Evaluation of a microelectrode array-based assay for neural network ontogeny using training set chemicals

Toxicological Sciences

Volumn 154, Issue 1, 2016, Pages 126-139

  Brown, Jasmine P ^a   Hall, Diana ^a   Frank, Christopher L ^a   Wallace, Kathleen ^a   Mundy, William R ^a   Shafer, Timothy J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Alternatives to animal testing; Developmental; Electrophysiology; In vitro and alternatives; Neurotoxicity; Neurotoxicology; Screening

Indexed keywords

BISINDOLYLMALEIMIDE; COMPACTIN; DOMOIC ACID; LOPERAMIDE; PARACETAMOL; VANADATE SODIUM; INDOLE DERIVATIVE; KAINIC ACID; MALEIMIDE DERIVATIVE; MEVINOLIN; VANADIC ACID;

ANIMAL CELL; ARTICLE; ASSAY; BRAIN CELL; CELL MATURATION; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEVELOPMENTAL TOXICITY; DRUG CYTOTOXICITY; ELECTRIC ACTIVITY; FIRING RATE; HAZARD; MICROARRAY ANALYSIS; MICROELECTRODE; NERVE CELL NETWORK; NEUROTOXICITY; NONHUMAN; ONTOGENY; PRIMARY CELL; RANDOM FOREST; RAT; SPIKE; TRAINING; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; NERVE CELL; PRIMARY CELL CULTURE; PROCEDURES; TOXICITY TESTING;

ACETAMINOPHEN; ANIMALS; INDOLES; KAINIC ACID; LOPERAMIDE; LOVASTATIN; MALEIMIDES; MICROELECTRODES; NERVE NET; NEURONS; PRIMARY CELL CULTURE; RATS; TOXICITY TESTS; VANADATES;

EID: 85006263555     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfw147     Document Type: Article

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