Exosomes and communication between tumours and the immune system: Are all exosomes equal?

Biochemical Society Transactions

Volumn 41, Issue 1, 2013, Pages 263-267

  Bobrie, Angelique ^a,b,c   Thery, Clotilde ^a,b  

^a INSTITUT CURIE   (France)

^b PSL RESEARCH UNIVERSITY   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Exosome; Extracellular vesicle; Milk fat globule epidermal growth factor Factor VIII protein (Mfge8); Rab27a; Tumour immunity

Indexed keywords

CELL COMMUNICATION; CELL FUNCTION; CELL HETEROGENEITY; CELL SUBPOPULATION; CELLULAR SECRETION; CONFERENCE PAPER; EXOSOME; HUMAN; IMMUNE SYSTEM; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR MICROENVIRONMENT;

EXOSOMES; HUMANS; LIPID BILAYERS; NEOPLASMS;

EID: 84873153440     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20120245     Document Type: Conference Paper

References (31)

1. Al-Nedawi, K., Meehan, B., Micallef, J., Lhotak, V., May, L., Guha, A. and Rak, J. (2008) Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat. Cell Biol. 10, 619-624 (Pubitemid 351627382)
2. Andreola, G., Rivoltini, L., Castelli, C., Huber, V., Perego, P., Deho, P., Squarcina, P., Accornero, P., Lozupone, F., Lugini, L. et al. (2002) Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J. Exp. Med. 195, 1303-1316 (Pubitemid 34564332)
3. Clayton, A., Mitchell, J. P., Court, J., Mason, M. D. and Tabi, Z. (2007) Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2. Cancer Res. 67, 7458-7466 (Pubitemid 47214451)
4. Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. et al. (2012) Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat. Med. 18, 883-891
5. Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Sena-Esteves, M., Curry, Jr, W. T., Carter, B. S., Krichevsky, A. M. and Breakefield, X. O. (2008) Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat. Cell Biol. 10, 1470-1476
6. Bobrie, A., Colombo, M., Raposo, G. and Théry, C. (2011) Exosome secretion: molecular mechanisms and roles in immune responses. Traffic 12, 1659-1668
7. Simons, M. and Raposo, G. (2009) Exosomes: vesicular carriers for intercellular communication. Curr. Opin. Cell Biol. 21, 575-581
8. Théry, C., Ostrowski, M. and Segura, E. (2009) Membrane vesicles as conveyors of immune responses. Nat. Rev. Immunol. 9, 581-593
9. Théry, C., Amigorena, S., Raposo, G. and Clayton, A. (2006) Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr. Protoc. Cell Biol., Chapter 3, Unit 3. 22
10. Bobrie, A., Colombo, M., Krumeich, S., Raposo, G. and Théry, C. (2012) Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation. J. Extracell. Vesicles 1, 18397
11. Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J. and Geuze, H. J. (1996) B lymphocytes secrete antigen-presenting vesicles. J. Exp. Med. 183, 1161-1172 (Pubitemid 26113979)
12. Théry, C., Regnault, A., Garin, J., Wolfers, J., Zitvogel, L., Ricciardi-Castagnoli, P., Raposo, G. and Amigorena, S. (1999) Molecular characterization of dendritic cell-derived exosomes: selective accumulation of the heat shock protein hsc73. J. Cell Biol. 147, 599-610 (Pubitemid 29523465)
13. Zitvogel, L., Regnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi-Castagnoli, P., Raposo, G. and Amigorena, S. (1998) Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat. Med. 4, 594-600 (Pubitemid 28237359)
14. Andre, F., Schartz, N. E., Movassagh, M., Flament, C., Pautier, P., Morice, P., Pomel, C., Lhomme, C., Escudier, B., Le Chevalier, T. et al. (2002) Malignant effusions and immunogenic tumour-derived exosomes. Lancet 360, 295-305 (Pubitemid 34874721)
15. Wolfers, J., Lozier, A., Raposo, G., Regnault, A., Théry, C., Masurier, C., Flament, C., Pouzieux, S., Faure, F., Tursz, T. et al. (2001) Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat. Med. 7, 297-303 (Pubitemid 32224344)
