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Volumn 21, Issue 9, 2013, Pages 2623-2634

Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1

(14) Murugan, Ravichandran N a Park, Jung Eun b Lim, Dan c Ahn, Mija a Cheong, Chaejoon a Kwon, Taeho b,d,e Nam, Ky Youb f Choi, Sun Ho b,g Kim, Bo Yeon d Yoon, Do Young e Yaffe, Michael B c Yu, Dae Yeul d Lee, Kyung S b Bang, Jeong Kyu a

a Korea Basic Science Institute (KBSI) (South Korea)

b NATIONAL CANCER INSTITUTE (United States)

c MASSACHUSETTS INSTITUTE OF TECHNOLOGY (United States)

d Korea Research Institute of Bioscience and Biotechnology (KRIBB) (South Korea)

e Konkuk University (South Korea)

f Yonsei University (South Korea)

g Dong A Pharmaceutical Company (South Korea)

Author keywords

Cyclic peptomers; Kinase inhibitors; Polo box domain (PBD); Solid phase peptide synthesis

Indexed keywords

ARGININE; PHENYLALANINE; PL 116; PL 120; POLO LIKE KINASE 1; POLO LIKE KINASE INHIBITOR; PROLINE; PYRROLIDINE DERIVATIVE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CYCLIZATION; DRUG DESIGN; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PEPTIDE SYNTHESIS; PROTEIN DOMAIN; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION;

CELL CYCLE PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDE LIBRARY; PEPTIDES, CYCLIC; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84876113037 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.02.020 Document Type: Article

Times cited : (39)

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