Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response

Molecular Cell

Volumn 63, Issue 4, 2016, Pages 553-566

  Hourihan, John M ^a,b   Moronetti Mazzeo, Lorenza E ^a,b   Fernández Cárdenas, L Paulette ^a,b   Blackwell, T Keith ^a,b  

^a JOSLIN DIABETES CENTER   (United States)

^b HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENITE SODIUM; CYSTEINE; GLUTATHIONE; HYDROGEN PEROXIDE; MEMBRANE PROTEIN; PARAQUAT; PROTEIN IRE 1; QUIESCIN SULFHYDRYL OXIDASE; REACTIVE OXYGEN METABOLITE; SKN 1 PROTEIN; SYNAPTOPHYSIN; THIOL OXIDASE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; ANTIOXIDANT; CAENORHABDITIS ELEGANS PROTEIN; DNA BINDING PROTEIN; ERN1 PROTEIN, HUMAN; IRE-1 PROTEIN, C ELEGANS; MITOGEN ACTIVATED PROTEIN KINASE P38; NFE2L2 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE; SKN-1 PROTEIN, C ELEGANS; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DISULFIDE BOND; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENE INTERACTION; GENE SILENCING; HEAT STRESS; HUMAN; HUMAN CELL; MAMMAL CELL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; RNA SPLICING; SULFENYLATION; UNFOLDED PROTEIN RESPONSE; ANIMAL; CYTOPLASM; ENDOPLASMIC RETICULUM; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HEP-G2 CELL LINE; LONGEVITY; METABOLISM; MITOCHONDRION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TIME FACTOR;

ANIMALS; ANTIOXIDANTS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CYSTEINE; CYTOPLASM; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; ENDORIBONUCLEASES; HEP G2 CELLS; HUMANS; LONGEVITY; MITOCHONDRIA; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION; UNFOLDED PROTEIN RESPONSE;

EID: 84992727818     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.07.019     Document Type: Article

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