High levels of intracellular polyamines promote histone acetyltransferase activity resulting in chromatin hyperacetylation

Journal of Cellular Biochemistry

Volumn 77, Issue 3, 2000, Pages 345-360

  Hobbs, Cheryl A ^a   Gilmour, Susan K ^a  

^a LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Chromatin remodeling; Nucleosome; Ornithine decarboxylase; Transcription; Tumorigenesis

Indexed keywords

HISTONE; HISTONE ACETYLTRANSFERASE; ORNITHINE DECARBOXYLASE; POLYAMINE;

ACETYLATION; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CHROMATIN; CONTROLLED STUDY; DRUG DESIGN; ENZYME ACTIVITY; GENE EXPRESSION; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; NUCLEOSOME; POLYAMINE SYNTHESIS; PRIORITY JOURNAL;

3T3 CELLS; ACETYLATION; ACETYLTRANSFERASES; ANIMALS; CELL CYCLE; CELL LINE; CHROMATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; GENES, REPORTER; HISTONE ACETYLTRANSFERASES; HYDROXAMIC ACIDS; LUCIFERASES; MICE; MODELS, BIOLOGICAL; NUCLEOSOMES; ORNITHINE DECARBOXYLASE; POLYAMINES; PROTEIN ISOFORMS; RETROVIRIDAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION, GENETIC;

ANIMALIA; UNIDENTIFIED RETROVIRUS;

EID: 0034100422     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(20000601)77:3<345::AID-JCB1>3.0.CO;2-P     Document Type: Article

References (67)