16. Escola, J. M., Kleijmeer, M. J., Stoorvogel, W., Griffith, J. M., Yoshie, O. and Geuze, H. J. (1998) Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J. Biol. Chem. 273, 20121-20127 (Pubitemid 28377568)
17. Aalberts, M., van Dissel-Emiliani, F. M., van Adrichem, N. P., van Wijnen, M., Wauben, M. H., Stout, T. A. and Stoorvogel, W. (2012) Identification of distinct populations of prostasomes that differentially express prostate stem cell antigen, annexin A1 and GLIPR2 in humans. Biol. Reprod. 86, 82
18. Ostrowski, M., Carmo, N. B., Krumeich, S., Fanget, I., Raposo, G., Savina, A., Moita, C. F., Schauer, K., Hume, A. N., Freitas, R. P. et al. (2010) Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat. Cell Biol. 12, 19-30
19. Bobrie, A., Krumeich, S., Reyal, F., Recchi, C., Moita, L. F., Seabra, M. C., Ostrowski, M. and Théry, C. (2012) Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer Res. 72, 4920-4930
20. Savina, A., Vidal, M. and Colombo, M. I. (2002) The exosome pathway in K562 cells is regulated by Rab11. J. Cell Sci. 115, 2505-2515 (Pubitemid 34778068)
21. Hsu, C., Morohashi, Y., Yoshimura, S., Manrique-Hoyos, N., Jung, S., Lauterbach, M. A., Bakhti, M., Grønborg, M., Möbius, W., Rhee, J. et al. (2010) Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. J. Cell Biol. 189, 223-232
22. Van Niel, G., Mallegol, J., Bevilacqua, C., Candalh, C., Brugière, S., Tomaskovic-Crook, E., Heath, J. K., Cerf-Bensussan, N. and Heyman, M. (2001) Intestinal epithelial cells secrete exosome-like vesicles. Gastroenterology 121, 337-349 (Pubitemid 32729381)
23. Filipazzi, P., Burdek, M., Villa, A., Rivoltini, L. and Huber, V. (2012) Recent advances on the role of tumor exosomes in immunosuppression and disease progression. Semin. Cancer Biol. 22, 342-349
24. Clayton, A. (2012) Cancer cells use exosomes as tools to manipulate immunity and the microenvironment. Oncoimmunology 1, 78-80
25. Zhang, H. G., Zhuang, X., Sun, D., Liu, Y., Xiang, X. and Grizzle, W. (2012) Exosomes and immune surveillance of neoplastic lesions: a review. Biotech. Histochem. 87, 161-168
26. Zeelenberg, I. S., Ostrowski, M., Krumeich, S., Bobrie, A., Jancic, C., Boissonnas, A., Delcayre, A., Le Pecq, J. B., Combadière, B., Amigorena, S. and Théry, C. (2008) Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses. Cancer Res. 68, 1228-1235 (Pubitemid 351272243)
27. Hartman, Z. C., Wei, J., Glass, O. K., Guo, H., Lei, G., Yang, X. Y., Osada, T., Hobeika, A., Delcayre, A., Le Pecq, J. B. et al. (2011) Increasing vaccine potency through exosome antigen targeting. Vaccine 29, 9361-9367
28. Rountree, R. B., Mandl, S. J., Nachtwey, J. M., Dalpozzo, K., Do, L., Lombardo, J. R., Schoonmaker, P. L., Brinkmann, K., Dirmeier, U., Laus, R. and Delcayre, A. (2011) Exosome targeting of tumor antigens expressed by cancer vaccines can improve antigen immunogenicity and therapeutic efficacy. Cancer Res. 71, 5235-5244
29. Fayard, B., Bianchi, F., Dey, J., Moreno, E., Djaffer, S., Hynes, N. E. and Monard, D. (2009) The serine protease inhibitor protease nexin-1 controls mammary cancer metastasis through LRP-1-mediated MMP-9 expression. Cancer Res. 69, 5690-5698
30. Viaud, S., Ploix, S., Lapierre, V., Théry, C., Commere, P. H., Tramalloni, D., Gorrichon, K., Virault-Rocroy, P., Tursz, T., Lantz, O. et al. (2011) Updated technology to produce highly immunogenic dendritic cell-derived exosomes of clinical grade: a critical role of interferon-γ. J. Immunother. 34, 65-75
31. Dai, S., Wei, D., Wu, Z., Zhou, X., Wei, X., Huang, H. and Li, G. (2008) Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol. Ther. 16, 782-790 (Pubitemid 351426181)