-
1
-
-
77956506654
-
Thrombin down-regulates the TGF-β-mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the EPCR-dependent activation of PAR-1
-
Bae J-S, Kim I-S, Rezaie AR. Thrombin down-regulates the TGF-β-mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the EPCR-dependent activation of PAR-1. J Cell Physiol 2010; 225: 233–9.
-
(2010)
J Cell Physiol
, vol.225
, pp. 233-239
-
-
Bae, J.-S.1
Kim, I.-S.2
Rezaie, A.R.3
-
3
-
-
0033613183
-
How the protease thrombin talks to cells
-
Coughlin SR. How the protease thrombin talks to cells. Proc Natl Acad Sci USA 1999; 96: 11023–7.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 11023-11027
-
-
Coughlin, S.R.1
-
4
-
-
66249144426
-
The structure and function of G-protein-coupled receptors
-
Rosenbaum DM, Rasmussen SGF, Kobilka BK. The structure and function of G-protein-coupled receptors. Nature 2009; 459: 356–63.
-
(2009)
Nature
, vol.459
, pp. 356-363
-
-
Rosenbaum, D.M.1
Rasmussen, S.G.F.2
Kobilka, B.K.3
-
5
-
-
84858164791
-
Action of molecular switches in GPCRs – theoretical and experimental studies
-
Trzaskowski B, Latek D, Yuan S, Ghoshdastider U, Debinski A, Filipek S. Action of molecular switches in GPCRs – theoretical and experimental studies. CMC 2012; 19: 1090–109.
-
(2012)
CMC
, vol.19
, pp. 1090-1109
-
-
Trzaskowski, B.1
Latek, D.2
Yuan, S.3
Ghoshdastider, U.4
Debinski, A.5
Filipek, S.6
-
6
-
-
84939522532
-
Universal allosteric mechanism for Gα activation by GPCRs
-
Flock T, Ravarani CNJ, Sun D, Venkatakrishnan AJ, Kayikci M, Tate CG, Veprintsev DB, Babu MM. Universal allosteric mechanism for Gα activation by GPCRs. Nature 2015; 524: 173–9.
-
(2015)
Nature
, vol.524
, pp. 173-179
-
-
Flock, T.1
Ravarani, C.N.J.2
Sun, D.3
Venkatakrishnan, A.J.4
Kayikci, M.5
Tate, C.G.6
Veprintsev, D.B.7
Babu, M.M.8
-
7
-
-
1642279517
-
Protease-activated receptors: contribution to physiology and disease
-
Ossovskaya VS, Bunnett NW. Protease-activated receptors: contribution to physiology and disease. Physiol Rev 2004; 84: 579–621.
-
(2004)
Physiol Rev
, vol.84
, pp. 579-621
-
-
Ossovskaya, V.S.1
Bunnett, N.W.2
-
8
-
-
0034624973
-
Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
-
Camerer E, Huang W, Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci USA 2000; 97: 5255–60.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 5255-5260
-
-
Camerer, E.1
Huang, W.2
Coughlin, S.R.3
-
9
-
-
84887338267
-
Proteinase-activated receptors (PARs) – focus on receptor–receptor-interactions and their physiological and pathophysiological impact
-
Gieseler F, Ungefroren H, Settmacher U, Hollenberg MD, Kaufmann R. Proteinase-activated receptors (PARs) – focus on receptor–receptor-interactions and their physiological and pathophysiological impact. Cell Commun Signal 2013; 11: 86–112.
-
(2013)
Cell Commun Signal
, vol.11
, pp. 86-112
-
-
Gieseler, F.1
Ungefroren, H.2
Settmacher, U.3
Hollenberg, M.D.4
Kaufmann, R.5
-
10
-
-
84897483186
-
Quantitative phosphoproteomics unveils temporal dynamics of thrombin signaling in human endothelial cells
-
van den Biggelaar M, Hernández-Fernaud JR, van den Eshof BL, Neilson LJ, Meijer AB, Mertens K, Zanivan S. Quantitative phosphoproteomics unveils temporal dynamics of thrombin signaling in human endothelial cells. Blood 2014; 123: e22–36.
-
(2014)
Blood
, vol.123
, pp. e22-36
-
-
van den Biggelaar, M.1
Hernández-Fernaud, J.R.2
van den Eshof, B.L.3
Neilson, L.J.4
Meijer, A.B.5
Mertens, K.6
Zanivan, S.7
-
11
-
-
0034648757
-
Thrombin signalling and protease-activated receptors
-
Coughlin SR. Thrombin signalling and protease-activated receptors. Nature 2000; 407: 258–64.
-
(2000)
Nature
, vol.407
, pp. 258-264
-
-
Coughlin, S.R.1
-
12
-
-
84856225536
-
Rap1–Rac1 circuits potentiate platelet activation
-
Stefanini L, Boulaftali Y, Ouellette TD, Holinstat M, Desire L, Leblond B, Andre P, Conley PB, Bergmeier W. Rap1–Rac1 circuits potentiate platelet activation. Arterioscler Thromb Vasc Biol 2012; 32: 434–41.
