Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein e-deficient mice

Drug Design, Development and Therapy

Volumn 9, Issue , 2015, Pages 5203-5211

  Preusch, Michael R ^a,b   Ieronimakis, Nicholas ^a   Wijelath, Errol S ^c   Cabbage, Sara ^a   Ricks, Jerry ^a   Bea, Florian ^b   Reyes, Morayma ^a   van Ryn, Joanne ^d   Rosenfeld, Michael E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Coagulation; Inflammation; Macrophages; Thrombin

Indexed keywords

CD45 ANTIGEN; CHOLESTEROL; DABIGATRAN ETEXILATE; NITRIC OXIDE; ONCOSTATIN M; THROMBIN; ANTITHROMBIN; APOLIPOPROTEIN E; DABIGATRAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA SINUS; ARTERY ENDOTHELIUM; ARTICLE; ATHEROSCLEROSIS; BODY WEIGHT; BRACHIOCEPHALIC TRUNK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DRUG EFFECT; ENDOTHELIUM CELL; ERYTHROCYTE COUNT; FLOW CYTOMETRY; HYPERLIPOPROTEINEMIA TYPE 3; IMMUNOCYTOCHEMISTRY; LEUKOCYTE COUNT; MACROPHAGE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; THROMBOCYTE COUNT; AGE; ANIMAL; C57BL MOUSE; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

AGE FACTORS; ANIMALS; ANTIGENS, CD45; ANTITHROMBINS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; DABIGATRAN; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FLOW CYTOMETRY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ONCOSTATIN M; SINUS OF VALSALVA;

EID: 84941686619     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S86969     Document Type: Article

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