Nox NADPH oxidases and the endoplasmic reticulum

Antioxidants and Redox Signaling

Volumn 20, Issue 17, 2014, Pages 2755-2775

  Laurindo, Francisco R M ^a   Araujo, Thaís L S ^a   Abrahão, Thalita B ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM; DUAL OXIDASE 1; DUAL OXIDASE 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OXIDOREDUCTASE; PROTEIN DISULFIDE ISOMERASE; PROTEIN IRE1; PROTEIN P22; PROTEIN P47; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG;

APOPTOSIS; CALCIUM BINDING; CALCIUM SIGNALING; CALCIUM TRANSPORT; CATALYSIS; CELL COMPARTMENTALIZATION; CELL MIGRATION; CELLULAR DISTRIBUTION; COMPLEX FORMATION; DIMERIZATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME GLYCOSYLATION; ENZYME LOCALIZATION; ENZYME SYNTHESIS; HUMAN; NONHUMAN; PATHOPHYSIOLOGY; PHAGOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SURVIVAL; UNFOLDED PROTEIN RESPONSE; ANIMAL; CLASSIFICATION; ENZYMOLOGY; GENETICS; METABOLISM; OXIDATIVE STRESS; PATHOLOGY;

ANIMALS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HUMANS; NADPH OXIDASE; OXIDATIVE STRESS; PROTEIN FOLDING; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84901008099     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2013.5605     Document Type: Review

References (201)

1. Ago T, Kuroda J, Pain J, Fu C, Li H, and Sadoshima J. Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ Res 106: 1253-1264, 2010
2. Ahamed J, Versteeg HH, Kerver M, Chen VM, Mueller BM, Hogg PJ, and Ruf W. Disulfide isomerization switches tissue factor from coagulation to cell signaling. Proc Natl Acad Sci U S A 103: 13932-13937, 2006
3. Amanso AM, Debbas V, and Laurindo FR. Proteasome inhibition represses unfolded protein response and Nox4, sensitizing vascular cells to endoplasmic reticulum stressinduced death. PLoS One 6: E14591, 2011
4. Ambasta RK, Kumar P, Griendling KK, Schmidt HH, Busse R, and Brandes RP. Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J Biol Chem 279: 45935-45941, 2004
5. Ameziane-El-Hassani R, Morand S, Boucher JL, Frapart YM, Apostolou D, Agnandji D, Gnidehou S, Ohayon R, Noël-Hudson MS, Francon J, Lalaoui K, Virion A, and Dupuy C. Dual oxidase-2 has an intrinsic Ca2 +-dependent H2O2-generating activity. J Biol Chem 280: 30046-30054, 2005
6. Anilkumar N, Jose GS, Sawyer I, Santos CX, Sand C, Brewer AC, Warren D, and Shah AM. A 28-kDa splice variant of NADPH Oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells. Arterioscler Thromb Vasc Biol 33: E104-112, 2013
7. Appenzeller-Herzog C and Ellgaard L. The human PDI family: Versatility packed into a single fold. Biochim Biophys Acta 1783: 535-548, 2008
8. Avezov E, Cross BC, Kaminski Schierle GS, Winters M, Harding HP, Melo EP, Kaminski CF, and Ron D. Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox. J Cell Biol 15: 337-349, 2013
9. Babior BM. NADPH oxidase: An update. Blood 93: 1464-1476, 1999
10. Babior BM. NADPH oxidase. Curr Opin Immunol 16: 42-47, 2004
11. Balaban RS, Nemoto S, and Finkel T. Mitochondria, oxidants, and aging. Cell 120: 483-495, 2005
12. Bedard K, Jaquet V, and Krause KH. NOX5: From basic biology to signaling and disease. Free Radic Biol Med 52: 725-734, 2012
13. Bedard K and Krause KH. The NOX family of ROSgenerating NADPH oxidases: Physiology and pathophysiology. Physiol Rev 87: 245-313, 2007
14. BelAiba RS, Djordjevic T, Petry A, Diemer K, Bonello S, Banfi B, Hess J, Pogrebniak A, Bickel C, and Görlach A. NOX5 variants are functionally active in endothelial cells. Free Radic Biol Med 42: 446-459, 2007
15. Benham AM, van Lith M, Sitia R, and Braakman I. Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum. Philos Trans R Soc Lond B Biol Sci 368: 20110403, 2013
16. Bernales S, McDonald KL, and Walter P. Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol 4: E423, 2006
17. Bertoni A, Giuliano P, Galgani M, Rotoli D, Ulianich L, Adornetto A, Santillo MR, Porcellini A, and Avvedimento VE. Early and late events induced by polyQ-expanded proteins: Identification of a common pathogenic property of polYQ-expanded proteins. J Biol Chem 286: 4727-4741, 2011
18. Bi S, Hong PW, Lee B, and Baum LG. Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry. Proc Natl Acad Sci U S A 108: 10650-10655, 2011
19. Biberstine-Kinkade KJ, DeLeo FR, Epstein RI, LeRoy BA, Nauseef WM, and Dinauer MC. Heme-ligating histidines in flavocytochrome b(558): Identification of specific histidines in gp91(phox). J Biol Chem 276: 31105-31112, 2001
20. Block K, Gorin Y, and Abboud HE. Subcellular localization of Nox4 and regulation in diabetes. Proc Natl Acad Sci U S A 106: 14385-14390, 2009
21. Block K, Gorin Y, Hoover P, Williams P, Chelmicki T, Clark RA, Yoneda T, and Abboud HE. NAD(P)H oxidases regulate HIF-2alpha protein expression. J Biol Chem 282: 8019-8026, 2007
22. Bravo-Sagua R, Rodriguez AE, Kuzmicic J, Gutierrez T, Lopez-Crisosto C, Quiroga C, Diaz-Elizondo J, Chiong M, Gillette TG, Rothermel BA, and Lavandero S. Cell death and survival through the endoplasmic reticulummitochondrial axis. Curr Mol Med 13: 317-329, 2013
