Structural Optimization of Indole Derivatives Acting at Colchicine Binding Site as Potential Anticancer Agents

ACS Medicinal Chemistry Letters

Volumn 6, Issue 9, 2015, Pages 993-997

  Hwang, Dong Jin ^a   Wang, Jin ^a   Li, Wei ^a   Miller, Duane D ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

antiproliferative activity; Colchicine binding site; liver microsomal stability; melanoma; multiple drug resistance; prostate cancer; structure activity relationship (SAR); tubulin polymerization inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; COLCHICINE; INDOLE DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN; PACLITAXEL;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL CYCLE M PHASE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG HALF LIFE; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; LIVER MICROSOME METABOLISM; MALE; METABOLIC STABILITY; MICROTUBULE ASSEMBLY; MOLECULAR MODEL; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE CANCER CELL LINE; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; TUBULIN POLYMERIZATION ASSAY;

EID: 84941549087     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.5b00208     Document Type: Article

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