1. Ait-Si-Ali S, Ramirez S, Barre FX, Dkhissi F, Magnaghi-Jaulin L, Girault JA, Robin P, Knibiehler M, Pritchard LL, Ducommun B, Trouche D, Harel-Bellan A. 1998. Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A. Nature 396:184-186.
2. Ausio J, van Holde KE. 1986. Histone hyperacetylation: its effects on nucleosome conformation and stability. Biochemistry 25:1421-1428.
3. Auvinen M, Paasinen A, Andersson LC, Holtta E. 1992. Ornithine decarboxylase activity is critical for cell transformation. Nature 360:355-358.
4. Bannister AJ, Kouzarides T. 1996. The CBP co-activator is a histone acetyltransferase. Nature 384:641-643.
5. Braunstein M, Rose AB, Holmes SG, Allis CD, Broach JR. 1993. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev 7:592-604.
6. Brownell JE, Zhou J, Ranalli T, Kobayashi R, Edmondson DG, Roth SY, Allis CD. 1996. Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell 84:843-851.
7. Bryans M, Harley E, Gilmour SK. 1996. Elevated cellular polyamine levels enhance promoter activity in vivo. Biochem Biophys Res Commun 226:618-625.
8. Candau R, Zhou JX, Allis CD, Berger SL. 1997. Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function in vivo. EMBO J 16:555-565.
9. Casti A, Guarnieri C, Dall'asta R, Clo C. 1977. Effect of spermine on acetylation of histories in rabbit heart. J Mol Cell Cardiol 9:63-71.
10. Celano P, Baylin SB, Casero RA. 1989. Polyamines differentially modulate the transcription of growth-associated genes in human colon carcinoma cells. J Biol Chem 264: 8922-8927.
11. Clifford A, Morgan D, Yuspa SH, Soler AP, Gilmour S. 1995. Role of ornithine decarboxylase in epidermal tumorigenesis. Cancer Res 55:1680-1686.
12. Cohen SC. 1998. A guide to the polyamines. New York: Oxford University Press.
13. Dod B, Kervabon A, Parello J. 1982. Effect of cations on the acetylation of chromatin in vitro. Eur J Biochem 121: 401-405.
14. Dumuis-Kervabon A, Encontre I, Etienne G, Jauregui-Adell J, Mery J, Mesnier D, Parello J. 1986. A chromatin core particle obtained by selective cleavage of histones by clostripain. EMBO J 5:1735-1742.
15. Edmondson DG, Smith MM, Roth SY. 1996. Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4. Genes Dev 10:1247-1259.
16. Estepa I, Pestana A. 1981. Activation by polyamines of the acetylation of endogenous histones in isolated chromatin and nuclei from Artemia. Eur J Biochem 119:431-436.
17. Filhol O, Cochet C, Delagoutte T, Chambaz EM. 1991. Polyamine binding activity of casein kinase II. Biochem Biophys Res Commun 180:945-952.
18. Fredlund JO, Johansson MC, Dahlberg E, Oredsson SM. 1995. Ornithine decarboxylase and S-adenosylmethionine decarboxylase expression during the cell cycle of Chinese hamster ovary cells. Exp Cell Res 216:86-92.
19. Giles RH, Peters DJ, Breuning MH. 1998. Conjunction dysfunction: CBP/p300 in human disease. Trends Genet 14:178-183.
20. Hathaway GM, Traugh JA. 1984. Kinetics of activation of casein kinase II by polyamines and reversal of 2,3-bisphosphoglycerate inhibition. J Biol Chem 259:7011-7015.
21. He LZ, Guidez F, Tribioli C, Peruzzi D, Ruthardt M, Zelent A, Pandolfi PP. 1998. Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL. Nature Genet 18:126-135.
22. Janknecht R, Hunter T. 1996. Transcription. A growing coactivator network. Nature 383:22-23.
23. Jeong S, Stein A. 1994. Micrococcal nuclease digestion of nuclei reveals extended nucleosome ladders having anomalous DNA lengths for chromatin assembled on nonreplicating plasmids in transfected cells. Nucleic Acids Res 22:370-375.
24. Kadosh D, Struhl K. 1998. Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo. Mol Cell Biol 18:5121-5127.
25. Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin SC, Heyman RA, Rose DW, Glass CK, Rosenfeld MG. 1996. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85:403-414.
26. Keaveney M, Struhl K. 1998. Activator-mediated recruitment of the RNA polymerase II machinery is the predominant mechanism for transcriptional activation in yeast. Mol Cell 1:917-924.
27. Koza RA, Megosh LC, Palmieri M, O'Brien TG. 1991. Constitutively elevated levels of ornithine and polyamines in mouse epidermal papillomas. Carcinogenesis 12:1619-1625.
28. Kuo MH, Zhou J, Jambeck P, Churchill ME, Allis CD. 1998. Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo. Genes Dev 12:627-639.
29. Laitinen J, Stenius K, Eloranta TO, Holtta E. 1998. Polyamines may regulate S-phase progression but not the dynamic changes of chromatin during the cell cycle. J Cell Biochem 68:200-212.
30. Lee DY, Hayes JJ, Pruss D, Wolffe AP. 1993. A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell 72:73-84.
31. Libby PR, Bertram JS. 1980. Biphasic effect of polyamines on chromatin-bound histone deacetylase. Arch Biochem Biophys 201:359-361.
32. Lin RJ, Nagy L, Inoue S, Shao W, Miller WH Jr, Evans RM. 1998. Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 391:811-814.
33. Martinez-Balbas MA, Bannister AJ, Martin K, Haus-Seuffert P, Meisterernst M, Kouzarides T. 1998. The acetyltransferase activity of CBP stimulates transcription. EMBO J 17:2886-2893.
