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Volumn 6, Issue , 2016, Pages

Intrinsic cellular signaling mechanisms determine the sensitivity of cancer cells to virus-induced apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR;

EID: 84995595336     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep37213     Document Type: Article
Times cited : (4)

References (57)
  • 1
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch, S. M., Francis, H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 124, 619-626 (1994).
    • (1994) J Cell Biol , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 2
    • 78650939093 scopus 로고    scopus 로고
    • ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells
    • Grassian, A. R., Schafer, Z. T., Brugge, J. S. ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells. J Biol Chem 286, 79-90, doi: 10. 1074/jbc. M110. 169821 (2011).
    • (2011) J Biol Chem , vol.286 , pp. 79-90
    • Grassian, A.R.1    Schafer, Z.T.2    Brugge, J.S.3
  • 3
    • 0042696985 scopus 로고    scopus 로고
    • Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis
    • Reginato, M. J. et al. Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol 5, 733-740, doi: 10. 1038/ncb1026 (2003).
    • (2003) Nat Cell Biol , vol.5 , pp. 733-740
    • Reginato, M.J.1
  • 4
    • 69949101473 scopus 로고    scopus 로고
    • Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
    • Schafer, Z. T. et al. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 461, 109-113, doi: 10. 1038/nature08268 (2009).
    • (2009) Nature , vol.461 , pp. 109-113
    • Schafer, Z.T.1
  • 5
    • 84887621878 scopus 로고    scopus 로고
    • Anoikis molecular pathways and its role in cancer progression
    • Paoli, P., Giannoni, E., Chiarugi, P. Anoikis molecular pathways and its role in cancer progression. Biochim Biophys Acta 1833, 3481-3498, doi: 10. 1016/j. bbamcr. 2013. 06. 026 (2013).
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 3481-3498
    • Paoli, P.1    Giannoni, E.2    Chiarugi, P.3
  • 6
    • 84863357474 scopus 로고    scopus 로고
    • Anoikis resistance: An essential prerequisite for tumor metastasis
    • Kim, Y. N., Koo, K. H., Sung, J. Y., Yun, U. J., Kim, H. Anoikis resistance: an essential prerequisite for tumor metastasis. Int J Cell Biol 2012, 306879, doi: 10. 1155/2012/306879 (2012).
    • (2012) Int J Cell Biol , vol.2012 , pp. 306879
    • Kim, Y.N.1    Koo, K.H.2    Sung, J.Y.3    Yun, U.J.4    Kim, H.5
  • 7
    • 0034648698 scopus 로고    scopus 로고
    • Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: Inhibition by PKB/Akt but not Raf signalling
    • Rytomaa, M., Lehmann, K., Downward, J. Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling. Oncogene 19, 4461-4468, doi: 10. 1038/sj. onc. 1203805 (2000).
    • (2000) Oncogene , vol.19 , pp. 4461-4468
    • Rytomaa, M.1    Lehmann, K.2    Downward, J.3
  • 8
    • 0030913673 scopus 로고    scopus 로고
    • Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
    • Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P. H., Downward, J. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J 16, 2783-2793, doi: 10. 1093/emboj/16. 10. 2783 (1997).
    • (1997) EMBO J , vol.16 , pp. 2783-2793
    • Khwaja, A.1    Rodriguez-Viciana, P.2    Wennstrom, S.3    Warne, P.H.4    Downward, J.5
  • 9
    • 84887456252 scopus 로고    scopus 로고
    • The epigenetics of epithelial-mesenchymal plasticity in cancer
    • Tam, W. L., Weinberg, R. A. The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med 19, 1438-1449, doi: 10. 1038/nm. 3336 (2013).
    • (2013) Nat Med , vol.19 , pp. 1438-1449
    • Tam, W.L.1    Weinberg, R.A.2
  • 10
    • 43049103824 scopus 로고    scopus 로고
    • The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    • Gregory, P. A. et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 10, 593-601, doi: 10. 1038/ncb1722 (2008).
