메뉴 건너뛰기




Volumn , Issue , 2015, Pages 323-334

New Drugs Under Development for Cardiovascular Prevention

Author keywords

Cardiovascular prevention; Drug effects; Hypertension; Pharmacology; Therapy

Indexed keywords


EID: 84997783817     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-801387-8.000302     Document Type: Chapter
Times cited : (1)

References (92)
  • 1
    • 84864863840 scopus 로고    scopus 로고
    • New drugs, procedure and devices for hypertension
    • Laurent S., Schlaich M., Esler M. New drugs, procedure and devices for hypertension. Lancet 2012, 380:591-600.
    • (2012) Lancet , vol.380 , pp. 591-600
    • Laurent, S.1    Schlaich, M.2    Esler, M.3
  • 2
    • 67649873328 scopus 로고    scopus 로고
    • Vascular aging: a tale of EVA and ADAM in cardiovascular risk assessment and prevention
    • Nilsson P., Boutouyrie P., Laurent S. Vascular aging: a tale of EVA and ADAM in cardiovascular risk assessment and prevention. Hypertension 2009, 54:3-10.
    • (2009) Hypertension , vol.54 , pp. 3-10
    • Nilsson, P.1    Boutouyrie, P.2    Laurent, S.3
  • 3
    • 0037251741 scopus 로고    scopus 로고
    • Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes
    • Aronson D. Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes. J Hypertens 2003, 21:3-12.
    • (2003) J Hypertens , vol.21 , pp. 3-12
    • Aronson, D.1
  • 4
    • 23744467295 scopus 로고    scopus 로고
    • Glycation products as markers and predictors of the progression of diabetic complications
    • Monnier V.M., Sell D.R., Genuth S. Glycation products as markers and predictors of the progression of diabetic complications. Ann N Y Acad Sci 2005, 1043:567-581.
    • (2005) Ann N Y Acad Sci , vol.1043 , pp. 567-581
    • Monnier, V.M.1    Sell, D.R.2    Genuth, S.3
  • 5
    • 0030596135 scopus 로고    scopus 로고
    • Changes in biomechanical properties, composition of collagen and elastin, and advanced glycation endproducts of the rat aorta in relation to age
    • Bruel A., Oxlund H. Changes in biomechanical properties, composition of collagen and elastin, and advanced glycation endproducts of the rat aorta in relation to age. Atherosclerosis 1996, 127:155-165.
    • (1996) Atherosclerosis , vol.127 , pp. 155-165
    • Bruel, A.1    Oxlund, H.2
  • 6
    • 0037379212 scopus 로고    scopus 로고
    • Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy
    • Herrmann K.L., McCulloch A.D., Omens J.H. Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy. Am J Physiol Heart Circ Physiol 2003, 284:H1277-H1284.
    • (2003) Am J Physiol Heart Circ Physiol , vol.284 , pp. H1277-H1284
    • Herrmann, K.L.1    McCulloch, A.D.2    Omens, J.H.3
  • 8
    • 10744223527 scopus 로고    scopus 로고
    • ACTION I Investigator Group Randomized trial of an inhibitor of formation of advanced glycation end products in diabetic nephropathy
    • Bolton W.K., Cattran D.C., Williams M.E., Adler S.G., Appel G.B., Cartwright K., et al. ACTION I Investigator Group Randomized trial of an inhibitor of formation of advanced glycation end products in diabetic nephropathy. Am J Nephrol 2004, 24:32-40.
    • (2004) Am J Nephrol , vol.24 , pp. 32-40
    • Bolton, W.K.1    Cattran, D.C.2    Williams, M.E.3    Adler, S.G.4    Appel, G.B.5    Cartwright, K.6
  • 9
    • 0035949502 scopus 로고    scopus 로고
    • Improved arterial compliance by a novel advanced glycation end-product crosslink breaker
    • Kass D.A., Shapiro E.P., Kawaguchi M., Capriotti A.R., Scuteri A., deGroof R.C., et al. Improved arterial compliance by a novel advanced glycation end-product crosslink breaker. Circulation 2001, 104:1464-1470.
    • (2001) Circulation , vol.104 , pp. 1464-1470
    • Kass, D.A.1    Shapiro, E.P.2    Kawaguchi, M.3    Capriotti, A.R.4    Scuteri, A.5    deGroof, R.C.6
  • 10
    • 33846849277 scopus 로고    scopus 로고
    • Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension
    • Zieman S.J., Melenovsky V., Clattenburg L., Corretti M.C., Capriotti A., Gerstenblith G., et al. Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension. J Hypertens 2007, 25:577-583.
    • (2007) J Hypertens , vol.25 , pp. 577-583
    • Zieman, S.J.1    Melenovsky, V.2    Clattenburg, L.3    Corretti, M.C.4    Capriotti, A.5    Gerstenblith, G.6
  • 14
    • 0023203678 scopus 로고
    • Antihypertensive effect of sustained release isosorbide dinitrate for isolated systolic hypertension in the elderly
    • Duchier J., Iannascoli F., Safar M. Antihypertensive effect of sustained release isosorbide dinitrate for isolated systolic hypertension in the elderly. Am J Cardiol 1987, 60:99-108.
