Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: Synthesis, biological evaluation, and structure-activity relationships

Journal of Medicinal Chemistry

Volumn 52, Issue 6, 2009, Pages 1701-1711

  Lu, Yan ^a   Li, Chien Ming ^b   Wang, Zhao ^a   Ross, Charles R ^c   Chen, Jianjun ^a   Dalton, James T ^b   Li, Wei ^a   Miller, Duane D ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(2 FLUOROPHENYL)(2 PHENYLTHIAZOL 4 YL) METHANONE; (2 METHOXYPHENYL)(2 PHENYLTHIAZOL 4 YL) METHANONE; (2 PHENYLTHIAZOL 4 YL)(3,4,5 TRIMETHOXY PHENYL) METHANONE; (3 METHOXYPHENYL)(2 PHENYLTHIAZOL 4 YL) METHANONE; (3,4 DIMETHOXYPHENYL)(2 PHENYLTHIAZOL 4 YL) METHANONE; (3,5 DIMETHOXYPHENYL)(2 PHENYLTHIAZOL 4 YL) METHANONE; (4 METHOXYPHENYL)(2 PHENYLTHIAZOL 4 YL) METHANONE; 2 (2 FLUOROPHENYL) N METHOXY N METHYL 4,5 DIHYDROTHIAZOLE 4 CARBOXAMIDE; 2 (3,4 DIMETHOXYPHENYL) N METHOXY N METHYL 4,5 DIHYDROTHIAZOLE 4 CARBOXAMIDE; 2 (4 BROMOPHENYL) N METHOXY N METHYL 4,5 DIHYDROTHIAZOLE 4 CARBOXAMIDE; 2 (4 CYANOPHENYL) N METHOXY N METHYL 2 (4 NITROPHENYL) 4,5 DIHYDROTHIAZOLE 4 CARBOXAMIDE; 2 ARYLTHIAZOLIDINE 4 CARBOXYLIC; 2 PHENYL 4,5 DIHYDROTHIAZOLE 4 CARBOXYLIC ACID; 2 PHENYL N (3,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDROTHIAZOLE 4 CARBOXAMIDE; 2 PHENYL N (3,4,5 TRIMETHOXYPHENYL)THIAZOLE 4 CARBOXAMIDE; 2 PHENYL N (3,4,5 TRIMETHOXYPHENYL)THIAZOLIDINE 4 CARBOXAMIDE; 2 PHENYL THIAZOLE 4 CARBOXYLIC ACID METHOXYMETHYLAMIDE; ANTINEOPLASTIC AGENT; N METHOXY N METHYL 2 (4 ETHYL) 4,5 DIHYDROTHIAZOLE 4 CARBOXAMIDE; N METHOXY N METHYL 2 (4 NITROPHENYL) 4,5 DIHYDROTHIAZOLE 4 CARBOXAMIDE; N METHOXY N METHYL 2 (PYRIDIN 4 YL) 4,5 DIHYDROTHIAZOLE 4 CARBOXAMIDE; N METHOXY N METHYL 2 (PYRIMIDIN 2 YL) 4,5 DIHYDROTHIAZOLE 4 CARBOXAMIDE; N METHOXY N METHYL 2 (THIOPHEN 2 YL) 4,5 DIHYDROTHIAZOLE 4 CARBOXAMIDE; N METHOXY N METHYL 2 2 (4 TRIFLUOROMETHYLPHENYL) 4,5 DIHYDROTHIAZOLE 4 CARBOXAMIDE; N METHOXY N METHYL 2 4 TOLYL 4,5 DIHYDROTHIAZOLE 4 CARBOXAMIDE; N METHOXY N METHYL 2 PHENYL 4,5 DIHYDROTHIAZOLE 4 CARBOXAMIDE; N METHOXY N METHYLTHIAZOLE 4 CARBOXAMIDE; N,2 BIS (3,4,5 TRIMETHOXYPHENYL)THIAZOLIDINE 4 CARBOXAMIDE; PHENYL (2 PHENYLTHIAZOL 4 YL) METHANONE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MELANOMA; MOUSE; NONHUMAN; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 64349111929     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801449a     Document Type: Article

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