Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathways

Experimental Gerontology

Volumn 87, Issue , 2017, Pages 113-120

  Frasca, Daniela ^a   Diaz, Alain ^a   Romero, Maria ^a   Blomberg, Bonnie B ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; B cells; Inflammation; SASP; Vaccine responses

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR; BIOLOGICAL MARKER; CYTOKINE; MICRORNA;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL METABOLISM; CELL SELECTION; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ETHNICITY; FEMALE; FLOW CYTOMETRY; HEMAGGLUTINATION INHIBITION TEST; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; IMMUNOPHENOTYPING; MALE; MEMORY CELL; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; RNA EXTRACTION; SENESCENCE; SIGNAL TRANSDUCTION; UBIQUITINATION; VIRUS STRAIN; WESTERN BLOTTING; AGING; B LYMPHOCYTE SUBPOPULATION; BLOOD; CELL AGING; CELL LINE; CYTOLOGY; MAPK SIGNALING; METABOLISM; MIDDLE AGED; PHYSIOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; AGING; AMP-ACTIVATED PROTEIN KINASES; B-LYMPHOCYTE SUBSETS; BIOMARKERS; CELL AGING; CELL LINE; CYTOKINES; FEMALE; HEMAGGLUTINATION INHIBITION TESTS; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; METABOLIC NETWORKS AND PATHWAYS; MICRORNAS; MIDDLE AGED;

EID: 85002378015     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2016.12.001     Document Type: Article

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