23. Brodsky JL. Cleaning up: ER-Associated degradation to the rescue. Cell 151: 1163-1167, 2012
24. Buchberger A, Bukau B, and Sommer T. Protein quality control in the cytosol and the endoplasmic reticulum: Brothers in arms. Mol Cell 40: 238-252, 2010
25. Campbell-Valois FX, Trost M, Chemali M, Dill BD, Laplante A, Duclos S, Sadeghi S, Rondeau C, Morrow IC, Bell C, Gagnon E, Hatsuzawa K, Thibault P, and Desjardins M. Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome. Mol Cell Proteomics 11: M111.016378, 2012
26. Cardoso AR, Chausse B, Da Cunha FM, Luévano-Martí-nez LA, Marazzi TB, Pessoa PS, Queliconi BB, and Kowaltowski AJ. Mitochondrial compartmentalization of redox processes. Free Radic Biol Med 52: 2201-2208, 2012
27. Chen F, Pandey D, Chadli A, Catravas JD, Chen T, and Fulton DJ. Hsp90 regulates NADPH oxidase activity and is necessary for superoxide but not hydrogen peroxide production. Antioxid Redox Signal 14: 2107-2119, 2011
28. Chen K, Craige SE, and Keaney JF. Downstream targets and intracellular compartmentalization in Nox signaling. Antioxid Redox Signal 11: 2467-2480, 2009
29. Chen K, Kirber MT, Xiao H, Yang Y, and Keaney JF. Regulation of ROS signal transduction by NADPH oxidase 4 localization. J Cell Biol 181: 1129-1139, 2008
30. Chen W, Shang WH, Adachi Y, Hirose K, Ferrari DM, and Kamata T. A possible biochemical link between NADPH oxidase (Nox) 1 redox-signalling and ERp72. Biochem J 416: 55-63, 2008
31. Cho J, Furie BC, Coughlin SR, and Furie B. A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. J Clin Invest 118: 1123-1131, 2008
32. Cho J, Kennedy DR, Lin L, Huang M, Merrill-Skoloff G, Furie BC, and Furie B. Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of b3 integrins. Blood 120: 647-655, 2012
33. Cho K, Cho S, Lee SO, Oh C, Kang K, Ryoo J, Lee S, Kang S, and Ahn K. Redox-regulated peptide transfer from the transporter associated with antigen processing to major histocompatibility complex class I molecules by protein disulfide isomerase. Antioxid Redox Signal 15: 621-633, 2011
34. Csala M, Kereszturi E , Mandl J, and Bánhegyi G. The endoplasmic reticulum as the extracellular space inside the cell: Role in protein folding and glycosylation. Antioxid Redox Signal 16: 1100-1108, 2012
35. Cui XL, Chang B, and Myatt L. Expression and distribution of NADPH oxidase isoforms in human myometrium-role in angiotensin II-induced hypertrophy. Biol Reprod 82: 305-312, 2010
36. Dahan I, Issaeva I, Gorzalczany Y, Sigal N, Hirshberg M, and Pick E. Mapping of functional domains in the p22(phox) subunit of flavocytochrome b(559) participating in the assembly of the NADPH oxidase complex by "peptide walking". J Biol Chem 277: 8421-8432, 2002
37. Dahan I, Molshanski-Mor S, and Pick E. Inhibition of NADPH oxidase activation by peptides mapping within the dehydrogenase region of Nox2-A "peptide walking" study. J Leukoc Biol 91: 501-515, 2012
38. Dahan I and Pick E. Strategies for identifying synthetic peptides to act as inhibitors of NADPH oxidases, or "all that you did and did not want to know about Nox inhibitory peptides". Cell Mol Life Sci 69: 2283-2305, 2012
39. De A Paes AM, Veríssimo-Filho S, Guimarães LL, Silva AC, Takiuti JT, Santos CX, Janiszewski M, Laurindo FR, and Lopes LR. Protein disulfide isomerase redox-dependent association with p47(phox): Evidence for an organizer role in leukocyte NADPH oxidase activation. J Leukoc Biol 90: 799-810, 2011
40. Debeurme F, Picciocchi A, Dagher MC, Grunwald D, Beaumel S, Fieschi F, and Stasia MJ. Regulation of NADPH oxidase activity in phagocytes: Relationship between FAD/NADPH binding and oxidase complex assembly. J Biol Chem 285: 33197-33208, 2010
41. DeLeo FR, Burritt JB, Yu L, Jesaitis AJ, Dinauer MC, and Nauseef WM. Processing and maturation of flavocytochrome b558 include incorporation of heme as a prerequisite for heterodimer assembly. J Biol Chem 275: 13986-13993, 2000
42. Deng Q, Harvie EA, and Huttenlocher A. Distinct signalling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury. Cell Microbiol 14: 517-528, 2012
43. Djordjevic T, Pogrebniak A, BelAiba RS, Bonello S, Wotzlaw C, Acker H, Hess J, and Görlach A. The expression of the NADPH oxidase subunit p22phox is regulated by a redox-sensitive pathway in endothelial cells. Free Radic Biol Med 38: 616-630, 2005
44. Doussiere J, Poinas A, Blais C, and Vignais PV. Phenylarsine oxide as an inhibitor of the activation of the neutrophil NADPH oxidase-identification of the beta subunit of the flavocytochrome b component of the NADPH oxidase as a target site for phenylarsine oxide by photoaffinity labeling and photoinactivation. Eur J Biochem 251: 649-658, 1998
45. Drerup MM, Schlücking K, Hashimoto K, Manishankar P, Steinhorst L, Kuchitsu K, and Kudla J. The calcineurin Blike calcium sensors CBL1 and CBL9 together with their interacting protein kinase CIPK26 regulate the arabidopsis NADPH oxidase RBOHF. Mol Plant 6: 559-569, 2013
46. Edens WA, Sharling L, Cheng G, Shapira R, Kinkade JM, Lee T, Edens HA, Tang X, Sullards C, Flaherty DB, Benian GM, and Lambeth JD. Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox. J Cell Biol 154: 879-891, 2001