    • (2008) Nat Cell Biol , vol.10 , pp. 593-601
    • Gregory, P.A.1
  • 11
    • 84881075538 scopus 로고    scopus 로고
    • The role of epithelial-mesenchymal transition programming in invasion and metastasis: A clinical perspective
    • Creighton, C. J., Gibbons, D. L., Kurie, J. M. The role of epithelial-mesenchymal transition programming in invasion and metastasis: a clinical perspective. Cancer Manag Res 5, 187-195, doi: 10. 2147/CMAR. S35171 (2013).
    • (2013) Cancer Manag Res , vol.5 , pp. 187-195
    • Creighton, C.J.1    Gibbons, D.L.2    Kurie, J.M.3
  • 12
    • 79955102595 scopus 로고    scopus 로고
    • Targets of miR-200c mediate suppression of cell motility and anoikis resistance
    • Howe, E. N., Cochrane, D. R., Richer, J. K. Targets of miR-200c mediate suppression of cell motility and anoikis resistance. Breast Cancer Res 13, R45, doi: 10. 1186/bcr2867 (2011).
    • (2011) Breast Cancer Res , vol.13 , pp. R45
    • Howe, E.N.1    Cochrane, D.R.2    Richer, J.K.3
  • 13
    • 84869801719 scopus 로고    scopus 로고
    • MiR-200c targets a NF-kappaB up-regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer
    • Howe, E. N., Cochrane, D. R., Cittelly, D. M., Richer, J. K. miR-200c targets a NF-kappaB up-regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer. PLoS ONE 7, e49987, doi: 10. 1371/journal. pone. 0049987 (2012).
    • (2012) PLoS ONE , vol.7 , pp. 49987
    • Howe, E.N.1    Cochrane, D.R.2    Cittelly, D.M.3    Richer, J.K.4
  • 14
    • 84876283185 scopus 로고    scopus 로고
    • MiRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs
    • Riaz, M. et al. miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs. Breast Cancer Res 15, R33, doi: 10. 1186/bcr3415 (2013).
    • (2013) Breast Cancer Res , vol.15 , pp. R33
    • Riaz, M.1
  • 15
    • 84881314954 scopus 로고    scopus 로고
    • The management of early-stage and metastatic triple-negative breast cancer: A review
    • 15., ers, C. K., Zagar, T. M., Carey, L. A. The management of early-stage and metastatic triple-negative breast cancer: a review. Hematol Oncol Clin North Am 27, 737-749, doi: 10. 1016/j. hoc. 2013. 05. 003 (2013).
    • (2013) Hematol Oncol Clin North Am , vol.27 , pp. 737-749
    • Anders, C.K.1    Zagar, T.M.2    Carey, L.A.3
  • 16
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • TCGA
    • TCGA. Comprehensive molecular portraits of human breast tumours. Nature 490, 61-70, doi: 10. 1038/nature11412 (2012).
    • (2012) Nature , vol.490 , pp. 61-70
  • 17
    • 0028113326 scopus 로고
    • E1a induces the expression of epithelial characteristics
    • Frisch, S. M. E1a induces the expression of epithelial characteristics. J Cell Biol 127, 1085-1096 (1994).
    • (1994) J Cell Biol , vol.127 , pp. 1085-1096
    • Frisch, S.M.1
  • 18
    • 0034601442 scopus 로고    scopus 로고
    • Evidence for a function of CtBP in epithelial gene regulation and anoikis
    • Grooteclaes, M. L., Frisch, S. M. Evidence for a function of CtBP in epithelial gene regulation and anoikis. Oncogene 19, 3823-3828, doi: 10. 1038/sj. onc. 1203721 (2000).
    • (2000) Oncogene , vol.19 , pp. 3823-3828
    • Grooteclaes, M.L.1    Frisch, S.M.2
  • 19
    • 0020578315 scopus 로고
    • Role of adenovirus types 5 and 12 early region 1b tumor antigens in oncogenic transformation
    • Bernards, R., Schrier, P. I., Bos, J. L., Van der Eb, A. J. Role of adenovirus types 5 and 12 early region 1b tumor antigens in oncogenic transformation. Virology 127, 45-53 (1983).
    • (1983) Virology , vol.127 , pp. 45-53
    • Bernards, R.1    Schrier, P.I.2    Bos, J.L.3    Vander Eb, A.J.4
  • 20
    • 0033912223 scopus 로고    scopus 로고
    • Adenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF
    • Liu, Y., Colosimo, A. L., Yang, X. J., Liao, D. Adenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF. Mol Cell Biol 20, 5540-5553 (2000).