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 434-441
-
-
Stefanini, L.1
Boulaftali, Y.2
Ouellette, T.D.3
Holinstat, M.4
Desire, L.5
Leblond, B.6
Andre, P.7
Conley, P.B.8
Bergmeier, W.9
-
13
-
-
0029090212
-
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
-
Stoyanov B, Volinia S, Hanck T, Rubio I, Loubtchenkov M, Malek D, Stoyanova S, Vanhaesebroeck B, Dhand R, Nürnberg B. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science 1995; 269: 690–3.
-
(1995)
Science
, vol.269
, pp. 690-693
-
-
Stoyanov, B.1
Volinia, S.2
Hanck, T.3
Rubio, I.4
Loubtchenkov, M.5
Malek, D.6
Stoyanova, S.7
Vanhaesebroeck, B.8
Dhand, R.9
Nürnberg, B.10
-
14
-
-
0032795986
-
Modulation of osteoblast-like cell behavior by activation of protease-activated receptor-1
-
Abraham LA, Macfarlane SR, Seatter MJ, Mackie EJ, Kanke T, Hunter GD, Plevin R. Modulation of osteoblast-like cell behavior by activation of protease-activated receptor-1. J Bone Miner Res 1999; 14: 1320–9.
-
(1999)
J Bone Miner Res
, vol.14
, pp. 1320-1329
-
-
Abraham, L.A.1
Macfarlane, S.R.2
Seatter, M.J.3
Mackie, E.J.4
Kanke, T.5
Hunter, G.D.6
Plevin, R.7
-
15
-
-
0033593667
-
Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets
-
Klages B, Brandt U, Simon MI, Schultz G, Offermanns S. Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol 1999; 144: 745–54.
-
(1999)
J Cell Biol
, vol.144
, pp. 745-754
-
-
Klages, B.1
Brandt, U.2
Simon, M.I.3
Schultz, G.4
Offermanns, S.5
-
16
-
-
84905447408
-
Biased signaling of protease-activated receptors
-
Zhao P, Metcalf M, Bunnett NW. Biased signaling of protease-activated receptors. Front Endocrinol 2014; 5: 943–59.
-
(2014)
Front Endocrinol
, vol.5
, pp. 943-959
-
-
Zhao, P.1
Metcalf, M.2
Bunnett, N.W.3
-
17
-
-
0031015426
-
Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency
-
Offermanns S, Mancino V, Revel JP, Simon MI. Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency. Science 1997; 275: 533–6.
-
(1997)
Science
, vol.275
, pp. 533-536
-
-
Offermanns, S.1
Mancino, V.2
Revel, J.P.3
Simon, M.I.4
-
18
-
-
16944366731
-
Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities
-
Donovan FM, Pike CJ, Cotman CW, Cunningham DD. Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci 1997; 17: 5316–26.
-
(1997)
J Neurosci
, vol.17
, pp. 5316-5326
-
-
Donovan, F.M.1
Pike, C.J.2
Cotman, C.W.3
Cunningham, D.D.4
-
19
-
-
84904998392
-
Functional role of protease activated receptors in vascular biology
-
Alberelli MA, De Candia E. Functional role of protease activated receptors in vascular biology. Vascul Pharmacol 2014; 62: 72–81.
-
(2014)
Vascul Pharmacol
, vol.62
, pp. 72-81
-
-
Alberelli, M.A.1
De Candia, E.2
-
20
-
-
57649115436
-
Protease-activated receptor 4 uses anionic residues to interact with α-thrombin in the absence or presence of protease-activated receptor 1
-
Nieman MT. Protease-activated receptor 4 uses anionic residues to interact with α-thrombin in the absence or presence of protease-activated receptor 1. Biochemistry 2008; 47: 13279–86.
-
(2008)
Biochemistry
, vol.47
, pp. 13279-13286
-
-
Nieman, M.T.1
-
21
-
-
84887491969
-
Protease-activated receptor 1 (PAR1) and PAR4 heterodimers are required for PAR1-enhanced cleavage of PAR4 by thrombin
-
Arachiche A, Mumaw MM, la Fuente de M, Nieman MT. Protease-activated receptor 1 (PAR1) and PAR4 heterodimers are required for PAR1-enhanced cleavage of PAR4 by thrombin. J Biol Chem 2013; 288: 32553–62.
-
(2013)
J Biol Chem
, vol.288
, pp. 32553-32562
-
-
Arachiche, A.1
Mumaw, M.M.2
la Fuente de, M.3
Nieman, M.T.4
-
22
-
-
84888178878
-
Cofactoring and dimerization of proteinase-activated receptors
-
Lin H, Liu AP, Smith TH, Trejo J. Cofactoring and dimerization of proteinase-activated receptors. Pharmacol Rev 2013; 65: 1198–213.
-
(2013)
Pharmacol Rev
, vol.65
, pp. 1198-1213
-
-
Lin, H.1
Liu, A.P.2
Smith, T.H.3
Trejo, J.4
-
23
-
-
84888645407
-
Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond
-
Danckwardt S, Hentze MW, Kulozik AE. Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond. J Mol Med 2013; 91: 1257–71.
-
(2013)
J Mol Med
, vol.91
, pp. 1257-1271
-
-
Danckwardt, S.1
Hentze, M.W.2
Kulozik, A.E.3
-
25
-
-
0026504693
-
Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor
-
Hung DT, Vu TH, Nelken NA, Coughlin SR. Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor. J Cell Biol 1992; 116: 827–32.
