Flexibility versus Rigidity for Orally Bioavailable Cyclic Hexapeptides

ChemBioChem

Volumn 16, Issue 16, 2015, Pages 2289-2293

  Nielsen, Daniel S ^a   Lohman, Rink Jan ^a   Hoang, Huy N ^a   Hill, Timothy A ^a   Jones, Alun ^a   Lucke, Andrew J ^a   Fairlie, David P ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

cyclic peptides; NMR spectroscopy; oral bioavailability; peptides; permeability

Indexed keywords

CYCLOPEPTIDE; HEXAPEPTIDE; MACROCYCLIC COMPOUND; PROLINE; SOLVENT; AMINO ACID; OLIVE OIL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG CONFORMATION; ENTROPY; HYDROGEN BOND; MALE; MEMBRANE PERMEABILITY; METABOLIC STABILITY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT; SURFACE AREA; VOLUME OF DISTRIBUTION; ANIMAL; BIOAVAILABILITY; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; HALF LIFE TIME; LIVER MICROSOME; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL DRUG ADMINISTRATION; PERMEABILITY; PROTEIN TERTIARY STRUCTURE; WISTAR RAT;

ADMINISTRATION, ORAL; AMINO ACIDS; ANIMALS; BIOLOGICAL AVAILABILITY; CIRCULAR DICHROISM; ENTROPY; HALF-LIFE; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICROSOMES, LIVER; MODELS, MOLECULAR; OLIVE OIL; PEPTIDES, CYCLIC; PERMEABILITY; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, WISTAR; SOLVENTS;

EID: 84945190129     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201500441     Document Type: Article

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