The transcription factor GLI2 as a downstream mediator of transforming growth factor-β-induced fibroblast activation in SSc

Annals of the Rheumatic Diseases

Volumn 76, Issue 4, 2017, Pages 756-764

  Liang, Ruifang ^a   Šumová, Barbora ^a,b   Cordazzo, Cinzia ^a,c   Mallano, Tatjana ^a   Zhang, Yun ^a   Wohlfahrt, Thomas ^a   Dees, Clara ^a   Ramming, Andreas ^a   Krasowska, Dorota ^d   Michalska Jakubus, Mal Gorzata ^d   Distler, Oliver ^e   Schett, Georg ^a   Šenolt, Ladislav ^b   Distler, Jörg H W ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b CHARLES UNIVERSITY   (Czech Republic)

^c UNIVERSITY OF PISA   (Italy)

^d Medical University of Lublin   (United States)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Fibroblasts; Systemic Sclerosis; Treatment

Indexed keywords

CRE RECOMBINASE; DNA; GANT 61; PROTEIN INHIBITOR; SMAD3 PROTEIN; SMOOTHENED PROTEIN; TRANSCRIPTION FACTOR GLI2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG; VISMODEGIB; ALPHA 2(I) COLLAGEN; ANILIDE; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; KRUPPEL LIKE FACTOR; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN SERINE THREONINE KINASE; PTERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; RECOMBINANT PROTEIN; SD-208; SONIC HEDGEHOG PROTEIN; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFIBROTIC EFFECT; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DNA BINDING; DOWNSTREAM PROCESSING; DRUG ACTIVITY; DRUG TARGETING; FEMALE; FIBROBLAST CULTURE; HUMAN; LUNG FIBROSIS; MALE; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; SKIN FIBROSIS; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMICALLY INDUCED; DRUG EFFECTS; FIBROBLAST; FIBROSIS; GENE INACTIVATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MIDDLE AGED; PATHOLOGY; SKIN; SYSTEMIC SCLEROSIS; TRANSGENIC MOUSE; YOUNG ADULT;

ADULT; AGED; ANILIDES; ANIMALS; CELLS, CULTURED; COLLAGEN TYPE I; CONNECTIVE TISSUE GROWTH FACTOR; FEMALE; FIBROBLASTS; FIBROSIS; GENE KNOCKOUT TECHNIQUES; HEDGEHOG PROTEINS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MIDDLE AGED; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN-SERINE-THREONINE KINASES; PTERIDINES; PULMONARY FIBROSIS; PYRIDINES; PYRIMIDINES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT PROTEINS; RNA, MESSENGER; SCLERODERMA, SYSTEMIC; SIGNAL TRANSDUCTION; SKIN; SMAD3 PROTEIN; SMOOTHENED RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; YOUNG ADULT;

EID: 84994805525     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2016-209698     Document Type: Article

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