Omapatrilat reduces pulse pressure and proximal aortic stiffness in patients with systolic hypertension: Results of the conduit hemodynamics of omapatrilat international research study

Circulation

Volumn 105, Issue 25, 2002, Pages 2955-2961

  Mitchell, Gary F ^a   Izzo Jr , Joseph L ^a   Lacourcière, Yves ^a   Ouellet, Jean Pascal ^a   Neutel, Joel ^a   Qian, Chunlin ^a   Kerwin, Linda J ^a   Block, Alan J ^a   Pfeffer, Marc A ^a  

^a CARDIOVASCULAR ENGINEERING INC   (United States)

Author keywords

Aorta; Hemodynamics; Hypertension; Natriuretic peptides

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; ENKEPHALINASE INHIBITOR; NATRIURETIC FACTOR; OMAPATRILAT; VASOPEPTIDASE INHIBITOR;

ADULT; AGED; AORTA FLOW; AORTA STENOSIS; ARTICLE; CALCULATION; CALIBRATION; CARDIOVASCULAR RISK; CAROTID ARTERY PULSE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY HEMODYNAMICS; DOPPLER ECHOCARDIOGRAPHY; DOUBLE BLIND PROCEDURE; DRUG MECHANISM; DRUG PROTEIN BINDING; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; NATRIURESIS; PERIPHERAL CIRCULATION; PREDICTION; PRIORITY JOURNAL; PULSATILE FLOW; PULSE PRESSURE; RANDOMIZED CONTROLLED TRIAL; RIGIDITY; SYSTOLIC HYPERTENSION; TONOMETRY;

ADULT; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANTIHYPERTENSIVE AGENTS; AORTA; BLOOD PRESSURE; DOUBLE-BLIND METHOD; ENALAPRIL; FEMALE; HEMODYNAMIC PROCESSES; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; PROTEASE INHIBITORS; PYRIDINES; SYSTOLE; THIAZEPINES;

EID: 0037173041     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000020500.77568.3C     Document Type: Article

References (36)

1. Cardiovascular risk assessment using pulse pressure in the first National Health and Nutrition Examination Survey (NHANES I)
2. Relation of pulse pressure and blood pressure reduction to the incidence of myocardial infarction
3. Isolated systolic hypertension: Prognostic information provided by pulse pressure
4. Relation of arterial pressure waveform to left ventricular and carotid anatomy in normotensive subjects
5. Impact of arterial stiffening on left ventricular structure
6. Endothelial dysfunction, hemodynamic forces, and atherogenesis
7. Protection from atherosclerotic lesion formation by reduction of artery wall motion
8. Resistance and conduit arteries following converting enzyme inhibition in hypertension
9. Natriuretic peptides
10. Vasopeptidase inhibitors: A new therapeutic concept in cardiovascular disease?
11. Effect of a nonhypotensive long-term infusion of ANP on the mechanical and structural properties of the arterial wall in Wistar-Kyoto and spontaneously hypertensive rats
12. Measurement of aortic input impedance in the rat
13. Noninvasive determination of aortic input impedance and external left ventricular power output: A validation and repeatability study of a new technique
14. A comparison of techniques for measuring pulse wave velocity in the rat
15. Pulsatile hemodynamics in congestive heart failure
16. Aortic input impedance in normal man: Relationship to pressure wave forms
17. Forward and backward waves in the arterial system
18. Equipotent antihypertensive agents variously affect pulsatile hemodynamics and regression of cardiac hypertrophy in spontaneously hypertensive rats
19. Effect of a purified atrial natriuretic factor on rat and rabbit vascular strips and vascular beds
20. Atrial natriuretic polypeptide inhibits hypertrophy of vascular smooth muscle cells
21. Clearance receptor-binding atrial natriuretic peptides inhibit mitogenesis and proliferation of rat aortic smooth muscle cells
22. Difference in effect of atrial natriuretic peptide on cGMP in aortic and coronary smooth muscle cells
23. Activation of vagal depressor reflexes by atriopeptins inhibits renal sympathetic nerve activity
24. α-ANP alters reflex control of lumbar and renal sympathetic nerve activity and heart rate
25. Effects of α-human atrial natriuretic peptide on the interrelationship of arterial pressure, aortic nerve activity, and aortic diameter
26. Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham heart study
27. Pulse pressure and cardiovascular mortality in normotensive and hypertensive subjects
28. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients
29. Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age
30. Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure
31. Nitric oxide synthase inhibition increases aortic stiffness measured by pulse wave velocity in rats
32. Nitric oxide regulates local arterial distensibility in vivo
33. Endothelium-derived nitric oxide regulates arterial elasticity in human arteries in vivo
34. Vasopeptidase inhibition exhibits endothelial protection in salt-induced hypertension
35. Pulse pressure, arterial compliance and cardiovascular morbidity and mortality
36. Improvement in blood pressure, arterial stiffness and wave reflections with a very-low-dose perindopril/indapamide combination in hypertensive patient: A comparison with atenolol