    • (2000) Mol Cell Biol , vol.20 , pp. 5540-5553
    • Liu, Y.1    Colosimo, A.L.2    Yang, X.J.3    Liao, D.4
  • 21
    • 0036088252 scopus 로고    scopus 로고
    • Adenovirus-5 E1A: Paradox and paradigm
    • Frisch, S. M., Mymryk, J. S. Adenovirus-5 E1A: paradox and paradigm. Nat Rev Mol Cell Biol 3, 441-452 (2002).
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 441-452
    • Frisch, S.M.1    Mymryk, J.S.2
  • 22
    • 0033102394 scopus 로고    scopus 로고
    • Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP
    • Lipinski, K. S. et al. Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP. Virology 255, 94-105, doi: 10. 1006/viro. 1998. 9583 (1999).
    • (1999) Virology , vol.255 , pp. 94-105
    • Lipinski, K.S.1
  • 23
    • 47749130885 scopus 로고    scopus 로고
    • Intrinsic structural disorder in adenovirus E1A: A viral molecular hub linking multiple diverse processes
    • Pelka, P., Ablack, J. N., Fonseca, G. J., Yousef, A. F., Mymryk, J. S. Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes. J Virol 82, 7252-7263 (2008).
    • (2008) J Virol , vol.82 , pp. 7252-7263
    • Pelka, P.1    Ablack, J.N.2    Fonseca, G.J.3    Yousef, A.F.4    Mymryk, J.S.5
  • 24
    • 84855326431 scopus 로고    scopus 로고
    • Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis
    • Zhao, B. et al. Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev 26, 54-68, doi: 10. 1101/gad. 173435. 111 (2012).
    • (2012) Genes Dev , vol.26 , pp. 54-68
    • Zhao, B.1
  • 25
    • 84923183206 scopus 로고    scopus 로고
    • The emerging roles of YAP and TAZ in cancer
    • Moroishi, T., Hansen, C. G., Guan, K. L. The emerging roles of YAP and TAZ in cancer. Nat Rev Cancer 15, 73-79, doi: 10. 1038/nrc3876 (2015).
    • (2015) Nat Rev Cancer , vol.15 , pp. 73-79
    • Moroishi, T.1    Hansen, C.G.2    Guan, K.L.3
  • 26
    • 84886875955 scopus 로고    scopus 로고
    • Activation of the leukotriene b4 receptor 2-reactive oxygen species (BLT2-ROS) cascade following detachment confers anoikis resistance in prostate cancer cells
    • Lee, J. W., Kim, J. H. Activation of the Leukotriene B4 Receptor 2-Reactive Oxygen Species (BLT2-ROS) Cascade following Detachment Confers Anoikis Resistance in Prostate Cancer Cells. J Biol Chem 288, 30054-30063, doi: 10. 1074/jbc. M113. 481283 (2013).
    • (2013) J Biol Chem , vol.288 , pp. 30054-30063
    • Lee, J.W.1    Kim, J.H.2
  • 27
    • 84862308505 scopus 로고    scopus 로고
    • A novel epidermal growth factor receptor variant lacking multiple domains directly activates transcription and is overexpressed in tumors
    • Piccione, E. C. et al. A novel epidermal growth factor receptor variant lacking multiple domains directly activates transcription and is overexpressed in tumors. Oncogene 31, 2953-2967, doi: 10. 1038/onc. 2011. 465 (2012).
    • (2012) Oncogene , vol.31 , pp. 2953-2967
    • Piccione, E.C.1
  • 28
    • 0037421970 scopus 로고    scopus 로고
    • Selective PDZ protein-dependent stimulation of phosphatidylinositol 3-kinase by the adenovirus E4-ORF1 oncoprotein
    • Frese, K. K. et al. Selective PDZ protein-dependent stimulation of phosphatidylinositol 3-kinase by the adenovirus E4-ORF1 oncoprotein. Oncogene 22, 710-721, doi: 10. 1038/sj. onc. 1206151 (2003).
