The antiviral alkaloid berberine reduces Chikungunya virus-induced mitogen-activated protein kinase signaling

Journal of Virology

Volumn 90, Issue 21, 2016, Pages 9743-9757

  Varghese, Finny S ^a   Thaa, Bastian ^b   Amrun, Siti Naqiah ^c   Simarmata, Diane ^c   Rausalu, Kai ^d   Nyman, Tuula A ^e   Merits, Andres ^d   McInerney, Gerald M ^b   Ng, Lisa F P ^c   Ahola, Tero ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b KAROLINSKA INSTITUTE   (Sweden)

^c AGENCY FOR SCIENCE   (Singapore)

^d UNIVERSITY OF TARTU   (Estonia)

^e UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BERBERINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; ALKALOID; ANTIVIRUS AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CELL MEDIATED CYTOTOXICITY; CHIKUNGUNYA; CHIKUNGUNYA VIRUS; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; ENZYME ACTIVATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; NORTHERN BLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRION; VIRUS ENTRY; VIRUS LOAD; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TITRATION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL LINE; DRUG EFFECT; HAMSTER; HEK293 CELL LINE; METABOLISM; PHOSPHORYLATION; VERO CELL LINE; VIRUS ACTIVATION;

ALKALOIDS; ANIMALS; ANTIVIRAL AGENTS; BERBERINE; CELL LINE; CHIKUNGUNYA FEVER; CHIKUNGUNYA VIRUS; CRICETINAE; HEK293 CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; VERO CELLS; VIRUS ACTIVATION; VIRUS REPLICATION;

EID: 84993159425     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01382-16     Document Type: Article

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