-
(1992)
J Cell Biol
, vol.116
, pp. 827-832
-
-
Hung, D.T.1
Vu, T.H.2
Nelken, N.A.3
Coughlin, S.R.4
-
26
-
-
17044427680
-
Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation
-
Feistritzer C, Riewald M. Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood 2005; 105: 3178–84.
-
(2005)
Blood
, vol.105
, pp. 3178-3184
-
-
Feistritzer, C.1
Riewald, M.2
-
27
-
-
33847329718
-
Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells
-
Bae JS, Yang L, Rezaie AR. Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells. Proc Natl Acad Sci USA 2007; 104: 2867–72.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 2867-2872
-
-
Bae, J.S.1
Yang, L.2
Rezaie, A.R.3
-
28
-
-
64549153208
-
Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 Kinase
-
Bae J-S, Vaughan PJ, Kim Y-U, Pike CJ, Cotman CW, Park M-K, Rezaie AR, Cunningham DD. Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 Kinase. J Cell Physiol 2009; 219: 744–51.
-
(2009)
J Cell Physiol
, vol.219
, pp. 744-751
-
-
Bae, J.-S.1
Vaughan, P.J.2
Kim, Y.-U.3
Pike, C.J.4
Cotman, C.W.5
Park, M.-K.6
Rezaie, A.R.7
Cunningham, D.D.8
-
29
-
-
0032557654
-
Signaling pathways involved in thrombin-induced cell protection
-
Donovan FM, Cunningham DD. Signaling pathways involved in thrombin-induced cell protection. J Biol Chem 1998; 273: 12746–52.
-
(1998)
J Biol Chem
, vol.273
, pp. 12746-12752
-
-
Donovan, F.M.1
Cunningham, D.D.2
-
30
-
-
34248374907
-
Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization
-
McLaughlin JN, Patterson MM, Malik AB. Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization. Proc Natl Acad Sci USA 2007; 104: 5662–7.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 5662-5667
-
-
McLaughlin, J.N.1
Patterson, M.M.2
Malik, A.B.3
-
31
-
-
33748495552
-
Protease-activated receptors in cardiovascular diseases
-
Leger AJ, Covic L, Kuliopulos A. Protease-activated receptors in cardiovascular diseases. Circulation 2006; 114: 1070–7.
-
(2006)
Circulation
, vol.114
, pp. 1070-1077
-
-
Leger, A.J.1
Covic, L.2
Kuliopulos, A.3
-
32
-
-
13444249470
-
Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response
-
Steinhoff M, Buddenkotte J, Shpacovitch V, Rattenholl A, Moormann C, Vergnolle N, Luger TA, Hollenberg MD. Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev 2005; 26: 1–43.
-
(2005)
Endocr Rev
, vol.26
, pp. 1-43
-
-
Steinhoff, M.1
Buddenkotte, J.2
Shpacovitch, V.3
Rattenholl, A.4
Moormann, C.5
Vergnolle, N.6
Luger, T.A.7
Hollenberg, M.D.8
-
34
-
-
84862908085
-
Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes
-
Madhusudhan T, Wang H, Straub BK, Gröne E, Zhou Q, Shahzad K, Müller-Krebs S, Schwenger V, Gerlitz B, Grinnell BW. Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes. Blood 2012; 119: 874–83.
-
(2012)
Blood
, vol.119
, pp. 874-883
-
-
Madhusudhan, T.1
Wang, H.2
Straub, B.K.3
Gröne, E.4
Zhou, Q.5
Shahzad, K.6
Müller-Krebs, S.7
Schwenger, V.8
Gerlitz, B.9
Grinnell, B.W.10
-
35
-
-
84913570652
-
Thrombin receptor protease-activated receptor 4 is a key regulator of exaggerated intimal thickening in diabetes mellitus
-
Pavic G, Grandoch M, Dangwal S, Jobi K, Rauch BH, Doller A, Oberhuber A, Akhyari P, Schrör K, Fischer JW. Thrombin receptor protease-activated receptor 4 is a key regulator of exaggerated intimal thickening in diabetes mellitus. Circulation 2014; 130: 1700–11.
-
(2014)
Circulation
, vol.130
, pp. 1700-1711
-
-
Pavic, G.1
Grandoch, M.2
Dangwal, S.3
Jobi, K.4
Rauch, B.H.5
Doller, A.6
Oberhuber, A.7
Akhyari, P.8
Schrör, K.9
Fischer, J.W.10
-
36
-
-
84929493532
-
Increased expression of protease-activated receptor 4 and trefoil factor 2 in human colorectal cancer
-
Yu G, Jiang P, Xiang Y, Zhang Y, Zhu Z, Zhang C, Lee S, Lee W, Zhang Y. Increased expression of protease-activated receptor 4 and trefoil factor 2 in human colorectal cancer. PLoS ONE 2015; 10: e0122678.
-
(2015)
PLoS ONE
, vol.10
-
-
Yu, G.1
Jiang, P.2
Xiang, Y.3
Zhang, Y.4
Zhu, Z.5
Zhang, C.6
Lee, S.7
Lee, W.8
Zhang, Y.9
-
37
-
-
84919964433
-
Blockade of proteinase-activated receptor 4 inhibits neutrophil recruitment in experimental inflammation in mice
-
Gomides LF, Lima OCO, Matos NA, Freitas KM, Francischi JN, Tavares JC, Klein A. Blockade of proteinase-activated receptor 4 inhibits neutrophil recruitment in experimental inflammation in mice. Inflamm Res 2014; 63: 935–41.