    • (2003) Oncogene , vol.22 , pp. 710-721
    • Frese, K.K.1
  • 29
    • 62749128485 scopus 로고    scopus 로고
    • E4orf1 limits the oncolytic potential of the E1B-55K deletion mutant adenovirus
    • Thomas, M. A., Broughton, R. S., Goodrum, F. D., Ornelles, D. A. E4orf1 limits the oncolytic potential of the E1B-55K deletion mutant adenovirus. J Virol 83, 2406-2416, doi: 10. 1128/JVI. 01972-08 (2009).
    • (2009) J Virol , vol.83 , pp. 2406-2416
    • Thomas, M.A.1    Broughton, R.S.2    Goodrum, F.D.3    Ornelles, D.A.4
  • 30
    • 17144403770 scopus 로고    scopus 로고
    • Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication
    • Shea, C. et al. Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. EMBO J 24, 1211-1221, doi: 10. 1038/sj. emboj. 7600597 (2005).
    • (2005) EMBO J , vol.24 , pp. 1211-1221
    • Shea, C.1
  • 31
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • Park, S. M., Gaur, A. B., Lengyel, E., Peter, M. E. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 22, 894-907, doi: 10. 1101/gad. 1640608 (2008).
    • (2008) Genes Dev , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 32
    • 84858703841 scopus 로고    scopus 로고
    • The miR-200 and miR-221/222 microRNA families: Opposing effects on epithelial identity
    • Howe, E. N., Cochrane, D. R., Richer, J. K. The miR-200 and miR-221/222 microRNA families: opposing effects on epithelial identity. J Mammary Gland Biol Neoplasia 17, 65-77, doi: 10. 1007/s10911-012-9244-6 (2012).
    • (2012) J Mammary Gland Biol Neoplasia , vol.17 , pp. 65-77
    • Howe, E.N.1    Cochrane, D.R.2    Richer, J.K.3
  • 33
    • 84879984887 scopus 로고    scopus 로고
    • Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family
    • Yu, Y. et al. Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family. Int J Cancer 133, 1368-1379, doi: 10. 1002/ijc. 28151 (2013).
    • (2013) Int J Cancer , vol.133 , pp. 1368-1379
    • Yu, Y.1
  • 34
    • 84863115693 scopus 로고    scopus 로고
    • Subtype and pathway specific responses to anticancer compounds in breast cancer
    • Heiser, L. M. et al. Subtype and pathway specific responses to anticancer compounds in breast cancer. Proc Natl Acad Sci USA 109, 2724-2729, doi: 10. 1073/pnas. 1018854108 (2012).
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 2724-2729
    • Heiser, L.M.1
  • 35
    • 84885722700 scopus 로고    scopus 로고
    • Profiles of Basal and stimulated receptor signaling networks predict drug response in breast cancer lines
    • Niepel, M. et al. Profiles of Basal and stimulated receptor signaling networks predict drug response in breast cancer lines. Sci Signal 6, ra84, doi: 10. 1126/scisignal. 2004379 (2013).
    • (2013) Sci Signal , vol.6 , pp. 84
    • Niepel, M.1
  • 36
    • 79959847002 scopus 로고    scopus 로고
    • Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis
    • Kim, E. K. et al. Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis. Oncogene 30, 2954-2963, doi: 10. 1038/onc. 2011. 22 (2011).
    • (2011) Oncogene , vol.30 , pp. 2954-2963
    • Kim, E.K.1
  • 37
    • 78549271170 scopus 로고    scopus 로고
    • MTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis
    • Zhang, F. et al. mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis. Cancer Res 70, 9360-9370, doi: 10. 1158/0008-5472. CAN-10-0207 (2010).
    • (2010) Cancer Res , vol.70 , pp. 9360-9370
    • Zhang, F.1
  • 38
    • 84868212354 scopus 로고    scopus 로고
    • Targeting of mTORC2 prevents cell migration and promotes apoptosis in breast cancer
    • Li, H. et al. Targeting of mTORC2 prevents cell migration and promotes apoptosis in breast cancer. Breast Cancer Res Treat 134, 1057-1066, doi: 10. 1007/s10549-012-2036-2 (2012).