    • (1987) Am J Cardiol , vol.60 , pp. 99-108
    • Duchier, J.1    Iannascoli, F.2    Safar, M.3
  • 16
    • 0026580759 scopus 로고
    • Mechanism of nitrate-induced improvement on arterial compliance depends on vascular territory
    • Laurent S., Arcaro G., Benetos A., Lafleche A., Hoeks A., Safar M. Mechanism of nitrate-induced improvement on arterial compliance depends on vascular territory. J Cardiovasc Pharmacol 1992, 19:641-649.
    • (1992) J Cardiovasc Pharmacol , vol.19 , pp. 641-649
    • Laurent, S.1    Arcaro, G.2    Benetos, A.3    Lafleche, A.4    Hoeks, A.5    Safar, M.6
  • 17
    • 77953807828 scopus 로고    scopus 로고
    • Clinical potential of combined organic nitrate and phosphodiesterase type 5 inhibitor in treatment-resistant hypertension
    • Oliver J.J., Dear J.W., Webb D.J. Clinical potential of combined organic nitrate and phosphodiesterase type 5 inhibitor in treatment-resistant hypertension. Hypertension 2010, 56:62-67.
    • (2010) Hypertension , vol.56 , pp. 62-67
    • Oliver, J.J.1    Dear, J.W.2    Webb, D.J.3
  • 18
    • 33750579081 scopus 로고    scopus 로고
    • Effect of regular phosphodiesterase type 5 inhibition in hypertension
    • Oliver J.J., Melville V.P., Webb D.J. Effect of regular phosphodiesterase type 5 inhibition in hypertension. Hypertension 2006, 48:622-627.
    • (2006) Hypertension , vol.48 , pp. 622-627
    • Oliver, J.J.1    Melville, V.P.2    Webb, D.J.3
  • 20
    • 33646078807 scopus 로고    scopus 로고
    • New NO-releasing pharmacodynamic hybrids of losartan and its active metabolite: design, synthesis, and biopharmacological properties
    • Breschi M.C., Calderone V., Digiacomo M., Macchia M., Martelli A., Martinotti E., et al. New NO-releasing pharmacodynamic hybrids of losartan and its active metabolite: design, synthesis, and biopharmacological properties. J Med Chem 2006, 49:2628-2639.
    • (2006) J Med Chem , vol.49 , pp. 2628-2639
    • Breschi, M.C.1    Calderone, V.2    Digiacomo, M.3    Macchia, M.4    Martelli, A.5    Martinotti, E.6
  • 21
    • 35449004560 scopus 로고    scopus 로고
    • WB1106, a novel nitric oxide-releasing derivative of telmisartan, inhibits hypertension and improves glucose metabolism in rats
    • Li Y.Q., Ji H., Zhang Y.H., Shi W.B., Meng Z.K., Chen X.Y., et al. WB1106, a novel nitric oxide-releasing derivative of telmisartan, inhibits hypertension and improves glucose metabolism in rats. Eur J Pharmacol 2007, 577:100-108.
    • (2007) Eur J Pharmacol , vol.577 , pp. 100-108
    • Li, Y.Q.1    Ji, H.2    Zhang, Y.H.3    Shi, W.B.4    Meng, Z.K.5    Chen, X.Y.6
  • 22
    • 64849109591 scopus 로고    scopus 로고
    • Treatment of patients with hypertension and arthritis pain: new concepts
    • Weber M.A. Treatment of patients with hypertension and arthritis pain: new concepts. Am J Med 2009, 122:S16-S22.
    • (2009) Am J Med , vol.122 , pp. S16-S22
    • Weber, M.A.1
  • 23
    • 0035834159 scopus 로고    scopus 로고
    • Vasopeptidase inhibitors: a new therapeutic concept in cardiovascular disease?
    • Corti R., Burnett J.C., Rouleau J.L., Ruschitzka F., Lüscher T.F. Vasopeptidase inhibitors: a new therapeutic concept in cardiovascular disease?. Circulation 2001, 104:1856-1862.
    • (2001) Circulation , vol.104 , pp. 1856-1862
    • Corti, R.1    Burnett, J.C.2    Rouleau, J.L.3    Ruschitzka, F.4    Lüscher, T.F.5
  • 24
    • 70449601972 scopus 로고    scopus 로고
    • Inhibition of zinc metallopeptidases in cardiovascular disease-from unity to trinity, or duality?
    • Dive V., Chang C.F., Yiotakis A., Sturrock E.D. Inhibition of zinc metallopeptidases in cardiovascular disease-from unity to trinity, or duality?. Curr Pharm Des 2009, 15:3606-3621.
    • (2009) Curr Pharm Des , vol.15 , pp. 3606-3621
    • Dive, V.1    Chang, C.F.2    Yiotakis, A.3    Sturrock, E.D.4
  • 25
    • 34548746991 scopus 로고    scopus 로고
    • Towards triple vasopeptidase inhibitors for the treatment of cardiovascular diseases
    • Daull P., Jeng A.Y., Battistini B. Towards triple vasopeptidase inhibitors for the treatment of cardiovascular diseases. J Cardiovasc Pharmacol 2007, 50:247-256.
