNOS uncoupling
-
Elrod JW, Duranski MR, Langston W, Greer JJ, Tao L, Dugas TR, Kevil CG, Champion HC, Lefer DJ. eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling. Circ Res 99: 78-85, 2006.
-
(2006)
Circ Res
, vol.99
, pp. 78-85
-
-
Elrod, J.W.1
Duranski, M.R.2
Langston, W.3
Greer, J.J.4
Tao, L.5
Dugas, T.R.6
Kevil, C.G.7
Champion, H.C.8
Lefer, D.J.9
-
14
-
-
0029910141
-
Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1
-
Garcia-Cardena G, Fan R, Stern DF, Liu J, Sessa WC. Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1. J Biol Chem 271: 27237-27240, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 27237-27240
-
-
Garcia-Cardena, G.1
Fan, R.2
Stern, D.F.3
Liu, J.4
Sessa, W.C.5
-
15
-
-
0039397709
-
Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo
-
Garcia-Cardena G, Martasek P, Masters BS, Skidd PM, Couet J, Li S, Lisanti MP, Sessa WC. Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo. J Biol Chem 272: 25437-25440, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 25437-25440
-
-
Garcia-Cardena, G.1
Martasek, P.2
Masters, B.S.3
Skidd, P.M.4
Couet, J.5
Li, S.6
Lisanti, M.P.7
Sessa, W.C.8
-
16
-
-
0034698050
-
Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1
-
Gratton JP, Fontana J, O'Connor DS, Garcia-Cardena G, McCabe TJ, Sessa WC. Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1. J Biol Chem 275: 22268-22272, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 22268-22272
-
-
Gratton, J.P.1
Fontana, J.2
O'Connor, D.S.3
Garcia-Cardena, G.4
McCabe, T.J.5
Sessa, W.C.6
-
17
-
-
33748307456
-
Altered endothelial nitric oxide synthase target-ing and conformation and caveolin-1 expression in the diabetic kidney
-
Komers R, Schutzer WE, Reed JF, Lindsley JN, Oyama TT, Buck DC, Mader SL, Anderson S. Altered endothelial nitric oxide synthase target-ing and conformation and caveolin-1 expression in the diabetic kidney. Diabetes 55: 1651-1659, 2006.
-
(2006)
Diabetes
, vol.55
, pp. 1651-1659
-
-
Komers, R.1
Schutzer, W.E.2
Reed, J.F.3
Lindsley, J.N.4
Oyama, T.T.5
Buck, D.C.6
Mader, S.L.7
Anderson, S.8
-
18
-
-
0037399439
-
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
-
Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM, Mitch WE, Harrison DG. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest 111: 1201-1209, 2003.
-
(2003)
J Clin Invest
, vol.111
, pp. 1201-1209
-
-
Landmesser, U.1
Dikalov, S.2
Price, S.R.3
McCann, L.4
Fukai, T.5
Holland, S.M.6
Mitch, W.E.7
Harrison, D.G.8
-
19
-
-
32844463192
-
Effect of hereditary obesity on renal expressions of NO synthase, caveolin-1, AKt, guanylate cyclase, and calmodulin
-
Li Z, Rodríguez-Iturbe B, Ni Z, Shahkarami A, Sepassi L, Vaziri ND. Effect of hereditary obesity on renal expressions of NO synthase, caveolin-1, AKt, guanylate cyclase, and calmodulin. Kidney Int 68: 2766-2772, 2005.
-
(2005)
Kidney Int
, vol.68
, pp. 2766-2772
-
-
Li, Z.1
Rodríguez-Iturbe, B.2
Ni, Z.3
Shahkarami, A.4
Sepassi, L.5
Vaziri, N.D.6
-
20
-
-
34948904709
-
Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice
-
Murata T, Lin MI, Huang Y, Yu J, Bauer PM, Giordano FJ, Sessa WC. Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice. J Exp Med 204: 2373-2382, 2007.
-
(2007)
J Exp Med
, vol.204
, pp. 2373-2382
-
-
Murata, T.1
Lin, M.I.2
Huang, Y.3
Yu, J.4
Bauer, P.M.5
Giordano, F.J.6
Sessa, W.C.7
-
21
-
-
34447509229
-
Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells
-
Murata T, Lin MI, Stan RV, Bauer PM, Yu J, Sessa WC. Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells. J Biol Chem 282: 16631-16643, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 16631-16643
-
-
Murata, T.1
Lin, M.I.2
Stan, R.V.3
Bauer, P.M.4
Yu, J.5
Sessa, W.C.6
-
22
-
-
57149123016
-
Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium
-
Penumathsa SV, Thirunavukkarasu M, Zhan L, Maulik G, Menon VP, Bagchi D, Maulik N. Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium. J Cell Mol Med 12: 2350-2361, 2008.
