메뉴 건너뛰기




Volumn 21, Issue 5, 2017, Pages 1033-1041

The roles of bone-derived exosomes and exosomal microRNAs in regulating bone remodelling

Author keywords

bone remodelling; exosome; microRNA; osteoblast; osteoclast

Indexed keywords

5' NUCLEOTIDASE; BETA1 INTEGRIN; ENDOGLIN; EPHRIN A2; GROWTH FACTOR; HERMES ANTIGEN; MICRORNA; MICROSOMAL AMINOPEPTIDASE; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE;

EID: 85005938329     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.13039     Document Type: Review
Times cited : (157)

References (86)
  • 1
    • 84922833524 scopus 로고    scopus 로고
    • Induction of osteoclast progenitors in inflammatory conditions: key to bone destruction in arthritis
    • Sucur A, Katavic V, Kelava T, et al. Induction of osteoclast progenitors in inflammatory conditions: key to bone destruction in arthritis. Int Orthop. 2014; 38: 1893–903.
    • (2014) Int Orthop , vol.38 , pp. 1893-1903
    • Sucur, A.1    Katavic, V.2    Kelava, T.3
  • 2
    • 80455178567 scopus 로고    scopus 로고
    • In vivo fluorescence imaging of bone-resorbing osteoclasts
    • Kowada T, Kikuta J, Kubo A, et al. In vivo fluorescence imaging of bone-resorbing osteoclasts. J Am Chem Soc. 2011; 133: 17772–6.
    • (2011) J Am Chem Soc , vol.133 , pp. 17772-17776
    • Kowada, T.1    Kikuta, J.2    Kubo, A.3
  • 3
    • 84961990597 scopus 로고    scopus 로고
    • Meta analysis of osteoporosis: fracture risks, medication and treatment
    • Liu W, Yang LH, Kong XC, et al. Meta analysis of osteoporosis: fracture risks, medication and treatment. Minerva Med. 2015; 106: 203–14.
    • (2015) Minerva Med , vol.106 , pp. 203-214
    • Liu, W.1    Yang, L.H.2    Kong, X.C.3
  • 4
    • 84877157804 scopus 로고    scopus 로고
    • Steroids and osteoporosis: the quest for mechanisms
    • Manolagas SC. Steroids and osteoporosis: the quest for mechanisms. J Clin Invest. 2013; 123: 1919–21.
    • (2013) J Clin Invest , vol.123 , pp. 1919-1921
    • Manolagas, S.C.1
  • 5
    • 84893736988 scopus 로고    scopus 로고
    • Osteoclast-derived coupling factors in bone remodeling
    • Henriksen K, Karsdal MA, Martin TJ. Osteoclast-derived coupling factors in bone remodeling. Calcif Tissue Int. 2014; 94: 88–97.
    • (2014) Calcif Tissue Int , vol.94 , pp. 88-97
    • Henriksen, K.1    Karsdal, M.A.2    Martin, T.J.3
  • 6
    • 84898472352 scopus 로고    scopus 로고
    • A review of denosumab for the treatment of osteoporosis
    • Miyazaki T, Tokimura F, Tanaka S. A review of denosumab for the treatment of osteoporosis. Patient Prefer Adherence. 2014; 8: 463–71.
    • (2014) Patient Prefer Adherence , vol.8 , pp. 463-471
    • Miyazaki, T.1    Tokimura, F.2    Tanaka, S.3
  • 7
    • 42749088910 scopus 로고    scopus 로고
    • Osteoclast-osteoblast communication
    • Matsuo K, Irie N. Osteoclast-osteoblast communication. Arch Biochem Biophys. 2008; 473: 201–9.
    • (2008) Arch Biochem Biophys , vol.473 , pp. 201-209
    • Matsuo, K.1    Irie, N.2
  • 8
    • 28544433422 scopus 로고    scopus 로고
    • Osteoclast precursors, RANKL/RANK, and immunology
    • Xing L, Schwarz EM, Boyce BF. Osteoclast precursors, RANKL/RANK, and immunology. Immunol Rev. 2005; 208: 19–29.
    • (2005) Immunol Rev , vol.208 , pp. 19-29
    • Xing, L.1    Schwarz, E.M.2    Boyce, B.F.3
  • 9
    • 84873828600 scopus 로고    scopus 로고
    • Osteoclast migration, differentiation and function: novel therapeutic targets for rheumatic diseases
    • Kikuta J, Ishii M. Osteoclast migration, differentiation and function: novel therapeutic targets for rheumatic diseases. Rheumatology (Oxford, England). 2013; 52: 226–34.
