Endoplasmic Reticulum Thiol Oxidase Deficiency Leads to Ascorbic Acid Depletion and Noncanonical Scurvy in Mice

Molecular Cell

Volumn 48, Issue 1, 2012, Pages 39-51

  Zito, Ester ^a   Hansen, Henning Gram ^a,c   Yeo, Giles S H ^a   Fujii, Junichi ^b   Ron, David ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b YAMAGATA UNIVERSITY   (Japan)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ASCORBIC ACID; CYSTEINYL SULFENIC ACID; DISULFIDE; ENDOPLASMIC RETICULUM THIOL OXIDASE; ENDOPLASMIC RETICULUM THIOL OXIDASE 1ALPHA; ENDOPLASMIC RETICULUM THIOL OXIDASE 1BETA; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; HYDROGEN PEROXIDE; HYDROXYPROLINE; PEROXIREDOXIN 4; PROCOLLAGEN; PROCOLLAGEN 4 HYDROXYPROLINE; SULFENIC ACID DERIVATIVE; THIOL DERIVATIVE; THIOL OXIDASE; TUBULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISULFIDE BOND; ENDOPLASMIC RETICULUM THIOL OXIDASE DEFICIENCY; ENZYME DEFICIENCY; EXTRACELLULAR MATRIX; GENE MUTATION; HYDROXYLATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN MODIFICATION; PROTEIN SECRETION; SCURVY;

ANIMALS; ASCORBIC ACID; CELLS, CULTURED; CONNECTIVE TISSUE; DISEASE MODELS, ANIMAL; DISULFIDES; ENDOPLASMIC RETICULUM; FEMALE; GLYCOPROTEINS; MALE; MICE; MICE, MUTANT STRAINS; MUTATION; OXIDATION-REDUCTION; OXIDOREDUCTASES; PEROXIREDOXINS; PROCOLLAGEN; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; SCURVY; SULFENIC ACIDS; TRANSFORMING GROWTH FACTOR BETA;

MUS;

EID: 84867395326     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.08.010     Document Type: Article

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