    • (2007) J Cardiovasc Pharmacol , vol.50 , pp. 247-256
    • Daull, P.1    Jeng, A.Y.2    Battistini, B.3
  • 26
    • 0037173041 scopus 로고    scopus 로고
    • Omapatrilat reduces pulse pressure and proximal aortic stiffness in patients with systolic hypertension: results of the conduit hemodynamics of omapatrilat international research study
    • Mitchell G.F., Izzo J.L., Lacourcière Y., Ouellet J.P., Neutel J., Qian C., et al. Omapatrilat reduces pulse pressure and proximal aortic stiffness in patients with systolic hypertension: results of the conduit hemodynamics of omapatrilat international research study. Circulation 2002, 105:2955-2961.
    • (2002) Circulation , vol.105 , pp. 2955-2961
    • Mitchell, G.F.1    Izzo, J.L.2    Lacourcière, Y.3    Ouellet, J.P.4    Neutel, J.5    Qian, C.6
  • 27
    • 0343656714 scopus 로고
    • Antihypertensive effect of the atriopeptidase inhibitor SCH 34826 in essential hypertension
    • Kosoglou T., Herron J.M., Chen R., Given B., Sybertz E.J., Affrime M.B. Antihypertensive effect of the atriopeptidase inhibitor SCH 34826 in essential hypertension. Circulation 1990, 82:2201-2210.
    • (1990) Circulation , vol.82 , pp. 2201-2210
    • Kosoglou, T.1    Herron, J.M.2    Chen, R.3    Given, B.4    Sybertz, E.J.5    Affrime, M.B.6
  • 28
    • 0034110537 scopus 로고    scopus 로고
    • Antihypertensive effects of fasidotril, a dual inhibitor of neprilysin and ACE, in rats and humans
    • Laurent S., Boutouyrie P., Azizi M., Marie C., Gros C., Schwartz J.C., et al. Antihypertensive effects of fasidotril, a dual inhibitor of neprilysin and ACE, in rats and humans. Hypertension 2000, 35:1148-1153.
    • (2000) Hypertension , vol.35 , pp. 1148-1153
    • Laurent, S.1    Boutouyrie, P.2    Azizi, M.3    Marie, C.4    Gros, C.5    Schwartz, J.C.6
  • 29
    • 0035802711 scopus 로고    scopus 로고
    • Vasopeptidase inhibitors
    • Weber M.A. Vasopeptidase inhibitors. Lancet 2001, 358:1525-1532.
    • (2001) Lancet , vol.358 , pp. 1525-1532
    • Weber, M.A.1
  • 30
    • 1642452758 scopus 로고    scopus 로고
    • Omapatrilat and enalapril in patients with hypertension: the Omapatrilat Cardiovascular Treatment vs. Enalapril (OCTAVE) trial
    • Kostis J.B., Packer M., Black H.R., Schmieder R., Henry D., Levy E. Omapatrilat and enalapril in patients with hypertension: the Omapatrilat Cardiovascular Treatment vs. Enalapril (OCTAVE) trial. Am J Hypertens 2004, 17:103-111.
    • (2004) Am J Hypertens , vol.17 , pp. 103-111
    • Kostis, J.B.1    Packer, M.2    Black, H.R.3    Schmieder, R.4    Henry, D.5    Levy, E.6
  • 31
    • 0037341656 scopus 로고    scopus 로고
    • Vasopeptidase inhibition: a double-edged sword?
    • Campbell D.J. Vasopeptidase inhibition: a double-edged sword?. Hypertension 2003, 41:383-389.
    • (2003) Hypertension , vol.41 , pp. 383-389
    • Campbell, D.J.1
  • 32
    • 0037097061 scopus 로고    scopus 로고
    • Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors
    • Adam A., Cugno M., Molinaro G., Perez M., Lepage Y., Agostoni A. Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors. Lancet 2002, 359:2088-2089.
    • (2002) Lancet , vol.359 , pp. 2088-2089
    • Adam, A.1    Cugno, M.2    Molinaro, G.3    Perez, M.4    Lepage, Y.5    Agostoni, A.6
  • 33
    • 40149102678 scopus 로고    scopus 로고
    • Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin-mediated angioedema
    • Fryer R.M., Segreti J., Banfor P.N., Widomski D.L., Backes B.J., Lin C.W., et al. Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin-mediated angioedema. Br J Pharmacol 2008, 153:947-955.
    • (2008) Br J Pharmacol , vol.153 , pp. 947-955
    • Fryer, R.M.1    Segreti, J.2    Banfor, P.N.3    Widomski, D.L.4    Backes, B.J.5    Lin, C.W.6
  • 34
    • 40049093528 scopus 로고    scopus 로고
    • Ilepatril (AVE-7688), a vasopeptidase inhibitor for the treatment of hypertension
    • Tabrizchi R. Ilepatril (AVE-7688), a vasopeptidase inhibitor for the treatment of hypertension. Curr Opin Investig Drugs 2008, 9:301-309.
