Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke

Regulatory Toxicology and Pharmacology

Volumn 81, Issue , 2016, Pages S93-S122

  Oviedo, Alberto ^a   Lebrun, Stefan ^a   Kogel, Ulrike ^a   Ho, Jenny ^a   Tan, Wei Teck ^a   Titz, Bjoern ^a   Leroy, Patrice ^a   Vuillaume, Gregory ^a   Bera, Monali ^a   Martin, Florian ^a   Rodrigo, Gregory ^a   Esposito, Marco ^a   Dempsey, Ruth ^a   Ivanov, Nikolai V ^a   Hoeng, Julia ^a   Peitsch, Manuel C ^a   Vanscheeuwijck, Patrick ^a  

^a PHILIP MORRIS PRODUCTS S A   (Switzerland)

Author keywords

Heat not burn; Inhalation; Menthol; Potential reduced risk product; Pulmonary inflammation; Toxicity

Indexed keywords

ALDEHYDE DERIVATIVE; CARBON MONOXIDE; CARBOXYHEMOGLOBIN; CIGARETTE SMOKE; MENTHOL; NICOTINE; AEROSOL; BIOLOGICAL MARKER; GENETIC MARKER; SMOKE; TRANSCRIPTOME;

AEROSOL; AIR FILTER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATMOSPHERE; BLOOD LEVEL; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; LONG TERM EXPOSURE; LUNG PARENCHYMA; LUNG TOXICITY; MALE; METABOLITE; NONHUMAN; NOSE EPITHELIUM; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SHAM PROCEDURE; TOBACCO HEATING SYSTEM; TOXIC INHALATION; TOXICITY TESTING; URINE LEVEL; ADVERSE EFFECTS; ANALYSIS; ANIMAL; BIOLOGY; BLOOD; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECTS; ELECTRONIC CIGARETTE; EQUIPMENT DESIGN; EXPOSURE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC MARKER; GENETICS; GENOMICS; HARM REDUCTION; HEAT; HUMAN; LUNG; METABOLISM; NOSE MUCOSA; PROCEDURES; PRODUCT SAFETY; RISK ASSESSMENT; SMOKE; SMOKING; SPRAGUE DAWLEY RAT; TIME FACTOR; TOBACCO; TOBACCO INDUSTRY; TOXICITY; TOXICOGENETICS; URINE;

AEROSOLS; ANIMALS; BIOMARKERS; COMPUTATIONAL BIOLOGY; CONSUMER PRODUCT SAFETY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRONIC CIGARETTES; EQUIPMENT DESIGN; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC MARKERS; GENOMICS; HARM REDUCTION; HOT TEMPERATURE; HUMANS; INHALATION EXPOSURE; LUNG; MALE; MENTHOL; NASAL MUCOSA; RATS, SPRAGUE-DAWLEY; RISK ASSESSMENT; SMOKE; SMOKING; TIME FACTORS; TOBACCO INDUSTRY; TOBACCO PRODUCTS; TOXICITY TESTS; TOXICOGENETICS; TRANSCRIPTOME;

EID: 85006857304     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2016.11.004     Document Type: Article

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