Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations

Journal of Nutritional Biochemistry

Volumn 38, Issue , 2016, Pages 154-161

  Castro Acosta, Monica L ^a   Smith, Leanne ^a   Miller, Rosalind J ^b   McCarthy, Danielle I ^c   Farrimond, Jonathan A ^c   Hall, Wendy L ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c SUNTORY LTD   (Japan)

Author keywords

Anthocyanins; Berries; Incretins; Insulin; Polyphenols; Postprandial glycemia; Randomized controlled trial

Indexed keywords

8 ISOPROSTANE; 8 ISOPROSTANE F2ALPHA; ANTHOCYANIN; BLACK CURRANT EXTRACT; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INCRETIN; INSULIN; PLACEBO; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; PLANT EXTRACT;

ADULT; ANTIDIABETIC ACTIVITY; ARTERIAL STIFFNESS; ARTICLE; BEVERAGE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; GLUCOSE BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; INCRETIN BLOOD LEVEL; INJECTION SITE DISCOMFORT; INSULIN BLOOD LEVEL; INSULINEMIA; MALE; MIDDLE AGED; PATIENT COMPLIANCE; POSTPRANDIAL STATE; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; ANALYSIS; ANTAGONISTS AND INHIBITORS; BLOOD; CARBOHYDRATE LOADING DIET; CHEMISTRY; CLINICAL TRIAL; COMPARATIVE STUDY; FRUIT; FUNCTIONAL FOOD; HYPERGLYCEMIA; HYPERINSULINISM; LOW CARBOHYDRATE DIET; MEAL; METABOLISM; RIBES; SECRETION (PROCESS);

ADULT; ANTHOCYANINS; BEVERAGES; BLOOD GLUCOSE; CROSS-OVER STUDIES; DIET, CARBOHYDRATE LOADING; DIET, CARBOHYDRATE-RESTRICTED; DOUBLE-BLIND METHOD; FEMALE; FRUIT; FUNCTIONAL FOOD; HUMANS; HYPERGLYCEMIA; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; INCRETINS; MALE; MEALS; MIDDLE AGED; PLANT EXTRACTS; POSTPRANDIAL PERIOD; RIBES;

EID: 84992493130     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2016.09.002     Document Type: Article

References (37)