    • (2013) Rheumatology (Oxford, England) , vol.52 , pp. 226-234
    • Kikuta, J.1    Ishii, M.2
  • 10
    • 0022371241 scopus 로고
    • The pathomechanics of osteoporoses
    • Frost HM. The pathomechanics of osteoporoses. Clin Orthop Relat Res. 1985; 200: 198–225.
    • (1985) Clin Orthop Relat Res , vol.200 , pp. 198-225
    • Frost, H.M.1
  • 11
    • 84943659307 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling in bone homeostasis
    • Sanchez-Duffhues G, Hiepen C, Knaus P, et al. Bone morphogenetic protein signaling in bone homeostasis. Bone. 2015; 80: 43–59.
    • (2015) Bone , vol.80 , pp. 43-59
    • Sanchez-Duffhues, G.1    Hiepen, C.2    Knaus, P.3
  • 13
    • 77950636786 scopus 로고    scopus 로고
    • The birth of the osteoclast
    • Chambers TJ. The birth of the osteoclast. Ann N Y Acad Sci. 2010; 1192: 19–26.
    • (2010) Ann N Y Acad Sci , vol.1192 , pp. 19-26
    • Chambers, T.J.1
  • 15
    • 33846031926 scopus 로고    scopus 로고
    • The molecular understanding of osteoclast differentiation
    • Asagiri M, Takayanagi H. The molecular understanding of osteoclast differentiation. Bone. 2007; 40: 251–64.
    • (2007) Bone , vol.40 , pp. 251-264
    • Asagiri, M.1    Takayanagi, H.2
  • 16
    • 84884254939 scopus 로고    scopus 로고
    • Advances in the regulation of osteoclasts and osteoclast functions
    • Boyce BF. Advances in the regulation of osteoclasts and osteoclast functions. J Dent Res. 2013; 92: 860–7.
    • (2013) J Dent Res , vol.92 , pp. 860-867
    • Boyce, B.F.1
  • 18
    • 84865765939 scopus 로고    scopus 로고
    • Intercellular cross-talk among bone cells: new factors and pathways
    • Sims NA, Walsh NC. Intercellular cross-talk among bone cells: new factors and pathways. Current Osteoporos Rep. 2012; 10: 109–17.
    • (2012) Current Osteoporos Rep , vol.10 , pp. 109-117
    • Sims, N.A.1    Walsh, N.C.2
  • 19
    • 84964883964 scopus 로고    scopus 로고
    • DC-STAMP: a key regulator in osteoclast differentiation
    • Chiu YG, Ritchlin CT. DC-STAMP: a key regulator in osteoclast differentiation. J Cell Physiol. 2016; 231: 2402–7.
    • (2016) J Cell Physiol , vol.231 , pp. 2402-2407
    • Chiu, Y.G.1    Ritchlin, C.T.2
  • 20
    • 84971006467 scopus 로고    scopus 로고
    • Characterization of regulatory extracellular vesicles from osteoclasts
    • Huynh N, VonMoss L, Smith D, et al. Characterization of regulatory extracellular vesicles from osteoclasts. J Dent Res. 2016; 95: 673–9.
    • (2016) J Dent Res , vol.95 , pp. 673-679
    • Huynh, N.1    VonMoss, L.2    Smith, D.3
  • 21
    • 84907904739 scopus 로고    scopus 로고
    • MicroRNAs in the skeleton: cell-restricted or potent intercellular communicators?
    • van der Eerden BC. MicroRNAs in the skeleton: cell-restricted or potent intercellular communicators? Arch Biochem Biophys. 2014; 561: 46–55.
    • (2014) Arch Biochem Biophys , vol.561 , pp. 46-55
    • van der Eerden, B.C.1
  • 22
    • 84930678778 scopus 로고    scopus 로고
    • Osteoblast-derived microvesicles: a novel mechanism for communication between osteoblasts and osteoclasts
    • Deng L, Wang Y, Peng Y, et al. Osteoblast-derived microvesicles: a novel mechanism for communication between osteoblasts and osteoclasts. Bone. 2015; 79: 37–42.
    • (2015) Bone , vol.79 , pp. 37-42
    • Deng, L.1    Wang, Y.2    Peng, Y.3
  • 23
    • 84906888575 scopus 로고    scopus 로고
    • Exosomes in prostate cancer: putting together the pieces of a puzzle
    • Soekmadji C, Russell PJ, Nelson CC. Exosomes in prostate cancer: putting together the pieces of a puzzle. Cancers. 2013; 5: 1522–44.