47. Ejlerskov P, Christensen DP, Beyaie D, Burritt JB, Paclet MH, Gorlach A, van Deurs B, and Vilhardt F. NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophages. J Biol Chem 287: 4835-4852, 2012
48. El Jamali A, Valente AJ, Lechleiter JD, Gamez MJ, Pearson DW, Nauseef WM, and Clark RA. Novel redoxdependent regulation of NOX5 by the tyrosine kinase c-Abl. Free Radic Biol Med 44: 868-881, 2008
49. El-Benna J, Dang PM, and Gougerot-Pocidalo MA. Priming of the neutrophil NADPH oxidase activation: Role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane. Semin Immunopathol 30: 279-289, 2008
50. Essex DW. Redox control of platelet function. Antioxid Redox Signal 11: 1191-1225, 2009
51. Evangelista AM, Thompson MD, Bolotina VM, Tong X, and Cohen RA. Nox4-And Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration. Free Radic Biol Med 53: 2327-2334, 2012
52. Fernandes DC, Bonatto D, and Laurindo FRM. The evolving concepto f oxidative stress. In: Studies on Cardiovascular Disorders, edited by Sauer H, Shah AM, and Laurindo FRM. New York, NY: Humana Press, 2010, pp. 1-41
53. Fernandes DC, Manoel AH, Wosniak J, and Laurindo FR. Protein disulfide isomerase overexpression in vascular smooth muscle cells induces spontaneous preemptive NADPH oxidase activation and Nox1 mRNA expression: Effects of nitrosothiol exposure. Arch Biochem Biophys 484: 197-204, 2009
54. Finegold AA, Shatwell KP, Segal AW, Klausner RD, and Dancis A. Intramembrane bis-heme motif for transmembrane electron transport conserved in a yeast iron reductase and the human NADPH oxidase. J Biol Chem 271: 31021-31024, 1996
55. Garcia RC and Segal AW. Changes in the subcellular distribution of the cytochrome b-245 on stimulation of human neutrophils. Biochem J 219: 233-242, 1984
56. Gilbert J, Ou W, Silver J, and Benjamin T. Downregulation of protein disulfide isomerase inhibits infection by the mouse polyomavirus. J Virol 80: 10868-10870, 2006
57. Goyal P, Weissmann N, Rose F, Grimminger F, Schäfers HJ, Seeger W, and Hänze J. Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells. Biochem Biophys Res Commun 329: 32-39, 2005
58. Grasberger H, De Deken X, Miot F, Pohlenz J, and Refetoff S. Missense mutations of dual oxidase 2 (DUOX2) implicated in congenital hypothyroidism have impaired trafficking in cells reconstituted with DUOX2 maturation factor. Mol Endocrinol 21: 1408-1421, 2007
59. Griendling KK, Sorescu D, and Ushio-Fukai M. NAD(P)H oxidase: Role in cardiovascular biology and disease. Circ Res 86: 494-501, 2000
60. Gu F, Nguyên DT, Stuible M, Dubé N, Tremblay ML, and Chevet E. Protein-Tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress. J Biol Chem 279: 49689-49693, 2004
61. Gu MX, Fu Y, Sun XL, Ding YZ, Li CH, Pang W, Pan S, and Zhu Y. Proteomic analysis of endothelial lipid rafts reveals a novel role of statins in antioxidation. J Proteome Res 11: 2365-2373, 2012
62. Hahn NE, Meischl C, Kawahara T, Musters RJ, Verhoef VM, van Der Velden J, Vonk AB, Paulus WJ, van Rossum AC, Niessen HW, and Krijnen PA. NOX5 expression is increased in intramyocardial blood vessels and cardiomyocytes after acute myocardial infarction in humans. Am J Pathol 180: 2222-2229, 2012
63. Han CH, Nisimoto Y, Lee SH, Kim ET, and Lambeth JD. Characterization of the flavoprotein domain of gp91phox which has NADPH diaphorase activity. J Biochem 129: 513-520, 2001
64. Han CY, Umemoto T, Omer M, Den Hartigh LJ, Chiba T, LeBoeuf R, Buller CL, Sweet IR, Pennathur S, Abel ED, and Chait A. NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes. J Biol Chem 287: 10379-10393, 2012
65. Harper AM, Chaplin MF, and Segal AW. Cytochrome b-245 from human neutrophils is a glycoprotein. Biochem J 227: 783-788, 1985
66. Harrison CB, Selemidis S, Guida E, King PT, Sobey CG, and Drummond GR. NOX2b: A novel splice variant of NOX2 that regulates NADPH oxidase activity in macrophages. PLoS One 7: E48326, 2012
67. Hashida S, Yuzawa S, Suzuki NN, Fujioka Y, Takikawa T, Sumimoto H, Inagaki F, and Fujii H. Binding of FAD to cytochrome b558 is facilitated during activation of the phagocyte NADPH oxidase, leading to superoxide production. J Biol Chem 279: 26378-26386, 2004
68. Hatahet F and Ruddock LW. Substrate recognition by the protein disulfide isomerases. FEBS J 274: 5223-5234, 2007
69. Hatahet F and Ruddock LW. Protein disulfide isomerase: A critical evaluation of its function in disulfide bond formation. Antioxid Redox Signal 11: 2807-2850, 2009
70. Hayee B, Antonopoulos A, Murphy EJ, Rahman FZ, Sewell G, Smith BN, McCartney S, Furman M, Hall G, Bloom SL, Haslam SM, Morris HR, Boztug K, Klein C, Winchester B, Pick E, Linch DC, Gale RE, Smith AM, Dell A, and Segal AW. G6PC3 mutations are associated with a major defect of glycosylation: A novel mechanism for neutrophil dysfunction. Glycobiology 21: 914-924, 2011
71. Helmcke I, Heumüller S, Tikkanen R, Schröder K, and Brandes RP. Identification of structural elements in Nox1 and Nox4 controlling localization and activity. Antioxid Redox Signal 11: 1279-1287, 2009
