메뉴 건너뛰기




Volumn 26, Issue 4, 2012, Pages 682-692

Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia

Author keywords

connectivity map; HDAC inhibitors; infant ALL; MLL

Indexed keywords

ENTINOSTAT; PANOBINOSTAT; ROMIDEPSIN; TRICHOSTATIN A; TSA; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT; VPA;

EID: 84859633464     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.278     Document Type: Article
Times cited : (64)

References (49)
  • 2
    • 40749150603 scopus 로고    scopus 로고
    • Acute lymphoblastic leukaemia
    • DOI 10.1016/S0140-6736(08)60457-2, PII S0140673608604572
    • Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet 2008; 371: 1030-1043. (Pubitemid 351389536)
    • (2008) The Lancet , vol.371 , Issue.9617 , pp. 1030-1043
    • Pui, C.-H.1    Robison, L.L.2    Look, A.T.3
  • 6
    • 77951749557 scopus 로고    scopus 로고
    • The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4
    • Bursen A, Schwabe K, Ruster B, Henschler R, Ruthardt M, Dingermann T et al. The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4. Blood 2010; 115: 3570-3579.
    • (2010) Blood , vol.115 , pp. 3570-3579
    • Bursen, A.1    Schwabe, K.2    Ruster, B.3    Henschler, R.4    Ruthardt, M.5    Dingermann, T.6
  • 7
    • 1642281239 scopus 로고    scopus 로고
    • Definitive hematopoiesis requires the mixed-lineage leukemia gene
    • DOI 10.1016/S1534-5807(04)00061-9, PII S1534580704000619
    • Ernst P, Fisher JK, Avery W, Wade S, Foy D, Korsmeyer SJ. Definitive hematopoiesis requires the mixed-lineage leukemia gene. Dev Cell 2004; 6: 437-443. (Pubitemid 38364574)
    • (2004) Developmental Cell , vol.6 , Issue.3 , pp. 437-443
    • Ernst, P.1    Fisher, J.K.2    Avery, W.3    Wade, S.4    Foy, D.5    Korsmeyer, S.J.6
  • 8
    • 77957990791 scopus 로고    scopus 로고
    • Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis
    • Gan T, Jude CD, Zaffuto K, Ernst P. Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis. Leukemia 2010; 24: 1732-1741.
    • (2010) Leukemia , vol.24 , pp. 1732-1741
    • Gan, T.1    Jude, C.D.2    Zaffuto, K.3    Ernst, P.4
  • 10
    • 77950966577 scopus 로고    scopus 로고
    • Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants
    • Stam RW, Schneider P, Hagelstein JA, van der Linden MH, Stumpel DJ, de Menezes RX et al. Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants. Blood 2010; 115: 2835-2844.
    • (2010) Blood , vol.115 , pp. 2835-2844
    • Stam, R.W.1    Schneider, P.2    Hagelstein, J.A.3    Van Der Linden, M.H.4    Stumpel, D.J.5    De Menezes, R.X.6
  • 11
    • 33846522525 scopus 로고    scopus 로고
    • The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling
    • DOI 10.1093/hmg/ddl444
    • Bitoun E, Oliver PL, Davies KE. The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. Hum Mol Genet 2007; 16: 92-106. (Pubitemid 46152547)
    • (2007) Human Molecular Genetics , vol.16 , Issue.1 , pp. 92-106
    • Bitoun, E.1    Oliver, P.L.2    Davies, K.E.3
  • 12
    • 76249112147 scopus 로고    scopus 로고
    • Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options
    • Stumpel DJ, Schneider P, van Roon EH, Boer JM, de Lorenzo P, Valsecchi MG et al. Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options. Blood 2009; 114: 5490-5498.
    • (2009) Blood , vol.114 , pp. 5490-5498
    • Stumpel, D.J.1    Schneider, P.2    Van Roon, E.H.3    Boer, J.M.4    De Lorenzo, P.5    Valsecchi, M.G.6
  • 17
    • 0025201303 scopus 로고
    • In vitro drug sensitivity of cells from children with leukemia using the MTT assay with improved culture conditions
    • Pieters R, Loonen AH, Huismans DR, Broekema GJ, Dirven MW, HeyenbrokMW et al. In vitro drug sensitivity of cells from children with leukemia using the MTT assay with improved culture conditions. Blood 1990; 76: 2327-2336.
    • (1990) Blood , vol.76 , pp. 2327-2336
    • Pieters, R.1    Loonen, A.H.2    Huismans, D.R.3    Broekema, G.J.4    Dirven, M.W.5    Heyenbrok, M.W.6
  • 18
    • 0036081355 scopus 로고    scopus 로고
    • Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