    • (2013) Cancers , vol.5 , pp. 1522-1544
    • Soekmadji, C.1    Russell, P.J.2    Nelson, C.C.3
  • 24
    • 84863076731 scopus 로고    scopus 로고
    • The protein interaction network of extracellular vesicles derived from human colorectal cancer cells
    • Choi DS, Yang JS, Choi EJ, et al. The protein interaction network of extracellular vesicles derived from human colorectal cancer cells. J Proteome Res. 2012; 11: 1144–51.
    • (2012) J Proteome Res , vol.11 , pp. 1144-1151
    • Choi, D.S.1    Yang, J.S.2    Choi, E.J.3
  • 25
    • 84904704297 scopus 로고    scopus 로고
    • Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
    • Colombo M, Raposo G, Thery C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014; 30: 255–89.
    • (2014) Annu Rev Cell Dev Biol , vol.30 , pp. 255-289
    • Colombo, M.1    Raposo, G.2    Thery, C.3
  • 26
    • 84873153440 scopus 로고    scopus 로고
    • Exosomes and communication between tumours and the immune system: are all exosomes equal?
    • Bobrie A, Thery C. Exosomes and communication between tumours and the immune system: are all exosomes equal? Biochem Soc Trans. 2013; 41: 263–7.
    • (2013) Biochem Soc Trans , vol.41 , pp. 263-267
    • Bobrie, A.1    Thery, C.2
  • 27
    • 71549122588 scopus 로고    scopus 로고
    • Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells
    • Hong BS, Cho JH, Kim H, et al. Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells. BMC Genom. 2009; 10: 556.
    • (2009) BMC Genom , vol.10 , pp. 556
    • Hong, B.S.1    Cho, J.H.2    Kim, H.3
  • 30
    • 84890130042 scopus 로고    scopus 로고
    • Novel bone endocrine networks integrating mineral and energy metabolism
    • Pi M, Quarles LD. Novel bone endocrine networks integrating mineral and energy metabolism. Current Osteoporos Rep. 2013; 11: 391–9.
    • (2013) Current Osteoporos Rep , vol.11 , pp. 391-399
    • Pi, M.1    Quarles, L.D.2
  • 31
    • 79751499788 scopus 로고    scopus 로고
    • Disorders of bone remodeling
    • Feng X, McDonald JM. Disorders of bone remodeling. Annu Rev Pathol. 2011; 6: 121–45.
    • (2011) Annu Rev Pathol , vol.6 , pp. 121-145
    • Feng, X.1    McDonald, J.M.2
  • 32
    • 85001682075 scopus 로고    scopus 로고
    • Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity
    • Sun W, Zhao C, Li Y, et al. Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity. Cell discov. 2016; 2: 16015.
    • (2016) Cell discov , vol.2 , pp. 16015
    • Sun, W.1    Zhao, C.2    Li, Y.3
  • 33
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: exosomes, microvesicles, and friends
    • Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013; 200: 373–83.
    • (2013) J Cell Biol , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 34
    • 36348935057 scopus 로고    scopus 로고
    • Malignant ascites-derived exosomes of ovarian carcinoma patients contain CD24 and EpCAM
    • Runz S, Keller S, Rupp C, et al. Malignant ascites-derived exosomes of ovarian carcinoma patients contain CD24 and EpCAM. Gynecol Oncol. 2007; 107: 563–71.
    • (2007) Gynecol Oncol , vol.107 , pp. 563-571
    • Runz, S.1    Keller, S.2    Rupp, C.3
  • 35
    • 67349263394 scopus 로고    scopus 로고
    • Trafficking and function of the tetraspanin CD63
    • Pols MS, Klumperman J. Trafficking and function of the tetraspanin CD63. Exp Cell Res. 2009; 315: 1584–92.
    • (2009) Exp Cell Res , vol.315 , pp. 1584-1592
    • Pols, M.S.1    Klumperman, J.2
  • 36
    • 79953229234 scopus 로고    scopus 로고
    • Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells
    • Antonyak MA, Li B, Boroughs LK, et al. Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells. Proc Natl Acad Sci USA. 2011; 108: 4852–7.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 4852-4857
    • Antonyak, M.A.1    Li, B.2    Boroughs, L.K.3
  • 37
    • 84944871300 scopus 로고    scopus 로고
    • Identification and proteomic analysis of osteoblast-derived exosomes
    • Ge M, Ke R, Cai T, et al. Identification and proteomic analysis of osteoblast-derived exosomes. Biochem Biophys Res Commun. 2015; 467: 27–32.