72. Henderson B and Pockley AG. Proteotoxic stress and circulating cell stress proteins in the cardiovascular diseases. Cell Stress Chaperones 17: 303-311, 2012
73. Henderson LM, Banting G, and Chappell JB. The arachidonate-Activable, NADPH oxidase-Associated H+ channel. Evidence that gp91-phox functions as an essential part of the channel. J Biol Chem 270: 5909-5916, 1995
74. Hernández-Oñate MA, Esquivel-Naranjo EU, Mendoza-Mendoza A, Stewart A, and Herrera-Estrella AH. An injury-response mechanism conserved across kingdoms determines entry of the fungus Trichoderma atroviride into development. Proc Natl Acad Sci U S A 109: 14918-14923, 2012
75. Hilenski LL, Clempus RE, Quinn MT, Lambeth JD, and Griendling KK. Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 24: 677-683, 2004
76. Hong J, Resnick M, Behar J, Wands J, DeLellis RA, and Cao W. Role of Rac1 in regulation of NOX5-S function in Barrett's esophageal adenocarcinoma cells. Am J Physiol Cell Physiol 301: C413-C420, 2011
77. Hu Q, Yu ZX, Ferrans VJ, Takeda K, Irani K, and Ziegelstein RC. Critical role of NADPH oxidase-derived reactive oxygen species in generating Ca2 + oscillations in human aortic endothelial cells stimulated by histamine. J Biol Chem 277: 32546-32551, 2002
78. Huang YF, Liu SY, Yen CL, Yang PW, and Shieh CC. Thapsigargin and flavin adenine dinucleotide ex vivo treatment rescues trafficking-defective gp91phox in chronic granulomatous disease leukocytes. Free Radic Biol Med 47: 932-940, 2009
79. Imaoka S. Chemical stress on protein disulfide isomerases and inhibition of their functions. Int Rev Cell Mol Biol 290: 121-166, 2011
80. Inanami O, Johnson JL, and Babior BM. The leukocyte NADPH oxidase subunit p47PHOX: The role of the cysteine residues. Arch Biochem Biophys 350: 36-40, 1998
81. Jackson HM, Kawahara T, Nisimoto Y, Smith SM, and Lambeth JD. Nox4 B-loop creates an interface between the transmembrane and dehydrogenase domains. J Biol Chem 285: 10281-10290, 2010
82. Jagnandan D, Church JE, Banfi B, Stuehr DJ, Marrero MB, and Fulton DJ. Novel mechanism of activation of NADPH oxidase 5. calcium sensitization via phosphorylation. J Biol Chem 282: 6494-6507, 2007
83. Janiszewski M, Lopes LR, Carmo AO, Pedro MA, Brandes RP, Santos CX, and Laurindo FR. Regulation of NAD(P)H oxidase by associated protein disulfide isomerase in vascular smooth muscle cells. J Biol Chem 280: 40813-40819, 2005
84. Jaronen M, Vehviläinen P, Malm T, Keksa-Goldsteine V, Pollari E, Valonen P, Koistinaho J, and Goldsteins G. Protein disulfide isomerase in ALS mouse glia links protein misfolding with NADPH oxidase-catalyzed superoxide production. Hum Mol Genet 22: 646-655, 2013
85. Jasuja R, Passam FH, Kennedy DR, Kim SH, van Hessem L, Lin L, Bowley SR, Joshi SS, Dilks JR, Furie B, Furie BC, and Flaumenhaft R. Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents. J Clin Invest 122: 2104-2113, 2012
86. Jessop CE, Watkins RH, Simmons JJ, Tasab M, and Bulleid NJ. Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins. J Cell Sci 122: 4287-4295, 2009
87. Jordan PA and Gibbins JM. Extracellular disulfide exchange and the regulation of cellular function. Antioxid Redox Signal 8: 312-324, 2006
88. Karlsson A and Dahlgren C. Assembly and activation of the neutrophil NADPH oxidase in granule membranes. Antioxid Redox Signal 4: 49-60, 2002
89. Kawahara T, Jackson HM, Smith SM, Simpson PD, and Lambeth JD. Nox5 forms a functional oligomer mediated by self-Association of its dehydrogenase domain. Biochemistry 50: 2013-2025, 2011
90. Kawahara T and Lambeth JD. Phosphatidylinositol (4,5)-bisphosphate modulates Nox5 localization via an N-Terminal polybasic region. Mol Biol Cell 19: 4020-4031, 2008
91. Kawahara T, Quinn MT, and Lambeth JD. Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes. BMC Evol Biol 7: 109, 2007
92. Klappa P, Ruddock LW, Darby NJ, and Freedman RB. The b¢ domain provides the principal peptide-binding site of protein disulfide isomerase but all domains contribute to binding of misfolded proteins. EMBO J 17: 927-935, 1998
93. Kovacic HN, Irani K, and Goldschmidt-Clermont PJ. Redox regulation of human Rac1 stability by the proteasome in human aortic endothelial cells. J Biol Chem 276: 45856-45861, 2001
94. Kuroda J, Ago T, Matsushima S, Zhai P, Schneider MD, and Sadoshima J. NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proc Natl Acad Sci U S A 107: 15565-15570, 2010
95. Kuroda J, Nakagawa K, Yamasaki T, Nakamura K, Takeya R, Kuribayashi F, Imajoh-Ohmi S, Igarashi K, Shibata Y, Sueishi K, and Sumimoto H. The superoxideproducing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells. Genes Cells 10: 1139-1151, 2005
96. Lara-Ortíz T, Riveros-Rosas H, and Aguirre J. Reactive oxygen species generated by microbial NADPH oxidase NoxA regulate sexual development in Aspergillus nidulans. Mol Microbiol 50: 1241-1255, 2003
97. Lassègue B and Griendling KK. NADPH oxidases: Functions and pathologies in the vasculature. Arterioscler Thromb Vasc Biol 30: 653-661, 2010