    • (2008) Curr Opin Investig Drugs , vol.9 , pp. 301-309
    • Tabrizchi, R.1
  • 35
    • 30344480238 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of the vasopeptidase inhibitor AVE7688 in humans
    • Azizi M., Bissery A., Peyrard S., Guyene T.T., Ozoux M.L., Floch A., et al. Pharmacokinetics and pharmacodynamics of the vasopeptidase inhibitor AVE7688 in humans. Clin Pharmacol Ther 2006, 79:49-61.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 49-61
    • Azizi, M.1    Bissery, A.2    Peyrard, S.3    Guyene, T.T.4    Ozoux, M.L.5    Floch, A.6
  • 36
    • 79953200072 scopus 로고    scopus 로고
    • Endothelin-converting enzyme/neutral endopeptidase inhibitor SLV338 prevents hypertensive cardiac remodeling in a blood pressure-independent manner
    • Kalk P., Sharkovska Y., Kashina E., von Websky K., Relle K., Pfab T., et al. Endothelin-converting enzyme/neutral endopeptidase inhibitor SLV338 prevents hypertensive cardiac remodeling in a blood pressure-independent manner. Hypertension 2011, 57:755-763.
    • (2011) Hypertension , vol.57 , pp. 755-763
    • Kalk, P.1    Sharkovska, Y.2    Kashina, E.3    von Websky, K.4    Relle, K.5    Pfab, T.6
  • 37
    • 74849136063 scopus 로고    scopus 로고
    • Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors
    • Jullien N., Makritis A., Georgiadis D., Beau F., Yiotakis A., Dive V. Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors. J Med Chem 2010, 53:208-220.
    • (2010) J Med Chem , vol.53 , pp. 208-220
    • Jullien, N.1    Makritis, A.2    Georgiadis, D.3    Beau, F.4    Yiotakis, A.5    Dive, V.6
  • 38
    • 77956817833 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi)
    • Gu J., Noe A., Chandra P., Al-Fayoumi S., Ligueros-Saylan M., Sarangapani R., Maahs S., et al. Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi). J Clin Pharmacol 2010, 50:401-414.
    • (2010) J Clin Pharmacol , vol.50 , pp. 401-414
    • Gu, J.1    Noe, A.2    Chandra, P.3    Al-Fayoumi, S.4    Ligueros-Saylan, M.5    Sarangapani, R.6    Maahs, S.7
  • 39
    • 77950628157 scopus 로고    scopus 로고
    • Blood pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study
    • Ruilope L.M., Dukat A., Bohm M., Lacourciere Y., Gong J., Lefkowitz M.P. Blood pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study. Lancet 2010, 375:1255-1266.
    • (2010) Lancet , vol.375 , pp. 1255-1266
    • Ruilope, L.M.1    Dukat, A.2    Bohm, M.3    Lacourciere, Y.4    Gong, J.5    Lefkowitz, M.P.6
  • 40
    • 67349208215 scopus 로고    scopus 로고
    • New aspects of rapid aldosterone signaling
    • Grossmann C., Gekle M. New aspects of rapid aldosterone signaling. Mol Cell Endocrinol 2009, 308:53-62.
    • (2009) Mol Cell Endocrinol , vol.308 , pp. 53-62
    • Grossmann, C.1    Gekle, M.2
  • 41
    • 78149238346 scopus 로고    scopus 로고
    • Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism
    • Amar L., Azizi M., Menard J., Peyrard S., Watson C., Plouin P.F. Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism. Hypertension 2010, 56:831-838.
    • (2010) Hypertension , vol.56 , pp. 831-838
    • Amar, L.1    Azizi, M.2    Menard, J.3    Peyrard, S.4    Watson, C.5    Plouin, P.F.6
  • 42
    • 80255141746 scopus 로고    scopus 로고
    • Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo- and active-controlled phase 2 trial
    • Calhoun D.A., White W.B., Krum H., Guo W., Bermann G., Trapani A., et al. Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo- and active-controlled phase 2 trial. Circulation 2011, 124:1945-1955.
    • (2011) Circulation , vol.124 , pp. 1945-1955
    • Calhoun, D.A.1    White, W.B.2    Krum, H.3    Guo, W.4    Bermann, G.5    Trapani, A.6
  • 43
    • 70449506384 scopus 로고    scopus 로고
    • The renin-angiotensin-aldosterone system
    • Informa Healthcare, London, G. Mancia, G. Grassi, S.E. Kjeldsen (Eds.)
    • Steckelings U.M., Unger T. The renin-angiotensin-aldosterone system. Manual of hypertension of the European society of hypertension 2008, 110-116. Informa Healthcare, London. G. Mancia, G. Grassi, S.E. Kjeldsen (Eds.).
    • (2008) Manual of hypertension of the European society of hypertension , pp. 110-116
    • Steckelings, U.M.1    Unger, T.2
  • 44
    • 67650541842 scopus 로고    scopus 로고
    • Devil and angel in the renin-angiotensin system: ACE-angiotensin II-AT1 receptor axis vs. ACE2-angiotensin-(1-7)-Mas receptor axis
    • Iwai M., Horiuchi M. Devil and angel in the renin-angiotensin system: ACE-angiotensin II-AT1 receptor axis vs. ACE2-angiotensin-(1-7)-Mas receptor axis. Hypertens Res Off J Jpn Soc Hypertens 2009, 32:533-536.