    • (2015) Biochem Biophys Res Commun , vol.467 , pp. 27-32
    • Ge, M.1    Ke, R.2    Cai, T.3
  • 38
    • 84990197797 scopus 로고    scopus 로고
    • Isolation and characterization of exosome from human embryonic stem cell-derived C-Myc-immortalized mesenchymal stem cells
    • Lai RC, Yeo RW, Padmanabhan J, et al. Isolation and characterization of exosome from human embryonic stem cell-derived C-Myc-immortalized mesenchymal stem cells. Methods Mol Biol. 2016; 1416: 477–94.
    • (2016) Methods Mol Biol , vol.1416 , pp. 477-494
    • Lai, R.C.1    Yeo, R.W.2    Padmanabhan, J.3
  • 39
    • 11144357428 scopus 로고    scopus 로고
    • ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome
    • Yang X, Matsuda K, Bialek P, et al. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell. 2004; 117: 387–98.
    • (2004) Cell , vol.117 , pp. 387-398
    • Yang, X.1    Matsuda, K.2    Bialek, P.3
  • 40
    • 84918547106 scopus 로고    scopus 로고
    • Altered microRNA expression profile in exosomes during osteogenic differentiation of human bone marrow-derived mesenchymal stem cells
    • Xu JF, Yang GH, Pan XH, et al. Altered microRNA expression profile in exosomes during osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. PLoS One. 2014; 9: e114627.
    • (2014) PLoS One , vol.9
    • Xu, J.F.1    Yang, G.H.2    Pan, X.H.3
  • 41
    • 84955577585 scopus 로고    scopus 로고
    • Exosomes derived from mineralizing osteoblasts promote ST2 cell osteogenic differentiation by alteration of microRNA expression
    • Cui Y, Luan J, Li H, et al. Exosomes derived from mineralizing osteoblasts promote ST2 cell osteogenic differentiation by alteration of microRNA expression. FEBS Lett. 2016; 590: 185–92.
    • (2016) FEBS Lett , vol.590 , pp. 185-192
    • Cui, Y.1    Luan, J.2    Li, H.3
  • 42
    • 84969277811 scopus 로고    scopus 로고
    • Exosome: a novel approach to stimulate bone regeneration through regulation of osteogenesis and angiogenesis
    • Qin Y, Sun R, Wu C, et al. Exosome: a novel approach to stimulate bone regeneration through regulation of osteogenesis and angiogenesis. Int J Mol Sci. 2016; 17: 712.
    • (2016) Int J Mol Sci , vol.17 , pp. 712
    • Qin, Y.1    Sun, R.2    Wu, C.3
  • 43
    • 84959421655 scopus 로고    scopus 로고
    • Bone marrow stromal/stem cell-derived extracellular vesicles regulate osteoblast activity and differentiation in vitro and promote bone regeneration in vivo
    • Qin Y, Wang L, Gao Z, et al. Bone marrow stromal/stem cell-derived extracellular vesicles regulate osteoblast activity and differentiation in vitro and promote bone regeneration in vivo. Sci Rep. 2016; 6: 21961.
    • (2016) Sci Rep , vol.6 , pp. 21961
    • Qin, Y.1    Wang, L.2    Gao, Z.3
  • 44
    • 77049089562 scopus 로고    scopus 로고
    • Transforming growth factor beta1 induces osteogenic differentiation of murine bone marrow stromal cells
    • Zhao L, Jiang S, Hantash BM. Transforming growth factor beta1 induces osteogenic differentiation of murine bone marrow stromal cells. Tissue Eng Part A. 2010; 16: 725–33.
    • (2010) Tissue Eng Part A , vol.16 , pp. 725-733
    • Zhao, L.1    Jiang, S.2    Hantash, B.M.3
  • 45
    • 79958202199 scopus 로고    scopus 로고
    • BMP-9 induced osteogenic differentiation of mesenchymal stem cells: molecular mechanism and therapeutic potential
    • Luther G, Wagner ER, Zhu G, et al. BMP-9 induced osteogenic differentiation of mesenchymal stem cells: molecular mechanism and therapeutic potential. Curr Gene Ther. 2011; 11: 229–40.
    • (2011) Curr Gene Ther , vol.11 , pp. 229-240
    • Luther, G.1    Wagner, E.R.2    Zhu, G.3
  • 46
    • 84888176716 scopus 로고    scopus 로고
    • BMP9 signaling in stem cell differentiation and osteogenesis
    • Lamplot JD, Qin J, Nan G, et al. BMP9 signaling in stem cell differentiation and osteogenesis. Am J Stem Cells. 2013; 2: 1–21.