98. Lassègue B, San Martín A, and Griendling KK. Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system. Circ Res 110: 1364-1390, 2012
99. Laurindo FR, Fernandes DC, Amanso AM, Lopes LR, and Santos CX. Novel role of protein disulfide isomerase in the regulation of NADPH oxidase activity: Pathophysiological implications in vascular diseases. Antioxid Redox Signal 10: 1101-1113, 2008
100. Laurindo FR, Pescatore LA, and Fernandes Dde C. Protein disulfide isomerase in redox cell signaling and homeostasis. Free Radic Biol Med 52: 1954-1969, 2012
101. Lee CF, Qiao M, Schröder K, Zhao Q, and Asmis R. Nox4 is a novel inducible source of reactive oxygen species in monocytes and macrophages and mediates oxidized low density lipoprotein-induced macrophage death. Circ Res 106: 1489-1497, 2010
102. Lee M, Spokes KC, Aird WC, and Abid MR. Intracellular Ca2 + can compensate for the lack of NADPH oxidasederived ROS in endothelial cells. FEBS Lett 16: 3131-3136, 2010
103. Li G, Scull C, Ozcan L, and Tabas I. NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis. J Cell Biol 191: 1113-1125, 2010
104. Li JM and Shah AM. Intracellular localization and preassembly of the NADPH oxidase complex in cultured endothelial cells. J Biol Chem 277: 19952-19960, 2002
105. Li J, Zhu H, Shen E, Wan L, Arnold JM, and Peng T. Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes. Diabetes 59: 2033-2042, 2010
106. Liao X, Sluimer JC, Wang Y, Subramanian M, Brown K, Pattison JS, Robbins J, Martinez J, and Tabas I. Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell Metab 15: 545-553, 2012
107. Liberman M, Johnson RC, Handy DE, Loscalzo J, and Leopold JA. Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification. Biochem Biophys Res Commun 413: 436-441, 2011
108. Lin SJ, Huang YF, Chen JY, Heyworth PG, Noack D, Wang JY, Lin CY, Chiang BL, Yang CM, Liu CC, and Shieh CC. Molecular quality control machinery contributes to the leukocyte NADPH oxidase deficiency in chronic granulomatous disease. Biochim Biophys Acta 1586: 275-286, 2002
109. Lob HE, Schultz D, Marvar PJ, Davisson RL, and Harrison DG. Role of the NADPH oxidases in the subfornical organ in angiotensin II-induced hypertension. Hypertension 61: 382-387, 2013
110. Loughlin DT and Artlett CM. Precursor of advanced glycation end products mediates ER-stress-induced caspase-3 activation of human dermal fibroblasts through NAD(P)H oxidase 4. PLoS One 5: E11093, 2010
111. Lyle AN, Deshpande NN, Taniyama Y, Seidel-Rogol B, Pounkova L, Du P, Papaharalambus C, Lassègue B, and Griendling KK. Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells. Circ Res 105: 249-259, 2009
112. Malhotra JD, Miao H, Zhang K, Wolfson A, Pennathur S, Pipe SW, and Kaufman RJ. Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proc Natl Acad Sci U S A 105: 18525-18530, 2008
113. Mandel R, Ryser HJ, Ghani F, Wu M, and Peak D. Inhibition of a reductive function of the plasma membrane by bacitracin and antibodies against protein disulfideisomerase. Proc Natl Acad Sci U S A 90: 4112-4116, 1993
114. Marciniak SJ and Ron D. Endoplasmic reticulum stress signaling in disease. Physiol Rev 86: 1133-1149, 2006
115. Markovic I, Stantchev TS, Fields KH, Tiffany LJ, Tomiç M, Weiss CD, Broder CC, Strebel K, and Clouse KA. Thiol/disulfide exchange is a prerequisite for CXCR4-Tropic HIV-1 envelope-mediated T-cell fusion during viral entry. Blood 103: 1586-1594, 2004
116. Martyn KD, Frederick LM, von Loehneysen K, Dinauer MC, and Knaus UG. Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal 18: 69-82, 2006
117. Matsushima S, Kuroda J, Ago T, Zhai P, Park JY, Xie LH, Tian B, and Sadoshima J. Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy. Circ Res 112: 651-663, 2013
118. Mehmeti I, Lortz S, and Lenzen S. The H2O2-sensitive HyPer protein targeted to the endoplasmic reticulum as a mirror of the oxidizing thiol-disulfide milieu. Free Radic Biol Med 53: 1451-1458, 2012
119. Merksamer PI, Trusina A, and Papa FR. Real-Time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Cell 135: 933-947, 2008
120. Mitchell L, Hobbs GA, Aghajanian A, and Campbell SL. Redox regulation of Ras and Rho GTPases: Mechanism and function. Antioxid Redox Signal 18: 250-258, 2013
121. Morand S, Agnandji D, Noel-Hudson MS, Nicolas V, Buisson S, and Macon-Lemaitre L, Gnidehou S, Kaniewski J, Ohayon R, Virion A, and Dupuy C. Targeting of the dual oxidase 2 N-Terminal region to the plasma membrane. J Biol Chem 279: 30244-30251, 2004
122. Muller C, Bandemer J, Vindis C, Camaré C, Mucher E, Guéraud F, Larroque-Cardoso P, Bernis C, Auge N, Salvayre R, and Negre-Salvayre A. Protein disulfide isomerase modification and inhibition contribute to ER stress and apoptosis induced by oxidized low density lipoproteins. Antioxid Redox Signal 18: 731-742, 2013
123. Nguyen MV, Zhang L, Lhomme S, Mouz N, Lenormand JL, Lardy B, and Morel F. Recombinant Nox4 cytosolic domain produced by a cell or cell-free base systems exhibits constitutive diaphorase activity. Biochem Biophys Res Commun 419: 453-458, 2012
