메뉴 건너뛰기




Volumn 71, Issue 11, 2016, Pages 1395-1406

Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience

Author keywords

aging; animal models; Health span; longevity; preclinical studies

Indexed keywords

AGED; AGING; ANIMAL; CHRONIC DISEASE; DISEASE MODEL; FEMALE; HUMAN; LONGEVITY; MALE; MOUSE; ORGANIZATION; PHYSIOLOGY;

EID: 84994424579     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glw106     Document Type: Article
Times cited : (41)

References (123)
  • 1
    • 84907857762 scopus 로고    scopus 로고
    • Translational geroscience: Emphasizing function to achieve optimal longevity
    • Seals DR, Melov S. Translational geroscience: emphasizing function to achieve optimal longevity. Aging. 2014;6:718-730. doi:10.18632/ aging.100694
    • (2014) Aging. , vol.6 , pp. 718-730
    • Seals, D.R.1    Melov, S.2
  • 2
    • 84964890856 scopus 로고    scopus 로고
    • Measures of healthspan as indices of aging in mice-a recommendation
    • Richardson A, Fischer KE, Speakman JR, et al. Measures of healthspan as indices of aging in mice-a recommendation. J Gerontol A Biol Sci Med Sci. 2016;71:427-430. doi:10.1093/gerona/glv080
    • (2016) J Gerontol A Biol Sci Med Sci. , vol.71 , pp. 427-430
    • Richardson, A.1    Fischer, K.E.2    Speakman, J.R.3
  • 3
    • 0041466271 scopus 로고    scopus 로고
    • Differences among eight inbred strains of mice in motor ability and motor learning on a rotorod
    • McFadyen MP, Kusek G, Bolivar VJ, Flaherty L. Differences among eight inbred strains of mice in motor ability and motor learning on a rotorod. Genes Brain Behav. 2003;2:214-219
    • (2003) Genes Brain Behav. , vol.2 , pp. 214-219
    • McFadyen, M.P.1    Kusek, G.2    Bolivar, V.J.3    Flaherty, L.4
  • 4
    • 84879273216 scopus 로고    scopus 로고
    • Reducing mouse anxiety during handling: Effect of experience with handling tunnels
    • Gouveia K, Hurst JL. Reducing mouse anxiety during handling: effect of experience with handling tunnels. PLoS One. 2013;8:e66401. doi:10.1371/journal.pone.0066401
    • (2013) PLoS One. , vol.8 , pp. e66401
    • Gouveia, K.1    Hurst, J.L.2
  • 5
    • 77957680809 scopus 로고    scopus 로고
    • Taming anxiety in laboratory mice
    • Hurst JL, West RS. Taming anxiety in laboratory mice. Nat Methods. 2010;7:825-826. doi:10.1038/nmeth.1500
    • (2010) Nat Methods. , vol.7 , pp. 825-826
    • Hurst, J.L.1    West, R.S.2
  • 6
    • 34247209601 scopus 로고    scopus 로고
    • Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms
    • Costa DA, Cracchiolo JR, Bachstetter AD, et al. Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms. Neurobiol Aging. 2007;28:831-844
    • (2007) Neurobiol Aging. , vol.28 , pp. 831-844
    • Costa, D.A.1    Cracchiolo, J.R.2    Bachstetter, A.D.3
  • 7
    • 77949431920 scopus 로고    scopus 로고
    • Responses to environmental enrichment differ with sex and genotype in a transgenic mouse model of Huntington's disease
    • Wood NI, Carta V, Milde S, et al. Responses to environmental enrichment differ with sex and genotype in a transgenic mouse model of Huntington's disease. PLoS One. 2010;5:e9077. doi:10.1371/journal. pone.0009077
    • (2010) PLoS One. , vol.5 , pp. e9077
    • Wood, N.I.1    Carta, V.2    Milde, S.3
  • 8
    • 30944442060 scopus 로고    scopus 로고
    • Prognostic value of usual gait speed in well-functioning older people-results from the Health, Aging and Body Composition Study
    • Cesari M, Kritchevsky SB, Penninx BW, et al. Prognostic value of usual gait speed in well-functioning older people-results from the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2005;53:1675-1680
    • (2005) J Am Geriatr Soc. , vol.53 , pp. 1675-1680
    • Cesari, M.1    Kritchevsky, S.B.2    Penninx, B.W.3
  • 9
    • 84877129998 scopus 로고    scopus 로고
    • Motor assessment using the NIH Toolbox
    • Reuben DB, Magasi S, McCreath HE, et al. Motor assessment using the NIH Toolbox. Neurology. 2013;80:S65-S75. doi:10.1212/ WNL.0b013e3182872e01
    • (2013) Neurology. , vol.80 , pp. S65-S75
    • Reuben, D.B.1    Magasi, S.2    McCreath, H.E.3
  • 10
    • 78650878358 scopus 로고    scopus 로고
    • Gait speed and survival in older adults
    • Studenski S, Perera S, Patel K, et al. Gait speed and survival in older adults. JAMA. 2011;305:50-58. doi:10.1001/jama.2010.1923
    • (2011) JAMA. , vol.305 , pp. 50-58
    • Studenski, S.1    Perera, S.2    Patel, K.3
  • 11
    • 0028292936 scopus 로고
    • A short physical performance battery assessing lower extremity function: Association with selfreported disability and prediction of mortality and nursing home admission
    • Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with selfreported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49:M85-M94
    • (1994) J Gerontol. , vol.49 , pp. M85-M94
    • Guralnik, J.M.1    Simonsick, E.M.2    Ferrucci, L.3
  • 12
    • 84899071546 scopus 로고    scopus 로고
    • The FNIH sarcopenia project: Rationale, study description, conference recommendations, and final estimates
    • Studenski SA, Peters KW, Alley DE, et al. The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci. 2014;69:547-558. doi:10.1093/ gerona/glu010
    • (2014) J Gerontol A Biol Sci Med Sci. , vol.69 , pp. 547-558
    • Studenski, S.A.1    Peters, K.W.2    Alley, D.E.3
  • 13
    • 84898611733 scopus 로고    scopus 로고
    • Battery of behavioral tests in mice that models age-associated changes in human motor function
