Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments

EMBO Journal

Volumn 34, Issue 18, 2015, Pages 2334-2349

  Kirstein, Janine ^a   Morito, Daisuke ^b   Kakihana, Taichi ^b,e   Sugihara, Munechika ^b   Minnen, Anita ^c,d   Hipp, Mark S ^d   Nussbaum Krammer, Carmen ^c   Kasturi, Prasad ^d   Hartl, F Ulrich ^d   Nagata, Kazuhiro ^b   Morimoto, Richard I ^c  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b KYOTO SANGYO UNIVERSITY   (Japan)

^c NORTHWESTERN UNIVERSITY   (United States)

^d MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^e OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

ageing; ER; proteostasis; redox homeostasis

Indexed keywords

GREEN FLUORESCENT PROTEIN; POLYGLUTAMINE; PROTEASOME; PROTEIN AGGREGATE;

ADULT; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; CELL ORGANELLE; CONTROLLED STUDY; CYTOSOL; DISULFIDE BOND; ENDOPLASMIC RETICULUM; GENETIC CODE; HEAT SHOCK RESPONSE; HELA CELL LINE; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; LIFESPAN; MUSCLE CELL; NERVE CELL; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN HOMEOSTASIS; PROTEIN QUALITY; PROTEIN SYNTHESIS; YOUNG ADULT; ANIMAL; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; PROTEOSTASIS DEFICIENCY;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; ENDOPLASMIC RETICULUM; HUMANS; OXIDATION-REDUCTION; PROTEOSTASIS DEFICIENCIES;

EID: 84941731816     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201591711     Document Type: Article

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