    • (2009) Hypertens Res Off J Jpn Soc Hypertens , vol.32 , pp. 533-536
    • Iwai, M.1    Horiuchi, M.2
  • 45
    • 84872617624 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin-angiotensin system
    • Santos R.A., Ferreira A.J., Verano-Braga T., Bader M. Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin-angiotensin system. J Endocrinol 2013, 216:R1-R17.
    • (2013) J Endocrinol , vol.216 , pp. R1-R17
    • Santos, R.A.1    Ferreira, A.J.2    Verano-Braga, T.3    Bader, M.4
  • 46
    • 63849169364 scopus 로고    scopus 로고
    • The angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptor
    • Porrello E.R., Delbridge L.M.D., Thomas W.G. The angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptor. Front Biosci Landmark Ed 2009, 14:958-972.
    • (2009) Front Biosci Landmark Ed , vol.14 , pp. 958-972
    • Porrello, E.R.1    Delbridge, L.M.D.2    Thomas, W.G.3
  • 47
    • 22544448655 scopus 로고    scopus 로고
    • The AT2 receptor-a matter of love and hate
    • Steckelings U.M., Kaschina E., Unger T. The AT2 receptor-a matter of love and hate. Peptides 2005, 26:1401-1409.
    • (2005) Peptides , vol.26 , pp. 1401-1409
    • Steckelings, U.M.1    Kaschina, E.2    Unger, T.3
  • 48
    • 84902291577 scopus 로고    scopus 로고
    • Angiotensin-(1-7)
    • Santos R.A. Angiotensin-(1-7). Hypertension 2014, 63:1138-1147.
    • (2014) Hypertension , vol.63 , pp. 1138-1147
    • Santos, R.A.1
  • 49
    • 0024421343 scopus 로고
    • Preliminary biochemical characterization of two angiotensin II receptor subtypes
    • Whitebread S., Mele M., Kamber B., de Gasparo M. Preliminary biochemical characterization of two angiotensin II receptor subtypes. Biochem Biophys Res Commun 1989, 163:284-291.
    • (1989) Biochem Biophys Res Commun , vol.163 , pp. 284-291
    • Whitebread, S.1    Mele, M.2    Kamber, B.3    de Gasparo, M.4
  • 50
    • 8644281991 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist
    • Wan Y., Wallinder C., Plouffe B., Beaudry H., Mahalingam A.K., Wu X., et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem 2004, 47:5995-6008.
    • (2004) J Med Chem , vol.47 , pp. 5995-6008
    • Wan, Y.1    Wallinder, C.2    Plouffe, B.3    Beaudry, H.4    Mahalingam, A.K.5    Wu, X.6
  • 53
    • 84856201427 scopus 로고    scopus 로고
    • Direct AT2 receptor stimulation in L-NAME-induced hypertension: the effect on pulse wave velocity and aortic remodeling
    • Paulis L., Becker S.T., Lucht K., Schwengel K., Slavic S., Kaschina E., et al. Direct AT2 receptor stimulation in L-NAME-induced hypertension: the effect on pulse wave velocity and aortic remodeling. Hypertension 2012, 59:485-492.
    • (2012) Hypertension , vol.59 , pp. 485-492
    • Paulis, L.1    Becker, S.T.2    Lucht, K.3    Schwengel, K.4    Slavic, S.5    Kaschina, E.6
  • 54
    • 84856120678 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats
    • Rehman A., Leibowitz A., Yamamoto N., Rautureau Y., Paradis P., Schiffrin E.L. Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats. Hypertension 2012, 59:291-299.
    • (2012) Hypertension , vol.59 , pp. 291-299
    • Rehman, A.1    Leibowitz, A.2    Yamamoto, N.3    Rautureau, Y.4    Paradis, P.5    Schiffrin, E.L.6
  • 55
    • 84894449097 scopus 로고    scopus 로고
    • The angiotensin type 2 receptor agonist compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke
    • Joseph J.P., Mecca A.P., Regenhardt R.W., Bennion D.M., Rodríguez V., Desland F., et al. The angiotensin type 2 receptor agonist compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke. Neuropharmacology 2014, 81:134-141.
    • (2014) Neuropharmacology , vol.81 , pp. 134-141
    • Joseph, J.P.1    Mecca, A.P.2    Regenhardt, R.W.3    Bennion, D.M.4    Rodríguez, V.5    Desland, F.6
  • 56
    • 84899675171 scopus 로고    scopus 로고
    • Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats
    • McCarthy C.A., Vinh A., Miller A.A., Hallberg A., Alterman M., Callaway J.K., et al. Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats. PLoS One 2014, 9:e95762.
    • (2014) PLoS One , vol.9
    • McCarthy, C.A.1    Vinh, A.2    Miller, A.A.3    Hallberg, A.4    Alterman, M.5    Callaway, J.K.6
  • 57
    • 84920528695 scopus 로고    scopus 로고
    • Angiotensin A.T.(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages via increased interleukin-10 production
    • Dhande I., Ma W., Hussain T. Angiotensin A.T.(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages via increased interleukin-10 production. Hypertens Res 2015, 38:21-29.