    • Justice JN, Carter CS, Beck HJ, et al. Battery of behavioral tests in mice that models age-associated changes in human motor function. Age. 2014;36:583-592
    • (2014) Age. , vol.36 , pp. 583-592
    • Justice, J.N.1    Carter, C.S.2    Beck, H.J.3
  • 15
    • 84933683518 scopus 로고    scopus 로고
    • Generation and behavior characterization of CaMKIIbeta knockout mice
    • Bachstetter AD, Webster SJ, Tu T, et al. Generation and behavior characterization of CaMKIIbeta knockout mice. PLoS One. 2014;9:e105191. doi:10.1371/journal.pone.0105191
    • (2014) PLoS One. , vol.9 , pp. e105191
    • Bachstetter, A.D.1    Webster, S.J.2    Tu, T.3
  • 17
    • 84930429038 scopus 로고    scopus 로고
    • Cognitive aging: A report from the Institute of Medicine
    • Blazer DG, Yaffe K, Karlawish J. Cognitive aging: a report from the Institute of Medicine. JAMA. 2015;313:2121-2122. doi:10.1001/ jama.2015.4380
    • (2015) JAMA. , vol.313 , pp. 2121-2122
    • Blazer, D.G.1    Yaffe, K.2    Karlawish, J.3
  • 18
    • 0037157572 scopus 로고    scopus 로고
    • What we need to know about age related memory loss
    • Small GW. What we need to know about age related memory loss. BMJ. 2002;324:1502-1505
    • (2002) BMJ. , vol.324 , pp. 1502-1505
    • Small, G.W.1
  • 19
    • 0012742294 scopus 로고    scopus 로고
    • Evidence for general cognitive ability (g) in heterogeneous stock mice and an analysis of potential confounds
    • Galsworthy MJ, Paya-Cano JL, Monleón S, Plomin R. Evidence for general cognitive ability (g) in heterogeneous stock mice and an analysis of potential confounds. Genes Brain Behav. 2002;1:88-95
    • (2002) Genes Brain Behav. , vol.1 , pp. 88-95
    • Galsworthy, M.J.1    Paya-Cano, J.L.2    Monleón, S.3    Plomin, R.4
  • 20
    • 33845573537 scopus 로고    scopus 로고
    • Investigation of age-related cognitive decline using mice as a model system: Behavioral correlates
    • Murphy GG, Rahnama NP, Silva AJ. Investigation of age-related cognitive decline using mice as a model system: behavioral correlates. Am J Geriatr Psychiatry. 2006;14:1004-1011
    • (2006) Am J Geriatr Psychiatry. , vol.14 , pp. 1004-1011
    • Murphy, G.G.1    Rahnama, N.P.2    Silva, A.J.3
  • 21
    • 0034242442 scopus 로고    scopus 로고
    • The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: A latent variable analysis
    • Miyake A, Friedman NP, Emerson MJ, Witzki AH, Howerter A, Wager TD. The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis. Cogn Psychol. 2000;41:49-100
    • (2000) Cogn Psychol. , vol.41 , pp. 49-100
    • Miyake, A.1    Friedman, N.P.2    Emerson, M.J.3    Witzki, A.H.4    Howerter, A.5    Wager, T.D.6
  • 22
    • 0034928713 scopus 로고    scopus 로고
    • An integrative theory of prefrontal cortex function
    • Miller EK, Cohen JD. An integrative theory of prefrontal cortex function. Ann Rev Neurosci. 2001;24:167-202
    • (2001) Ann Rev Neurosci. , vol.24 , pp. 167-202
    • Miller, E.K.1    Cohen, J.D.2
  • 23
    • 84870495282 scopus 로고    scopus 로고
    • Characterizing cognitive aging of working memory and executive function in animal models
    • Bizon JL, Foster TC, Alexander GE, Glisky EL. Characterizing cognitive aging of working memory and executive function in animal models. Front Aging Neurosci. 2012;4:19. doi:10.3389/fnagi.2012.00021
    • (2012) Front Aging Neurosci. , vol.4 , pp. 19
    • Bizon, J.L.1    Foster, T.C.2    Alexander, G.E.3    Glisky, E.L.4
  • 24
    • 84864395383 scopus 로고    scopus 로고
    • Age-associated learning and memory deficits in two mouse versions of the Stone T-maze
    • Pistell PJ, Spangler EL, Kelly-Bell B, Miller MG, de Cabo R, Ingram DK. Age-associated learning and memory deficits in two mouse versions of the Stone T-maze. Neurobiol Aging. 2012;33:2431-2439. doi:10.1016/j. neurobiolaging.2011.12.004
    • (2012) Neurobiol Aging. , vol.33 , pp. 2431-2439
    • Pistell, P.J.1    Spangler, E.L.2    Kelly-Bell, B.3    Miller, M.G.4    De Cabo, R.5    Ingram, D.K.6
  • 25
    • 0032961182 scopus 로고    scopus 로고
    • Tests used to assess the cognitive abilities of aged rats: Their relation to each other and to hippocampal morphology and neurotrophin expression
    • McLay RN, Freeman SM, Harlan RE, Kastin AJ, Zadina JE. Tests used to assess the cognitive abilities of aged rats: their relation to each other and to hippocampal morphology and neurotrophin expression. Gerontology. 1999;45:143-155
    • (1999) Gerontology. , vol.45 , pp. 143-155
    • McLay, R.N.1    Freeman, S.M.2    Harlan, R.E.3    Kastin, A.J.4    Zadina, J.E.5
  • 26
    • 0032167861 scopus 로고    scopus 로고
    • A new continuous alternation task in T-maze detects hippocampal dysfunction in mice A strain comparison and lesion study
    • Gerlai R. A new continuous alternation task in T-maze detects hippocampal dysfunction in mice. A strain comparison and lesion study. Behav Brain Res. 1998;95:91-101
    • (1998) Behav Brain Res. , vol.95 , pp. 91-101
    • Gerlai, R.1
  • 29
    • 78549266131 scopus 로고    scopus 로고
    • The polypill in the prevention of cardiovascular diseases: Key concepts, current status, challenges, and future directions
    • Lonn E, Bosch J, Teo KK, Pais P, Xavier D, Yusuf S. The polypill in the prevention of cardiovascular diseases: key concepts, current status, challenges, and future directions. Circulation. 2010;122:2078-2088. doi:10.1161/ CIRCULATIONAHA.109.873232
    • (2010) Circulation. , vol.122 , pp. 2078-2088
