Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass

Journal of Bone and Mineral Research

Volumn 28, Issue 4, 2013, Pages 875-885

  Ellman, Rachel ^a,b   Spatz, Jordan ^a,b,c   Cloutier, Alison ^b   Palme, Rupert ^d   Christiansen, Blaine A ^b,e   Bouxsein, Mary L ^b,c  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

disuse; functional adaptation; mechanical loading; mechanostat; weight bearing

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE DENSITY; BONE MASS; BONE MATURATION; BONE STRUCTURE; CONTROLLED STUDY; FEMALE; FEMUR; FEMUR SHAFT; GAIT; GASTROCNEMIUS MUSCLE; HINDLIMB; KINEMATICS; LOADING TEST; LOCOMOTION; MECHANICAL STIMULATION; MORPHOLOGICAL ADAPTATION; MOUSE; MUSCLE ATROPHY; MUSCLE MASS; NONHUMAN; TRABECULAR BONE; WEIGHT BEARING; ANATOMY AND HISTOLOGY; ANIMAL; BAGG ALBINO MOUSE; BIOMECHANICS; BONE; C57BL MOUSE; CHEMISTRY; FECES; IMMOBILIZATION; METABOLISM; ORGAN SIZE; PHYSIOLOGY; SKELETAL MUSCLE;

CORTICOSTERONE;

ANIMALS; BIOMECHANICAL PHENOMENA; BODY WEIGHT; BONE AND BONES; BONE DENSITY; CORTICOSTERONE; FECES; FEMALE; FEMUR; GAIT; HINDLIMB SUSPENSION; MICE, INBRED BALB C; MICE, INBRED C57BL; MUSCLE, SKELETAL; ORGAN SIZE; WEIGHT-BEARING;

EID: 84875308404     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1814     Document Type: Article

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