Design, Synthesis, in Vitro, and in Vivo Anticancer and Antiangiogenic Activity of Novel 3-Arylaminobenzofuran Derivatives Targeting the Colchicine Site on Tubulin

Journal of Medicinal Chemistry

Volumn 58, Issue 7, 2015, Pages 3209-3222

  Romagnoli, Romeo ^a   Baraldi, Pier Giovanni ^a   Salvador, Maria Kimatrai ^a   Prencipe, Filippo ^a   Lopez Cara, Carlota ^b   Schiaffino Ortega, Santiago ^b   Brancale, Andrea ^c   Hamel, Ernest ^d   Castagliuolo, Ignazio ^f   Mitola, Stefania ^e   Ronca, Roberto ^e   Bortolozzi, Roberta ^f   Porcuì, Elena ^f   Basso, Giuseppe ^f   Viola, Giampietro ^f  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF GRANADA   (Spain)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e UNIVERSITY OF BRESCIA   (Italy)

^f UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3,4,5 TRIMETHOXYPHENYLAMINO) 4 METHOXYBENZOFURAN 2 CARBOXYLATE; 3 (3,4,5 TRIMETHOXYPHENYLAMINO) 5 METHOXYBENZOFURAN 2 CARBOXYLATE; 3 (3,4,5 TRIMETHOXYPHENYLAMINO) 6 METHOXYBENZOFURAN 2 CARBOXYLATE; 3 (3,4,5 TRIMETHOXYPHENYLAMINO) 7 ETHOXYBENZOFURAN 2 CARBOXYLATE; 3 (3,4,5 TRIMETHOXYPHENYLAMINO) 7 METHOXYBENZOFURAN 2 CARBOXYLATE; 3 AMINO 4 METHOXYBENZOFURAN 2 CARBOXYLATE; 3 AMINO 5 METHOXYBENZOFURAN 2 CARBOXYLATE; 3 AMINO 6 METHOXYBENZOFURAN 2 CARBOXYLATE; 3 AMINO 7 ETHOXYBENZOFURAN 2 CARBOXYLATE; 3 AMINO 7 METHOXYBENZOFURAN 2 CARBOXYLATE; 3 AMINOBENZOFURAN 2 CARBOXYLATE; 3 ARYLAMINOBENZOFURAN DERIVATIVE; 3 [(3,4,5 TRIMETHOXYPHENYL)AMINO]BENZOFURAN 2 CARBOXYLATE; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; BENZOFURAN DERIVATIVE; COLCHICINE; COMBRETASTATIN A4 PHOSPHATE; TUBULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MICROTUBULE ASSEMBLY; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; ANIMAL; BAGG ALBINO MOUSE; BINDING SITE; C57BL MOUSE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; CHICK EMBRYO; DOSE RESPONSE; DRUG EFFECTS; MALE; METABOLISM; MOLECULARLY TARGETED THERAPY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOFURANS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; CHICK EMBRYO; COLCHICINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MALE; MICE, INBRED BALB C; MICE, INBRED C57BL; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 84927647021     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00155     Document Type: Article

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