A novel epidermal growth factor receptor variant lacking multiple domains directly activates transcription and is overexpressed in tumors

Oncogene

Volumn 31, Issue 24, 2012, Pages 2953-2967

  Piccione, E C ^a   Lieu, T J ^a   Gentile, C F ^a   Williams, T R ^a   Connolly, A J ^a   Godwin, A K ^b   Koong, A C ^a   Wong, A J ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

EGFR; ER stress; GRP78; transcription; unfolded protein response

Indexed keywords

CASPASE; CHAPERONE; DITHIOTHREITOL; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUCOSE REGULATED PROTEIN 78; LEPTOMYCIN B; MEMBRANE PROTEIN; PROTEIN TYROSINE KINASE; PROTEIN VARIANT; TUNICAMYCIN;

ARTICLE; CANCER CELL; CELL DEATH; CELL NUCLEUS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE LOCATION; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC REGULATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MINI LEEK GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN FUNCTION; REGULATOR GENE; RNA SPLICING; SENSITIZATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR GENE; UNFOLDED PROTEIN RESPONSE;

ADENOCARCINOMA; CELL LINE, TUMOR; CELL NUCLEUS; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAT-SHOCK PROTEINS; HUMANS; LUNG; LUNG NEOPLASMS; MELANOMA; NEOPLASMS; OVARIAN NEOPLASMS; OVARY; PROMOTER REGIONS, GENETIC; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; SKIN; SKIN NEOPLASMS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; UNFOLDED PROTEIN RESPONSE;

EID: 84862308505     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.465     Document Type: Article

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