-
(2014)
Inflamm Res
, vol.63
, pp. 935-941
-
-
Gomides, L.F.1
Lima, O.C.O.2
Matos, N.A.3
Freitas, K.M.4
Francischi, J.N.5
Tavares, J.C.6
Klein, A.7
-
38
-
-
0034608013
-
Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1
-
O'Brien PJ, Prevost N, Molino M, Hollinger MK, Woolkalis MJ, Woulfe DS, Brass LF. Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1. J Biol Chem 2000; 275: 13502–9.
-
(2000)
J Biol Chem
, vol.275
, pp. 13502-13509
-
-
O'Brien, P.J.1
Prevost, N.2
Molino, M.3
Hollinger, M.K.4
Woolkalis, M.J.5
Woulfe, D.S.6
Brass, L.F.7
-
39
-
-
0029952336
-
Ligand cross-reactivity within the protease-activated receptor family
-
Blackhart BD, Emilsson K, Nguyen D, Teng W, Martelli AJ, Nystedt S, Sundelin J, Scarborough RM. Ligand cross-reactivity within the protease-activated receptor family. J Biol Chem 1996; 271: 16466–71.
-
(1996)
J Biol Chem
, vol.271
, pp. 16466-16471
-
-
Blackhart, B.D.1
Emilsson, K.2
Nguyen, D.3
Teng, W.4
Martelli, A.J.5
Nystedt, S.6
Sundelin, J.7
Scarborough, R.M.8
-
40
-
-
36249020418
-
‘Role reversal’ for the receptor PAR1 in sepsis-induced vascular damage
-
Kaneider NC, Leger AJ, Agarwal A, Nguyen N, Perides G, Derian C, Covic L, Kuliopulos A. ‘Role reversal’ for the receptor PAR1 in sepsis-induced vascular damage. Nat Immunol 2007; 8: 1303–12.
-
(2007)
Nat Immunol
, vol.8
, pp. 1303-1312
-
-
Kaneider, N.C.1
Leger, A.J.2
Agarwal, A.3
Nguyen, N.4
Perides, G.5
Derian, C.6
Covic, L.7
Kuliopulos, A.8
-
41
-
-
27744589182
-
A role for proteinase-activated receptor 2 and PKC in thrombin-mediated induction of decay-accelerating factor on human endothelial cells
-
Lidington EA, Steinberg R, Kinderlerer AR, Landis RC, Ohba M, Samarel A, Haskard DO, Mason JC. A role for proteinase-activated receptor 2 and PKC in thrombin-mediated induction of decay-accelerating factor on human endothelial cells. Am J Physiol Cell Physiol 2005; 289: C1437–47.
-
(2005)
Am J Physiol Cell Physiol
, vol.289
, pp. C1437-C1447
-
-
Lidington, E.A.1
Steinberg, R.2
Kinderlerer, A.R.3
Landis, R.C.4
Ohba, M.5
Samarel, A.6
Haskard, D.O.7
Mason, J.C.8
-
42
-
-
81755184108
-
Protease-activated receptor-2 modulates protease-activated receptor-1-driven neointimal hyperplasia
-
Sevigny LM, Austin KM, Zhang P, Kasuda S, Koukos G, Sharifi S, Covic L, Kuliopulos A. Protease-activated receptor-2 modulates protease-activated receptor-1-driven neointimal hyperplasia. Arterioscler Thromb Vasc Biol 2011; 31: e100–6.
-
(2011)
Arterioscler Thromb Vasc Biol
, vol.31
, pp. e100-e106
-
-
Sevigny, L.M.1
Austin, K.M.2
Zhang, P.3
Kasuda, S.4
Koukos, G.5
Sharifi, S.6
Covic, L.7
Kuliopulos, A.8
-
43
-
-
38449083544
-
Dual regulation of endothelial junctional permeability
-
Komarova YA, Mehta D, Malik AB. Dual regulation of endothelial junctional permeability. Sci STKE; 2007; 2007: re8.
-
(2007)
Sci STKE
, vol.2007
, pp. re8
-
-
Komarova, Y.A.1
Mehta, D.2
Malik, A.B.3
-
44
-
-
1642368761
-
Termination of protease-activated receptor-1 signaling by arrestins is independent of receptor phosphorylation
-
Chen CH, Paing MM, Trejo J. Termination of protease-activated receptor-1 signaling by arrestins is independent of receptor phosphorylation. J Biol Chem 2004; 279: 10020–31.
-
(2004)
J Biol Chem
, vol.279
, pp. 10020-10031
-
-
Chen, C.H.1
Paing, M.M.2
Trejo, J.3
-
45
-
-
0037059795
-
Arrestins regulate protease-activated receptor-1 desensitization but not internalization or down-regulation
-
Paing MM, Stutts AB, Kohout TA, Lefkowitz RJ, Trejo J. Arrestins regulate protease-activated receptor-1 desensitization but not internalization or down-regulation. J Biol Chem 2002; 277: 1292–300.