    • Lonn, E.1    Bosch, J.2    Teo, K.K.3    Pais, P.4    Xavier, D.5    Yusuf, S.6
  • 30
    • 84855353573 scopus 로고    scopus 로고
    • Heart disease and stroke statistics- 2012 update: A report from the American Heart Association
    • Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics- 2012 update: a report from the American Heart Association. Circulation. 2012;125:e2-e220. doi:10.1161/CIR.0b013e31828124ad
    • (2012) Circulation. , vol.125 , pp. e2-e220
    • Roger, V.L.1    Go, A.S.2    Lloyd-Jones, D.M.3
  • 31
    • 84903632930 scopus 로고    scopus 로고
    • You're only as old as your arteries: Translational strategies for preserving vascular endothelial function with aging
    • Seals DR, Kaplon RE, Gioscia-Ryan RA, LaRocca TJ. You're only as old as your arteries: translational strategies for preserving vascular endothelial function with aging. Physiology. 2014;29:250-264. doi:10.1152/physiol. 00059.2013
    • (2014) Physiology. , vol.29 , pp. 250-264
    • Seals, D.R.1    Kaplon, R.E.2    Gioscia-Ryan, R.A.3    LaRocca, T.J.4
  • 32
    • 84864120303 scopus 로고    scopus 로고
    • Translational evidence that impaired autophagy contributes to arterial ageing
    • LaRocca TJ, Henson GD, Thorburn A, Sindler AL, Pierce GL, Seals DR. Translational evidence that impaired autophagy contributes to arterial ageing. J Physiol. 2012;590:3305-3316. doi:10.1113/jphysiol.2012.229690
    • (2012) J Physiol. , vol.590 , pp. 3305-3316
    • LaRocca, T.J.1    Henson, G.D.2    Thorburn, A.3    Sindler, A.L.4    Pierce, G.L.5    Seals, D.R.6
  • 33
    • 0021989647 scopus 로고
    • Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: Comparison between urban and rural communities in China
    • Avolio AP, Deng FQ, Li WQ, et al. Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: comparison between urban and rural communities in China. Circulation. 1985;71:202-210
    • (1985) Circulation. , vol.71 , pp. 202-210
    • Avolio, A.P.1    Deng, F.Q.2    Li, W.Q.3
  • 34
    • 76349084693 scopus 로고    scopus 로고
    • Arterial stiffness and cardiovascular events: The Framingham Heart Study
    • Mitchell GF, Hwang SJ, Vasan RS, et al. Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation. 2010;121:505-511. doi:10.1161/CIRCULATIONAHA.109.886655
    • (2010) Circulation. , vol.121 , pp. 505-511
    • Mitchell, G.F.1    Hwang, S.J.2    Vasan, R.S.3
  • 35
    • 2542449089 scopus 로고    scopus 로고
    • Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: The Framingham Heart Study
    • Mitchell GF, Parise H, Benjamin EJ, et al. Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension. 2004;43:1239-1245
    • (2004) Hypertension. , vol.43 , pp. 1239-1245
    • Mitchell, G.F.1    Parise, H.2    Benjamin, E.J.3
  • 36
    • 84863113703 scopus 로고    scopus 로고
    • Sodium nitrite de-stiffening of large elastic arteries with aging: Role of normalization of advanced glycation end-products
    • Fleenor BS, Sindler AL, Eng JS, Nair DP, Dodson RB, Seals DR. Sodium nitrite de-stiffening of large elastic arteries with aging: role of normalization of advanced glycation end-products. Exp Gerontol. 2012;47:588-594. doi:10.1016/j.exger.2012.05.004
    • (2012) Exp Gerontol. , vol.47 , pp. 588-594
    • Fleenor, B.S.1    Sindler, A.L.2    Eng, J.S.3    Nair, D.P.4    Dodson, R.B.5    Seals, D.R.6
  • 37
    • 84858333077 scopus 로고    scopus 로고
    • Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice
    • Fleenor BS, Seals DR, Zigler ML, Sindler AL. Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice. Aging Cell. 2012;11:269-276. doi:10.1111/j.1474-9726.2011.00783.x
    • (2012) Aging Cell. , vol.11 , pp. 269-276
    • Fleenor, B.S.1    Seals, D.R.2    Zigler, M.L.3    Sindler, A.L.4
  • 38
    • 51649116447 scopus 로고    scopus 로고
    • Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats
    • Pacher P, Nagayama T, Mukhopadhyay P, Bátkai S, Kass DA. Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats. Nat Protoc. 2008;3:1422-1434. doi:10.1038/ nprot.2008.138
    • (2008) Nat Protoc. , vol.3 , pp. 1422-1434
    • Pacher, P.1    Nagayama, T.2    Mukhopadhyay, P.3    Bátkai, S.4    Kass, D.A.5
  • 39
    • 82855169312 scopus 로고    scopus 로고
    • Pressure-volume relation analysis of mouse ventricular function
    • Cingolani OH, Kass DA. Pressure-volume relation analysis of mouse ventricular function. Am J Physiol Heart Circ Physiol. 2011;301:H2198-H2206. doi:10.1152/ajpheart.00781.2011
    • (2011) Am J Physiol Heart Circ Physiol. , vol.301 , pp. H2198-H2206
    • Cingolani, O.H.1    Kass, D.A.2
  • 40
    • 33750837558 scopus 로고    scopus 로고
    • Noninvasive indexes of cardiac systolic and diastolic function in hyperthyroid and senescent mouse
    • Taffet GE, Hartley CJ, Wen X, Pham T, Michael LH, Entman ML. Noninvasive indexes of cardiac systolic and diastolic function in hyperthyroid and senescent mouse. Am J Physiol. 1996;270:H2204-H2209
    • (1996) Am J Physiol. , vol.270 , pp. H2204-H2209
    • Taffet, G.E.1    Hartley, C.J.2    Wen, X.3    Pham, T.4    Michael, L.H.5    Entman, M.L.6
  • 43
    • 0029586902 scopus 로고
    • New index of combined systolic and diastolic myocardial performance: A simple and reproducible measure of cardiac function-a study in normals and dilated cardiomyopathy
    • Tei C, Ling LH, Hodge DO, et al. New index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function-a study in normals and dilated cardiomyopathy. J Cardiol. 1995;26:357-366
