Design and validation of novel chikungunya virus protease inhibitors

Antimicrobial Agents and Chemotherapy

Volumn 60, Issue 12, 2016, Pages 7382-7395

  Das, Pratyush Kumar ^a,b   Puusepp, Laura ^a   Varghese, Finny S ^b,d   Utt, Age ^a   Ahola, Tero ^b   Kananovich, Dzmitry G ^c   Lopp, Margus ^c   Merits, Andres ^a   Karelson, Mati ^a  

^a UNIVERSITY OF TARTU   (Estonia)

^b UNIVERSITY OF HELSINKI   (Finland)

^c TALLINN UNIVERSITY OF TECHNOLOGY   (Estonia)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

POLYPROTEIN; PROTEINASE INHIBITOR; RECOMBINANT PROTEIN; SYNTHETIC PEPTIDE; VIRUS RNA; ANTIVIRUS AGENT; CARBOXYLIC ACID; CYCLOPROPANE DERIVATIVE; CYSTEINE PROTEINASE; NSP2 PROTEINASE; RNA HELICASE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CHIKUNGUNYA VIRUS; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; EC50; ENZYME ACTIVE SITE; ENZYME INHIBITION; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; STEREOISOMERISM; VALIDATION STUDY; VIRUS GENOME; VIRUS INHIBITION; VIRUS REPLICATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; EPITHELIUM CELL; GENETICS; GROWTH, DEVELOPMENT AND AGING; HAMSTER; IC50; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; VIROLOGY; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIVIRAL AGENTS; CARBOXYLIC ACIDS; CATALYTIC DOMAIN; CELL LINE; CHIKUNGUNYA VIRUS; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; CYCLOPROPANES; CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; EPITHELIAL CELLS; GENOME, VIRAL; INHIBITORY CONCENTRATION 50; MOLECULAR DOCKING SIMULATION; POLYPROTEINS; PROTEASE INHIBITORS; RNA HELICASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 84996503543     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01421-16     Document Type: Article

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