Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.

Disease models & mechanisms

Volumn 3, Issue 3-4, 2010, Pages 246-253

  Wempe, Frank ^a   De Zolt, Silke ^a   Koli, Katri ^a   Bangsow, Thorsten ^a   Parajuli, Nirmal ^a   Dumitrascu, Rio ^a   Sterner Kock, Anja ^a   Weissmann, Norbert ^a   Keski Oja, Jorma ^a   von Melchner, Harald ^a  

^a GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE; SESTRIN 2 PROTEIN, MOUSE; SIGNAL PEPTIDE; TRANSFORMING GROWTH FACTOR BETA;

ALLELE; ANIMAL; ARTICLE; BIOSYNTHESIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; DISEASE MODEL; ENZYME INDUCTION; ENZYMOLOGY; FIBROBLAST; GENE SILENCING; GENETICS; LUNG; LUNG EMPHYSEMA; METABOLISM; MOUSE; MOUSE MUTANT; MUTATION; PATHOLOGY; SIGNAL TRANSDUCTION;

ALLELES; ANIMALS; DISEASE MODELS, ANIMAL; ENZYME INDUCTION; FIBROBLASTS; GENE SILENCING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LATENT TGF-BETA BINDING PROTEINS; LUNG; MICE; MICE, KNOCKOUT; MUTATION; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PULMONARY EMPHYSEMA; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 77952041057     PISSN: None     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.004234     Document Type: Article

References (0)