    • (2013) Am J Stem Cells , vol.2 , pp. 1-21
    • Lamplot, J.D.1    Qin, J.2    Nan, G.3
  • 47
    • 84955605332 scopus 로고    scopus 로고
    • Hijacking the cellular mail: exosome mediated differentiation of mesenchymal stem cells
    • Narayanan R, Huang CC, Ravindran S. Hijacking the cellular mail: exosome mediated differentiation of mesenchymal stem cells. Stem Cells Int. 2016; 2016: 3808674.
    • (2016) Stem Cells Int , vol.2016 , pp. 3808674
    • Narayanan, R.1    Huang, C.C.2    Ravindran, S.3
  • 48
    • 84921407934 scopus 로고    scopus 로고
    • Tartrate-resistant acid phosphatase (TRAP) co-localizes with receptor activator of NF-KB ligand (RANKL) and osteoprotegerin (OPG) in lysosomal-associated membrane protein 1 (LAMP1)-positive vesicles in rat osteoblasts and osteocytes
    • Solberg LB, Stang E, Brorson SH, et al. Tartrate-resistant acid phosphatase (TRAP) co-localizes with receptor activator of NF-KB ligand (RANKL) and osteoprotegerin (OPG) in lysosomal-associated membrane protein 1 (LAMP1)-positive vesicles in rat osteoblasts and osteocytes. Histochem Cell Biol. 2015; 143: 195–207.
    • (2015) Histochem Cell Biol , vol.143 , pp. 195-207
    • Solberg, L.B.1    Stang, E.2    Brorson, S.H.3
  • 49
    • 84884254033 scopus 로고    scopus 로고
    • Monocyte exosomes stimulate the osteogenic gene expression of mesenchymal stem cells
    • Ekstrom K, Omar O, Graneli C, et al. Monocyte exosomes stimulate the osteogenic gene expression of mesenchymal stem cells. PLoS One. 2013; 8: e75227.
    • (2013) PLoS One , vol.8
    • Ekstrom, K.1    Omar, O.2    Graneli, C.3
  • 50
    • 80052387310 scopus 로고    scopus 로고
    • The stimulation of an osteogenic response by classical monocyte activation
    • Omar OM, Graneli C, Ekstrom K, et al. The stimulation of an osteogenic response by classical monocyte activation. Biomaterials. 2011; 32: 8190–204.
    • (2011) Biomaterials , vol.32 , pp. 8190-8204
    • Omar, O.M.1    Graneli, C.2    Ekstrom, K.3
  • 51
    • 84960427882 scopus 로고    scopus 로고
    • Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
    • Li D, Liu J, Guo B, et al. Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nat Commun. 2016; 7: 10872.
    • (2016) Nat Commun , vol.7 , pp. 10872
    • Li, D.1    Liu, J.2    Guo, B.3
  • 52
    • 60649085328 scopus 로고    scopus 로고
    • Proteomic analysis of extracellular matrix and vesicles
    • Xiao Z, Blonder J, Zhou M, et al. Proteomic analysis of extracellular matrix and vesicles. J Proteomics. 2009; 72: 34–45.
    • (2009) J Proteomics , vol.72 , pp. 34-45
    • Xiao, Z.1    Blonder, J.2    Zhou, M.3
  • 53
    • 84930681731 scopus 로고    scopus 로고
    • Matrix vesicles: are they anchored exosomes?
    • Shapiro IM, Landis WJ, Risbud MV. Matrix vesicles: are they anchored exosomes? Bone. 2015; 79: 29–36.
    • (2015) Bone , vol.79 , pp. 29-36
    • Shapiro, I.M.1    Landis, W.J.2    Risbud, M.V.3
  • 54
    • 66049112958 scopus 로고    scopus 로고
    • MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis
    • Nakamachi Y, Kawano S, Takenokuchi M, et al. MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum. 2009; 60: 1294–304.
    • (2009) Arthritis Rheum , vol.60 , pp. 1294-1304
    • Nakamachi, Y.1    Kawano, S.2    Takenokuchi, M.3
  • 55
    • 26944441255 scopus 로고    scopus 로고
    • Dicing and slicing: the core machinery of the RNA interference pathway
    • Hammond SM. Dicing and slicing: the core machinery of the RNA interference pathway. FEBS Lett. 2005; 579: 5822–9.