    • (1995) J Cardiol. , vol.26 , pp. 357-366
    • Tei, C.1    Ling, L.H.2    Hodge, D.O.3
  • 44
    • 33646227422 scopus 로고    scopus 로고
    • Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats
    • Mager DE, Wan R, Brown M, et al. Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats. FASEB J. 2006;20:631-637
    • (2006) FASEB J. , vol.20 , pp. 631-637
    • Mager, D.E.1    Wan, R.2    Brown, M.3
  • 45
    • 0032742484 scopus 로고    scopus 로고
    • JG cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin promoter
    • Sinn PL, Zhang X, Sigmund CD. JG cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin promoter. Am J Physiol. 1999;277:F634-F642
    • (1999) Am J Physiol. , vol.277 , pp. F634-F642
    • Sinn, P.L.1    Zhang, X.2    Sigmund, C.D.3
  • 46
    • 0030035583 scopus 로고    scopus 로고
    • The aging immune system: Primer and prospectus
    • Miller RA. The aging immune system: primer and prospectus. Science. 1996;273:70-74
    • (1996) Science. , vol.273 , pp. 70-74
    • Miller, R.A.1
  • 47
    • 77950265945 scopus 로고    scopus 로고
    • Linking functional decline of telomeres, mitochondria and stem cells during ageing
    • Sahin E, Depinho RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature. 2010;464:520-528. doi:10.1038/nature08982
    • (2010) Nature. , vol.464 , pp. 520-528
    • Sahin, E.1    Depinho, R.A.2
  • 48
    • 84888320636 scopus 로고    scopus 로고
    • Age-dependent dysregulation of innate immunity
    • Shaw AC, Goldstein DR, Montgomery RR. Age-dependent dysregulation of innate immunity. Nat Rev Immunol. 2013;13:875-887. doi:10.1038/ nri3547
    • (2013) Nat Rev Immunol. , vol.13 , pp. 875-887
    • Shaw, A.C.1    Goldstein, D.R.2    Montgomery, R.R.3
  • 49
    • 78649526394 scopus 로고    scopus 로고
    • Sterile inflammation: Sensing and reacting to damage
    • Chen GY, Nuñez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol. 2010;10:826-837. doi:10.1038/nri2873
    • (2010) Nat Rev Immunol. , vol.10 , pp. 826-837
    • Chen, G.Y.1    Nuñez, G.2
  • 50
    • 0033911488 scopus 로고    scopus 로고
    • Inflamm-aging An evolutionary perspective on immunosenescence
    • Franceschi C, Bonafe M, Valensin S, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann NY Acad Sci. 2000;908:244-254
    • (2000) Ann NY Acad Sci. , vol.908 , pp. 244-254
    • Franceschi, C.1    Bonafe, M.2    Valensin, S.3
  • 51
    • 84896985687 scopus 로고    scopus 로고
    • Proinflammatory cytokines, aging, and age-related diseases
    • Michaud M, Balardy L, Moulis G, et al. Proinflammatory cytokines, aging, and age-related diseases. J Am Med Dir Assoc. 2013;14:877-882. doi:10.1016/j.jamda.2013.05.009
    • (2013) J Am Med Dir Assoc. , vol.14 , pp. 877-882
    • Michaud, M.1    Balardy, L.2    Moulis, G.3
  • 52
    • 34247129982 scopus 로고    scopus 로고
    • Insulin resistance and inflammation as precursors of frailty: The Cardiovascular Health Study
    • Barzilay JI, Blaum C, Moore T, et al. Insulin resistance and inflammation as precursors of frailty: the Cardiovascular Health Study. Arch Intern Med. 2007;167:635-641
    • (2007) Arch Intern Med. , vol.167 , pp. 635-641
    • Barzilay, J.I.1    Blaum, C.2    Moore, T.3
  • 55
    • 67349178333 scopus 로고    scopus 로고
    • Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailty
    • Qu T, Yang H, Walston JD, Fedarko NS, Leng SX. Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailty. Cytokine. 2009;46:319-324
    • (2009) Cytokine. , vol.46 , pp. 319-324
    • Qu, T.1    Yang, H.2    Walston, J.D.3    Fedarko, N.S.4    Leng, S.X.5
  • 56
    • 84899077849 scopus 로고    scopus 로고
    • Skeletal muscle ATP kinetics are impaired in frail mice
    • Akki A, Yang H, Gupta A, et al. Skeletal muscle ATP kinetics are impaired in frail mice. Age. 2014;36:21-30
    • (2014) Age. , vol.36 , pp. 21-30
    • Akki, A.1    Yang, H.2    Gupta, A.3
  • 57
    • 84863728010 scopus 로고    scopus 로고
    • Inflammation and mortality in a frail mouse model
    • Ko F, Yu Q, Xue QL, et al. Inflammation and mortality in a frail mouse model. Age. 2012;34:705-715
    • (2012) Age. , vol.34 , pp. 705-715
    • Ko, F.1    Yu, Q.2    Xue, Q.L.3
  • 58
    • 44349088093 scopus 로고    scopus 로고
    • The physical and biological characterization of a frail mouse model
    • Walston J, Fedarko N, Yang H, et al. The physical and biological characterization of a frail mouse model. J Gerontol A Biol Sci Med Sci. 2008;63:391-398
    • (2008) J Gerontol A Biol Sci Med Sci. , vol.63 , pp. 391-398
    • Walston, J.1    Fedarko, N.2    Yang, H.3
  • 60
    • 84861885929 scopus 로고    scopus 로고
    • The critical role of metabolic pathways in aging
    • Barzilai N, Huffman DM, Muzumdar RH, Bartke A. The critical role of metabolic pathways in aging. Diabetes. 2012;61:1315-1322. doi:10.2337/ db11-1300
    • (2012) Diabetes. , vol.61 , pp. 1315-1322
    • Barzilai, N.1    Huffman, D.M.2    Muzumdar, R.H.3    Bartke, A.4
  • 61
    • 84869444066 scopus 로고    scopus 로고
    • Insulin resistance and aging: A cause or a protective response
    • Barzilai N, Ferrucci L. Insulin resistance and aging: a cause or a protective response? J Gerontol A Biol Sci Med Sci. 2012;67:1329-1331. doi:10.1093/gerona/gls145
    • (2012) J Gerontol A Biol Sci Med Sci , vol.67 , pp. 1329-1331
    • Barzilai, N.1    Ferrucci, L.2
  • 62
    • 77956534963 scopus 로고    scopus 로고
    • Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
