Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism

Osteoarthritis and Cartilage

Volumn 25, Issue 2, 2017, Pages 287-296

  Shen, T ^a,b   Alvarez Garcia, O ^a   Li, Y ^b   Olmer, M ^a   Lotz, M K ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Autophagy; mTOR; Osteoarthritis; Sestrins

Indexed keywords

ADENYLATE KINASE; DEOXYGLUCOSE; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; PROTEIN SESN1; PROTEIN SESN2; SESTRIN; SMALL INTERFERING RNA; TUNICAMYCIN; UNCLASSIFIED DRUG; HEAT SHOCK PROTEIN; NUCLEAR PROTEIN; SESN1 PROTEIN, HUMAN; SESN2 PROTEIN, HUMAN; SESN3 PROTEIN, HUMAN;

ADULT; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL SURVIVAL; CELL VIABILITY; CHONDROCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FEMALE; GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KNEE MENISCUS; KNEE OSTEOARTHRITIS; MALE; METABOLIC STRESS; MOUSE; NONHUMAN; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; SESN GENE; STRESS; UPREGULATION; ADOLESCENT; ANIMAL; ARTICULAR CARTILAGE; DRUG EFFECTS; GENE KNOCKDOWN; METABOLISM; MIDDLE AGED; OSTEOARTHRITIS; PROCEDURES; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; ANIMALS; CARTILAGE, ARTICULAR; CHONDROCYTES; DEOXYGLUCOSE; FEMALE; GENE KNOCKDOWN TECHNIQUES; HEAT-SHOCK PROTEINS; HUMANS; MALE; MICE; MIDDLE AGED; NUCLEAR PROTEINS; OSTEOARTHRITIS; OXIDATIVE STRESS; RNA, SMALL INTERFERING; TUNICAMYCIN; YOUNG ADULT;

EID: 85001759307     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2016.09.017     Document Type: Article

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