Improving the passive permeability of macrocyclic peptides: Balancing permeability with other physicochemical properties

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 2, 2015, Pages 322-327

  Thansandote, Praew ^a   Harris, Robert M ^a   Dexter, Hannah L ^a   Simpson, Graham L ^a   Pal, Sandeep ^a   Upton, Richard J ^a   Valko, Klara ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Macrocyclic peptides; Medicinal chemistry; Passive permeability; Physicochemical properties; Protein protein interactions; Therapeutic peptides

Indexed keywords

CYCLOPEPTIDE;

ARTICLE; CELL MEMBRANE PERMEABILITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HYDROGEN BOND; LIPOPHILICITY; PASSIVE PERMEABILITY; PHYSICAL CHEMISTRY; PROTEIN CONFORMATION; PROTEIN METHYLATION; PROTEIN SYNTHESIS; SOLUBILITY; CHEMISTRY; METABOLISM; PERMEABILITY; PROTEIN TERTIARY STRUCTURE; STEREOISOMERISM;

HYDROGEN BONDING; PEPTIDES, CYCLIC; PERMEABILITY; PROTEIN STRUCTURE, TERTIARY; SOLUBILITY; STEREOISOMERISM;

EID: 84920272791     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.11.034     Document Type: Article

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