A multiplexed assay for determination of neurotoxicant effects on spontaneous network activity and viability from microelectrode arrays

NeuroToxicology

Volumn 49, Issue , 2015, Pages 79-85

  Wallace, Kathleen ^a   Strickland, Jenna D ^b   Valdivia, Pablo ^b   Mundy, William R ^a   Shafer, Timothy J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b AXION BIOSYSTEMS   (United States)

Author keywords

Microelectrode array; Multiplexed assay; Screening

Indexed keywords

BETA CYFLUTHRIN; DOMOIC ACID; FIPRONIL; GLYPHOSATE; INSECTICIDE; LACTATE DEHYDROGENASE; LINDANE; NEUROTOXICANT; TOXIC SUBSTANCE; TRIBUTYLTIN; UNCLASSIFIED DRUG; NEUROTOXIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIPHASIC ALTERATION; BRAIN CORTEX; CELL ACTIVITY; CELL ASSAY; CELL FUNCTION; CELL HEALTH; CELL METABOLISM; CELL VIABILITY ASSAY KIT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; ENZYME RELEASE; HIGH THROUGHPUT SCREENING; MEAN FIRING RATE; MICROARRAY KIT; MICROELECTRODE ARRAY; MULTIPLEXED ASSAY; NERVE CELL NETWORK; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUS NETWORK ACTIVITY; ACTION POTENTIAL; ANIMAL; CELL CULTURE; CELL SURVIVAL; CEREBELLUM CORTEX; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; MICROELECTRODE; NERVE CELL;

RATTUS;

ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; CELL SURVIVAL; CELLS, CULTURED; CEREBELLAR CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; L-LACTATE DEHYDROGENASE; MICROELECTRODES; NERVE NET; NEURONS; NEUROTOXINS; RATS;

EID: 84930945887     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2015.05.007     Document Type: Article

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