    • Ayala JE, Samuel VT, Morton GJ, et al. Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Dis Model Mech. 2010;3:525-534. doi:10.1242/dmm.006239
    • (2010) Dis Model Mech. , vol.3 , pp. 525-534
    • Ayala, J.E.1    Samuel, V.T.2    Morton, G.J.3
  • 63
    • 0034060145 scopus 로고    scopus 로고
    • Fecal glucocorticoids: A noninvasive method of measuring adrenal activity in wild and captive rodents
    • Harper JM, Austad SN. Fecal glucocorticoids: a noninvasive method of measuring adrenal activity in wild and captive rodents. Physiol Biochem Zool. 2000;73:12-22
    • (2000) Physiol Biochem Zool. , vol.73 , pp. 12-22
    • Harper, J.M.1    Austad, S.N.2
  • 64
    • 81755176061 scopus 로고    scopus 로고
    • Does reduced IGF-1R signaling in Igf1r+/? Mice alter aging
    • Bokov AF, Garg N, Ikeno Y, et al. Does reduced IGF-1R signaling in Igf1r+/mice alter aging PloS One. 2011;6:e26891. doi:10.1371/journal. pone.0026891
    • (2011) PloS One , vol.6 , pp. e26891
    • Bokov, A.F.1    Garg, N.2    Ikeno, Y.3
  • 65
    • 83455201537 scopus 로고    scopus 로고
    • Hyperinsulinemic-euglycemic clamps in conscious, unrestrained mice
    • Ayala JE, Bracy DP, Malabanan C, et al. Hyperinsulinemic-euglycemic clamps in conscious, unrestrained mice. J Vis Exp. 2011;16:3188. doi:10.3791/3188
    • (2011) J Vis Exp. , vol.16 , pp. 3188
    • Ayala, J.E.1    Bracy, D.P.2    Malabanan, C.3
  • 67
    • 0000567961 scopus 로고    scopus 로고
    • Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat
    • Barzilai N, Banerjee S, Hawkins M, Chen W, Rossetti L. Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. J Clin Invest. 1998;101:1353-1361
    • (1998) J Clin Invest. , vol.101 , pp. 1353-1361
    • Barzilai, N.1    Banerjee, S.2    Hawkins, M.3    Chen, W.4    Rossetti, L.5
  • 68
    • 23944523318 scopus 로고    scopus 로고
    • Relationship between body composition changes and changes in physical function and metabolic risk factors in aging
    • St-Onge MP. Relationship between body composition changes and changes in physical function and metabolic risk factors in aging. Curr Opin Clin Nutr Metab Care. 2005;8:523-528
    • (2005) Curr Opin Clin Nutr Metab Care. , vol.8 , pp. 523-528
    • St-Onge, M.P.1
  • 69
    • 73449125077 scopus 로고    scopus 로고
    • Body composition changes with aging: The cause or the result of alterations in metabolic rate and macronutrient oxidation
    • St-Onge MP, Gallagher D. Body composition changes with aging: the cause or the result of alterations in metabolic rate and macronutrient oxidation? Nutrition. 2010;26:152-155. doi:10.1016/j.nut.2009.07.004
    • (2010) Nutrition , vol.26 , pp. 152-155
    • St-Onge, M.P.1    Gallagher, D.2
  • 70
    • 78349299099 scopus 로고    scopus 로고
    • Fat tissue, aging, and cellular senescence
    • Tchkonia T, Morbeck DE, Von Zglinicki T, et al. Fat tissue, aging, and cellular senescence. Aging Cell. 2010;9:667-684. doi:10.1111/j.1474-9726.2010.00608.x
    • (2010) Aging Cell. , vol.9 , pp. 667-684
    • Tchkonia, T.1    Morbeck, D.E.2    Von Zglinicki, T.3
  • 71
    • 69949106011 scopus 로고    scopus 로고
    • Role of visceral adipose tissue in aging
    • Huffman DM, Barzilai N. Role of visceral adipose tissue in aging. Biochim Biophys Acta. 2009;1790:1117-1123. doi:10.1016/j.bbagen.2009.01.008
    • (2009) Biochim Biophys Acta. , vol.1790 , pp. 1117-1123
    • Huffman, D.M.1    Barzilai, N.2
  • 72
    • 84856442945 scopus 로고    scopus 로고
    • A guide to analysis of mouse energy metabolism
    • Tschop MH, Speakman JR, Arch JR, et al. A guide to analysis of mouse energy metabolism. Nat Methods. 2011;9:57-63. doi:10.1038/ nmeth.1806
    • (2011) Nat Methods. , vol.9 , pp. 57-63
    • Tschop, M.H.1    Speakman, J.R.2    Arch, J.R.3
  • 73
    • 58149132163 scopus 로고    scopus 로고
    • Assessment methods in human body composition
    • Lee SY, Gallagher D. Assessment methods in human body composition. Curr Opin Clin Nutr Metab Care. 2008;11:566-572. doi:10.1097/ MCO.0b013e32830b5f23
    • (2008) Curr Opin Clin Nutr Metab Care. , vol.11 , pp. 566-572
    • Lee, S.Y.1    Gallagher, D.2
  • 74
    • 0034110088 scopus 로고    scopus 로고
    • Chemical versus dual energy x-ray absorptiometry for detecting age-associated body compositional changes in male rats
    • Feely RS, Larkin LM, Halter JB, Dengel DR. Chemical versus dual energy x-ray absorptiometry for detecting age-associated body compositional changes in male rats. Exp Gerontol. 2000;35:417-427
    • (2000) Exp Gerontol. , vol.35 , pp. 417-427
    • Feely, R.S.1    Larkin, L.M.2    Halter, J.B.3    Dengel, D.R.4
  • 75
    • 77955050326 scopus 로고    scopus 로고
    • Evaluation of a quantitative magnetic resonance imaging system for whole body composition analysis in rodents
    • Nixon JP, Zhang M, Wang C, et al. Evaluation of a quantitative magnetic resonance imaging system for whole body composition analysis in rodents. Obesity. 2010;18:1652-1659. doi:10.1038/oby.2009.471
    • (2010) Obesity. , vol.18 , pp. 1652-1659
    • Nixon, J.P.1    Zhang, M.2    Wang, C.3
  • 76
    • 1542470485 scopus 로고    scopus 로고
    • Quantitative magnetic resonance (QMR) method for bone and whole-body-composition analysis
    • Taicher GZ, Tinsley FC, Reiderman A, Heiman ML. Quantitative magnetic resonance (QMR) method for bone and whole-body-composition analysis. Anal Bioanal Chem. 2003;377:990-1002
    • (2003) Anal Bioanal Chem. , vol.377 , pp. 990-1002