-
(2002)
J Biol Chem
, vol.277
, pp. 1292-1300
-
-
Paing, M.M.1
Stutts, A.B.2
Kohout, T.A.3
Lefkowitz, R.J.4
Trejo, J.5
-
46
-
-
11244328357
-
Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking
-
Stalheim L, Ding Y, Gullapalli A, Paing MM, Wolfe BL, Morris DR, Trejo J. Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking. Mol Pharmacol 2005; 67: 78–87.
-
(2005)
Mol Pharmacol
, vol.67
, pp. 78-87
-
-
Stalheim, L.1
Ding, Y.2
Gullapalli, A.3
Paing, M.M.4
Wolfe, B.L.5
Morris, D.R.6
Trejo, J.7
-
47
-
-
0034689003
-
Beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2
-
DeFea KA, Zalevsky J, Thoma MS, Déry O, Mullins RD, Bunnett NW. Beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol 2000; 148: 1267–81.
-
(2000)
J Cell Biol
, vol.148
, pp. 1267-1281
-
-
DeFea, K.A.1
Zalevsky, J.2
Thoma, M.S.3
Déry, O.4
Mullins, R.D.5
Bunnett, N.W.6
-
48
-
-
84907059506
-
Endothelial cell protein C receptor: a multiliganded and multifunctional receptor
-
Mohan Rao LV, Esmon CT, Pendurthi UR. Endothelial cell protein C receptor: a multiliganded and multifunctional receptor. Blood 2014; 124: 1553–62.
-
(2014)
Blood
, vol.124
, pp. 1553-1562
-
-
Mohan Rao, L.V.1
Esmon, C.T.2
Pendurthi, U.R.3
-
49
-
-
37049012509
-
The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells
-
Bae JS, Yang L, Manithody C, Rezaie AR. The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells. Blood 2007; 110: 3909–16.
-
(2007)
Blood
, vol.110
, pp. 3909-3916
-
-
Bae, J.S.1
Yang, L.2
Manithody, C.3
Rezaie, A.R.4
-
50
-
-
84929377699
-
Activated protein C: biased for translation
-
Griffin JH, Zlokovic BV, Mosnier LO. Activated protein C: biased for translation. Blood 2015; 125: 2898–907.
-
(2015)
Blood
, vol.125
, pp. 2898-2907
-
-
Griffin, J.H.1
Zlokovic, B.V.2
Mosnier, L.O.3
-
51
-
-
33751189598
-
Melagatran reduces advanced atherosclerotic lesion size and may promote plaque stability in apolipoprotein E-deficient mice
-
Bea F, Kreuzer J, Preusch M, Schaab S, Isermann B, Rosenfeld ME, Katus H, Blessing E. Melagatran reduces advanced atherosclerotic lesion size and may promote plaque stability in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2006; 26: 2787–92.
-
(2006)
Arterioscler Thromb Vasc Biol
, vol.26
, pp. 2787-2792
-
-
Bea, F.1
Kreuzer, J.2
Preusch, M.3
Schaab, S.4
Isermann, B.5
Rosenfeld, M.E.6
Katus, H.7
Blessing, E.8
-
52
-
-
79959580714
-
The occupancy of endothelial protein C receptor by its ligand modulates the PAR-1 dependent signaling specificity of coagulation proteases
-
Rezaie AR. The occupancy of endothelial protein C receptor by its ligand modulates the PAR-1 dependent signaling specificity of coagulation proteases. IUBMB Life 2011; 63: 390–6.
-
(2011)
IUBMB Life
, vol.63
, pp. 390-396
-
-
Rezaie, A.R.1
-
53
-
-
77951684623
-
Signal transduction by protease-activated receptors
-
Soh UJK, Soh UJ, Dores MR, Chen B, Trejo J. Signal transduction by protease-activated receptors. Br J Pharmacol 2010; 160: 191–203.
-
(2010)
Br J Pharmacol
, vol.160
, pp. 191-203
-
-
Soh, U.J.K.1
Soh, U.J.2
Dores, M.R.3
Chen, B.4
Trejo, J.5
-
54
-
-
0037088585
-
β-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation
-
Tohgo A, Pierce KL, Choy EW, Lefkowitz RJ, Luttrell LM. β-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation. J Biol Chem 2002; 277: 9429–36.
-
(2002)
J Biol Chem
, vol.277
, pp. 9429-9436
-
-
Tohgo, A.1
Pierce, K.L.2
Choy, E.W.3
Lefkowitz, R.J.4
Luttrell, L.M.5
-
55
-
-
0037458614
-
The stability of the G protein-coupled receptor–β-arrestin interaction determines the mechanism and functional consequence of ERK activation
-
Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, Luttrell LM. The stability of the G protein-coupled receptor–β-arrestin interaction determines the mechanism and functional consequence of ERK activation. J Biol Chem 2003; 278: 6258–67.
-
(2003)
J Biol Chem
, vol.278
, pp. 6258-6267
-
-
Tohgo, A.1
Choy, E.W.2
Gesty-Palmer, D.3
Pierce, K.L.4
Laporte, S.5
Oakley, R.H.6
Caron, M.G.7
Lefkowitz, R.J.8
Luttrell, L.M.9
-
56
-
-
40349108549
-
β-Arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction
-
DeFea K. β-Arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction. Br J Pharmacol 2009; 153: S298–309.
