Proteolytic processing of middle east respiratory syndrome coronavirus spikes expands virus tropism

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 43, 2016, Pages 12262-12267

  Park, Jung Eun ^a   Li, Kun ^b   Barlan, Arlene ^a   Fehr, Anthony R ^c   Perlman, Stanley ^b,c   McCray, Paul B ^b,c   Gallagher, Tom ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

Coronavirus; Protease; Receptor; Virus entry

Indexed keywords

CATHEPSIN L; CORONAVIRUS SPIKE GLYCOPROTEIN; PROTEINASE; VITRONECTIN;

AIRWAY EPITHELIAL CELL; CELL SURFACE; CONFERENCE PAPER; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENDOSOME; HUMAN; HUMAN CELL; LUNG INFECTION; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN SECRETION; RECEPTOR BINDING; SEVERE ACUTE RESPIRATORY SYNDROME; VIRAL TROPISM; VIRUS ENTRY; VIRUS VIRULENCE; CORONAVIRUS INFECTION; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; LUNG; PATHOGENICITY; PATHOLOGY; VIRION; VIROLOGY;

CORONAVIRUS INFECTIONS; GENE EXPRESSION REGULATION, VIRAL; HUMANS; LUNG; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MUTATION; PROTEOLYSIS; SPIKE GLYCOPROTEIN, CORONAVIRUS; VIRAL TROPISM; VIRION; VIRUS INTERNALIZATION;

EID: 84992315704     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1608147113     Document Type: Article

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