    • (2005) FEBS Lett , vol.579 , pp. 5822-5829
    • Hammond, S.M.1
  • 56
    • 26944431852 scopus 로고    scopus 로고
    • Small RNA asymmetry in RNAi: function in RISC assembly and gene regulation
    • Hutvagner G. Small RNA asymmetry in RNAi: function in RISC assembly and gene regulation. FEBS Lett. 2005; 579: 5850–7.
    • (2005) FEBS Lett , vol.579 , pp. 5850-5857
    • Hutvagner, G.1
  • 57
    • 1642374097 scopus 로고    scopus 로고
    • Specificity of microRNA target selection in translational repression
    • Doench JG, Sharp PA. Specificity of microRNA target selection in translational repression. Genes Dev. 2004; 18: 504–11.
    • (2004) Genes Dev , vol.18 , pp. 504-511
    • Doench, J.G.1    Sharp, P.A.2
  • 58
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - microRNAs with a role in cancer
    • Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer. 2006; 6: 259–69.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 59
    • 84879024861 scopus 로고    scopus 로고
    • Secretion of microvesicular miRNAs in cellular and organismal aging
    • Weilner S, Schraml E, Redl H, et al. Secretion of microvesicular miRNAs in cellular and organismal aging. Exp Gerontol. 2013; 48: 626–33.
    • (2013) Exp Gerontol , vol.48 , pp. 626-633
    • Weilner, S.1    Schraml, E.2    Redl, H.3
  • 60
    • 84857126923 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/beta-catenin signaling
    • Egea V, Zahler S, Rieth N, et al. Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/beta-catenin signaling. Proc Natl Acad Sci USA. 2012; 109: E309–16.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. E309-E316
    • Egea, V.1    Zahler, S.2    Rieth, N.3
  • 61
    • 84903134495 scopus 로고    scopus 로고
    • let-7 enhances osteogenesis and bone formation while repressing adipogenesis of human stromal/mesenchymal stem cells by regulating HMGA2
    • Wei J, Li H, Wang S, et al. let-7 enhances osteogenesis and bone formation while repressing adipogenesis of human stromal/mesenchymal stem cells by regulating HMGA2. Stem Cells Dev. 2014; 23: 1452–63.
    • (2014) Stem Cells Dev , vol.23 , pp. 1452-1463
    • Wei, J.1    Li, H.2    Wang, S.3
  • 62
    • 79960015376 scopus 로고    scopus 로고
    • A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2
    • Zhang Y, Xie RL, Croce CM, et al. A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2. Proc Natl Acad Sci USA. 2011; 108: 9863–8.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 9863-9868
    • Zhang, Y.1    Xie, R.L.2    Croce, C.M.3
  • 63
    • 52949114558 scopus 로고    scopus 로고
    • A microRNA signature for a BMP2-induced osteoblast lineage commitment program
    • Li Z, Hassan MQ, Volinia S, et al. A microRNA signature for a BMP2-induced osteoblast lineage commitment program. Proc Natl Acad Sci USA. 2008; 105: 13906–11.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 13906-13911
    • Li, Z.1    Hassan, M.Q.2    Volinia, S.3
  • 64
    • 77149136767 scopus 로고    scopus 로고
    • MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation
    • Huang J, Zhao L, Xing L, et al. MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells. 2010; 28: 357–64.
    • (2010) Stem Cells , vol.28 , pp. 357-364
    • Huang, J.1    Zhao, L.2    Xing, L.3
  • 65
    • 84885900540 scopus 로고    scopus 로고
    • Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes
    • Lauvrak SU, Munthe E, Kresse SH, et al. Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes. Br J Cancer. 2013; 109: 2228–36.
    • (2013) Br J Cancer , vol.109 , pp. 2228-2236
    • Lauvrak, S.U.1    Munthe, E.2    Kresse, S.H.3
  • 66
    • 77954209607 scopus 로고    scopus 로고
    • MicroRNA hsa-miR-135b regulates mineralization in osteogenic differentiation of human unrestricted somatic stem cells
    • Schaap-Oziemlak AM, Raymakers RA, Bergevoet SM, et al. MicroRNA hsa-miR-135b regulates mineralization in osteogenic differentiation of human unrestricted somatic stem cells. Stem Cells Dev. 2010; 19: 877–85.
    • (2010) Stem Cells Dev , vol.19 , pp. 877-885
    • Schaap-Oziemlak, A.M.1    Raymakers, R.A.2    Bergevoet, S.M.3
  • 67
    • 84892416479 scopus 로고    scopus 로고
    • Upregulation of miR-135b is involved in the impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients
    • Xu S, Cecilia Santini G, De Veirman K, et al. Upregulation of miR-135b is involved in the impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients. PLoS One. 2013; 8: e79752.
