Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry

Journal of Medicinal Chemistry

Volumn 59, Issue 20, 2016, Pages 9503-9512

  Furukawa, Akihiro ^a,b   Townsend, Chad E ^a   Schwochert, Joshua ^a   Pye, Cameron R ^a   Bednarek, Maria A ^c   Lokey, R Scott ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b DAIICHI SANKYO CO   (Japan)

^c MEDIMMUNE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ATENOLOL; CYCLIC PEPTOMER SCAFFOLD; CYCLOPEPTIDE; FUNCTIONAL GROUP; HEXAPEPTIDE; MULTIDRUG RESISTANCE PROTEIN; PROPRANOLOL; UNCLASSIFIED DRUG; VERAPAMIL; WARFARIN; PEPTIDE LIBRARY;

ARTICLE; CELL MEMBRANE PERMEABILITY; CHEMICAL STRUCTURE; COMPARATIVE STUDY; CONTROLLED STUDY; GEOMETRY; HYDROGEN BOND; LIPOPHILICITY; METHYLATION; MOLECULAR LIBRARY; STEREOCHEMISTRY; CACO-2 CELL LINE; CHEMISTRY; DRUG EFFECTS; HUMAN; PEPTIDE LIBRARY; SYNTHESIS;

CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; HUMANS; HYDROGEN BONDING; MOLECULAR STRUCTURE; PEPTIDE LIBRARY; PEPTIDES, CYCLIC;

EID: 84994009729     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b01246     Document Type: Article

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