-
(2009)
Br J Pharmacol
, vol.153
, pp. S298-309
-
-
DeFea, K.1
-
57
-
-
35748944113
-
Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation
-
Shenoy SK, Barak LS, Xiao K, Ahn S, Berthouze M, Shukla AK, Luttrell LM, Lefkowitz RJ. Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation. J Biol Chem 2007; 282: 29549–62.
-
(2007)
J Biol Chem
, vol.282
, pp. 29549-29562
-
-
Shenoy, S.K.1
Barak, L.S.2
Xiao, K.3
Ahn, S.4
Berthouze, M.5
Shukla, A.K.6
Luttrell, L.M.7
Lefkowitz, R.J.8
-
58
-
-
33645834348
-
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
-
Shenoy SK, Lefkowitz RJ. Angiotensin II-stimulated signaling through G proteins and beta-arrestin. Sci STKE 2005; 2005: cm14.
-
(2005)
Sci STKE
, vol.2005
, pp. cm14
-
-
Shenoy, S.K.1
Lefkowitz, R.J.2
-
59
-
-
2442714117
-
Distinct roles for Src tyrosine kinase in 2-adrenergic receptor signaling to MAPK and in receptor internalization
-
Huang J, Sun Y, Huang XY. Distinct roles for Src tyrosine kinase in 2-adrenergic receptor signaling to MAPK and in receptor internalization. J Biol Chem 2004; 279: 21637–42.
-
(2004)
J Biol Chem
, vol.279
, pp. 21637-21642
-
-
Huang, J.1
Sun, Y.2
Huang, X.Y.3
-
60
-
-
33846245114
-
Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR
-
Sun Y, Huang J, Xiang Y, Bastepe M, Jüppner H, Kobilka BK, Zhang JJ, Huang X-Y. Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. EMBO J 2006; 26: 53–64.
-
(2006)
EMBO J
, vol.26
, pp. 53-64
-
-
Sun, Y.1
Huang, J.2
Xiang, Y.3
Bastepe, M.4
Jüppner, H.5
Kobilka, B.K.6
Zhang, J.J.7
Huang, X.-Y.8
-
61
-
-
22744449073
-
An Akt/β-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
-
Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG. An Akt/β-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 2005; 122: 261–73.
-
(2005)
Cell
, vol.122
, pp. 261-273
-
-
Beaulieu, J.M.1
Sotnikova, T.D.2
Marion, S.3
Lefkowitz, R.J.4
Gainetdinov, R.R.5
Caron, M.G.6
-
62
-
-
33747149560
-
Protease-activated receptor-2 simultaneously directs β-arrestin-1-dependent inhibition and Gαq-dependent activation of phosphatidylinositol 3-kinase
-
Wang P, DeFea KA. Protease-activated receptor-2 simultaneously directs β-arrestin-1-dependent inhibition and Gαq-dependent activation of phosphatidylinositol 3-kinase. Biochemistry 2006; 45: 9374–85.
-
(2006)
Biochemistry
, vol.45
, pp. 9374-9385
-
-
Wang, P.1
DeFea, K.A.2
-
63
-
-
36749006304
-
Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110 alpha and beta by protease-activated receptor 2 and beta-arrestins
-
Wang P, Kumar P, Wang C, DeFea KA. Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110 alpha and beta by protease-activated receptor 2 and beta-arrestins. Biochem J 2007; 408: 221–30.
-
(2007)
Biochem J
, vol.408
, pp. 221-230
-
-
Wang, P.1
Kumar, P.2
Wang, C.3
DeFea, K.A.4
-
64
-
-
34547107639
-
Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2
-
Zoudilova M, Kumar P, Ge L, Wang P, Bokoch GM, DeFea KA. Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. J Biol Chem 2007; 282: 20634–46.
-
(2007)
J Biol Chem
, vol.282
, pp. 20634-20646
-
-
Zoudilova, M.1
Kumar, P.2
Ge, L.3
Wang, P.4
Bokoch, G.M.5
DeFea, K.A.6
-
65
-
-
84905658091
-
Biased and G protein-independent signaling of chemokine receptors
-
Steen A, Larsen O, Thiele S, Rosenkilde MM. Biased and G protein-independent signaling of chemokine receptors. Front Immunol 2014; 5: 277–90.
-
(2014)
Front Immunol
, vol.5
, pp. 277-290
-
-
Steen, A.1
Larsen, O.2
Thiele, S.3
Rosenkilde, M.M.4
-
67
-
-
0034074308
-
Colocalization of thrombin, PAI-1, and vitronectin in the atherosclerotic vessel wall a potential regulatory mechanism of thrombin activity by PAI-1/vitronectin complexes
-
Stoop AA, Lupu F, Pannekoek H. Colocalization of thrombin, PAI-1, and vitronectin in the atherosclerotic vessel wall a potential regulatory mechanism of thrombin activity by PAI-1/vitronectin complexes. Arterioscler Thromb Vasc Biol 2000; 20: 1143–9.
-
(2000)
Arterioscler Thromb Vasc Biol
, vol.20
, pp. 1143-1149
-
-
Stoop, A.A.1
Lupu, F.2
Pannekoek, H.3
-
68
-
-
77956646450
-
Early atherosclerosis exhibits an enhanced procoagulant state
-
Borissoff JI, Heeneman S, Kilinç E, Kassák P, van Oerle R, Winckers K, Govers-Riemslag JWP, Hamulyák K, Hackeng TM, Daemen MJAP, ten Cate H, Spronk HMH. Early atherosclerosis exhibits an enhanced procoagulant state. Circulation 2010; 122: 821–30.