    • Taicher, G.Z.1    Tinsley, F.C.2    Reiderman, A.3    Heiman, M.L.4
  • 77
    • 2342625391 scopus 로고    scopus 로고
    • Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis
    • Tinsley FC, Taicher GZ, Heiman ML. Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis. Obes Res. 2004;12:150-160
    • (2004) Obes Res. , vol.12 , pp. 150-160
    • Tinsley, F.C.1    Taicher, G.Z.2    Heiman, M.L.3
  • 78
    • 33744913541 scopus 로고    scopus 로고
    • Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults
    • Walston J, Hadley EC, Ferrucci L, et al. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc. 2006;54:991-1001
    • (2006) J Am Geriatr Soc. , vol.54 , pp. 991-1001
    • Walston, J.1    Hadley, E.C.2    Ferrucci, L.3
  • 80
    • 34548459347 scopus 로고    scopus 로고
    • A comparison of two approaches to measuring frailty in elderly people
    • Rockwood K, Andrew M, Mitnitski A. A comparison of two approaches to measuring frailty in elderly people. J Gerontol A Biol Sci Med Sci. 2007;62:738-743
    • (2007) J Gerontol A Biol Sci Med Sci. , vol.62 , pp. 738-743
    • Rockwood, K.1    Andrew, M.2    Mitnitski, A.3
  • 82
    • 84858038607 scopus 로고    scopus 로고
    • A procedure for creating a frailty index based on deficit accumulation in aging mice
    • Parks RJ, Fares E, Macdonald JK, et al. A procedure for creating a frailty index based on deficit accumulation in aging mice. J Gerontol A Biol Sci Med Sci. 2012;67:217-227. doi:10.1093/gerona/glr193
    • (2012) J Gerontol A Biol Sci Med Sci. , vol.67 , pp. 217-227
    • Parks, R.J.1    Fares, E.2    Macdonald, J.K.3
  • 83
    • 84901047671 scopus 로고    scopus 로고
    • A clinical frailty index in aging mice: Comparisons with frailty index data in humans
    • Whitehead JC, Hildebrand BA, Sun M, et al. A clinical frailty index in aging mice: comparisons with frailty index data in humans. J Gerontol A Biol Sci Med Sci. 2014;69:621-632. doi:10.1093/gerona/glt136
    • (2014) J Gerontol A Biol Sci Med Sci. , vol.69 , pp. 621-632
    • Whitehead, J.C.1    Hildebrand, B.A.2    Sun, M.3
  • 84
    • 0033523043 scopus 로고    scopus 로고
    • Genetics of mouse behavior: Interactions with laboratory environment
    • Crabbe JC, Wahlsten D, Dudek BC. Genetics of mouse behavior: interactions with laboratory environment. Science. 1999;284:1670-1672
    • (1999) Science. , vol.284 , pp. 1670-1672
    • Crabbe, J.C.1    Wahlsten, D.2    Dudek, B.C.3
  • 85
    • 84922471063 scopus 로고    scopus 로고
    • Bed rest promotes reductions in walking speed, functional parameters, and aerobic fitness in older, healthy adults
    • Coker RH, Hays NP, Williams RH, Wolfe RR, Evans WJ. Bed rest promotes reductions in walking speed, functional parameters, and aerobic fitness in older, healthy adults. J Gerontol A Biol Sci Med Sci. 2015;70:91-96 doi:10.1093/gerona/glu123
    • (2015) J Gerontol A Biol Sci Med Sci. , vol.70 , pp. 91-96
    • Coker, R.H.1    Hays, N.P.2    Williams, R.H.3    Wolfe, R.R.4    Evans, W.J.5
  • 87
  • 88
    • 0036092597 scopus 로고    scopus 로고
    • Hindlimb unloading rodent model: Technical aspects
    • Morey-Holton ER, Globus RK. Hindlimb unloading rodent model: technical aspects. J Appl Physiol. 2002;92:1367-1377
    • (2002) J Appl Physiol. , vol.92 , pp. 1367-1377
    • Morey-Holton, E.R.1    Globus, R.K.2
  • 89
    • 77955596389 scopus 로고    scopus 로고
    • Partial weight suspension: A novel murine model for investigating adaptation to reduced musculoskeletal loading
    • Wagner EB, Granzella NP, Saito H, Newman DJ, Young LR, Bouxsein ML. Partial weight suspension: a novel murine model for investigating adaptation to reduced musculoskeletal loading. J Appl Physiol. 2010;109:350-357. doi:10.1152/japplphysiol.00014.2009
    • (2010) J Appl Physiol. , vol.109 , pp. 350-357
    • Wagner, E.B.1    Granzella, N.P.2    Saito, H.3    Newman, D.J.4    Young, L.R.5    Bouxsein, M.L.6
  • 90
    • 84875308404 scopus 로고    scopus 로고
    • Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass
    • Ellman R, Spatz J, Cloutier A, Palme R, Christiansen BA, Bouxsein ML. Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass. J Bone Miner Res. 2013;28:875-885. doi:10.1002/jbmr.1814
    • (2013) J Bone Miner Res. , vol.28 , pp. 875-885
    • Ellman, R.1    Spatz, J.2    Cloutier, A.3    Palme, R.4    Christiansen, B.A.5    Bouxsein, M.L.6
  • 92
    • 73949091048 scopus 로고    scopus 로고
    • Impaired immune responses in the lungs of aged mice following influenza infection
    • Toapanta FR, Ross TM. Impaired immune responses in the lungs of aged mice following influenza infection. Respir Res. 2009;10:112. doi:10.1186/1465-9921-10-112
    • (2009) Respir Res. , vol.10 , pp. 112
    • Toapanta, F.R.1    Ross, T.M.2
  • 93
    • 84868302065 scopus 로고    scopus 로고
    • Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence
    • Hinojosa CA, Mgbemena V, Van Roekel S, et al. Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence. Exp Gerontol. 2012;47:958-965. doi:10.1016/j.exger.2012.08.013
    • (2012) Exp Gerontol. , vol.47 , pp. 958-965
    • Hinojosa, C.A.1    Mgbemena, V.2    Van Roekel, S.3
  • 94
    • 77956629425 scopus 로고    scopus 로고
    • Late effects of chemotherapy
    • Gururangan S. Late effects of chemotherapy. Cancer Treat Res. 2009;150:43-65. doi:10.1007/b109924-4
    • (2009) Cancer Treat Res. , vol.150 , pp. 43-65
    • Gururangan, S.1
  • 95
    • 77956635711 scopus 로고    scopus 로고
    • Auditory late effects of chemotherapy
