Integrating Enzymatic Self-Assembly and Mitochondria Targeting for Selectively Killing Cancer Cells without Acquired Drug Resistance

Journal of the American Chemical Society

Volumn 138, Issue 49, 2016, Pages 16046-16055

  Wang, Huaimin ^a,b   Feng, Zhaoqianqi ^a   Wang, Youzhi ^b   Zhou, Rong ^a   Yang, Zhimou ^b   Xu, Bing ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b NANKAI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CYTOLOGY; DISEASES; DRUG THERAPY; MOLECULAR BIOLOGY; OLIGOMERS; PHOSPHATASES; REDOX REACTIONS; SELF ASSEMBLY;

ALKALINE PHOSPHATASE; CYTOTOXIC AGENTS; DEPHOSPHORYLATIONS; MOLECULAR PROCESS; NANOSCALE ASSEMBLIES; REDOX POTENTIALS; SPATIAL CONTROL; SUBCELLULAR TARGETING;

CELLS;

ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENT; CYTOCHROME C; TETRAPEPTIDE; TRIPHENYL PHOSPHINIUM; UNCLASSIFIED DRUG; ORGANOPHOSPHATE; TRIPHENYL PHOSPHATE;

APOPTOSIS; ARTICLE; CANCER CELL LINE; CANCER RESISTANCE; CAVEOLA; CELL DEATH; CELL KILLING; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG CYTOTOXICITY; ENANTIOMER; ENDOCYTOSIS; ENDOSOME; ENZYME INSTRUCTED SELF ASSEMBLY; FEMALE; GLIOBLASTOMA CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LYSOSOME; MCF 7 CELL LINE; MITOCHONDRION; PROTEIN ASSEMBLY; PROTEIN DEPHOSPHORYLATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SAOS 2 CELL LINE; STEREOCHEMISTRY; TARGET CELL; BIOCATALYSIS; CELL LINE; CHEMISTRY; DRUG EFFECT; METABOLISM; PHOSPHORYLATION;

ALKALINE PHOSPHATASE; BIOCATALYSIS; CELL DEATH; CELL LINE; HUMANS; MITOCHONDRIA; ORGANOPHOSPHATES; PHOSPHORYLATION;

EID: 85006085688     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.6b09783     Document Type: Article

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