Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: Effects of farnesyltransferase inhibitors

Aging Cell

Volumn 7, Issue 3, 2008, Pages 383-393

  Verstraeten, Valerie L R M ^a,b,c   Ji, Julie Y ^a   Cummings, Kiersten S ^a   Lee, Richard T ^a   Lammerding, Jan ^a,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d Partners Research Facility   (United States)

Author keywords

Cell migration; Cellular mechanics; Farnesyltransferase inhibitors; Hutchinson Gilford progeria syndrome; Lamin; Wound healing

Indexed keywords

PROTEIN FARNESYLTRANSFERASE INHIBITOR;

ADOLESCENT; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL MIGRATION; CELL NUCLEUS; CELL STRESS; CELL VIABILITY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MALE; MECHANICAL STRESS; MECHANOTRANSDUCTION; PRIORITY JOURNAL; PROGERIA; SKIN FIBROBLAST; VASCULAR SMOOTH MUSCLE; WOUND HEALING IMPAIRMENT;

ADOLESCENT; AGED, 80 AND OVER; APOPTOSIS; CELL MOVEMENT; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; FARNESYLTRANSTRANSFERASE; FEMALE; FIBROBLASTS; HUMANS; MALE; METHIONINE; NUCLEAR PROTEINS; PROGERIA; SENSITIVITY AND SPECIFICITY; SKIN; WOUND HEALING;

EID: 43449096922     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2008.00382.x     Document Type: Article

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