34. Mizzen CA, Yang XJ, Kokubo T, Brownell JE, Bannister AJ, Owen-Hughes T, Workman J, Wang L, Berger SL, Kouzarides T, Nakatani Y, Allis CD. 1996. The TAF(II)250 subunit of TFIID has histone acetyltransferase activity. Cell 87:1261-1270.
35. Moshier JA, Dosescu J, Skunca M, Luk GD. 1993. Transformation of NIH/3T3 cells by ornithine decarboxylase overexpression. Cancer Res 53:2618-2622.
36. Moshier JA, Malecka-Panas E, Geng H, Dosescu J, Tureaud J, Skunca M, Majumdar AP. 1995. Ornithine decarboxylase transformation of NIH/3T3 cells is mediated by altered epidermal growth factor receptor activity. Cancer Res 55:5358-5365.
37. Muller S, Erard M, Burggraf E, Couppez M, Sautiere P, Champagne M, Van Regenmortel MH. 1982. Immunochemical detection of changes in chromatin subunits induced by histone H4 acetylation. EMBO J 1:939-944.
38. Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN, Bird A. 1998. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393:386-389.
39. O'Brien TG. 1976. The induction of ornithine decarboxylase as an early, possibly obligatory, event in mouse skin carcinogenesis. Cancer Res 36:2644-2653.
40. O'Brien TG, Simsiman RC, Boutwell RK. 1975. Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents. Cancer Res 35:1662-1670.
41. Ogryzko VV, Schiltz RL, Russanova V, Howard BH, Nakatani Y. 1996. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87:953-959.
42. Pazin MJ, Kadonaga JT. 1997. What's up and down with histone deacetylation and transcription? Cell 89:325-328.
43. Pegg AE. 1986. Recent advances in the biochemistry of polyamines in eukaryotes. Biochem J 234:249-262.
44. Peralta Soler A, Gilliard G, Megosh L, George K, O'Brien TG. 1998. Polyamines regulate expression of the neoplastic phenotype in mouse skin. Cancer Res 58:1654-1659.
45. Pohjanpelto P, Knuutila S. 1982. Polyamine deprivation causes major chromosome aberrations in a polyamine-dependent Chinese hamster ovary cell line. Exp Cell Res 141:333-339.
46. Pollard KJ, Samuels ML, Crowley KA, Hansen JC, Peterson CL. 1999. Functional interaction between GCN5 and polyamines: a new role for core histone acetylation. EMBO J 18:5622-5633.
47. Richon VM, Emiliani S, Verdin E, Webb Y, Breslow R, Rifkind RA, Marks PA. 1998. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci USA 95:3003-3007.
48. Roth SY. 1996. Something about silencing. Nature Genet 14:3-4.
49. Rundlett SE, Carmen AA, Suka N, Turner BM, Grunstein M. 1998. Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3. Nature 392:831-835.
50. Shore LJ, Soler AP, Gilmour SK. 1997. Ornithine decarboxylase expression leads to translocation and activation of protein kinase CK2 in vivo. J Biol Chem 272:12536-12543.
51. Smith MK, Goral MA, Wright JH, Matrisian LM, Morris RJ, Klein-Szanto AJ, Gilmour SK. 1997. Ornithine decarboxylase overexpression leads to increased epithelial tumor invasiveness. Cancer Res 57:2104-2108.
52. Smith MK, Trempus CS, Gilmour SK. 1998. Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin. Carcinogenesis 19:1409-1415.
53. Snyder RD. 1989. Polyamine depletion is associated with altered chromatin structure in HeLa cells. Biochem J 260:697-704.
54. Ha oncogene and form papillomas in skin grafts on athymic nude mouse hosts. Cancer Res 48:165-169.
55. Sunkara PS, Chang CC, Prakash NJ. 1983. Role of polyamines during chromosome condensation of mammalian cells. Cell Biol Int Rep 7:455-465.
56. Tabor CW, Tabor H. 1984. Polyamines. Annu Rev Biochem 53:749-790.
57. Taunton J, Hassig CA, Schreiber SL. 1996. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272:408-411.
58. Vu QA, Zhang DE, Chroneos ZC, Nelson DA. 1987. Polyamines inhibit the yeast histone deacetylase. FEBS Lett 220:79-83.
59. Wade PA, Pruss D, Wolffe AP. 1997. Histone acetylation: chromatin in action. Trends Biochem Sci 22:128-132.
60. Wang J-Y, McCormack SA, Viar MJ, Wang H, Tzen C-Y, Scott RE, Johnson LR. 1993. Decreased expression of protooncogenes c-fos, c-myc, and c-jun following polyamine depletion in IEC-6 cells. Am J Physiol 265:G331-G338.
61. Wang L, Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis CD, Berger SL. 1997. Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation. Mol Cell Biol 17:519-527.
62. Wolffe AP. 1994. Nucleosome positioning and modification: chromatin structures that potentiate transcription. Trends Biochem Sci 19:240-244.
63. Wolffe AP. 1997. Transcriptional control. Sinful repression. Nature 387:16-17.
64. Yaciuk P, Moran E. 1991. Analysis with specific polyclonal antiserum indicates that the E1A-associated 300-kDa product is a stable nuclear phosphoprotein that undergoes cell cycle phase-specific modification. Mol Cell Biol 11:5389-5397.
65. Yang XJ, Ogryzko VV, Nishikawa J, Howard BH, Nakatani Y. 1996. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382: 319-324.
66. Yoshida M, Horinouchi S, Beppu T. 1995. Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. BioEssays 17:423-430.
67. Yuspa SH, Koehler B, Kulesz-Martin M, Hennings H. 1981. Clonal growth of mouse epidermal cells in medium with reduced calcium concentration. J Invest Dermatol 76:144-146.