    • (2013) PLoS One , vol.8
    • Xu, S.1    Cecilia Santini, G.2    De Veirman, K.3
  • 68
    • 84862278575 scopus 로고    scopus 로고
    • Wnt5a signaling is a substantial constituent in bone morphogenetic protein-2-mediated osteoblastogenesis
    • Nemoto E, Ebe Y, Kanaya S, et al. Wnt5a signaling is a substantial constituent in bone morphogenetic protein-2-mediated osteoblastogenesis. Biochem Biophys Res Commun. 2012; 422: 627–32.
    • (2012) Biochem Biophys Res Commun , vol.422 , pp. 627-632
    • Nemoto, E.1    Ebe, Y.2    Kanaya, S.3
  • 69
    • 84906265350 scopus 로고    scopus 로고
    • miR-140-5p suppresses BMP2-mediated osteogenesis in undifferentiated human mesenchymal stem cells
    • Hwang S, Park SK, Lee HY, et al. miR-140-5p suppresses BMP2-mediated osteogenesis in undifferentiated human mesenchymal stem cells. FEBS Lett. 2014; 588: 2957–63.
    • (2014) FEBS Lett , vol.588 , pp. 2957-2963
    • Hwang, S.1    Park, S.K.2    Lee, H.Y.3
  • 70
    • 84871345038 scopus 로고    scopus 로고
    • miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells
    • Hassan MQ, Maeda Y, Taipaleenmaki H, et al. miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells. J Biol Chem. 2012; 287: 42084–92.
    • (2012) J Biol Chem , vol.287 , pp. 42084-42092
    • Hassan, M.Q.1    Maeda, Y.2    Taipaleenmaki, H.3
  • 71
    • 65949105697 scopus 로고    scopus 로고
    • miR-196a regulates proliferation and osteogenic differentiation in mesenchymal stem cells derived from human adipose tissue
    • Kim YJ, Bae SW, Yu SS, et al. miR-196a regulates proliferation and osteogenic differentiation in mesenchymal stem cells derived from human adipose tissue. J Bone Miner Res. 2009; 24: 816–25.
    • (2009) J Bone Miner Res , vol.24 , pp. 816-825
    • Kim, Y.J.1    Bae, S.W.2    Yu, S.S.3
  • 72
    • 84872575073 scopus 로고    scopus 로고
    • miR-181a promotes osteoblastic differentiation through repression of TGF-beta signaling molecules
    • Bhushan R, Grunhagen J, Becker J, et al. miR-181a promotes osteoblastic differentiation through repression of TGF-beta signaling molecules. Int J Biochem Cell Biol. 2013; 45: 696–705.
    • (2013) Int J Biochem Cell Biol , vol.45 , pp. 696-705
    • Bhushan, R.1    Grunhagen, J.2    Becker, J.3
  • 73
    • 79960633240 scopus 로고    scopus 로고
    • Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1
    • Zhang J, Tu Q, Bonewald LF, et al. Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1. J Bone Miner Res. 2011; 26: 1953–63.
    • (2011) J Bone Miner Res , vol.26 , pp. 1953-1963
    • Zhang, J.1    Tu, Q.2    Bonewald, L.F.3
  • 74
    • 84912133951 scopus 로고    scopus 로고
    • MiR-378 overexpression attenuates high glucose-suppressed osteogenic differentiation through targeting CASP3 and activating PI3K/Akt signaling pathway
    • You L, Gu W, Chen L, et al. MiR-378 overexpression attenuates high glucose-suppressed osteogenic differentiation through targeting CASP3 and activating PI3K/Akt signaling pathway. Int J Clin Exp Pathol. 2014; 7: 7249–61.
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 7249-7261
    • You, L.1    Gu, W.2    Chen, L.3
  • 75
    • 84892719952 scopus 로고    scopus 로고
    • MiR-503 regulates osteoclastogenesis via targeting RANK
    • Chen C, Cheng P, Xie H, et al. MiR-503 regulates osteoclastogenesis via targeting RANK. J Bone Miner Res. 2014; 29: 338–47.
    • (2014) J Bone Miner Res , vol.29 , pp. 338-347
    • Chen, C.1    Cheng, P.2    Xie, H.3
  • 76
    • 84899150663 scopus 로고    scopus 로고
    • Review of Signaling Pathways Governing MSC Osteogenic and Adipogenic Differentiation
    • James AW. Review of Signaling Pathways Governing MSC Osteogenic and Adipogenic Differentiation. Scientifica (Cairo). 2013; 2013: 684736.