    • (2012) Breast Cancer Res Treat , vol.134 , pp. 1057-1066
    • Li, H.1
  • 39
    • 79955486858 scopus 로고    scopus 로고
    • MTORC1 and mTORC2 regulate EMT motility and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways
    • Gulhati, P. et al. mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res 71, 3246-3256, doi: 10. 1158/0008-5472. CAN-10-4058 (2011).
    • (2011) Cancer Res , vol.71 , pp. 3246-3256
    • Gulhati, P.1
  • 40
    • 84860816141 scopus 로고    scopus 로고
    • Oncogenic EGFR signaling activates an mTORC2-NF-kappaB pathway that promotes chemotherapy resistance
    • Tanaka, K. et al. Oncogenic EGFR signaling activates an mTORC2-NF-kappaB pathway that promotes chemotherapy resistance. Cancer Discov 1, 524-538, doi: 10. 1158/2159-8290. CD-11-0124 (2011).
    • (2011) Cancer Discov , vol.1 , pp. 524-538
    • Tanaka, K.1
  • 41
    • 84875472185 scopus 로고    scopus 로고
    • MTOR complex 2 is involved in regulation of Cbl-dependent c-FLIP degradation and sensitivity of TRAIL-induced apoptosis
    • Zhao, L., Yue, P., Khuri, F. R., Sun, S. Y. mTOR complex 2 is involved in regulation of Cbl-dependent c-FLIP degradation and sensitivity of TRAIL-induced apoptosis. Cancer Res 73, 1946-1957, doi: 10. 1158/0008-5472. CAN-12-3710 (2013).
    • (2013) Cancer Res , vol.73 , pp. 1946-1957
    • Zhao, L.1    Yue, P.2    Khuri, F.R.3    Sun, S.Y.4
  • 42
    • 84862670200 scopus 로고    scopus 로고
    • Nuclear localization of parathyroid hormone-related peptide confers resistance to anoikis in prostate cancer cells
    • Park, S. I., McCauley, L. K. Nuclear localization of parathyroid hormone-related peptide confers resistance to anoikis in prostate cancer cells. Endocr Relat Cancer 19, 243-254, doi: 10. 1530/ERC-11-0278 (2012).
    • (2012) Endocr Relat Cancer , vol.19 , pp. 243-254
    • Park, S.I.1    McCauley, L.K.2
  • 43
    • 84879466738 scopus 로고    scopus 로고
    • Stabilization of Snail through AKT/GSK-3beta signaling pathway is required for TNF-alpha-induced epithelialmesenchymal transition in prostate cancer PC3 cells
    • Wang, H. et al. Stabilization of Snail through AKT/GSK-3beta signaling pathway is required for TNF-alpha-induced epithelialmesenchymal transition in prostate cancer PC3 cells. Eur J Pharmacol 714, 48-55, doi: 10. 1016/j. ejphar. 2013. 05. 046 (2013).
    • (2013) Eur J Pharmacol , vol.714 , pp. 48-55
    • Wang, H.1
  • 44
    • 84884571694 scopus 로고    scopus 로고
    • Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an atpdependent mechanism
    • Chen, C. H. et al. Autoregulation of the Mechanistic Target of Rapamycin (mTOR) Complex 2 Integrity Is Controlled by an ATPdependent Mechanism. J Biol Chem 288, 27019-27030, doi: 10. 1074/jbc. M113. 498055 (2013).
    • (2013) J Biol Chem , vol.288 , pp. 27019-27030
    • Chen, C.H.1
  • 45
    • 77953200528 scopus 로고    scopus 로고
    • Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism
    • Kumar, A. et al. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes 59, 1397-1406, doi: 10. 2337/db09-1061 (2010).
    • (2010) Diabetes , vol.59 , pp. 1397-1406
    • Kumar, A.1
  • 46
    • 84885187437 scopus 로고    scopus 로고
    • A Central Role for mTOR in Lipid Homeostasis
    • Lamming, D. W., Sabatini, D. M. A Central Role for mTOR in Lipid Homeostasis. Cell Metab 18, 465-469, doi: 10. 1016/j. cmet. 2013. 08. 002 (2013).