    • Meyer AK, Young NM. Auditory late effects of chemotherapy. Cancer Treat Res. 2009;150:195-213. doi:10.1007/b109924-13
    • (2009) Cancer Treat Res. , vol.150 , pp. 195-213
    • Meyer, A.K.1    Young, N.M.2
  • 96
    • 84884128116 scopus 로고    scopus 로고
    • Late effects of adjuvant chemotherapy for adult onset non-CNS cancer; Cognitive impairment, brain structure and risk of dementia
    • Koppelmans V, Breteler MM, Boogerd W, Seynaeve C, Schagen SB. Late effects of adjuvant chemotherapy for adult onset non-CNS cancer; cognitive impairment, brain structure and risk of dementia. Crit Rev Oncol Hematol. 2013;88:87-101. doi:10.1016/j.critrevonc.2013.04.002
    • (2013) Crit Rev Oncol Hematol. , vol.88 , pp. 87-101
    • Koppelmans, V.1    Breteler, M.M.2    Boogerd, W.3    Seynaeve, C.4    Schagen, S.B.5
  • 97
    • 33744723129 scopus 로고    scopus 로고
    • Possible acceleration of aging by adjuvant chemotherapy: A cause of early onset frailty
    • Maccormick RE. Possible acceleration of aging by adjuvant chemotherapy: a cause of early onset frailty Med Hypotheses. 2006;67:212-215
    • (2006) Med Hypotheses , vol.67 , pp. 212-215
    • Maccormick, R.E.1
  • 98
    • 84964698113 scopus 로고    scopus 로고
    • Accelerated aging among cancer survivors: From pediatrics to geriatrics
    • Henderson TO, Ness KK, Cohen HJ. Accelerated aging among cancer survivors: from pediatrics to geriatrics. Am Soc Clin Oncol Educ Book. 2014:e423-e430. doi:10.14694/EdBook-AM.2014.34.e423
    • (2014) Am Soc Clin Oncol Educ Book. , pp. e423-e430
    • Henderson, T.O.1    Ness, K.K.2    Cohen, H.J.3
  • 99
    • 84896723125 scopus 로고    scopus 로고
    • The impact of sustained and intermittent docetaxel chemotherapy regimens on cognition and neural morphology in healthy mice
    • Fardell JE, Zhang J, De Souza R, et al. The impact of sustained and intermittent docetaxel chemotherapy regimens on cognition and neural morphology in healthy mice. Psychopharmacology. 2014;231:841-852. doi:10.1007/s00213-013-3301-8
    • (2014) Psychopharmacology. , vol.231 , pp. 841-852
    • Fardell, J.E.1    Zhang, J.2    De Souza, R.3
  • 100
    • 40549128682 scopus 로고    scopus 로고
    • Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage
    • Maejima Y, Adachi S, Ito H, Hirao K, Isobe M. Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage. Aging Cell. 2008;7:125-136
    • (2008) Aging Cell. , vol.7 , pp. 125-136
    • Maejima, Y.1    Adachi, S.2    Ito, H.3    Hirao, K.4    Isobe, M.5
  • 101
    • 84907483645 scopus 로고    scopus 로고
    • Voluntary exercise prevents cisplatin-induced muscle wasting during chemotherapy in mice
    • Hojman P, Fjelbye J, Zerahn B, et al. Voluntary exercise prevents cisplatin-induced muscle wasting during chemotherapy in mice. PloS One. 2014;9:e109030. doi:10.1371/journal.pone.0109030
    • (2014) PloS One. , vol.9 , pp. e109030
    • Hojman, P.1    Fjelbye, J.2    Zerahn, B.3
  • 102
    • 33750359859 scopus 로고    scopus 로고
    • Keynote comment: Cancer survivorship and ageing-a double whammy
    • Cohen HJ. Keynote comment: cancer survivorship and ageing-a double whammy. Lancet Oncol. 2006;7:882-883
    • (2006) Lancet Oncol. , vol.7 , pp. 882-883
    • Cohen, H.J.1
  • 103
    • 80052667803 scopus 로고    scopus 로고
    • Malnutrition and nutrition-therapy: Our neglected responsibility
    • Chermesh I, Sobotka L, Hartman C, Meier R. Malnutrition and nutrition-therapy: our neglected responsibility. Gastroenterol Res Pract. 2011;2011:842085. doi:10.1155/2011/842085
    • (2011) Gastroenterol Res Pract. , vol.2011 , pp. 842085
    • Chermesh, I.1    Sobotka, L.2    Hartman, C.3    Meier, R.4
  • 104
    • 84863452209 scopus 로고    scopus 로고
    • Anorexia of aging: A true geriatric syndrome
    • Morley JE. Anorexia of aging: a true geriatric syndrome. J Nutr Health Aging. 2012;16:422-425
    • (2012) J Nutr Health Aging. , vol.16 , pp. 422-425
    • Morley, J.E.1
  • 106
    • 0036570115 scopus 로고    scopus 로고
    • Water, other fluids, and fatal coronary heart disease: The Adventist Health Study
    • Chan J, Knutsen SF, Blix GG, Lee JW, Fraser GE. Water, other fluids, and fatal coronary heart disease: the Adventist Health Study. Am J Epidemiol. 2002;155:827-833
    • (2002) Am J Epidemiol. , vol.155 , pp. 827-833
    • Chan, J.1    Knutsen, S.F.2    Blix, G.G.3    Lee, J.W.4    Fraser, G.E.5
  • 107
    • 57149087054 scopus 로고    scopus 로고
    • Risk factors and outcomes associated with hospital admission for dehydration
    • Wakefield BJ, Mentes J, Holman JE, Culp K. Risk factors and outcomes associated with hospital admission for dehydration. Rehabil Nurs. 2008;33:233-241
    • (2008) Rehabil Nurs. , vol.33 , pp. 233-241
    • Wakefield, B.J.1    Mentes, J.2    Holman, J.E.3    Culp, K.4
  • 108
    • 0032807457 scopus 로고    scopus 로고
    • The incidence and nature of surgical adverse events in Colorado and Utah in 1992
    • Gawande AA, Thomas EJ, Zinner MJ, Brennan TA. The incidence and nature of surgical adverse events in Colorado and Utah in 1992. Surgery. 1999;126:66-75
    • (1999) Surgery. , vol.126 , pp. 66-75
    • Gawande, A.A.1    Thomas, E.J.2    Zinner, M.J.3    Brennan, T.A.4
  • 110
    • 82955196857 scopus 로고    scopus 로고
    • Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: Mechanisms and effects on liver regeneration
    • Verweij M, van Ginhoven TM, Mitchell JR, et al. Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration. Liver Transpl. 2011;17:695-704. doi:10.1002/lt.22243