    • (2013) Scientifica (Cairo) , vol.2013 , pp. 684736
    • James, A.W.1
  • 77
    • 84876743029 scopus 로고    scopus 로고
    • miR-148a regulates osteoclastogenesis by targeting V-maf musculoaponeurotic fibrosarcoma oncogene homolog B
    • Cheng P, Chen C, He HB, et al. miR-148a regulates osteoclastogenesis by targeting V-maf musculoaponeurotic fibrosarcoma oncogene homolog B. J Bone Miner Res. 2013; 28: 1180–90.
    • (2013) J Bone Miner Res , vol.28 , pp. 1180-1190
    • Cheng, P.1    Chen, C.2    He, H.B.3
  • 78
    • 84872094361 scopus 로고    scopus 로고
    • miR-214 targets ATF4 to inhibit bone formation
    • Wang X, Guo B, Li Q, et al. miR-214 targets ATF4 to inhibit bone formation. Nat Med. 2013; 19: 93–100.
    • (2013) Nat Med , vol.19 , pp. 93-100
    • Wang, X.1    Guo, B.2    Li, Q.3
  • 79
    • 84928230801 scopus 로고    scopus 로고
    • miR-214 promotes osteoclastogenesis by targeting Pten/PI3k/Akt pathway
    • Zhao C, Sun W, Zhang P, et al. miR-214 promotes osteoclastogenesis by targeting Pten/PI3k/Akt pathway. RNA Biol. 2015; 12: 343–53.
    • (2015) RNA Biol , vol.12 , pp. 343-353
    • Zhao, C.1    Sun, W.2    Zhang, P.3
  • 80
    • 84964345760 scopus 로고    scopus 로고
    • Regulation of bone metabolism by Wnt signals
    • Kobayashi Y, Uehara S, Udagawa N, et al. Regulation of bone metabolism by Wnt signals. J Biochem. 2016; 159: 387–92.
    • (2016) J Biochem , vol.159 , pp. 387-392
    • Kobayashi, Y.1    Uehara, S.2    Udagawa, N.3
  • 81
    • 67849084531 scopus 로고    scopus 로고
    • Cross-talk among bone cells
    • Matsuo K. Cross-talk among bone cells. Curr Opin Nephrol Hypertens. 2009; 18: 292–7.
    • (2009) Curr Opin Nephrol Hypertens , vol.18 , pp. 292-297
    • Matsuo, K.1
  • 82
    • 84938561150 scopus 로고    scopus 로고
    • Non-coding RNAs in Exosomes: new Players in Cancer Biology
    • Silva M, Melo SA. Non-coding RNAs in Exosomes: new Players in Cancer Biology. Curr Genomics. 2015; 16: 295–303.
    • (2015) Curr Genomics , vol.16 , pp. 295-303
    • Silva, M.1    Melo, S.A.2
  • 83
    • 84919741824 scopus 로고    scopus 로고
    • Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation
    • Inder KL, Ruelcke JE, Petelin L, et al. Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation. J Extracell Vesicles. 2014; 3: 23784.
    • (2014) J Extracell Vesicles , vol.3 , pp. 23784
    • Inder, K.L.1    Ruelcke, J.E.2    Petelin, L.3
  • 84
    • 84931032854 scopus 로고    scopus 로고
    • Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation
    • Raimondi L, De Luca A, Amodio N, et al. Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation. Oncotarget. 2015; 6: 13772–89.
    • (2015) Oncotarget , vol.6 , pp. 13772-13789
    • Raimondi, L.1    De Luca, A.2    Amodio, N.3
  • 85
    • 84867619100 scopus 로고    scopus 로고
    • Exosomal secretion of death bullets: a new way of apoptotic escape?
    • Trokovic N, Pollanen R, Porola P, et al. Exosomal secretion of death bullets: a new way of apoptotic escape? Am J Physiol Endocrinol Metab. 2012; 303: E1015–24.
    • (2012) Am J Physiol Endocrinol Metab , vol.303 , pp. E1015-E1024
    • Trokovic, N.1    Pollanen, R.2    Porola, P.3
  • 86
    • 84979258371 scopus 로고    scopus 로고
    • Exosome-Mediated Targeted Delivery of miRNAs
    • Ohno S, Kuroda M. Exosome-Mediated Targeted Delivery of miRNAs. Methods Mol Biol. 2016; 1448: 261–70.
    • (2016) Methods Mol Biol , vol.1448 , pp. 261-270
    • Ohno, S.1    Kuroda, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.