    • Edgar R, Domrachev M, Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002; 30: 207-210. (Pubitemid 34679544)
    • (2002) Nucleic Acids Research , vol.30 , Issue.1 , pp. 207-210
    • Edgar, R.1    Domrachev, M.2    Lash, A.E.3
  • 19
    • 33845876254 scopus 로고    scopus 로고
    • The Connectivity Map: A new tool for biomedical research
    • DOI 10.1038/nrc2044, PII NRC2044
    • Lamb J. The Connectivity Map: a new tool for biomedical research. Nat Rev Cancer 2007; 7: 54-60. (Pubitemid 46020847)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.1 , pp. 54-60
    • Lamb, J.1
  • 20
    • 36348965968 scopus 로고    scopus 로고
    • D-HPLC analysis of the entire FLT3 gene in MLL rearranged and hyperdiploid acute lymphoblastic leukemia
    • DOI 10.3324/haematol.11220
    • Stam RW, den Boer ML, Schneider P, Meier M, Beverloo HB, Pieters R. D-HPLC analysis of the entire FLT3 gene in MLL rearranged and hyperdiploid acute lymphoblastic leukemia. Haematologica 2007; 92: 1565-1568. (Pubitemid 350144134)
    • (2007) Haematologica , vol.92 , Issue.11 , pp. 1565-1568
    • Stam, R.W.1    Den, B.M.L.2    Schneider, P.3    Meier, M.4    Beverloo, H.B.5    Pieters, R.6
  • 21
    • 33644872577 scopus 로고    scopus 로고
    • Limma: Linear models for microarray data
    • Gentleman VC SD R, Irizarry R, Huber W (eds). Springer: New York
    • Smyth GK. Limma: linear models for microarray data. In: Gentleman VC SD R, Irizarry R, Huber W (eds). Bioinformatics and Computational Biology Solutions using R and Bioconductor. Springer: New York, 2005, pp 397-420.
    • (2005) Bioinformatics and Computational Biology Solutions Using R and Bioconductor , pp. 397-420
    • Smyth, G.K.1
  • 22
    • 0001677717 scopus 로고
    • Controlling the false discovery rate - A practical and powerful approach to multiple testing
    • Benjamini Y HY. Controlling the false discovery rate - a practical and powerful approach to multiple testing. J Roy Stat Soc B 1995; 57: 289-300.
    • (1995) J Roy Stat Soc B , vol.57 , pp. 289-300
    • Benjamini, Y.H.Y.1
  • 24
    • 77954721993 scopus 로고    scopus 로고
    • Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: Biology and therapeutic targeting
    • Schafer E, Irizarry R, Negi S, McIntyre E, Small D, Figueroa ME et al. Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting. Blood 2010; 115: 4798-4809.
    • (2010) Blood , vol.115 , pp. 4798-4809
    • Schafer, E.1    Irizarry, R.2    Negi, S.3    McIntyre, E.4    Small, D.5    Figueroa, M.E.6
  • 25
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4: 44-57.
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • Huang Da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 26
    • 67650106003 scopus 로고    scopus 로고
    • Infant acute lymphoblastic leukemia: Lessons learned and future directions
    • Pieters R. Infant acute lymphoblastic leukemia: lessons learned and future directions. Curr Hematol Malig Rep 2009; 4: 167-174.
    • (2009) Curr Hematol Malig Rep , vol.4 , pp. 167-174
    • Pieters, R.1
  • 29
    • 29144509530 scopus 로고    scopus 로고
    • Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia
    • Stams WA, den Boer ML, Beverloo HB, Kazemier KM, van Wering ER, Janka-Schaub GE et al. Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia. Haematologica 2005; 90: 1697-1699. (Pubitemid 41814997)
    • (2005) Haematologica , vol.90 , Issue.12 , pp. 1697-1699
    • Stams, W.A.G.1    Den, B.M.L.2    Beverloo, H.B.3    Kazemier, K.M.4    Van Wering, E.R.5    Janka-Schaub, G.E.6    Pieters, R.7
  • 30
    • 43249104204 scopus 로고    scopus 로고
    • Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha
    • DOI 10.1096/fj.06-8050com
    • Kramer OH, Muller S, Buchwald M, Reichardt S, Heinzel T. Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha. FASEB J 2008; 22: 1369-1379. (Pubitemid 351656778)
    • (2008) FASEB Journal , vol.22 , Issue.5 , pp. 1369-1379
    • Kramer, O.H.1    Muller, S.2    Buchwald, M.3    Reichardt, S.4    Heinzel, T.5
  • 31
    • 0029930974 scopus 로고    scopus 로고
    • Infant leukaemia biology, aetiology and treatment
    • Greaves MF. Infant leukaemia biology, aetiology and treatment. Leukemia 1996; 10: 372-377. (Pubitemid 26102900)
