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Volumn 3, Issue 6, 2002, Pages 441-452

Adenovirus-5 E1A: Paradox and paradigm

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; VIRUS PROTEIN;

EID: 0036088252     PISSN: 14710072     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrm827     Document Type: Review
Times cited : (254)

References (146)
  • 4
    • 0020520517 scopus 로고
    • Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture
    • (1983) Nature , vol.304 , pp. 602-606
    • Ruley, H.E.1
  • 8
    • 0023907342 scopus 로고
    • Differential transformation of primary human embryo retinal cells by adenovirus E1 regions and combinations of E1A + ras
    • (1988) Oncogene , vol.3 , pp. 477-484
    • Byrd, P.1    Grand, R.2    Gallimore, P.3
  • 12
    • 0026639932 scopus 로고
    • The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7742-7746
    • Rao, L.1
  • 14
    • 0026642195 scopus 로고
    • Induction of apoptosis in fibroblasts by c-myc protein
    • (1992) Cell , vol.69 , pp. 119-128
    • Evan, G.I.1
  • 16
    • 0029985110 scopus 로고    scopus 로고
    • Tumour suppressive properties of the adenovirus 5 E1A oncogene
    • (1996) Oncogene , vol.13 , pp. 1581-1589
    • Mymryk, J.S.1
  • 17
    • 0032578861 scopus 로고    scopus 로고
    • Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo
    • (1998) Oncogene , vol.17 , pp. 2167-2175
    • Deng, J.1    Xia, W.2    Hung, M.C.3
  • 18
    • 0033930587 scopus 로고    scopus 로고
    • Transformation-defective adenovirus 5 E1A mutants exhibit antioncogenic properties in human BLM melanoma cells
    • (2000) Cancer Gene Ther. , vol.7 , pp. 1043-1050
    • Dickopp, A.1
  • 28
    • 0030901194 scopus 로고    scopus 로고
    • Phosphorylation within the transactivation domain of adenovirus E1A protein by mitogen-activated protein kinase regulates expression of early region 4
    • (1997) J. Virol. , vol.71 , pp. 3545-3553
    • Whalen, S.G.1
  • 29
    • 0029876717 scopus 로고    scopus 로고
    • Cyclin-dependent kinases phosphorylate the adenovirus E1A protein, enhancing its ability to bind pRB and disrupt pRB-E 2F complexes
    • (1996) J. Virol. , vol.70 , pp. 2911-2921
    • Mai, A.1    Piotrkowski, A.2    Harter, M.L.3
  • 34
    • 0027220154 scopus 로고
    • TATA-binding protein and the retinoblastoma gene product bind to overlapping epitopes on c-Myc and adenovirus E1A protein
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8489-8493
    • Hateboer, G.1
  • 39
    • 0027390599 scopus 로고
    • Transcriptional activation by the adenovirus larger E1A product is mediated by members of the cellular transcription factor ATF family which can directly associate with E1A
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 561-570
    • Chatton, B.1
  • 40
    • 0028223147 scopus 로고
    • Promoter targeting by adenovirus E1A through interaction with different cellular DNA-binding domains
    • (1994) Nature , vol.368 , pp. 520-525
    • Liu, F.1    Green, M.R.2
  • 41
    • 0025834681 scopus 로고
    • Interactions between adenovirus E1A and members of the AP-1 family of cellular transcription factors
    • (1991) Oncogene , vol.6 , pp. 1417-1422
    • Maguire, K.1
  • 44
    • 0034282565 scopus 로고    scopus 로고
    • Regulation of the 26S proteasome by adenovirus E1A
    • (2000) EMBO J. , vol.19 , pp. 4759-4773
    • Tumell, A.S.1
  • 45
    • 0035920243 scopus 로고    scopus 로고
    • RACK1 interacts with E1A and rescues E1A-induced yeast growth inhibition and mammalian cell apoptosis
    • (2001) J. Biol. Chem. , vol.276 , pp. 27026-27033
    • Sang, N.1
  • 48
    • 0033525094 scopus 로고    scopus 로고
    • Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A
    • (1999) Cell , vol.96 , pp. 405-413
    • Hamamori, Y.1
  • 49
    • 0033524942 scopus 로고    scopus 로고
    • A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity
    • (1999) Cell , vol.96 , pp. 393-403
    • Chakravarti, D.1
  • 50
    • 0032511884 scopus 로고    scopus 로고
    • Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A
    • (1998) Nature , vol.396 , pp. 184-186
    • Alt-Si-Ali, S.1
  • 55
    • 0032906633 scopus 로고    scopus 로고
