Activation of the leukotriene B4 receptor 2-reactive oxygen species (BLT2-ROS) cascade following detachment confers anoikis resistance in prostate cancer cells

Journal of Biological Chemistry

Volumn 288, Issue 42, 2013, Pages 30054-30063

  Lee, Jin Wook ^a   Kim, Jae Hong ^a  

^a Korea University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANOIKIS; CELL DETACHMENT; KEY REGULATORS; LEUKOTRIENE B4; MOLECULAR MECHANISM; OXYGEN SPECIES; PROSTATE CANCER CELLS; PROSTATE CANCERS;

CELLS;

DISEASES;

5 ETHYL 2 HYDROXY 4 [6 METHYL 6 (1H TETRAZOL 5 YL)HEPTYLOXY]ACETOPHENONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUKOTRIENE B4 RECEPTOR; LEUKOTRIENE B4 RECEPTOR 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

ANOIKIS; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ANOKIS RESISTANCE; APOPTOSIS; CANCER; CANCER BIOLOGY; NADPH OXIDASE; PROSTATE CANCER;

ANOIKIS; CELL LINE, TUMOR; HUMANS; LEUKOTRIENE ANTAGONISTS; MALE; NADPH OXIDASE; NEOPLASM PROTEINS; NF-KAPPA B; PROSTATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; RECEPTORS, LEUKOTRIENE B4; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TETRAZOLES;

EID: 84886875955     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.481283     Document Type: Article

References (49)