1. [1] Chong, M.F., Macdonald, R., Lovegrove, J.A., Fruit polyphenols and CVD risk: a review of human intervention studies. Br J Nutr 104:Suppl. 3 (2010), S28–S39.
2. [2] Rothwell, J.A., Pérez-Jiménez, J., Neveu, V., Medina-Ramon, A., M'Hiri, N., Garcia Lobato, P., et al. Phenol-explorer 3.0: a major update of the phenol-explorer database to incorporate data on the effects of food processing on polyphenol content. Database, 2013.
3. [3] Cassidy, A., O'Reilly, E.J., Kay, C., Sampson, L., Franz, M., Forman, J.P., et al. Habitual intake of flavonoid subclasses and incident hypertension in adults. Am J Clin Nutr 93 (2011), 338–347.
4. [4] Jennings, A., Welch, A.A., Fairweather-Tait, S.J., Kay, C., Minihane, A.M., Chowienczyk, P., et al. Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women. Am J Clin Nutr 96 (2012), 781–788.
5. [5] Jennings, A., Welch, A.A., Spector, T., Macgregor, A., Cassidy, A., Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women. J Nutr 144 (2014), 202–208.
6. [6] Mursu, J., Virtanen, J.K., Tuomainen, T.P., Nurmi, T., Voutilainen, S., Intake of fruit, berries, and vegetables and risk of type 2 diabetes in Finnish men: the Kuopio Ischaemic heart disease risk factor study. Am J Clin Nutr 99 (2014), 328–333.
7. [7] Adisakwattana, S., Ngamrojanavanich, N., Kalampakorn, K., Tiravanit, W., Roengsumran, S., Yibchok-Anun, S., Inhibitory activity of cyanidin-3-rutinoside on alpha-glucosidase. J Enzyme Inhib Med Chem 19 (2004), 313–316.
8. [8] Akkarachiyasit, S., Charoenlertkul, P., Yibchok-Anun, S., Adisakwattana, S., Inhibitory activities of Cyanidin and its glycosides and synergistic effect with Acarbose against intestinal alpha-glucosidase and pancreatic alpha-amylase. Int J Mol Sci 11 (2010), 3387–3396.
9. [9] Akkarachiyasit, S., Yibchok-Anun, S., Wacharasindhu, S., Adisakwattana, S., In vitro inhibitory effects of cyandin-3-rutinoside on pancreatic alpha-amylase and its combined effect with acarbose. Molecules 16 (2011), 2075–2083.
10. [10] McDougall, G.J., Kulkarni, N.N., Stewart, D., Current developments on the inhibitory effects of berry polyphenols on digestive enzymes. Biofactors 34 (2008), 73–80.
11. [11] Adisakwattana, S., Yibchok-Anun, S., Charoenlertkul, P., Wongsasiripat, N., Cyanidin-3-rutinoside alleviates postprandial hyperglycemia and its synergism with acarbose by inhibition of intestinal alpha-glucosidase. J Clin Biochem Nutr 49 (2011), 36–41.
12. [12] Manzano, S., Williamson, G., Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells. Mol Nutr Food Res 54 (2010), 1773–1780.
13. [13] Grussu, D., Stewart, D., McDougall, G.J., Berry polyphenols inhibit alpha-amylase in vitro: identifying active components in rowanberry and raspberry. J Agric Food Chem 59 (2011), 2324–2331.
14. [14] Torronen, R., Kolehmainen, M., Sarkkinen, E., Poutanen, K., Mykkanen, H., Niskanen, L., Berries reduce postprandial insulin responses to wheat and rye breads in healthy women. J Nutr 143 (2013), 430–436.
15. [15] Torronen, R., Kolehmainen, M., Sarkkinen, E., Mykkanen, H., Niskanen, L., Postprandial glucose, insulin, and free fatty acid responses to sucrose consumed with blackcurrants and lingonberries in healthy women. Am J Clin Nutr 96 (2012), 527–533.
16. [16] Torronen, R., Sarkkinen, E., Niskanen, T., Tapola, N., Kilpi, K., Niskanen, L., Postprandial glucose, insulin and glucagon-like peptide 1 responses to sucrose ingested with berries in healthy subjects. Br J Nutr 107 (2012), 1445–1451.
17. [17] Torronen, R., Sarkkinen, E., Tapola, N., Hautaniemi, E., Kilpi, K., Niskanen, L., Berries modify the postprandial plasma glucose response to sucrose in healthy subjects. Br J Nutr 103 (2010), 1094–1097.
18. [18] Edirisinghe, I., Banaszewski, K., Cappozzo, J., Sandhya, K., Ellis, C.L., Tadapaneni, R., et al. Strawberry anthocyanin and its association with postprandial inflammation and insulin. Br J Nutr 106 (2011), 913–922.
19. [19] Ceriello, A., Esposito, K., Piconi, L., Ihnat, M.A., Thorpe, J.E., Testa, R., et al. Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes 57 (2008), 1349–1354.
20. [20] Williams, S.B., Goldfine, A.B., Timimi, F.K., Ting, H.H., Roddy, M.A., Simonson, D.C., et al. Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation 97 (1998), 1695–1701.
21. [21] Hall, W.L., Sanders, K.A., Sanders, T.A., Chowienczyk, P.J., A high-fat meal enriched with eicosapentaenoic acid reduces postprandial arterial stiffness measured by digital volume pulse analysis in healthy men. J Nutr 138 (2008), 287–291.
22. [22] Chiasson, J.L., Josse, R.G., Gomis, R., Hanefeld, M., Karasik, A., Laakso, M., et al. Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet 359 (2002), 2072–2077.
23. [23] Törrönen, R., McDougall, G.J., Dobson, G., Stewart, D., Hellström, J., Mattila, P., et al. Fortification of blackcurrant juice with crowberry: impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects. J Funct Foods 4 (2012), 746–756.
24. [24] Williamson, G., Possible effects of dietary polyphenols on sugar absorption and digestion. Mol Nutr Food Res 57 (2013), 48–57.
25. [25] Kwon, O., Eck, P., Chen, S., Corpe, C.P., Lee, J.H., Kruhlak, M., et al. Inhibition of the intestinal glucose transporter GLUT2 by flavonoids. FASEB J 21 (2007), 366–377.
26. [26] Smith, C.D., Hirayama, B.A., Wright, E.M., Baculovirus-mediated expression of the Na+/glucose cotransporter in Sf9 cells. Biochim Biophys Acta 1104 (1992), 151–159.
27. [27] Wright, E.M., Loo, D.D., Hirayama, B.A., Biology of human sodium glucose transporters. Physiol Rev 91 (2011), 733–794.
28. [28] Gorboulev, V., Schurmann, A., Vallon, V., Kipp, H., Jaschke, A., Klessen, D., et al. Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes 61 (2012), 187–196.
29. [29] Mace, O.J., Schindler, M., Patel, S., The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine. J Physiol 590 (2012), 2917–2936.
30. [30] Moriya, R., Shirakura, T., Ito, J., Mashiko, S., Seo, T., Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice. Am J Phys Endocrinol Metab 297 (2009), E1358–E1365.
31. [31] Rodriguez-Mateos, A., Rendeiro, C., Bergillos-Meca, T., Tabatabaee, S., George, T.W., Heiss, C., et al. Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. Am J Clin Nutr 98 (2013), 1179–1191.
32. [32] Jin, Y., Alimbetov, D., George, T., Gordon, M.H., Lovegrove, J.A.A., randomised trial to investigate the effects of acute consumption of a blackcurrant juice drink on markers of vascular reactivity and bioavailability of anthocyanins in human subjects. Eur J Clin Nutr 65 (2011), 849–856.
33. [33] Czank, C., Cassidy, A., Zhang, Q., Morrison, D.J., Preston, T., Kroon, P.A., et al. Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13)C-tracer study. Am J Clin Nutr 97 (2013), 995–1003.
34. [34] Manach, C., Williamson, G., Morand, C., Scalbert, A., Rémésy, C., Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81 (2005), 230S–242S.
35. [35] Rechner, A.R., Kuhnle, G., H, H., Roedig-Penman, A., van den Braak, M.H., Moore, K.P., et al. The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites. Free Radic Res 36 (2002), 1229–1241.
36. [36] Ceriello, A., Postprandial hyperglycemia and diabetes complications: is it time to treat?. Diabetes 54 (2005), 1–7.
37. [37] Brennan, I.M., Feltrin, K.L., Nair, N.S., Hausken, T., Little, T.J., Gentilcore, D., et al. Effects of the phases of the menstrual cycle on gastric emptying, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women. Am J Physiol Gastrointest Liver Physiol 297 (2009), G602–G610.