    • (2015) Hypertens Res , vol.38 , pp. 21-29
    • Dhande, I.1    Ma, W.2    Hussain, T.3
  • 58
    • 79956120211 scopus 로고    scopus 로고
    • Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats
    • Gao J., Zhang H., Le K.D., Chao J., Gao L. Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats. Am J Hypertens 2011, 24:724-730.
    • (2011) Am J Hypertens , vol.24 , pp. 724-730
    • Gao, J.1    Zhang, H.2    Le, K.D.3    Chao, J.4    Gao, L.5
  • 59
    • 81055156294 scopus 로고    scopus 로고
    • Microbore liquid chromatography with UV detection to study the in vivo passage of compound 21, a non-peptidergic AT2 receptor agonist, to the striatum in rats
    • Shraim N., Mertens B., Clinckers R., Sarre S., Michotte Y., Van Eeckhaut A. Microbore liquid chromatography with UV detection to study the in vivo passage of compound 21, a non-peptidergic AT2 receptor agonist, to the striatum in rats. J Neurosci Methods 2011, 202:137-142.
    • (2011) J Neurosci Methods , vol.202 , pp. 137-142
    • Shraim, N.1    Mertens, B.2    Clinckers, R.3    Sarre, S.4    Michotte, Y.5    Van Eeckhaut, A.6
  • 61
    • 84861500874 scopus 로고    scopus 로고
    • Therapeutic targeting of the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas cascade in the renin-angiotensin system: a patent review
    • Ferreira A.J., Bader M., Santos R.A. Therapeutic targeting of the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas cascade in the renin-angiotensin system: a patent review. Expert Opin Ther Pat 2012, 22:567-574.
    • (2012) Expert Opin Ther Pat , vol.22 , pp. 567-574
    • Ferreira, A.J.1    Bader, M.2    Santos, R.A.3
  • 62
    • 84896129886 scopus 로고    scopus 로고
    • Contribution of the local RAS to hematopoietic function: a novel therapeutic target
    • Rodgers K.E., Dizerega G.S. Contribution of the local RAS to hematopoietic function: a novel therapeutic target. Front Endocrinol 2013, 4:157-163.
    • (2013) Front Endocrinol , vol.4 , pp. 157-163
    • Rodgers, K.E.1    Dizerega, G.S.2
  • 64
    • 84883202259 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects
    • Haschke M., Schuster M., Poglitsch M., Loibner H., Salzberg M., Bruggisser M., et al. Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects. Clin Pharmacokinet 2013, 52:783-792.
    • (2013) Clin Pharmacokinet , vol.52 , pp. 783-792
    • Haschke, M.1    Schuster, M.2    Poglitsch, M.3    Loibner, H.4    Salzberg, M.5    Bruggisser, M.6
  • 65
    • 42349105833 scopus 로고    scopus 로고
    • Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents
    • Hernández Prada J.A., Ferreira A.J., Katovich M.J., Shenoy V., Qi Y., Santos R.A.S., et al. Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents. Hypertension 2008, 51:1312-1317.
    • (2008) Hypertension , vol.51 , pp. 1312-1317
    • Hernández Prada, J.A.1    Ferreira, A.J.2    Katovich, M.J.3    Shenoy, V.4    Qi, Y.5    Santos, R.A.S.6
  • 66
    • 0036266596 scopus 로고    scopus 로고
    • Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
    • Nguyen G., Delarue F., Burcklé C., Bouzhir L., Giller T., Sraer J.D. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 2002, 109:1417-1427.
    • (2002) J Clin Invest , vol.109 , pp. 1417-1427
    • Nguyen, G.1    Delarue, F.2    Burcklé, C.3    Bouzhir, L.4    Giller, T.5    Sraer, J.D.6
  • 67
    • 84892468787 scopus 로고    scopus 로고
    • (Pro)renin receptor and V-ATPase: from Drosophila to humans
    • Rousselle A., Sihn G., Rotteveel M., Bader M. (Pro)renin receptor and V-ATPase: from Drosophila to humans. Clin Sci Lond Engl 2014, 126:529-536.
    • (2014) Clin Sci Lond Engl , vol.126 , pp. 529-536
    • Rousselle, A.1    Sihn, G.2    Rotteveel, M.3    Bader, M.4
  • 68
    • 9644283069 scopus 로고    scopus 로고
    • Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin
    • Ichihara A., Hayashi M., Kaneshiro Y., Suzuki F., Nakagawa T., Tada Y., et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin. J Clin Invest 2004, 114:1128-1135.
    • (2004) J Clin Invest , vol.114 , pp. 1128-1135
    • Ichihara, A.1    Hayashi, M.2    Kaneshiro, Y.3    Suzuki, F.4    Nakagawa, T.5    Tada, Y.6
  • 69
    • 76349122414 scopus 로고    scopus 로고
    • Signal transduction of the (pro)renin receptor as a novel therapeutic target for preventing end-organ damage
    • Funke-Kaiser H., Zollmann F.S., Schefe J.H., Unger T. Signal transduction of the (pro)renin receptor as a novel therapeutic target for preventing end-organ damage. Hypertens Res Off J Jpn Soc Hypertens 2010, 33:98-104.