1. Jemal, A., Siegel, R., Xu, J., and Ward, E. (2010) Cancer statistics, 2010. CA Cancer J. Clin. 60, 277-300
2. Rennebeck, G., Martelli, M., and Kyprianou, N. (2005) Anoikis and survival connections in the tumor microenvironment: is there a role in prostate cancer metastasis? Cancer Res. 65, 11230-11235
3. Sakamoto, S., and Kyprianou, N. (2010) Targeting anoikis resistance in prostate cancer metastasis. Mol. Aspects Med. 31, 205-214
4. Rungtabnapa, P., Nimmannit, U., Halim, H., Rojanasakul, Y., and Chanvorachote, P. (2011) Hydrogen peroxide inhibits non-small cell lung cancer cell anoikis through the inhibition of caveolin-1 degradation. Am. J. Physiol. Cell Physiol. 300, C235-245
5. Kumar, S., Park, S. H., Cieply, B., Schupp, J., Killiam, E., Zhang, F., Rimm, D. L., and Frisch, S. M. (2011) A pathway for the control of anoikis sensitivity by E-cadherin and epithelial-to-mesenchymal transition. Mol. Cell. Biol. 31, 4036-4051
6. Chiarugi, P., and Giannoni, E. (2008) Anoikis: a necessary death program for anchorage-dependent cells. Biochem. Pharmacol. 76, 1352-1364
7. Neiva, K. G., Zhang, Z., Miyazawa, M., Warner, K. A., Karl, E., and Nör, J. E. (2009) Cross talk initiated by endothelial cells enhances migration and inhibits anoikis of squamous cell carcinoma cells through STAT3/Akt/ ERK signaling. Neoplasia 11, 583-593
8. Greene, E. R., Huang, S., Serhan, C. N., and Panigrahy, D. (2011) Regulation of inflammation in cancer by eicosanoids. Prostaglandins Other Lipid Mediat. 96, 27-36
9. Chell, S. D., Witherden, I. R., Dobson, R. R., Moorghen, M., Herman, A. A., Qualtrough, D., Williams, A. C., and Paraskeva, C. (2006) Increased EP4 receptor expression in colorectal cancer progression promotes cell growth and anchorage independence. Cancer Res. 66, 3106-3113
10. Giannoni, E., Fiaschi, T., Ramponi, G., and Chiarugi, P. (2009) Redox regulation of anoikis resistance of metastatic prostate cancer cells: key role for Src and EGFR-mediated pro-survival signals. Oncogene 28, 2074 -2086
11. Nie, D., Che, M., Grignon, D., Tang, K., and Honn, K. V. (2001) Role of eicosanoids in prostate cancer progression. Cancer Metastasis Rev. 20, 195-206
12. Schneider, C., and Pozzi, A. (2011) Cyclooxygenases and lipoxygenases in cancer. Cancer Metastasis Rev. 30, 277-294
13. Larré, S., Tran, N., Fan, C., Hamadeh, H., Champigneulles, J., Azzouzi, R., Cussenot, O., Mangin, P., and Olivier, J. L. (2008) PGE2 and LTB4 tissue levels in benign and cancerous prostates. Prostaglandins Other Lipid Mediat. 87, 14-19
14. Nie, D., Nemeth, J., Qiao, Y., Zacharek, A., Li, L., Hanna, K., Tang, K., Hillman, G. G., Cher, M. L., Grignon, D. J., and Honn, K. V. (2003) Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase. Clin. Exp. Metastasis 20, 657-663
15. Pidgeon, G. P., Kandouz, M., Meram, A., and Honn, K. V. (2002) Mechanisms controlling cell cycle arrest and induction of apoptosis after 12- lipoxygenase inhibition in prostate cancer cells. Cancer Res. 62, 2721-2727
16. Tager, A. M., and Luster, A. D. (2003) BLT1 and BLT2: the leukotriene B4 receptors. Prostaglandins Leukot. Essent. Fatty Acids 69, 123-134
17. Rocconi, R. P., Kirby, T. O., Seitz, R. S., Beck, R., Straughn, J. M., Jr., Alvarez, R. D., and Huh, W. K. (2008) Lipoxygenase pathway receptor expression in ovarian cancer. Reprod. Sci. 15, 321-326
18. Hennig, R., Osman, T., Esposito, I., Giese, N., Rao, S. M., Ding, X. Z., Tong, W. G., Büchler, M. W., Yokomizo, T., Friess, H., and Adrian, T. E. (2008) BLT2 is expressed in PanINs, IPMNs, pancreatic cancer and stimulates tumour cell proliferation. Br. J. Cancer 99, 1064-1073
19. Yoo, M. H., Song, H., Woo, C. H., Kim, H., and Kim, J. H. (2004) Role of the BLT2, a leukotriene B4 receptor, in Ras transformation. Oncogene 23, 9259-9268
20. Kim, E. Y., Seo, J. M., Kim, C., Lee, J. E., Lee, K. M., and Kim, J. H. (2010) BLT2 promotes the invasion and metastasis of aggressive bladder cancer cells through a reactive oxygen species-linked pathway. Free Radic. Biol. Med. 49, 1072-1081
21. Kim, G. Y., Lee, J. W., Ryu, H. C., Wei, J. D., Seong, C. M., and Kim, J. H. (2010) Proinflammatory cytokine IL-1 stimulates IL-8 synthesis in mast cells via a leukotriene B4 receptor 2-linked pathway, contributing to angiogenesis. J. Immunol. 184, 3946-3954
22. Seo, J. M., Park, S., and Kim, J. H. (2012) Leukotriene B4 receptor-2 promotes invasiveness and metastasis of ovarian cancer cells through signal transducer and activator of transcription 3 (STAT3)-dependent up-regulation of matrix metalloproteinase. J. Biol. Chem. 287, 13840-13849
23. Lee, S. K., Na, S. Y., Jung, S. Y., Choi, J. E., Jhun, B. H., Cheong, J., Meltzer, P. S., Lee, Y. C., and Lee, J. W. (2000) Activating protein-1, nuclear factor- B, and serum response factor as novel target molecules of the canceramplified transcription coactivator ASC-2. Mol. Endocrinol. 14, 915-925
24. Chamulitrat, W., Schmidt, R., Tomakidi, P., Stremmel, W., Chunglok, W., Kawahara, T., and Rokutan, K. (2003) Association of gp91phox homolog Nox1 with anchorage-independent growth and MAP kinase-activation of transformed human keratinocytes. Oncogene 22, 6045-6053