    • P53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1202-1209
    • Liu, L.1
  • 56
    • 0032530486 scopus 로고    scopus 로고
    • DNA damage activates p53 through a phosphorylation-acetylation cascade
    • (1998) Genes Dev. , vol.12 , pp. 2831-2841
    • Sakaguchi, K.1
  • 57
    • 0031310741 scopus 로고    scopus 로고
    • Differential roles of p300 and PCAF acetyltransferases in muscle differentiation
    • (1997) Mol. Cell , vol.1 , pp. 35-45
    • Puri, P.L.1
  • 58
    • 0033231604 scopus 로고    scopus 로고
    • Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program
    • (1999) Mol. Cell , vol.4 , pp. 725-734
    • Sartorelli, V.1
  • 59
    • 0030030611 scopus 로고    scopus 로고
    • Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 593-602
    • Candau, R.1
  • 61
    • 0027533132 scopus 로고
    • Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth
    • (1993) J. Virol. , vol.67 , pp. 476-488
    • Wang, H.-G.1
  • 62
    • 0025895589 scopus 로고
    • E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 4253-4265
    • Wang, H.-G.1    Draetta, G.2    Moran, E.3
  • 63
  • 64
    • 0030892906 scopus 로고    scopus 로고
    • Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region
    • (1997) Oncogene , vol.14 , pp. 1047-1057
    • Somasundaram, K.1    El-Deiry, W.S.2
  • 65
    • 0035694469 scopus 로고    scopus 로고
    • Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases
    • (2001) Mol. Cell , vol.8 , pp. 1243-1254
    • Badev, N.A.1
  • 69
    • 0032189630 scopus 로고    scopus 로고
    • Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling
    • (1998) Nature , vol.395 , pp. 521-525
    • Waltzer, L.1    Bienz, M.2
  • 70
    • 0034636450 scopus 로고    scopus 로고
    • CBP/p300 histone acetyl-transferase activity is important for the G1/S transition
    • (2000) Oncogene , vol.19 , pp. 2430-2437
    • Ait-Si-Ali, S.1
  • 71
    • 17644445419 scopus 로고    scopus 로고
    • Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
    • (1998) Cell , vol.93 , pp. 361-372
    • Yao, T.P.1
  • 73
    • 0029010417 scopus 로고
    • Phosphorylation of the adenovirus E1A-associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells
    • (1995) EMBO J. , vol.14 , pp. 3496-3509
    • Kitabayashi, I.1
  • 74
    • 0028240768 scopus 로고
    • The adenovirus E1A 289R and 243R proteins inhibit the phosphorylation of p300
    • (1994) Oncogene , vol.9 , pp. 1733-1737
    • Banerjee, A.C.1
  • 77
    • 0025008680 scopus 로고
    • Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells
    • (1990) Oncogene , vol.5 , pp. 75-83
    • Frisch, S.M.1
  • 79
    • 0031215023 scopus 로고    scopus 로고
    • The epithelial cell default-phenotype hypothesis and its implications for cancer
    • (1997) Bioessays , vol.19 , pp. 705-709
    • Frisch, S.M.1
  • 81
    • 0036190459 scopus 로고    scopus 로고
    • CtBP, an unconventional transcriptional corepressor in development and oncogenesis
    • (2002) Mol. Cell , vol.9 , pp. 213-224
    • Chinnadural, G.1
  • 82
    • 0028838348 scopus 로고
    • Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved carboxy-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 10467-10471
    • Schaeper, U.1
  • 84
    • 0034644220 scopus 로고    scopus 로고
    • Functional link of BRCA1 and AT gene product in DNA damage response
    • (2000) Nature , vol.406 , pp. 210-214
    • Li, S.1
  • 90
    • 0026586276 scopus 로고
    • Effects of Ad5 E1A mutant viruses on the cell cycle in relation to the binding of cellular proteins including the retinoblastoma protein and cyclin A
    • (1992) Virology , vol.186 , pp. 15-24
    • Howe, J.A.1    Bayley, S.T.2
  • 92
    • 0035839104 scopus 로고    scopus 로고
    • The p400 complex is an essential E1A transformation target
    • (2001) Cell , vol.106 , pp. 297-307
    • Fuchs, M.1
  • 95
    • 0034682736 scopus 로고    scopus 로고
    • Involvement of the TIP 60 histone acetylase complex in DNA repair and apoptosis
    • (2000) Cell , vol.102 , pp. 463-473
    • Ikura, T.1
  • 99
    • 0034790436 scopus 로고    scopus 로고
    • Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression
    • (2001) Nature Genet. , vol.29 , pp. 206-211
    • Herceg, Z.1
  • 100
    • 0023914010 scopus 로고
    • Association between an oncogene and an anti-oncogene: The adenovirus E1A proteins bind to the retinoblastoma gene product
    • (1988) Nature , vol.334 , pp. 124-129
    • Whyte, P.1
  • 105
    • 0028032069 scopus 로고
    • Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation
    • (1994) EMBO J. , vol.13 , pp. 118-127
    • Mittnacht, S.1
  • 110
    • 0035797384 scopus 로고    scopus 로고
    • Rb targets histone H3 methylation and HP1 to promoters
    • (2001) Nature , vol.412 , pp. 561-565
    • Nielsen, S.J.1
  • 114
    • 0033941556 scopus 로고    scopus 로고
    • Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function
    • (2001) Mol. Cell. Biol. , vol.20 , pp. 5571-5580
    • Chen, T.T.1    Wang, J.Y.2
  • 116
    • 0033082231 scopus 로고    scopus 로고
    • RB regulates the stability and the apeptotic function of p53 via MDM2
    • (1999) Mol. Cell , vol.3 , pp. 181-193
    • Hsieh, J.K.1
  • 117
    • 0027262606 scopus 로고
    • Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis
    • (1993) Genes Dev. , vol.7 , pp. 535-545
    • Lowe, S.W.1    Ruley, H.E.2
  • 119
    • 0024723687 scopus 로고
    • Loss of Ras activity in Saccharomyces cerevisiae is suppressed by disruptions of a new kinase gene, YAKI, whose product may act downstream of the cAMP-dependent protein kinase
    • (1989) Genes Dev. , vol.3 , pp. 1336-1348
    • Garrett, S.1    Broach, J.2
  • 120
    • 0028070667 scopus 로고
    • Suppression of a yeast cyclic AMP-dependent protein kinase defect by overexpression of SOK1, a yeast gene exhibiting sequence similarity to a developmentally regulated mouse gene
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 5619-5627
    • Ward, M.P.1    Garrett, S.2
  • 121
    • 0028839101 scopus 로고
    • Minibrain: A new protein kinase family involved in postembryonic neurogenesis in Drosophila
    • (1995) Neuron , vol.14 , pp. 287-301
    • Tejedor, F.1
  • 123
    • 0032475973 scopus 로고    scopus 로고
    • Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases
    • (1998) J. Biol. Chem. , vol.273 , pp. 25893-25902
    • Becker, W.1
  • 124
    • 0035955696 scopus 로고    scopus 로고
    • Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells
    • (2001) J. Biol. Chem. , vol.276 , pp. 39819-39824
    • Yang, E.J.1    Ahn, Y.S.2    Chung, K.C.3
  • 125
    • 0030022273 scopus 로고    scopus 로고
    • Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII
    • (1996) J. Biol. Chem. , vol.271 , pp. 3488-3495
    • Kentrup, H.1
  • 128
    • 0027509346 scopus 로고
    • A region in the C-terminus of adenovirus 2/5E1A protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis
    • (1993) EMBO J. , vol.12 , pp. 469-478
    • Boyd, J.M.1
  • 129
    • 0036188940 scopus 로고    scopus 로고
    • Differentially expressed genes identified in human melanoma cell lines with different metastatic behaviour using high density oligonucleotide arrays
    • (2002) Melanoma Res. , vol.12 , pp. 57-69
    • De Wit, N.J.1
  • 132
    • 0029020945 scopus 로고
    • Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5451-5455
    • Missero, C.1
  • 133
    • 0031587821 scopus 로고    scopus 로고
    • Recruitment of p300/CBP in p53-dependent signal pathways
    • (1997) Cell , vol.89 , pp. 1175-1184
    • Avantaggiati, M.L.1
  • 134
    • 0030973238 scopus 로고    scopus 로고
    • Binding and modulation of p53 by p300/CBP coactivators
    • (1997) Nature , vol.387 , pp. 823-827
    • Lill, N.L.1
  • 139
    • 0034678364 scopus 로고    scopus 로고
    • P21 and retinoblastoma protein control the absence of DNA replication in terminally differentiated muscle cells
    • (2000) J. Cell Biol. , vol.149 , pp. 281-292
    • Mal, A.1
  • 140
    • 0029670376 scopus 로고    scopus 로고
    • Kp1 by the viral E1A oncoprotein in TGFβ-treated cells
    • (1996) Nature , vol.380 , pp. 262-265
    • Mal, A.1
  • 146
    • 0028296414 scopus 로고
    • Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
    • (1994) Genes Dev. , vol.8 , pp. 869-884
    • Eckner, R.1


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