124. Nguyen VD, Saaranen MJ, Karala AR, Lappi AK, Wang L, Raykhel IB, Alanen HI, Salo KE, Wang CC, and Ruddock LW. Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation. J Mol Biol 406: 503-515, 2011
125. Niethammer P, Grabher C, Look AT, and Mitchison TJ. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature 459: 996-999, 2009
126. Nisimoto Y, Jackson HM, Ogawa H, Kawahara T, and Lambeth JD. Constitutive NADPH-dependent electron transferase activity of the Nox4 dehydrogenase domain. Biochemistry 49: 2433-2442, 2010
127. O'Leary DP, Bhatt L, Woolley JF, Gough DR, Wang JH, Cotter TG, and Redmond HP. TLR-4 signalling accelerates colon cancer cell adhesion via NF-jB mediated transcriptional up-regulation of Nox-1. PLoS One 7: E44176, 2012
128. Oakley FD, Abbott D, Li Q, and Engelhardt JF. Signaling components of redox active endosomes: The redoxosomes. Antioxid Redox Signal 11: 1313-1333, 2009
129. Parkos CA, Allen RA, Cochrane CG, and Jesaitis AJ. Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000. J Clin Invest 80: 732-742, 1987
130. Pedruzzi E, Guichard C, Ollivier V, Driss F, Fay M, Prunet C, Marie JC, Pouzet C, Samadi M, Elbim C, O'dowd Y, Bens M, Vandewalle A, Gougerot-Pocidalo MA, Lizard G, and Ogier-Denis E. NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells. Mol Cell Biol 24: 10703-10717, 2004
131. Pescatore LA, Bonatto D, Forti FL, Sadok A, Kovacic H, and Laurindo FR. Protein disulfide isomerase is required for platelet-derived growth factor-induced vascular smooth muscle cell migration, Nox1 NADPH oxidase expression, and RhoGTPase activation. J Biol Chem 287: 29290-29300, 2012
132. Piccirella S, Czegle I, Lizák B, Margittai E, Senesi S, Papp E, Csala M, Fulceri R, Csermely P, Mandl J, Benedetti A, and Bánhegyi G. Uncoupled redox systems in the lumen of the endoplasmic reticulum. Pyridine nucleotides stay reduced in an oxidative environment. J Biol Chem 281: 4671-4677, 2006
133. Popescu NI, Lupu C, and Lupu F. Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure. Blood 116: 993-1001, 2010
134. Porter CD, Parkar MH, Verhoeven AJ, Levinsky RJ, Collins MK, and Kinnon C. p22-phox-deficient chronic granulomatous disease: Reconstitution by retrovirus-mediated expression and identification of a biosynthetic intermediate of gp91-phox. Blood 84: 2767-2775, 1994
135. Prosser BL, Khairallah RJ, Ziman AP, Ward CW, and Lederer WJ. X-ROS signaling in the heart and skeletal muscle: Stretch-dependent local ROS regulates [Ca(2 + )](i). J Mol Cell Cardiol 58: 172-181, 2013
136. Prosser BL, Ward CW, and Lederer WJ. X-ROS signaling: Rapid mechano-chemo transduction in heart. Science 333: 1440-1445, 2011
137. Quinn MT, Mullen ML, and Jesaitis AJ. Human neutrophil cytochrome b contains multiple hemes. Evidence for heme associated with both subunits. J Biol Chem 267: 7303-7309, 1992
138. Razzell W, Evans IR, Martin P, and Wood W. Calcium flashes orchestrate the wound inflammatory response through DUOX activation and hydrogen peroxide release. Curr Biol 23: 424-429, 2013
139. Reinhardt C, von Brühl ML, Manukyan D, Grahl L, Lorenz M, Altmann B, Dlugai S, Hess S, Konrad I, Orschiedt L, Mackman N, Ruddock L, Massberg S, and Engelmann B. Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation. J Clin Invest 118: 1110-1122, 2008
140. Rinnerthaler M, Büttner S, Laun P, Heeren G, Felder TK, Klinger H, Weinberger M, Stolze K, Grousl T, Hasek J, Benada O, Frydlova I, Klocker A, Simon-Nobbe B, Jansko B, Breitenbach-Koller H, Eisenberg T, Gourlay CW, Madeo F, Burhans W, and Breitenbach M. Yno1p/ Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast. Proc Natl Acad Sci U S A 109: 8658-8663, 2012
141. Ron D and Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8: 519-529, 2007
142. Rotrosen D, Yeung CL, Leto TL, Malech HL, and Kwong CH. Cytochrome b558: The flavin-binding component of the phagocyte NADPH oxidase. Science 256: 1459-1462, 1992
143. Roy A and Kolattukudy PE. Monocyte chemotactic protein-induced protein (MCPIP) promotes inflammatory angiogenesis via sequential induction of oxidative stress, endoplasmic reticulum stress and autophagy. Cell Signal 24: 2123-2131, 2012
144. Rutkevich LA, Cohen-Doyle MF, Brockmeier U, and Williams DB. Functional relationship between protein disulfide isomerase family members during the oxidative folding of human secretory proteins. Mol Biol Cell 21: 3093-3105, 2010
145. Rutkowski DT and Kaufman RJ. That which does not kill me makes me stronger: Adapting to chronic ER stress. Trends Biochem Sci 32: 469-476, 2007
146. Santos CX, Stolf BS, Takemoto PV, Amanso AM, Lopes LR, Souza EB, Goto H, and Laurindo FR. Protein disulfide isomerase (PDI) associates with NADPH oxidase and is required for phagocytosis of Leishmania chagasi promastigotes by macrophages. J Leukoc Biol 86: 989-998, 2009
147. Santos CX, Tanaka LY, Wosniak J, and Laurindo FR. Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: Roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase. Antioxid Redox Signal 11: 2409-2427, 2009
148. Segal AW, West I, Wientjes F, Nugent JH, Chavan AJ, Haley B, Garcia RC, Rosen H, and Scrace G. Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes. Biochem J 284 (Pt 3): 781-788, 1992