    • (2010) Hypertens Res Off J Jpn Soc Hypertens , vol.33 , pp. 98-104
    • Funke-Kaiser, H.1    Zollmann, F.S.2    Schefe, J.H.3    Unger, T.4
  • 70
    • 0029859206 scopus 로고    scopus 로고
    • Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release
    • Zini S., Fournie-Zaluski M.C., Chauvel E., Roques B.P., Corvol P., Llorens-Cortes C. Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release. Proc Natl Acad Sci U S A 1996, 93:11968-11973.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 11968-11973
    • Zini, S.1    Fournie-Zaluski, M.C.2    Chauvel, E.3    Roques, B.P.4    Corvol, P.5    Llorens-Cortes, C.6
  • 71
    • 39649093737 scopus 로고    scopus 로고
    • Orally active aminopeptidase A inhibitors reduce blood pressure: a new strategy for treating hypertension
    • Bodineau L., Frugière A., Marc Y., Inguimbert N., Fassot C., Balavoine F., et al. Orally active aminopeptidase A inhibitors reduce blood pressure: a new strategy for treating hypertension. Hypertension 2008, 51:1318-1325.
    • (2008) Hypertension , vol.51 , pp. 1318-1325
    • Bodineau, L.1    Frugière, A.2    Marc, Y.3    Inguimbert, N.4    Fassot, C.5    Balavoine, F.6
  • 72
    • 84898812938 scopus 로고    scopus 로고
    • Randomised, double-blind, placebo-controlled, dose-escalating phase I study of QGC001, a centrally acting aminopeptidase a inhibitor prodrug
    • Balavoine F., Azizi M., Bergerot D., De Mota N., Patouret R., Roques B.P., et al. Randomised, double-blind, placebo-controlled, dose-escalating phase I study of QGC001, a centrally acting aminopeptidase a inhibitor prodrug. Clin Pharmacokinet 2014, 53:385-395.
    • (2014) Clin Pharmacokinet , vol.53 , pp. 385-395
    • Balavoine, F.1    Azizi, M.2    Bergerot, D.3    De Mota, N.4    Patouret, R.5    Roques, B.P.6
  • 73
    • 0029116310 scopus 로고
    • Endothelins
    • Levin E.R. Endothelins. N Engl J Med 1995, 333:356-363.
    • (1995) N Engl J Med , vol.333 , pp. 356-363
    • Levin, E.R.1
  • 74
    • 0027369239 scopus 로고
    • Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist
    • Clozel M., Breu V., Burri K., Cassal J.M., Fischli W., Gray G.A., et al. Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist. Nature 1993, 365:759-761.
    • (1993) Nature , vol.365 , pp. 759-761
    • Clozel, M.1    Breu, V.2    Burri, K.3    Cassal, J.M.4    Fischli, W.5    Gray, G.A.6
  • 75
    • 0032546259 scopus 로고    scopus 로고
    • The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension investigators
    • Krum H., Viskoper R.J., Lacourciere Y., Budde M., Charlon V. The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension investigators. N Engl J Med 1998, 338:784-790.
    • (1998) N Engl J Med , vol.338 , pp. 784-790
    • Krum, H.1    Viskoper, R.J.2    Lacourciere, Y.3    Budde, M.4    Charlon, V.5
  • 76
    • 70350133404 scopus 로고    scopus 로고
    • A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trial
    • Weber M.A., Black H., Bakris G., Krum H., Linas S., Weiss R., et al. A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trial. Lancet 2009, 374:1423-1431.
    • (2009) Lancet , vol.374 , pp. 1423-1431
    • Weber, M.A.1    Black, H.2    Bakris, G.3    Krum, H.4    Linas, S.5    Weiss, R.6
  • 77
    • 1542514709 scopus 로고    scopus 로고
    • Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade
    • Goddard J., Johnston N.R., Hand M.F., Cumming A.D., Rabelink T.J., Rankin A.J., et al. Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade. Circulation 2004, 109:1186-1193.
    • (2004) Circulation , vol.109 , pp. 1186-1193
    • Goddard, J.1    Johnston, N.R.2    Hand, M.F.3    Cumming, A.D.4    Rabelink, T.J.5    Rankin, A.J.6
  • 78
    • 79953213661 scopus 로고    scopus 로고
    • Selective endothelin-A receptor antagonism reduces proteinuria, blood pressure, and arterial stiffness in chronic proteinuric kidney disease
    • Dhaun N., MacIntyre I.M., Kerr D., Melville V., Johnston N.R., Haughie S., et al. Selective endothelin-A receptor antagonism reduces proteinuria, blood pressure, and arterial stiffness in chronic proteinuric kidney disease. Hypertension 2011, 57:772-779.
    • (2011) Hypertension , vol.57 , pp. 772-779
    • Dhaun, N.1    MacIntyre, I.M.2    Kerr, D.3    Melville, V.4    Johnston, N.R.5    Haughie, S.6
  • 79
    • 70349980161 scopus 로고    scopus 로고
    • Next generation multifunctional angiotensin receptor blockers
    • Kurtz T.W., Klein U. Next generation multifunctional angiotensin receptor blockers. Hypertens Res 2009, 32:826-834.