-
(2010)
Circulation
, vol.122
, pp. 821-830
-
-
Borissoff, J.I.1
Heeneman, S.2
Kilinç, E.3
Kassák, P.4
van Oerle, R.5
Winckers, K.6
Govers-Riemslag, J.W.P.7
Hamulyák, K.8
Hackeng, T.M.9
Daemen, M.J.A.P.10
ten Cate, H.11
Spronk, H.M.H.12
-
69
-
-
80054108282
-
Thrombomodulin domains attenuate atherosclerosis by inhibiting thrombin-induced endothelial cell activation
-
Wei HJ, Li YH, Shi GY, Liu SL, Chang PC, Kuo CH, Wu HL. Thrombomodulin domains attenuate atherosclerosis by inhibiting thrombin-induced endothelial cell activation. Cardiovasc Res 2011; 92: 317–27.
-
(2011)
Cardiovasc Res
, vol.92
, pp. 317-327
-
-
Wei, H.J.1
Li, Y.H.2
Shi, G.Y.3
Liu, S.L.4
Chang, P.C.5
Kuo, C.H.6
Wu, H.L.7
-
70
-
-
84873592215
-
Genetic and pharmacological modifications of thrombin formation in apolipoprotein E-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner
-
Borissoff JI, Otten JJT, Heeneman S, Leenders P, van Oerle R, Soehnlein O, Loubele STBG, Hamulyák K, Hackeng TM, Daemen MJAP, Degen JL, Weiler H, Esmon CT, van Ryn J, Biessen EAL, Spronk HMH, ten Cate H. Genetic and pharmacological modifications of thrombin formation in apolipoprotein E-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner. PLoS ONE 2013; 8: e55784.
-
(2013)
PLoS ONE
, vol.8
-
-
Borissoff, J.I.1
Otten, J.J.T.2
Heeneman, S.3
Leenders, P.4
van Oerle, R.5
Soehnlein, O.6
Loubele, S.T.B.G.7
Hamulyák, K.8
Hackeng, T.M.9
Daemen, M.J.A.P.10
Degen, J.L.11
Weiler, H.12
Esmon, C.T.13
van Ryn, J.14
Biessen, E.A.L.15
Spronk, H.M.H.16
ten Cate, H.17
-
71
-
-
84941686619
-
Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice
-
Preusch MR, Ieronimakis N, Wijelath ES, Ricks J, Cabbage S, Bea F, Reyes M, van Ryn J, Rosenfeld ME. Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice. Drug Des Dev Ther 2015; 9: 5203–11.
-
(2015)
Drug Des Dev Ther
, vol.9
, pp. 5203-5211
-
-
Preusch, M.R.1
Ieronimakis, N.2
Wijelath, E.S.3
Ricks, J.4
Cabbage, S.5
Bea, F.6
Reyes, M.7
van Ryn, J.8
Rosenfeld, M.E.9
-
72
-
-
84900598078
-
Thrombin inhibition by dabigatran attenuates atherosclerosis in ApoE deficient mice
-
Pingel S, Tiyerili V, Mueller J, Werner N, Nickenig G, Mueller C. Thrombin inhibition by dabigatran attenuates atherosclerosis in ApoE deficient mice. Arch Med Sci 2014; 1: 154–60.
-
(2014)
Arch Med Sci
, vol.1
, pp. 154-160
-
-
Pingel, S.1
Tiyerili, V.2
Mueller, J.3
Werner, N.4
Nickenig, G.5
Mueller, C.6
-
73
-
-
84929223493
-
Targeting blood thrombogenicity precipitates atherothrombotic events in a mouse model of plaque destabilization
-
Liu X, Ni M, Ma L, Yang J, Wang L, Liu F, Dong M, Yang X, Zhang M, Lu H, Wang J, Zhang C, Jiang F, Zhang Y. Targeting blood thrombogenicity precipitates atherothrombotic events in a mouse model of plaque destabilization. Sci Rep 2015; 5: 10225.
-
(2015)
Sci Rep
, vol.5
, pp. 10225
-
-
Liu, X.1
Ni, M.2
Ma, L.3
Yang, J.4
Wang, L.5
Liu, F.6
Dong, M.7
Yang, X.8
Zhang, M.9
Lu, H.10
Wang, J.11
Zhang, C.12
Jiang, F.13
Zhang, Y.14
-
74
-
-
77954353979
-
Anticoagulant therapy in critical organ ischaemia/reperfusion injury
-
Loubele STBG, ten Cate H, Spronk HMH. Anticoagulant therapy in critical organ ischaemia/reperfusion injury. Thromb Haemost 2010; 104: 136–42.
-
(2010)
Thromb Haemost
, vol.104
, pp. 136-142
-
-
Loubele, S.T.B.G.1
ten Cate, H.2
Spronk, H.M.H.3
-
75
-
-
59049093517
-
Active site inhibited factor VIIa attenuates myocardial ischemia/reperfusion injury in mice
-
Loubele STBG, Spek CA, Leenders P, van Oerle R, Aberson HL, van der Voort D, Hamulyák K, Petersen LC, Spronk HMH, ten Cate H. Active site inhibited factor VIIa attenuates myocardial ischemia/reperfusion injury in mice. J Thromb Haemost 2009; 7: 290–8.