    • (2011) Liver Transpl. , vol.17 , pp. 695-704
    • Verweij, M.1    Van Ginhoven, T.M.2    Mitchell, J.R.3
  • 111
    • 78549280109 scopus 로고    scopus 로고
    • Anesthesia and perioperative stress: Consequences on neural networks and postoperative behaviors
    • Borsook D, George E, Kussman B, Becerra L. Anesthesia and perioperative stress: consequences on neural networks and postoperative behaviors. Prog Neurobiol. 2010;92:601-612. doi:10.1016/j.pneurobio.2010.08.006
    • (2010) Prog Neurobiol. , vol.92 , pp. 601-612
    • Borsook, D.1    George, E.2    Kussman, B.3    Becerra, L.4
  • 112
    • 84863229916 scopus 로고    scopus 로고
    • Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy
    • Lee C, Raffaghello L, Brandhorst S, et al. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med. 2012;4:124ra127. doi:10.1126/scitranslmed.3003293
    • (2012) Sci Transl Med. , vol.4 , pp. 124ra127
    • Lee, C.1    Raffaghello, L.2    Brandhorst, S.3
  • 113
    • 84880166032 scopus 로고    scopus 로고
    • Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice
    • Dolinsky VW, Rogan KJ, Sung MM, et al. Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice. Am J Physiol Endocrinol Metab. 2013;305:E243-E253. doi:10.1152/ajpendo.00044.2013
    • (2013) Am J Physiol Endocrinol Metab. , vol.305 , pp. E243-E253
    • Dolinsky, V.W.1    Rogan, K.J.2    Sung, M.M.3
  • 114
    • 84862297965 scopus 로고    scopus 로고
    • Accelerating drug discovery for Alzheimer's disease: Best practices for preclinical animal studies
    • Shineman DW, Basi GS, Bizon JL, et al. Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies. Alzheimers Res Ther. 2011;3:28. doi:10.1186/alzrt90
    • (2011) Alzheimers Res Ther. , vol.3 , pp. 28
    • Shineman, D.W.1    Basi, G.S.2    Bizon, J.L.3
  • 115
    • 33846677129 scopus 로고    scopus 로고
    • Comparison of treatment effects between animal experiments and clinical trials: Systematic review
    • Perel P, Roberts I, Sena E, et al. Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ. 2007;334:197
    • (2007) BMJ. , vol.334 , pp. 197
    • Perel, P.1    Roberts, I.2    Sena, E.3
  • 116
    • 77950679333 scopus 로고    scopus 로고
    • Can animal models of disease reliably inform human studies
    • van der Worp HB, Howells DW, Sena ES, et al. Can animal models of disease reliably inform human studies PLoS Med. 2010;7:e1000245. doi:10.1371/journal.pmed.1000245
    • (2010) PLoS Med , vol.7 , pp. e1000245
    • Van Der Worp, H.B.1    Howells, D.W.2    Sena, E.S.3
  • 117
    • 84892960440 scopus 로고    scopus 로고
    • Lost in translation: Animal models and clinical trials in cancer treatment
    • Mak IW, Evaniew N, Ghert M. Lost in translation: animal models and clinical trials in cancer treatment. Am J Transl Res. 2014;6:114-118
    • (2014) Am J Transl Res. , vol.6 , pp. 114-118
    • Mak, I.W.1    Evaniew, N.2    Ghert, M.3
  • 118
    • 84927524191 scopus 로고    scopus 로고
    • Glucose regulation, cognition, and brain MRI in type 2 diabetes: A systematic review
    • Geijselaers SL, Sep SJ, Stehouwer CD, Biessels GJ. Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review. Lancet Diabetes Endocrinol. 2015;3:75-89. doi:10.1016/S2213-8587(14)70148-2
    • (2015) Lancet Diabetes Endocrinol. , vol.3 , pp. 75-89
    • Geijselaers, S.L.1    Sep, S.J.2    Stehouwer, C.D.3    Biessels, G.J.4
  • 119
    • 0033533596 scopus 로고    scopus 로고
    • Diabetes and cardiovascular disease: A statement for healthcare professionals from the American Heart Association
    • Grundy SM, Benjamin IJ, Burke GL, et al. Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation. 1999;100:1134-1146
    • (1999) Circulation. , vol.100 , pp. 1134-1146
    • Grundy, S.M.1    Benjamin, I.J.2    Burke, G.L.3
  • 120
    • 77955517441 scopus 로고    scopus 로고
    • Diabetes and cancer: A consensus report
    • Giovannucci E, Harlan DM, Archer MC, et al. Diabetes and cancer: a consensus report. Diabetes Care. 2010;33:1674-1685. doi:10.2337/ dc10-0666
    • (2010) Diabetes Care. , vol.33 , pp. 1674-1685
    • Giovannucci, E.1    Harlan, D.M.2    Archer, M.C.3
  • 121
    • 76249097841 scopus 로고    scopus 로고
    • Genetic variation in the murine lifespan response to dietary restriction: From life extension to life shortening
    • Liao CY, Rikke BA, Johnson TE, Diaz V, Nelson JF. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell. 2010;9:92-95. doi:10.1111/j.1474-9726.2009.00533.x
    • (2010) Aging Cell. , vol.9 , pp. 92-95
    • Liao, C.Y.1    Rikke, B.A.2    Johnson, T.E.3    Diaz, V.4    Nelson, J.F.5
  • 122
    • 84892530622 scopus 로고    scopus 로고
    • Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation
    • Xu J, Gontier G, Chaker Z, Lacube P, Dupont J, Holzenberger M. Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation. Aging Cell. 2014;13:19-28. doi:10.1111/acel.12145
    • (2014) Aging Cell. , vol.13 , pp. 19-28
    • Xu, J.1    Gontier, G.2    Chaker, Z.3    Lacube, P.4    Dupont, J.5    Holzenberger, M.6
  • 123
    • 0347664057 scopus 로고    scopus 로고
    • IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    • Holzenberger M, Dupont J, Ducos B, et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. 2003;421:182-187.
    • (2003) Nature. , vol.421 , pp. 182-187
    • Holzenberger, M.1    Dupont, J.2    Ducos, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.