    • (2009) Hypertens Res , vol.32 , pp. 826-834
    • Kurtz, T.W.1    Klein, U.2
  • 80
    • 79959444835 scopus 로고    scopus 로고
    • Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-β
    • Casimiro-Garcia A., Filzen G.F., Flynn D., Bigge C.F., Chen J., Davis J.A., et al. Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-β. J Med Chem 2011, 54:4219-4233.
    • (2011) J Med Chem , vol.54 , pp. 4219-4233
    • Casimiro-Garcia, A.1    Filzen, G.F.2    Flynn, D.3    Bigge, C.F.4    Chen, J.5    Davis, J.A.6
  • 82
    • 36749079827 scopus 로고    scopus 로고
    • Pharmacological intervention strategies for affecting telomerase activity: future prospects to treat cancer and degenerative disease
    • Tarkanyi I., Aradi J. Pharmacological intervention strategies for affecting telomerase activity: future prospects to treat cancer and degenerative disease. Biochimie 2008, 90:156-172.
    • (2008) Biochimie , vol.90 , pp. 156-172
    • Tarkanyi, I.1    Aradi, J.2
  • 83
    • 33646745137 scopus 로고    scopus 로고
    • Lamin A-dependent nuclear defects in human aging
    • Scaffidi P., Misteli T. Lamin A-dependent nuclear defects in human aging. Science 2006, 312:1059-1063.
    • (2006) Science , vol.312 , pp. 1059-1063
    • Scaffidi, P.1    Misteli, T.2
  • 84
    • 0036843975 scopus 로고    scopus 로고
    • Lamins: building blocks or regulators of gene expression?
    • Hutchison C.J. Lamins: building blocks or regulators of gene expression?. Nat Rev Mol Cell Biol 2002, 3:848-858.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 848-858
    • Hutchison, C.J.1
  • 85
    • 43449096922 scopus 로고    scopus 로고
    • Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors
    • Verstraeten V.L., Ji J.Y., Cummings K.S., Lee R.T., Lammerding J. Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors. Aging Cell 2008, 7:383-393.
    • (2008) Aging Cell , vol.7 , pp. 383-393
    • Verstraeten, V.L.1    Ji, J.Y.2    Cummings, K.S.3    Lee, R.T.4    Lammerding, J.5
  • 86
    • 39049111972 scopus 로고    scopus 로고
    • Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation
    • Yang S.H., Qiao X., Fong L.G., Young S.G. Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation. Biochim Biophys Acta 2008, 1781:36-39.
    • (2008) Biochim Biophys Acta , vol.1781 , pp. 36-39
    • Yang, S.H.1    Qiao, X.2    Fong, L.G.3    Young, S.G.4
  • 87
    • 0030724491 scopus 로고    scopus 로고
    • Mutation of the mouse klotho gene leads to a syndrome resembling ageing
    • Kuro-o M., Matsumura Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T., et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997, 390:45-51.
    • (1997) Nature , vol.390 , pp. 45-51
    • Kuro-o, M.1    Matsumura, Y.2    Aizawa, H.3    Kawaguchi, H.4    Suga, T.5    Utsugi, T.6
  • 88
    • 0036785320 scopus 로고    scopus 로고
    • Klotho gene polymorphisms associated with bone density of aged postmenopausal women
    • Kawano K., Ogata N., Chiano M., Molloy H., Kleyn P., Spector T.D., et al. Klotho gene polymorphisms associated with bone density of aged postmenopausal women. J Bone Miner Res 2002, 17:1744-1751.
    • (2002) J Bone Miner Res , vol.17 , pp. 1744-1751
    • Kawano, K.1    Ogata, N.2    Chiano, M.3    Molloy, H.4    Kleyn, P.5    Spector, T.D.6
  • 89
    • 0038744264 scopus 로고    scopus 로고
    • KLOTHO allele status and the risk of early-onset occult coronary artery disease
    • Arking D.E., Becker D.M., Yanek L.R., Fallin D., Judge D.P., Moy T.F., et al. KLOTHO allele status and the risk of early-onset occult coronary artery disease. Am J Hum Genet 2003, 72:1154-1161.
    • (2003) Am J Hum Genet , vol.72 , pp. 1154-1161
    • Arking, D.E.1    Becker, D.M.2    Yanek, L.R.3    Fallin, D.4    Judge, D.P.5    Moy, T.F.6
  • 90
    • 33748741795 scopus 로고    scopus 로고
    • Klotho is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females
    • Kim Y., Kim J.H., Nam Y.J., Kong M., Kim Y.J., Yu K.H., et al. Klotho is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females. Neurosci Lett 2006, 407:189-194.
    • (2006) Neurosci Lett , vol.407 , pp. 189-194
    • Kim, Y.1    Kim, J.H.2    Nam, Y.J.3    Kong, M.4    Kim, Y.J.5    Yu, K.H.6
  • 92
    • 0034710838 scopus 로고    scopus 로고
    • In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome
    • Saito Y., Nakamura T., Ohyama Y., Suzuki T., Iida A., Shiraki-Iida T., et al. In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Biochem Biophys Res Commun 2000, 276:767-772.
    • (2000) Biochem Biophys Res Commun , vol.276 , pp. 767-772
    • Saito, Y.1    Nakamura, T.2    Ohyama, Y.3    Suzuki, T.4    Iida, A.5    Shiraki-Iida, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.