-
(2009)
J Thromb Haemost
, vol.7
, pp. 290-298
-
-
Loubele, S.T.B.G.1
Spek, C.A.2
Leenders, P.3
van Oerle, R.4
Aberson, H.L.5
van der Voort, D.6
Hamulyák, K.7
Petersen, L.C.8
Spronk, H.M.H.9
ten Cate, H.10
-
76
-
-
84868446992
-
Effects on platelet function of a direct acting antagonist of coagulation factor Xa
-
Ringwala SM, Dibattiste PM, Schneider DJ. Effects on platelet function of a direct acting antagonist of coagulation factor Xa. J Thromb Thrombolysis 2012; 34: 291–6.
-
(2012)
J Thromb Thrombolysis
, vol.34
, pp. 291-296
-
-
Ringwala, S.M.1
Dibattiste, P.M.2
Schneider, D.J.3
-
77
-
-
0034724445
-
Protease-activated receptor-2 modulates myocardial ischemia–reperfusion injury in the rat heart
-
Napoli C, Cicala C, Wallace JL, de Nigris F, Santagada V, Caliendo G, Franconi F, Ignarro LJ, Cirino G. Protease-activated receptor-2 modulates myocardial ischemia–reperfusion injury in the rat heart. Proc Natl Acad Sci USA 2000; 97: 3678–83.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 3678-3683
-
-
Napoli, C.1
Cicala, C.2
Wallace, J.L.3
de Nigris, F.4
Santagada, V.5
Caliendo, G.6
Franconi, F.7
Ignarro, L.J.8
Cirino, G.9
-
78
-
-
79951893447
-
Mechanisms of atrial structural changes caused by stretch occurring before and during early atrial fibrillation
-
De Jong AM, Maass AH, Oberdorf-Maass SU, van Veldhuisen DJ, van Gilst WH, van Gelder IC. Mechanisms of atrial structural changes caused by stretch occurring before and during early atrial fibrillation. Cardiovasc Res 2011; 89: 754–65.
-
(2011)
Cardiovasc Res
, vol.89
, pp. 754-765
-
-
De Jong, A.M.1
Maass, A.H.2
Oberdorf-Maass, S.U.3
van Veldhuisen, D.J.4
van Gilst, W.H.5
van Gelder, I.C.6
-
79
-
-
84923465521
-
Role of inflammation in atrial fibrillation pathophysiology and management
-
Harada M, van Wagoner DR, Nattel S. Role of inflammation in atrial fibrillation pathophysiology and management. Circ J 2015; 79: 495–502.
-
(2015)
Circ J
, vol.79
, pp. 495-502
-
-
Harada, M.1
van Wagoner, D.R.2
Nattel, S.3
-
80
-
-
0029099346
-
Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats
-
Wijffels MC, Kirchhof CJ, Dorland R, Allessie MA. Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation 1995; 92: 1954–68.
-
(1995)
Circulation
, vol.92
, pp. 1954-1968
-
-
Wijffels, M.C.1
Kirchhof, C.J.2
Dorland, R.3
Allessie, M.A.4
-
82
-
-
78650185878
-
Protease-activated receptor-2 induces myofibroblast differentiation and tissue factor up-regulation during bleomycin-induced lung injury
-
Borensztajn K, Bresser P, van der Loos C, Bot I, van den Blink B, den Bakker MA, Daalhuisen J, Groot AP, Peppelenbosch MP, von der Thüsen JH, Spek CA. Protease-activated receptor-2 induces myofibroblast differentiation and tissue factor up-regulation during bleomycin-induced lung injury. Am J Pathol 2010; 177: 2753–64.
-
(2010)
Am J Pathol
, vol.177
, pp. 2753-2764
-
-
Borensztajn, K.1
Bresser, P.2
van der Loos, C.3
Bot, I.4
van den Blink, B.5
den Bakker, M.A.6
Daalhuisen, J.7
Groot, A.P.8
Peppelenbosch, M.P.9
von der Thüsen, J.H.10
Spek, C.A.11
-
84
-
-
36048945107
-
Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy
-
Pawlinski R, Tencati M, Hampton CR, Shishido T, Bullard TA, Casey LM, Andrade-Gordon P, Kotzsch M, Spring D, Luther T. Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy. Circulation 2007; 116: 2298–306.
-
(2007)
Circulation
, vol.116
, pp. 2298-2306
-
-
Pawlinski, R.1
Tencati, M.2
Hampton, C.R.3
Shishido, T.4
Bullard, T.A.5
Casey, L.M.6
Andrade-Gordon, P.7
Kotzsch, M.8
Spring, D.9
Luther, T.10
-
85
-
-
84865210286
-
Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects
-
Schuepbach RA, Madon J, Ender M, Galli P, Riewald M. Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects. J Thromb Haemost 2012; 10: 1675–84.
-
(2012)
J Thromb Haemost
, vol.10
, pp. 1675-1684
-
-
Schuepbach, R.A.1
Madon, J.2
Ender, M.3
Galli, P.4
Riewald, M.5
|