149. Serrander L, Cartier L, Bedard K, Banfi B, Lardy B, Plastre O, Sienkiewicz A, Fórró L, Schlegel W, and Krause KH. NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation. Biochem J 406: 105-114, 2007
150. Serrander L, Jaquet V, Bedard K, Plastre O, Hartley O, Arnaudeau S, Demaurex N, Schlegel W, and Krause KH. NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation. Biochimie 89: 1159-1167, 2007
151. Sharma M, Urano F, and Jaeschke A. Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes. J Hepatol 56: 192-198, 2012
152. Sitia R and Braakman I. Quality control in the endoplasmic reticulum protein factory. Nature 426: 891-894, 2003
153. Spencer NY, Yan Z, Boudreau RL, Zhang Y, Luo M, Li Q, Tian X, Shah AM, Davisson RL, Davidson B, Banfi B, and Engelhardt JF. Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4. J Biol Chem 286: 8977-8987, 2011
154. Stolf BS, Smyrnias I, Lopes LR, Vendramin A, Goto H, Laurindo FR, Shah AM, and Santos CX. Protein disulfide isomerase and host-pathogen interaction. ScientificWorldJournal 11: 1749-1761, 2011
155. Sturrock A, Huecksteadt TP, Norman K, Sanders K, Murphy TM, Chitano P, Wilson K, Hoidal JR, and Kennedy TP. Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 292: L1543-L1555, 2007
156. Sun QA, Hess DT, Nogueira L, Yong S, Bowles DE, Eu J, Laurita KR, Meissner G, and Stamler JS. Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2 + release channel by NADPH oxidase 4. Proc Natl Acad Sci U S A 108: 16098-16103, 2011
157. Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, Gao Z, He BJ, Luczak ED, Joiner ML, Kutschke W, Yang J, Donahue JK, Weiss RM, Grumbach IM, Ogawa M, Chen PS, Efimov I, Dobrev D, Mohler PJ, Hund TJ, and Anderson ME. Oxidized CaMKII causes cardiac sinus node dysfunction in mice. J Clin Invest 121: 3277-3288, 2011
158. Tabas I and Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol 13: 184-190, 2011
159. Taillé C, El-Benna J, Lanone S, Dang MC, Ogier-Denis E, Aubier M, and Boczkowski J. Induction of heme oxygenase-1 inhibits NAD(P)H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability. J Biol Chem 279: 28681-28688, 2004
160. Takac I, Schröder K, Zhang L, Lardy B, Anilkumar N, Lambeth JD, Shah AM, Morel F, and Brandes RP. The Eloop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4. J Biol Chem 286: 13304-13313, 2011
161. Tavender TJ and Bulleid NJ. Molecular mechanisms regulating oxidative activity of the Ero1 family in the endoplasmic reticulum. Antioxid Redox Signal 13: 1177-1187, 2010
162. Tominaga K, Kawahara T, Sano T, Toida K, Kuwano Y, Sasaki H, Kawai T, Teshima-Kondo S, and Rokutan K. Evidence for cancer-Associated expression of NADPH oxidase 1 (Nox1)-based oxidase system in the human stomach. Free Radic Biol Med 43: 1627-1638, 2007
163. Tong X, Hou X, Jourd'heuil D, Weisbrod RM, and Cohen RA. Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat. Circ Res 107: 975-983, 2010
164. Touyz RM, Yao G, Quinn MT, Pagano PJ, and Schiffrin EL. p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: Role in NAD(P)H oxidase regulation by angiotensin II. Arterioscler Thromb Vasc Biol 25: 512-518, 2005
165. Tudzynski P, Heller J, and Siegmund U. Reactive oxygen species generation in fungal development and pathogenesis. Curr Opin Microbiol 15: 653-659, 2012
166. Turano C, Coppari S, Altieri F, and Ferraro A. Proteins of the PDI family: Unpredicted non-ER locations and functions. J Cell Physiol 193: 154-163, 2002
167. Uehara T, Nakamura T, Yao D, Shi ZQ, Gu Z, Ma Y, Masliah E, Nomura Y, and Lipton SA. S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature 441: 513-517, 2006
168. Ullevig S, Zhao Q, Lee CF, Seok Kim H, Zamora D, and Asmis R. NADPH oxidase 4 mediates monocyte priming and accelerated chemotaxis induced by metabolic stress. Arterioscler Thromb Vasc Biol 32: 415-426, 2012
169. Ushio-Fukai M. Compartmentalization of redox signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal 11: 1289-1299, 2009
170. Van Buul JD, Fernandez-Borja M, Anthony EC, and Hordijk PL. Expression and localization of NOX2 and NOX4 in primary human endothelial cells. Antioxid Redox Signal 7: 308-317, 2005
171. Versteeg HH and Ruf W. Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity. J Biol Chem 282: 25416-25424, 2007
172. Vilhardt F and van Deurs B. The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assembly. EMBO J 23: 739-748, 2004
173. Wan SW, Lin CF, Lu YT, Lei HY, and erson R, and Lin YS. Endothelial cell surface expression of protein disulfide isomerase activates b1 and b3 integrins and facilitates dengue virus infection. J Cell Biochem 113: 1681-1691, 2012
174. Wang C, Li W, Ren J, Fang J, Ke H, Gong W, Feng W, and Wang CC. Structural insights into the redox-regulated dynamic conformations of human protein disulfide isomerase. Antioxid Redox Signal 19: 36-45, 2013
175. Wang C, Yu J, Huo L, Wang L, Feng W, and Wang CC. Human protein-disulfide isomerase is a redox-regulated chaperone activated by oxidation of domain a¢. J Biol Chem 287: 1139-1149, 2012
