Identification of [1,2,3]triazolo[4,5-d ]pyrimidin-7(6H)-ones as novel inhibitors of chikungunya virus replication

Journal of Medicinal Chemistry

Volumn 57, Issue 10, 2014, Pages 4000-4008

  Gigante, Alba ^a   Canela, María Dolores ^a   Delang, Leen ^b   Priego, Eva María ^a   Camarasa, María José ^a   Querat, Gilles ^c   Neyts, Johan ^b   Leyssen, Pieter ^b   Pérez Pérez, María Jesús ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c EHESP School of Public Health   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2' METHOXYPHENYL) 5 METHYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 3 (3' ACETYLPHENY) 5 METHYL 3H [1,2,3]TRIAZOLO[4,5 D] PYRIMIDIN 7(6H) ONE; 3 (3' ACETYLPHENYL) 5 METHYL 7 METHYLAMINO 3H [1,2,3] TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 3 (3' ACETYLPHENYL) 5,6 DIMETHYL 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 3 (3' ACETYLPHENYL) 7 AMINO 5 METHYL 3H [1,2,3] TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 5 ETHYL 3 (3' ISOPROPOXYPHENYL) 3H [1,2,3]TRIAZOLO[4,5 D]PYRIMIDIN 7(6H) ONE; 9 (3' ACETYLPHENYL) 2 METHYL 1H PURIN 6(9H) ONE; 9 (3' ACETYLPHENYL) 2,8 DIMETHYL 1H PURIN 6(9H) ONE; ANTIVIRUS AGENT; CHLOROQUINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AEDES ALBOPICTUS; ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CHIKUNGUNYA; CHIKUNGUNYA ALPHAVIRUS; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DIMROTH ISOMER; DRUG STRUCTURE; DRUG SYNTHESIS; ISOMER; MICROWAVE IRRADIATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTON NUCLEAR MAGNETIC RESONANCE; VIRUS REPLICATION; VIRUS STRAIN;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; CHIKUNGUNYA VIRUS; PYRIMIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; VERO CELLS; VIRUS REPLICATION;

EID: 84901251058     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401844c     Document Type: Article

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