Structural basis of microtubule stabilization by laulimalide and peloruside A

Angewandte Chemie - International Edition

Volumn 53, Issue 6, 2014, Pages 1621-1625

  Prota, Andrea E ^a   Bargsten, Katja ^a   Northcote, Peter T ^b   Marsh, May ^a   Altmann, Karl Heinz ^c   Miller, John H ^b   Díaz, José Fernando ^d   Steinmetz, Michel O ^a  

^a PAUL SCHERRER INSTITUTE   (Switzerland)

^b VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

^c ETH ZURICH   (Switzerland)

^d CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

drug discovery; microtubules; molecular mechanism of action; structure elucidation; X ray crystallography

Indexed keywords

CANCER CELL GROWTH; COMBINATION CHEMOTHERAPY; DRUG DISCOVERY; MECHANISM OF ACTION; MICROTUBULES; MOLECULAR MECHANISM; STRUCTURAL FRAMEWORKS; STRUCTURE ELUCIDATION;

CHEMOTHERAPY; DIMERS; DRUG PRODUCTS; SELF ASSEMBLY; X RAY CRYSTALLOGRAPHY; X RAYS;

CYTOTOXICITY;

FUSED HETEROCYCLIC RINGS; LACTONE; LAULIMALIDE; MACROLIDE; PELORUSIDE A; TUBULIN;

ALLOSTERISM; ARTICLE; BINDING SITE; CHEMISTRY; DIMERIZATION; DRUG DEVELOPMENT; HUMAN; METABOLISM; MICROTUBULE; MOLECULAR DYNAMICS; MOLECULAR MECHANISM OF ACTION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; STRUCTURE ELUCIDATION; X RAY CRYSTALLOGRAPHY; X-RAY CRYSTALLOGRAPHY;

DRUG DISCOVERY; MICROTUBULES; MOLECULAR MECHANISM OF ACTION; STRUCTURE ELUCIDATION; X-RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; HUMANS; LACTONES; MACROLIDES; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TUBULIN;

EID: 84893516156     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201307749     Document Type: Article

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