176. Wang D, De Deken X, Milenkovic M, Song Y, Pirson I, Dumont JE, and Miot F. Identification of a novel partner of duox: EFP1, a thioredoxin-related protein. J Biol Chem 280: 3096-3103, 2005
177. Weyemi U, Lagente-Chevallier O, Boufraqech M, Prenois F, Courtin F, Caillou B, Talbot M, Dardalhon M, Al Ghuzlan A, Bidart JM, Schlumberger M, and Dupuy C. ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence. Oncogene 31: 1117-1129, 2012
178. Wilkinson B and Gilbert HF. Protein disulfide isomerase. Biochim Biophys Acta 1699: 35-44, 2004
179. Willems SH, Tape CJ, Stanley PL, Taylor NA, Mills IG, Neal DE, McCafferty J, and Murphy G. Thiol isomerases negatively regulate the cellular shedding activity of ADAM17. Biochem J 428: 439-450, 2010
180. Winterbourn CC. Reconciling the chemistry and biology of reactive oxygen species. Nat Chem Biol 4: 278-286, 2008
181. Woolley JF, Naughton R, Stanicka J, Gough DR, Bhatt L, Dickinson BC, Chang CJ, and Cotter TG. H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling. PLoS One 7: E34050, 2012
182. Wu J and Kaufman RJ. From acute ER stress to physiological roles of the unfolded protein response. Cell Death Differ 13: 374-384, 2006
183. Wu RF, Ma Z, Liu Z, and Terada LS. Nox4-derived H2O2 mediates endoplasmic reticulum signaling through local Ras activation. Mol Cell Biol 30: 3553-3568, 2010
184. Wu RF and Terada LS. Focal oxidant and Ras signaling on the ER surface activates autophagy. Autophagy 6: 828-829, 2010
185. Xu X, Liu T, Zhang A, Huo X, Luo Q, Chen Z, Yu L, Li Q, Liu L, Lun ZR, and Shen J. Reactive oxygen speciestriggered trophoblast apoptosis is initiated by endoplasmic reticulum stress via activation of caspase-12, CHOP, and the JNK pathway in Toxoplasma gondii infection in mice. Infect Immun 80: 2121-2132, 2012
186. Yoo SK, Freisinger CM, LeBert DC, and Huttenlocher A. Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish. J Cell Biol 199: 225-234, 2012
187. Yoo SK, Starnes TW, Deng Q, and Huttenlocher A. Lyn is a redox sensor that mediates leukocyte wound attraction in vivo. Nature 480: 109-112, 2011
188. Yoshida LS, Saruta F, Yoshikawa K, Tatsuzawa O, and Tsunawaki S. Mutation at histidine 338 of gp91(phox) depletes FAD and affects expression of cytochrome b558 of the human NADPH oxidase. J Biol Chem 273: 27879-27886, 1998
189. Young CN, Cao X, Guruju MR, Pierce JP, Morgan DA, Wang G, Iadecola C, Mark AL, and Davisson RL. ER stress in the brain subfornical organ mediates angiotensindependent hypertension. J Clin Invest 122: 3960-3964, 2012
190. Yu L, DeLeo FR, Biberstine-Kinkade KJ, Renee J, Nauseef WM, and Dinauer MC. Biosynthesis of flavocytochrome b558. gp91(phox) is synthesized as a 65-kDa precursor (p65) in the endoplasmic reticulum. J Biol Chem 274: 4364-4369, 1999
191. Yu L, Quinn MT, Cross AR, and Dinauer MC. Gp91(phox) is the heme binding subunit of the superoxide-generating NADPH oxidase. Proc Natl Acad Sci U S A 95: 7993-7998, 1998
192. Yu L, Zhen L, and Dinauer MC. Biosynthesis of the phagocyte NADPH oxidase cytochrome b558. Role of heme incorporation and heterodimer formation in maturation and stability of gp91phox and p22phox subunits. J Biol Chem 272: 27288-27294, 1997
193. Yun BW, Feechan A, Yin M, Saidi NB, Le Bihan T, Yu M, Moore JW, Kang JG, Kwon E, Spoel SH, Pallas JA, and Loake GJ. S-nitrosylation of NADPH oxidase regulates cell death in plant immunity. Nature 478: 264-268, 2011
194. Zhang F, Jin S, Yi F, Xia M, Dewey WL, and Li PL. Local production of O2-by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: CADPRmediated Ca2 + regulation. Cell Signal 20: 637-644, 2008
195. Zhang K and Kaufman RJ. From endoplasmic-reticulum stress to the inflammatory response. Nature 454: 455-462, 2008
196. Zhang L, Nguyen MV, Lardy B, Jesaitis AJ, Grichine A, Rousset F, Talbot M, Paclet MH, Qian G, and Morel F. New insight into the Nox4 subcellular localization in HEK293 cells: First monoclonal antibodies against Nox4. Biochimie 93: 457-468, 2011
197. Zhang M, Brewer AC, Schröder K, Santos CX, Grieve DJ, Wang M, Anilkumar N, Yu B, Dong X, Walker SJ, Brandes RP, and Shah AM. NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc Natl Acad Sci U S A 107: 18121-18126, 2010
198. Zhang Y and Ren J. Thapsigargin triggers cardiac contractile dysfunction via NADPH oxidase-mediated mitochondrial dysfunction: Role of Akt dephosphorylation. Free Radic Biol Med 51: 2172-2184, 2011
199. Zhu Y, Marchal CC, Casbon AJ, Stull N, von Löhneysen K, Knaus UG, Jesaitis AJ, McCormick S, Nauseef WM, and Dinauer MC. Deletion mutagenesis of p22phox subunit of flavocytochrome b558: Identification of regions critical for gp91phox maturation and NADPH oxidase activity. J Biol Chem 281: 30336-30346, 2006
200. Zimmerman MC, Takapoo M, Jagadeesha DK, Stanic B, Banfi B, Bhalla RC, and Miller FJ, Jr. Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells. Hypertension 58: 446-453, 2011
201. Zito E, Melo EP, Yang Y, Wahlander A , Neubert TA, and Ron D. Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin. Mol Cell 40: 787-797, 2010