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Volumn 3, Issue 10, 2012, Pages 1282-1289

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance

(16) Rand, Arthur C a Leung, Siegfried S F b Eng, Heather c Rotter, Charles J c Sharma, Raman c Kalgutkar, Amit S c Zhang, Yizhong c Varma, Manthena V c Farley, Kathleen A c Khunte, Bhagyashree c Limberakis, Chris c Price, David A c Liras, Spiros c Mathiowetz, Alan M c Jacobson, Matthew P b Lokey, R Scott a

a UNIVERSITY OF CALIFORNIA (United States)

b UNIVERSITY OF CALIFORNIA (United States)

c PFIZER INC (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPEPTIDE; CYCLOPEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; COMPUTER MODEL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG CONFORMATION; DRUG DESIGN; DRUG METABOLISM; DRUG PENETRATION; GASTROINTESTINAL TRACT; IN VITRO STUDY; IN VIVO STUDY; IONIZATION; NONHUMAN; PHARMACOKINETICS; PHYSICAL CHEMISTRY; PREDICTION; PRIORITY JOURNAL; RAT;

RATTUS;

EID: 84867025688 PISSN: 20402503 EISSN: 20402511 Source Type: Journal
DOI: 10.1039/c2md20203d Document Type: Article

Times cited : (117)

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