Evaluation of the Tobacco Heating System 2.2 (THS2.2). Part 5: microRNA expression from a 90-day rat inhalation study indicates that exposure to THS2.2 aerosol causes reduced effects on lung tissue compared with cigarette smoke

Regulatory Toxicology and Pharmacology

Volumn 81, Issue , 2016, Pages S82-S92

  Sewer, Alain ^a   Kogel, Ulrike ^a   Talikka, Marja ^a   Wong, Ee Tsin ^a   Martin, Florian ^a   Xiang, Yang ^a   Guedj, Emmanuel ^a   Ivanov, Nikolai V ^a   Hoeng, Julia ^a   Peitsch, Manuel C ^a  

^a PHILIP MORRIS PRODUCTS S A   (Switzerland)

Author keywords

Heat not burn; Inflammation related microRNAs; Inhalation toxicology study; microRNA expression; Modified risk tobacco product

Indexed keywords

CIGARETTE SMOKE; MICRORNA; MICRORNA 146A; MICRORNA 146B; MICRORNA 182; UNCLASSIFIED DRUG; AEROSOL; GENETIC MARKER; SMOKE; TRANSCRIPTOME;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EXPOSURE; FEMALE; GENE CONTROL; INFLAMMATION; LUNG PARENCHYMA; MALE; MODIFIED RISK TOBACCO PRODUCT; NONHUMAN; PRIORITY JOURNAL; RAT; RNA PROCESSING; TOBACCO; ADVERSE EFFECTS; ANIMAL; BIOLOGY; CHEMICALLY INDUCED; COMPARATIVE STUDY; DRUG EFFECTS; ELECTRONIC CIGARETTE; EQUIPMENT DESIGN; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC MARKER; GENETICS; GENOMICS; HARM REDUCTION; HEAT; HUMAN; LUNG; METABOLISM; PNEUMONIA; PROCEDURES; PRODUCT SAFETY; RISK ASSESSMENT; SMOKE; SMOKING; SPRAGUE DAWLEY RAT; TIME FACTOR; TOBACCO INDUSTRY; TOXICITY; TOXICITY TESTING; TOXICOGENETICS;

AEROSOLS; ANIMALS; COMPUTATIONAL BIOLOGY; CONSUMER PRODUCT SAFETY; ELECTRONIC CIGARETTES; EQUIPMENT DESIGN; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC MARKERS; GENOMICS; HARM REDUCTION; HOT TEMPERATURE; HUMANS; INHALATION EXPOSURE; LUNG; MALE; MICRORNAS; PNEUMONIA; RATS, SPRAGUE-DAWLEY; RISK ASSESSMENT; SMOKE; SMOKING; TIME FACTORS; TOBACCO INDUSTRY; TOBACCO PRODUCTS; TOXICITY TESTS; TOXICOGENETICS; TRANSCRIPTOME;

EID: 85006931239     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2016.11.018     Document Type: Article

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