25. Woo, C. H., Kim, T. H., Choi, J. A., Ryu, H. C., Lee, J. E., You, H. J., Bae, Y. S., and Kim, J. H. (2006) Inhibition of receptor internalization attenuates the TNF-induced ROS generation in non-phagocytic cells. Biochem. Biophys. Res. Commun. 351, 972-978
26. Park, H. S., Lee, S. H., Park, D., Lee, J. S., Ryu, S. H., Lee, W. J., Rhee, S. G., and Bae, Y. S. (2004) Sequential activation of phosphatidylinositol 3-kinase, βPix, Rac1, and Nox1 in growth factor-induced production of H2O2. Mol. Cell. Biol. 24, 4384-4394
27. Bae, Y. S., Lee, J. H., Choi, S. H., Kim, S., Almazan, F., Witztum, J. L., and Miller, Y. I. (2009) Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circ. Res. 104, 210-218
28. Lee, J. W., Kim, G. Y., and Kim, J. H. (2012) Androgen receptor is upregulated by a BLT2-linked pathway to contribute to prostate cancer progression. Biochem. Biophys. Res. Commun. 420, 428-433
29. Choi, J. A., Kim, E. Y., Song, H., Kim, C., and Kim, J. H. (2008) Reactive oxygen species are generated through a BLT2-linked cascade in Ras-transformed cells. Free Radic. Biol. Med. 44, 624-634
30. Choi, J. A., Lee, J. W., Kim, H., Kim, E. Y., Seo, J. M., Ko, J., and Kim, J. H. (2010) Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway. Carcinogenesis 31, 543-551
31. Cho, K. J., Seo, J. M., Lee, M. G., and Kim, J. H. (2010) BLT2 Is up-regulated in allergen-stimulated mast cells and mediates the synthesis of Th2 cytokines. J. Immunol. 185, 6329-6337
32. Ryu, H. C., Kim, C., Kim, J. Y., Chung, J. H., and Kim, J. H. (2010) UVB radiation induces apoptosis in keratinocytes by activating a pathway linked to "BLT2-reactive oxygen species." J. Invest. Dermatol. 130, 1095-1106
33. Cho, K. J., Seo, J. M., and Kim, J. H. (2011) Bioactive lipoxygenase metabolites stimulation of NADPH oxidases and reactive oxygen species. Mol. Cells 32, 1-5
34. Toruner, M., Fernandez-Zapico, M., Sha, J. J., Pham, L., Urrutia, R., and Egan, L. J. (2006) Antianoikis effect of nuclear factor-B through up-regulated expression of osteoprotegerin, BCL-2, and IAP-1. J. Biol. Chem. 281, 8686-8696
35. Yan, S. R., Joseph, R. R., Rosen, K., Reginato, M. J., Jackson, A., Allaire, N., Brugge, J. S., Jobin, C., and Stadnyk, A. W. (2005) Activation of NF-B following detachment delays apoptosis in intestinal epithelial cells. Oncogene 24, 6482-6491
36. Yokomizo, T., Kato, K., Terawaki, K., Izumi, T., and Shimizu, T. (2000) A second leukotriene B4 receptor, BLT2: a new therapeutic target in inflammation and immunological disorders. J. Exp. Med. 192, 421-432
37. Kim, G. Y., Lee, J. W., Cho, S. H., Seo, J. M., and Kim, J. H. (2009) Role of the low-affinity leukotriene B4 receptor BLT2 in VEGF-induced angiogenesis. Arterioscler. Thromb. Vasc. Biol. 29, 915-920
38. Kim, H., Choi, J. A., Park, G. S., and Kim, J. H. (2012) BLT2 up-Regulates Interleukin-8 production and promotes the invasiveness of breast cancer cells. PLoS One 7, e49186
39. Ghosh, J. (2003) Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase. Biochem. Biophys. Res. Commun. 307, 342-349
40. McCabe, N. P., Selman, S. H., and Jankun, J. (2006) Vascular endothelial growth factor production in human prostate cancer cells is stimulated by overexpression of platelet 12-lipoxygenase. Prostate 66, 779-787
41. Krishnamoorthy, S., and Honn, K. V. (2011) Eicosanoids and other lipid mediators and the tumor hypoxic microenvironment. Cancer Metastasis Rev. 30, 613-618
42. Oyoshi, M. K., He, R., Li, Y., Mondal, S., Yoon, J., Afshar, R., Chen, M., Lee, D. M., Luo, H. R., Luster, A. D., Cho, J. S., Miller, L. S., Larson, A., Murphy, G. F., and Geha, R. S. (2012) Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity 37, 747-758
43. Zhu, P., Tan, M. J., Huang, R. L., Tan, C. K., Chong, H. C., Pal, M., Lam, C. R., Boukamp, P., Pan, J. Y., Tan, S. H., Kersten, S., Li, H. Y., Ding, J. L., and Tan, N. S. (2011) Angiopoietin-like 4 protein elevates the prosurvival intracellular O2 :H2O2 ratio and confers anoikis resistance to tumors. Cancer Cell 19, 401-415
44. Terada, L. S., and Nwariaku, F. E. (2011) Escaping anoikis through ROS: ANGPTL4 controls integrin signaling through Nox1. Cancer Cell 19, 297-299
45. Giannoni, E., Buricchi, F., Grimaldi, G., Parri, M., Cialdai, F., Taddei, M. L., Raugei, G., Ramponi, G., and Chiarugi, P. (2008) Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival. Cell Death Differ. 15, 867-878
46. Kim, S. H., Park, Y. Y., Kim, S. W., Lee, J. S., Wang, D., and DuBois, R. N. (2011) ANGPTL4 induction by prostaglandin E2 under hypoxic conditions promotes colorectal cancer progression. Cancer Res. 71, 7010-7020
47. Morgan, M. J., and Liu, Z. G. (2011) Cross-talk of reactive oxygen species and NF-kB signaling. Cell Res. 21, 103-115
48. Desgrosellier, J. S., Barnes, L. A., Shields, D. J., Huang, M., Lau, S. K., Prévost, N., Tarin, D., Shattil, S. J., and Cheresh, D. A. (2009) An integrin αvβ3-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nat. Med. 15, 1163-1169
49. Pidgeon, G. P., Tang, K., Cai, Y. L., Piasentin, E., and Honn, K. V. (2003) Overexpression of platelet-type 12-lipoxygenase promotes tumor cell survival by enhancing v3 and v5 integrin expression. Cancer Res. 63, 4258-4267