-
(2008)
J Cell Mol Med
, vol.12
, pp. 2350-2361
-
-
Penumathsa, S.V.1
Thirunavukkarasu, M.2
Zhan, L.3
Maulik, G.4
Menon, V.P.5
Bagchi, D.6
Maulik, N.7
-
23
-
-
72149111666
-
Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production
-
Pope AJ, Karuppiah K, Kearns PN, Xia Y, Cardounel AJ. Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production. J Biol Chem 284: 35338-35347, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 35338-35347
-
-
Pope, A.J.1
Karuppiah, K.2
Kearns, P.N.3
Xia, Y.4
Cardounel, A.J.5
-
24
-
-
0035851197
-
Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities
-
Razani B, Engelman JA, Wang XB, Schubert W, Zhang XL, Marks CB, Macaluso F, Russell RG, Li M, Pestell RG, Di Vizio D, Hou H Jr, Kneitz B, Lagaud G, Christ GJ, Edelmann W, Lisanti MP. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem 276: 38121-38138, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 38121-38138
-
-
Razani, B.1
Engelman, J.A.2
Wang, X.B.3
Schubert, W.4
Zhang, X.L.5
Marks, C.B.6
Macaluso, F.7
Russell, R.G.8
Li, M.9
Pestell, R.G.10
di Vizio, D.11
Hou Jr., H.12
Kneitz, B.13
Lagaud, G.14
Christ, G.J.15
Edelmann, W.16
Lisanti, M.P.17
-
25
-
-
4444329629
-
Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo
-
Schafer A, Alp NJ, Cai S, Lygate CA, Neubauer S, Eigenthaler M, Bauersachs J, Channon KM. Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo. Arterioscler Thromb Vasc Biol 24: 1720-1726, 2004.
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 1720-1726
-
-
Schafer, A.1
Alp, N.J.2
Cai, S.3
Lygate, C.A.4
Neubauer, S.5
Eigenthaler, M.6
Bauersachs, J.7
Channon, K.M.8
-
26
-
-
67349092191
-
L-arginine and tetrahydrobiopterin protects against ischemia/reperfusioninduced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease
-
Settergren M, Bohm F, Malmstrom RE, Channon KM, Pernow J. L-arginine and tetrahydrobiopterin protects against ischemia/reperfusioninduced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease. Atherosclerosis 204: 73-78, 2009.
-
(2009)
Atherosclerosis
, vol.204
, pp. 73-78
-
-
Settergren, M.1
Bohm, F.2
Malmstrom, R.E.3
Channon, K.M.4
Pernow, J.5
-
27
-
-
0032482975
-
Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
-
Vasquez-Vivar J, Kalyanaraman B, Martasek P, Hogg N, Masters BS, Karoui H, Tordo P, Pritchard KA Jr. Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci USA 95: 9220-9225, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 9220-9225
-
-
Vasquez-Vivar, J.1
Kalyanaraman, B.2
Martasek, P.3
Hogg, N.4
Masters, B.S.5
Karoui, H.6
Tordo, P.7
Pritchard Jr., K.A.8
-
28
-
-
0037086565
-
The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: An EPR spin trapping study
-
Vasquez-Vivar J, Martasek P, Whitsett J, Joseph J, Kalyanaraman B. The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study. Biochem J 362: 733-739, 2002.
-
(2002)
Biochem J
, vol.362
, pp. 733-739
-
-
Vasquez-Vivar, J.1
Martasek, P.2
Whitsett, J.3
Joseph, J.4
Kalyanaraman, B.5
-
29
-
-
0037900056
-
Pathophysiological implications of insulin resistance on vascular endothelial function
-
Wheatcroft SB, Williams IL, Shah AM, Kearney MT. Pathophysiological implications of insulin resistance on vascular endothelial function. Diabet Med 20: 255-268, 2003.
-
(2003)
Diabet Med
, vol.20
, pp. 255-268
-
-
Wheatcroft, S.B.1
Williams, I.L.2
Shah, A.M.3
Kearney, M.T.4
-
30
-
-
42749088607
-
The adverse cardiopulmonary phenotype of caveolin-1 deficient mice is mediated by a dysfunctional endothelium
-
Wunderlich C, Schober K, Schmeisser A, Heerwagen C, Tausche AK, Steinbronn N, Brandt A, Kasper M, Schwencke C, Braun-Dullaeus RC, Strasser RH. The adverse cardiopulmonary phenotype of caveolin-1 deficient mice is mediated by a dysfunctional endothelium. J Mol Cell Cardiol 44: 938-947, 2008.
-
(2008)
J Mol Cell Cardiol
, vol.44
, pp. 938-947
-
-
Wunderlich, C.1
Schober, K.2
Schmeisser, A.3
Heerwagen, C.4
Tausche, A.K.5
Steinbronn, N.6
Brandt, A.7
Kasper, M.8
Schwencke, C.9
Braun-Dullaeus, R.C.10
Strasser, R.H.11
-
31
-
-
0032475865
-
2+/calmodulin-dependent and tetrahydrobiopterin regulatory process
-
2+/calmodulin-dependent and tetrahydrobiopterin regulatory process. J Biol Chem 273: 25804-25808, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 25804-25808
-
-
Xia, Y.1
Tsai, A.L.2
Berka, V.3
Zweier, J.L.4
-
32
-
-
68849084669
-
Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration
-
Zhao YY, Zhao YD, Mirza MK, Huang JH, Potula HH, Vogel SM, Brovkovych V, Yuan JX, Wharton J, Malik AB. Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration. J Clin Invest 119: 2009-2018, 2009.
-
(2009)
J Clin Invest
, vol.119
, pp. 2009-2018
-
-
Zhao, Y.Y.1
Zhao, Y.D.2
Mirza, M.K.3
Huang, J.H.4
Potula, H.H.5
Vogel, S.M.6
Brovkovych, V.7
Yuan, J.X.8
Wharton, J.9
Malik, A.B.10
|