    • (1996) Leukemia , vol.10 , Issue.2 , pp. 372-377
    • Greaves, M.F.1
  • 32
  • 33
    • 56749184298 scopus 로고    scopus 로고
    • Reflecting on 25 years with MYC
    • Meyer N, Penn LZ. Reflecting on 25 years with MYC. Nat Rev Cancer 2008; 8: 976-990.
    • (2008) Nat Rev Cancer , vol.8 , pp. 976-990
    • Meyer, N.1    Penn, L.Z.2
  • 35
    • 0037067661 scopus 로고    scopus 로고
    • The oncoprotein set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing
    • DOI 10.1074/jbc.M202256200
    • Cervoni N, Detich N, Seo SB, Chakravarti D, Szyf M. The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing. J Biol Chem 2002; 277: 25026-25031. (Pubitemid 34951806)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.28 , pp. 25026-25031
    • Cervoni, N.1    Detich, N.2    Seo, S.-B.3    Chakravarti, D.4    Szyf, M.5
  • 36
    • 18344372018 scopus 로고    scopus 로고
    • The RUNX genes: Gain or loss of function in cancer
    • DOI 10.1038/nrc1607
    • Blyth K, Cameron ER, Neil JC. The RUNX genes: gain or loss of function in cancer. Nat Rev Cancer 2005; 5: 376-387. (Pubitemid 40637829)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.5 , pp. 376-387
    • Blyth, K.1    Cameron, E.R.2    Neil, J.C.3
  • 37
    • 42949167771 scopus 로고    scopus 로고
    • The GTPase Ran: Regulation of cell life and potential roles in cell transformation
    • DOI 10.2741/2996
    • Rensen WM, Mangiacasale R, Ciciarello M, Lavia P. The GTPase Ran: regulation of cell life and potential roles in cell transformation. Front Biosci 2008; 13: 4097-4121. (Pubitemid 351611596)
    • (2008) Frontiers in Bioscience , vol.13 , Issue.11 , pp. 4097-4121
    • Rensen, W.M.1    Mangiacasale, R.2    Ciciarello, M.3    Lavia, P.4
  • 42
    • 60149100010 scopus 로고    scopus 로고
    • Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter
    • Chen MJ, Yokomizo T, Zeigler BM, Dzierzak E, Speck NA. Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature 2009; 457: 887-891.
    • (2009) Nature , vol.457 , pp. 887-891
    • Chen, M.J.1    Yokomizo, T.2    Zeigler, B.M.3    Dzierzak, E.4    Speck, N.A.5
  • 44
    • 77957564565 scopus 로고    scopus 로고
    • Ubiquitylation of the amino terminus of Myc by SCF(beta-TrCP) antagonizes SCF(Fbw7)-mediated turnover
    • Popov N, Schulein C, Jaenicke LA, Eilers M. Ubiquitylation of the amino terminus of Myc by SCF(beta-TrCP) antagonizes SCF(Fbw7)-mediated turnover. Nat Cell Biol 2010; 12: 973-981.
    • (2010) Nat Cell Biol , vol.12 , pp. 973-981
    • Popov, N.1    Schulein, C.2    Jaenicke, L.A.3    Eilers, M.4
  • 45
    • 0021911976 scopus 로고
    • Cooperation between cellular oncogenes in the transformation of primary rat embryo fibroblasts
    • Parada LF, Land H, Chen A, Morganstern J, Weinberg RA. Cooperation between cellular oncogenes in the transformation of primary rat embryo fibroblasts. Prog Med Virol 1985; 32: 115-128.
    • (1985) Prog Med Virol , vol.32 , pp. 115-128
    • Parada, L.F.1    Land, H.2    Chen, A.3    Morganstern, J.4    Weinberg, R.A.5
  • 47
    • 73949149251 scopus 로고    scopus 로고
    • Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
    • Piekarz RL, Frye R, Turner M, Wright JJ, Allen SL, Kirschbaum MH et al. Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma. J Clin Oncol 2009; 27: 5410-5417.
    • (2009) J Clin Oncol , vol.27 , pp. 5410-5417
    • Piekarz, R.L.1    Frye, R.2    Turner, M.3    Wright, J.J.4    Allen, S.L.5    Kirschbaum, M.H.6
  • 49
    • 79960225817 scopus 로고    scopus 로고
    • MLL-aberrant leukemia: Complete cytogenetic remission following treatment with a histone deacetylase inhibitor (HDACi)
    • Burbury KL, Bishton MJ, Johnstone RW, Dickinson MJ, Szer J, Prince HM. MLL-aberrant leukemia: complete cytogenetic remission following treatment with a histone deacetylase inhibitor (HDACi). Ann Hematol 2010; 90: 847-849.
    • (2010) Ann Hematol , vol.90 , pp. 847-849
    • Burbury, K.L.1    Bishton, M.J.2    Johnstone, R.W.3    Dickinson, M.J.4    Szer, J.5    Prince, H.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.