    • (2013) Cell Metab , vol.18 , pp. 465-469
    • Lamming, D.W.1    Sabatini, D.M.2
  • 47
    • 84865503043 scopus 로고    scopus 로고
    • Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2
    • Yuan, M., Pino, E., Wu, L., Kacergis, M., Soukas, A. A. Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2. J Biol Chem 287, 29579-29588, doi: 10. 1074/jbc. M112. 386854 (2012).
    • (2012) J Biol Chem , vol.287 , pp. 29579-29588
    • Yuan, M.1    Pino, E.2    Wu, L.3    Kacergis, M.4    Soukas, A.A.5
  • 48
    • 84860454425 scopus 로고    scopus 로고
    • Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c
    • Hagiwara, A. et al. Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c. Cell Metab 15, 725-738, doi: 10. 1016/j. cmet. 2012. 03. 015 (2012).
    • (2012) Cell Metab , vol.15 , pp. 725-738
    • Hagiwara, A.1
  • 49
    • 84887430714 scopus 로고    scopus 로고
    • MTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc
    • Masui, K. et al. mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. Cell Metab 18, 726-739, doi: 10. 1016/j. cmet. 2013. 09. 013 (2013).
    • (2013) Cell Metab , vol.18 , pp. 726-739
    • Masui, K.1
  • 50
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • TCGA
    • TCGA. Integrated genomic analyses of ovarian carcinoma. Nature 474, 609-615, doi: 10. 1038/nature10166 (2011).
    • (2011) Nature , vol.474 , pp. 609-615
  • 51
    • 84887228819 scopus 로고    scopus 로고
    • Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
    • Liu, P. et al. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol 15, 1340-1350, doi: 10. 1038/ncb2860 (2013).
    • (2013) Nat Cell Biol , vol.15 , pp. 1340-1350
    • Liu, P.1
  • 52
    • 58649114084 scopus 로고    scopus 로고
    • MTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice
    • Guertin, D. A. et al. mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell 15, 148-159, doi: 10. 1016/j. ccr. 2008. 12. 017 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 148-159
    • Guertin, D.A.1
  • 53
    • 27944464545 scopus 로고    scopus 로고
    • Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus
    • Berk, A. J. Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus. Oncogene 24, 7673-7685 (2005).
    • (2005) Oncogene , vol.24 , pp. 7673-7685
    • Berk, A.J.1
  • 54
    • 84871962435 scopus 로고    scopus 로고
    • MTOR inhibitor RAD001 promotes metastasis in a rat model of pancreatic neuroendocrine cancer
    • Pool, S. E. et al. mTOR inhibitor RAD001 promotes metastasis in a rat model of pancreatic neuroendocrine cancer. Cancer Res 73, 12-18, doi: 10. 1158/0008-5472. CAN-11-2089 (2013).
    • (2013) Cancer Res , vol.73 , pp. 12-18
    • Pool, S.E.1
  • 55
    • 79961180962 scopus 로고    scopus 로고
    • Inhibition of p53 by adenovirus type 12 E1B-55K deregulates cell cycle control and sensitizes tumor cells to genotoxic agents
    • Li, Q. et al. Inhibition of p53 by Adenovirus Type 12 E1B-55K Deregulates Cell Cycle Control and Sensitizes Tumor Cells to Genotoxic Agents. J Virol 85, 7976-7988, doi: 10. 1128/JVI. 00492-11 (2011).
    • (2011) J Virol , vol.85 , pp. 7976-7988
    • Li, Q.1
  • 56
    • 84877642396 scopus 로고    scopus 로고
    • Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents
    • Yang, H. et al. Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents. Mol Cancer Ther 12, 610-620, doi: 10. 1158/1535-7163. MCT-12-0930 (2013).
    • (2013) Mol Cancer Ther , vol.12 , pp. 610-620
    • Yang, H.1
  • 57
    • 84863126597 scopus 로고    scopus 로고
    • Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection
    • Yang, H., Zheng, Z., Zhao, L. Y., Li, Q., Liao, D. Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection. Cell Cycle 11, 582-593, doi: 10. 4161/cc. 11. 3. 19052 (2012).
    • (2012) Cell Cycle , vol.11 , pp. 582-593
    • Yang, H.1    Zheng, Z.2    Zhao, L.Y.3    Li, Q.4    Liao, D.5


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