Folate-vinca alkaloid conjugates for cancer therapy: A structure-activity relationship

Bioconjugate Chemistry

Volumn 25, Issue 3, 2014, Pages 560-568

  Leamon, Christopher P ^a   Vlahov, Iontcho R ^a   Reddy, Joseph A ^a   Vetzel, Marilynn ^a   Santhapuram, Hari Krishna R ^a   You, Fei ^a   Bloomfield, Alicia ^a   Dorton, Ryan ^a   Nelson, Melissa ^a   Kleindl, Paul ^a   Vaughn, Jeremy F ^a   Westrick, Elaine ^a  

^a Endocyte Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; HYDROPHILICITY; METABOLITES; MOLECULES; ONCOLOGY; PEPTIDES; SULFUR COMPOUNDS; TUMORS;

ANTITUMOUR ACTIVITY; CANCER THERAPY; FOLATE RECEPTOR; FOLATES; HYDROPHILIC SPACERS; IN-VITRO; SELF-IMMOLATIVE; SMALL-MOLECULE DRUGS; STRUCTURE-ACTIVITY RELATIONSHIPS; VINORELBINE;

ALKALOIDS;

AMINO ACID DERIVATIVE; ASPARAGINYLARGINYLASPARAGINYLASPARAGINYLCYSTEINE PEPTIDE; DEACETYLVINBLASTINE DERIVATIVE; DESACETYLVINBLASTINE HYDRAZIDE; FOLATE RECEPTOR; FOLIC ACID; NAVELBINE; SULFIDE; UNCLASSIFIED DRUG; VINCA ALKALOID; VINCRISTINE; VINDESINE; VINFLUNINE; VINTAFOLIDE; ANTINEOPLASTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CANCER THERAPY; CELL STRAIN KB; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONJUGATION; ENDOSOME; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; IC 50; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HUMAN; NEOPLASMS, EXPERIMENTAL; NUDE MOUSE; PATHOLOGY; STEREOISOMERISM; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; FOLIC ACID; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR CONFORMATION; NEOPLASMS, EXPERIMENTAL; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VINCA ALKALOIDS;

EID: 84896536541     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc400441s     Document Type: Article

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