Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable

Angewandte Chemie - International Edition

Volumn 53, Issue 45, 2014, Pages 12059-12063

  Nielsen, Daniel S ^a   Hoang, Huy N ^a   Lohman, Rink Jan ^a   Hill, Timothy A ^a   Lucke, Andrew J ^a   Craik, David J ^a   Edmonds, David J ^b   Griffith, David A ^b   Rotter, Charles J ^b   Ruggeri, Roger B ^b   Price, David A ^b   Liras, Spiros ^b   Fairlie, David P ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b PFIZER INC   (United States)

Author keywords

cyclic peptides; NMR; oral bioavailability; permeability

Indexed keywords

ALKYLATION; BIOCHEMISTRY; CHAINS; MECHANICAL PERMEABILITY; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PEPTIDES;

BRANCHED SIDE CHAINS; CYCLIC PEPTIDES; INTRA-MOLECULAR HYDROGEN BONDS; INVESTIGATE EFFECTS; MEMBRANE PERMEABILITY; ORAL BIOAVAILABILITIES; PHYSICOCHEMICAL PROPERTY; TEMPERATURE DEPENDENT;

HYDROGEN BONDS;

CYCLOPEPTIDE; OLIGOPEPTIDE;

AMINO ACID SEQUENCE; BIOAVAILABILITY; CHEMICAL STRUCTURE; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE; ORAL DRUG ADMINISTRATION; PROTEIN CONFORMATION;

ADMINISTRATION, ORAL; AMINO ACID SEQUENCE; BIOLOGICAL AVAILABILITY; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PROTEIN CONFORMATION;

EID: 84911489309     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201405364     Document Type: Article

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